非接觸式平板天線型生物感測器之設計與應用

Abstract

微波天線型感測器具有下列優異的特性-無需螢光與化學標記、即時檢測的技術、較低的樣本損害與在使用上不會對環境造成污染，因此近年來在感測器領域上，吸引了不少研究人員的高度興趣。在本研究中，我們的設計新穎之處為利用了超穎材料(metamaterial)與傳輸線概念的平面矩形天線型感測器，並提出利用天線背部接地面上的開口來作為一靈敏的感測區。透過多次實驗不僅證實了此天線型感測器具有體積小、工作頻率低、即時偵測、免標記、靈敏度高與低成本等優點，此外也指出了此天線型感測器在量測時不易受到環境的干擾，能有效的判別物質的介電係數與損耗正切。 在本研究中，我們亦量測一些液體樣本與固體樣本做為未來應用的範例，液體樣本如不同濃度的乙醇與甲醇、不同廠牌的紅酒與威士忌等，固體樣本如豬肉與洋菜膠。這些實驗中證實了此天線型感測器會因為物質不同的含水量或不同的成份，導致天線的共振頻率與匹配度產生變化。本實驗說明了未來以微波的架構作為感測器不僅承襲了傳統型感測器的優點，更進一步的改善了傳統型感測器的限制，使得感測器的應用變得更加廣闊，此為本研究最大的貢獻也是致力完成的目標。

The outstanding properties of microwave antenna sensor have drawn much attention in recent years. It provides numerous advantages, including real-time detection, and little sample for consumption. Since microwave antenna sensor does not require fluorescence and chemical markers labeling, and it does not cause environmental pollution. Utilizing a novel transmission line design, we have devised a patch antenna biosensor with metamaterial property in this study. A slot was fabricated on the backside of the antenna as an ultra sensitive sensing area. The sensors that we designed have been proven, through repeatable experiments, shown several advantages such as small size, low frequency, real-time, label free, sensitive and low cost. The measured results indicate that antenna sensor can effectively determine the permittivity and loss tangent, without being affected by environmental disturbances. In this study, we explored some of the possible future applications by measuring some liquid and solid samples. The liquid samples include not only ethanol and methanol in different concentrations but also red wine and whiskey from different manufacturers. The samples of solid included pork and agarose. These experiments confirmed the antenna sensor is capable of detecting the difference in either moisture contents or components of the materials on sensing area, by the change of the resonant frequency and matching degree. These experiments demonstrated that using composite structure for microwave as antenna sensor not only benefit from its advantages but also breaks the limits of traditional sensors. These results broaden the possible applications of microwave antenna.