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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝松蒼 | |
dc.contributor.author | Liang-Yi Chang | en |
dc.contributor.author | 張良伊 | zh_TW |
dc.date.accessioned | 2021-06-17T00:13:56Z | - |
dc.date.available | 2017-09-18 | |
dc.date.copyright | 2012-09-18 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-07-09 | |
dc.identifier.citation | References
Ahn, M., Moon, C., Lee, Y., Koh, C.S., Kohyama, K., Tanuma, N., Matsumoto, Y., Kim, H.M., Kim, S.R., Shin, T., 2004. Activation of extracellular signal-regulated kinases in the sciatic nerves of rats with experimental autoimmune neuritis. Neuroscience letters. 372, 57-61. Avellino, A.M., Hart, D., Dailey, A.T., MacKinnon, M., Ellegala, D., Kliot, M., 1995. Differential macrophage responses in the peripheral and central nervous system during wallerian degeneration of axons. Exp Neurol. 136, 183-98. Bahadori, M.H., Al-Tiraihi, T., Valojerdi, M.R., 2001. Sciatic nerve transection in neonatal rats induces apoptotic neuronal death in L5 dorsal root ganglion. J Neurocytol. 30, 125-30. Baser, S.M., Meer, J., Polinsky, R.J., Hallett, M., 1991. Sudomotor function in autonomic failure. Neurology. 41, 1564-6. Biemond, A., Beck, W., 1955. neural muscle atrophy with degeneration of the substantia nigra. Confin Neurol. 15, 142-53. Bloomgarden, Z.T., 2008. Diabetic nephropathy. Diabetes Care. 31, 823-7. Brigger, D., Muckle, R.J., 1975. Comparison of Sirius red and Congo red as stains for amyloid in animal tissues. J Histochem Cytochem. 23, 84-8. Bronaugh, R.L., Stewart, R.F., Congdon, E.R., 1982. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol Appl Pharmacol. 62, 481-8. Carr, P.A., Haftel, V., Alvarez, F.J., Cope, T.C., Fyffe, R.E., 1998. Effect of sciatic nerve transection or TTX application on enzyme activity in rat spinal cord. Neuroreport. 9, 357-61. Ceccatelli, S., Villar, M.J., Goldstein, M., Hokfelt, T., 1989. Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress. Proceedings of the National Academy of Sciences of the United States of America. 86, 9569-73. Colin, J., Houdas, Y., 1965. Initiation of sweating in man after abrupt rise in environmental temperature. J Appl Physiol. 20, 984-90. Corrow, K.A., Vizzard, M.A., 2007. Phosphorylation of extracellular signal-regulated kinases in urinary bladder in rats with cyclophosphamide-induced cystitis. Am J Physiol Regul Integr Comp Physiol. 293, R125-34. Cui, C.Y., Childress, V., Piao, Y., Michel, M., Johnson, A.A., Kunisada, M., Ko, M.S., Kaestner, K.H., Marmorstein, A.D., Schlessinger, D., 2012. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proceedings of the National Academy of Sciences of the United States of America. 109, 1199-203. Dale, H.H., Feldberg, W., 1934. The chemical transmission of secretory impulses to the sweat glands of the cat. J Physiol. 82, 121-8. Dalsgaard, C.J., Jonsson, C.E., Hokfelt, T., Cuello, A.C., 1983. Localization of substance P-immunoreactive nerve fibers in the human digital skin. Experientia. 39, 1018-20. Dalsgaard, C.J., Bjorklund, H., Jonsson, C.E., Hermansson, A., Dahl, D., 1984. Distribution of neurofilament-immunoreactive nerve fibers in human skin. Histochemistry. 81, 111-4. Diem, P., Laederach-Hofmann, K., Navarro, X., Mueller, B., Kennedy, W.R., Robertson, R.P., 2003. Diagnosis of diabetic autonomic neuropathy: a multivariate approach. European Journal of Clinical Investigation. 33, 693-697. Dobson, R.L., Sato, K., 1972. The secretion of salt and water by the eccrine sweat gland. Arch Dermatol. 105, 366-70. Donadio, V., Cortelli, P., Elam, M., Di Stasi, V., Montagna, P., Holmberg, B., Giannoccaro, M.P., Bugiardini, E., Avoni, P., Baruzzi, A., Liguori, R., 2010. Autonomic innervation in multiple system atrophy and pure autonomic failure. J Neurol Neurosurg Psychiatry. 81, 1327-35. Ebling, F.J., 1989. Apocrine glands in health and disorder. Int J Dermatol. 28, 508-11. Fawcett, J.W., Keynes, R.J., 1990. Peripheral nerve regeneration. Annu Rev Neurosci. 13, 43-60. Fink, D.J., Purkiss, D., Mata, M., 1987. Retrograde axonal transport in rat sciatic nerve after nerve crush injury. Brain Res Bull. 19, 29-33. Gibbons, C.H., Illigens, B.M., Wang, N., Freeman, R., 2009. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 72, 1479-86. Giorgadze, T.A., Shiina, N., Baloch, Z.W., Tomaszewski, J.E., Gupta, P.K., 2004. Improved detection of amyloid in fat pad aspiration: an evaluation of Congo red stain by fluorescent microscopy. Diagn Cytopathol. 31, 300-6. Giovannelli, L., Casamenti, F., Pepeu, G., 1998. C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals. J Neural Transm. 105, 935-48. Grant, M.P., Francis, N.J., Landis, S.C., 1995. The role of acetylcholine in regulating secretory responsiveness in rat sweat glands. Mol Cell Neurosci. 6, 32-42. Hall, S.M., 1989. Regeneration in the peripheral nervous system. Neuropathol Appl Neurobiol. 15, 513-29. Heim, O.E., Jr., 1955. The sweat gland in health and disease. Med Bull US Army Eur. 12, 121-3. Heumann, R., Korsching, S., Bandtlow, C., Thoenen, H., 1987. Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection. J Cell Biol. 104, 1623-31. Hoffman, G.E., Smith, M.S., Verbalis, J.G., 1993. c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol. 14, 173-213. Hongpaisan, J., Molander, C., 1993. The distribution of C-Fos protein immunolabeled cells in the spinal cord of the rat after electrical and noxious thermal stimulation following sciatic nerve crush, or transection and repair. Restor Neurol Neurosci. 5, 249-61. Hota, D., Bansal, V., Pattanaik, S., 2007. Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find Exp Clin Pharmacol. 29, 443-6. Hsieh, S.T., Chiang, H.Y., Lin, W.M., 2000. Pathology of nerve terminal degeneration in the skin. J Neuropathol Exp Neurol. 59, 297-307. Hsieh, Y.L., Chiang, H., Tseng, T.J., Hsieh, S.T., 2008. Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy. J Neuropathol Exp Neurol. 67, 93-104. Hsieh, Y.L., Lin, W.M., Lue, J.H., Chang, M.F., Hsieh, S.T., 2009. Effects of 4-methylcatechol on skin reinnervation: promotion of cutaneous nerve regeneration after crush injury. J Neuropathol Exp Neurol. 68, 1269-81. Ikeda, S., Nakagawa, S., 1998. Spinal cord transection induced c-fos protein in the rat motor cortex. Brain Res. 792, 164-7. Ji, R.R., Baba, H., Brenner, G.J., Woolf, C.J., 1999. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci. 2, 1114-9. Ji, R.R., Befort, K., Brenner, G.J., Woolf, C.J., 2002. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22, 478-85. Johnson, K.G., 1973. Sweat storage as a factor influencing sweat discharge in sheep. J Physiol. 235, 523-34. Karim, F., Wang, C.C., Gereau, R.W.t., 2001. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21, 3771-9. Kennedy, W.R., Sakuta, M., Sutherland, D., Goetz, F.C., 1984. Quantitation of the sweating deficiency in diabetes mellitus. Annals of Neurology. 15, 482-488. Kennedy, W.R., Navarro, X., 1989. Sympathetic sudomotor function in diabetic neuropathy. Arch Neurol. 46, 1182-6. Kim, S.H., Chung, J.M., 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50, 355-63. Kondo, T., Ohshima, T., Sato, Y., Mayama, T., Eisenmenger, W., 2000. Immunohistochemical study on the expression of c-Fos and c-Jun in human skin wounds. Histochem J. 32, 509-14. Lee, S.S., Lee, S.H., Han, S.H., 2003. Terminal changes in hereditary sensory and autonomic neuropathy: a long-term follow-up of a sporadic case. Clin Neurol Neurosurg. 105, 175-9. Lindenlaub, T., Sommer, C., 2004. Partial sciatic nerve transection. Methods Mol Med. 99, 47-53. Luo, K.R., Chao, C.C., Chen, Y.T., Huang, C.M., Yang, N.C., Kan, H.W., Wang, S.H., Yang, W.S., Hsieh, S.T., 2011. Quantitation of sudomotor innervation in skin biopsies of patients with diabetic neuropathy. J Neuropathol Exp Neurol. 70, 930-8. Luo, K.R., Chao, C.C., Hsieh, P.C., Lue, J.H., Hsieh, S.T., 2012. Effect of glycemic control on sudomotor denervation in type 2 diabetes. Diabetes Care. 35, 612-6. Ma, W., Quirion, R., 2005. The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert Opin Ther Targets. 9, 699-713. Manganelli, F., Iodice, V., Provitera, V., Pisciotta, C., Nolano, M., Perretti, A., Santoro, L., 2007. Small-fiber involvement in spinobulbar muscular atrophy (Kennedy's disease). Muscle Nerve. 36, 816-20. Mitchell, J., Greenspan, J., Daniels, T., Whitcher, J.P., Maibach, H.I., 1987. Anhidrosis (hypohidrosis) in Sjogren's syndrome. Journal of the American Academy of Dermatology. 16, 233-5. Miyazoe, S., Matsuo, H., Ohnishi, A., Tajima, F., Fujishita, S., Ichinose, K., Shibuya, N., 1998. Acquired idiopathic generalized anhidrosis with isolated sudomotor neuropathy. Ann Neurol. 44, 378-81. Moon, C., Ahn, M., Kim, H., Lee, Y., Koh, C.S., Matsumoto, Y., Shin, T., 2005. Activation of p38 mitogen-activated protein kinase in the early and peak phases of autoimmune neuritis in rat sciatic nerves. Brain Res. 1040, 208-13. Nakazato, Y., Tamura, N., Ohkuma, A., Yoshimaru, K., Shimazu, K., 2004. Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. Neurology. 63, 1476-80. Nejsum, L.N., Praetorius, J., Nielsen, S., 2005. NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands. Am J Physiol Cell Physiol. 289, C333-40. Noguchi, K., Obata, K., Dai, Y., 2004. Changes in DRG neurons and spinal excitability in neuropathy. Novartis Found Symp. 261, 103-10; discussion 110-5, 149-54. Nolano, M., Provitera, V., Caporaso, G., Stancanelli, A., Vitale, D.F., Santoro, L., 2010. Quantification of pilomotor nerves: a new tool to evaluate autonomic involvement in diabetes. Neurology. 75, 1089-97. Nonaka, I., Miyazawa, M., Sukegawa, T., Yonemoto, K., Kato, T., 1997. Muscle fiber atrophy and degeneration induced by experimental immobility and hindlimb suspension. Int J Sports Med. 18 Suppl 4, S292-4. Obata, K., Noguchi, K., 2004. MAPK activation in nociceptive neurons and pain hypersensitivity. Life sciences. 74, 2643-53. Perry, V.H., Brown, M.C., 1992. Role of macrophages in peripheral nerve degeneration and repair. Bioessays. 14, 401-6. Puchtler, H., Sweat, F., 1965. Congo red as a stain for fluorescence microscopy of amyloid. J Histochem Cytochem. 13, 693-4. Pyykonen, I., Koistinaho, J., 1991. c-fos protein like immunoreactivity in non-neuronal cells of rat peripheral nerve after transection. Acta Neuropathol. 82, 66-71. Quick, D.C., Kennedy, W.R., Yoon, K.S., 1984. Ultrastructure of the secretory epithelium, nerve fibers, and capillaries in the mouse sweat gland. Anat Rec. 208, 491-9. Roosterman, D., Goerge, T., Schneider, S.W., Bunnett, N.W., Steinhoff, M., 2006. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev. 86, 1309-79. Ruggiero, D.A., Anwar, M., Kim, J., Sica, A.L., Gootman, N., Gootman, P.M., 1997. Induction of c-fos gene expression by spinal cord transection in the rat. Brain Res. 763, 21-9. Said, G., 2007. Diabetic neuropathy--a review. Nat Clin Pract Neurol. 3, 331-40. Samorajski, T., 1957. Changes in phosphatase activity following transection of the sciatic nerve. J Histochem Cytochem. 5, 15-27. Sato, K., Kang, W.H., Saga, K., Sato, K.T., 1989. Biology of sweat glands and their disorders. I. Normal sweat gland function. Journal of the American Academy of Dermatology. 20, 537-63. Sheu, J.Y., Kulhanek, D.J., Eckenstein, F.P., 2000. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol. 166, 392-402. Stevens, L.M., Landis, S.C., 1987. Development and properties of the secretory response in rat sweat glands: relationship to the induction of cholinergic function in sweat gland innervation. Developmental Biology. 123, 179-90. Sweatt, J.D., 2001. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem. 76, 1-10. Thomson, C.E., Mitchell, L.S., Griffiths, I.R., Morrison, S., 1991. Retarded Wallerian degeneration following peripheral nerve transection in C57BL/6/Ola mice is associated with delayed down-regulation of the P0 gene. Brain Res. 538, 157-60. Tseng, M.T., Hsieh, S.C., Shun, C.T., Lee, K.L., Pan, C.L., Lin, W.M., Lin, Y.H., Yu, C.L., Hsieh, S.T., 2006. Skin denervation and cutaneous vasculitis in systemic lupus erythematosus. Brain. 129, 977-85. Vilches, J.J., Ceballos, D., Verdu, E., Navarro, X., 2002. Changes in mouse sudomotor function and sweat gland innervation with ageing. Autonomic neuroscience : basic & clinical. 95, 80-7. Wang, H., Dai, Y., Fukuoka, T., Yamanaka, H., Obata, K., Tokunaga, A., Noguchi, K., 2004. Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury. Eur J Neurosci. 19, 884-90. Zhang, L., Haraguchi, S., Koda, T., Hashimoto, K., Nakagawara, A., 2011. Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice. J Biomed Biotechnol. 2011, 831092. Zhao, S., Pang, Y., Beuerman, R.W., Thompson, H.W., Kline, D.G., 1998. Expression of c-Fos protein in the spinal cord after brachial plexus injury: comparison of root avulsion and distal nerve transection. Neurosurgery. 42, 1357-62; discussion 1362-3. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65864 | - |
dc.description.abstract | 失去分泌汗液功能是數個神經病變中的重要指標之一,例如:自主神經病變和糖尿病神經病變等。在之前的研究中,我們的實驗室已經建立了一套以面積為基準的支配汗腺神經定量方法,去探討在人類糖尿病的神經病變中,支配汗腺的神經分布,稱做汗腺神經支配指數〈SGII〉。而此篇研究旨在﹝1﹞研究神經損傷之後,汗腺的支配神經分布﹝2﹞探究分泌汗液的神經退化,對於汗腺的影響。我們利用大鼠為動物模式,橫斷坐骨神經至第七天的手術,發現在第七天的神經橫斷時,坐骨神經的神經纖維,從遠端到截斷處都已完全退化,我們利用坐骨神經的半薄片染色以及神經傳導的實驗去驗證。汗腺神經支配指數〈SGII〉的數值在手術側有明顯的下降﹝0.146 ± 0.011 vs. 0.015 ± 0.003, p < 0.0001﹞,而同樣的結果,也在表皮神經纖維密度〈IENFD〉實驗中被發現。
在肌肉的神經退化研究中,肌肉萎縮是一個眾所皆知的現象和問題。進一步,我們探討汗腺的萎縮,是否會在神經退化的情況下發生。在坐骨神經截斷兩週的老鼠腳掌上,我們發現分泌汗腺的管壁,在手術側有明顯變薄﹝0.215 ± 0.015 vs. 0.163 ± 0.004 μm, p = 0.032﹞同樣地,分泌汗腺管壁内徑與管壁直徑的比值,是在手術側增加的﹝0.160 ± 0.005 v.s. 0.270 ± 0.025μm, p = 0.013﹞這些觀察顯示,神經截斷導致的汗腺萎縮情形,是因汗腺分泌管壁的增加所造成。 我們進一步探討泌汗神經退化的相關分子機制,我們發現磷酸化的細胞外訊息轉導酶﹝pERK﹞的免疫反應和神經纖維結構蛋白﹝PGP9.5﹞會在相同的位置表現,且在神經截斷之後有顯的減少。另一方面,我們發現轉錄因子﹝c-fos﹞的免疫反應,會在神經退化後在汗腺的管壁上,有顯著的增加。 | zh_TW |
dc.description.abstract | Sudomotor failure is an important presentation of several neuropathies, such as autonomic neuropathy and diabetic neuropathy. In previous studies, our lab has established an area-based morphometry to quantify sweat gland innervations in human diabetic neuropathy, called sweat gland innervations index (SGII). This study aimed (1) to examine sweat gland innervation after nerve injury and (2) to explore the effect of sudomotor denervation on sweat glands. We applied a transection model of the sciatic nerve on rats. On day 7 of transection, nerve fibers distal to the transection were completely degenerated as validated with on semi-thin sections of the sciatic nerve and nerve conduction studies. Values of sweat gland innervations index (SGII) were significantly reduced (0.146 ± 0.011 vs. 0.015 ± 0.003, p < 0.0001). So was intra-epidermal nerve fiber density (IENFD) on operated side foot pad.
In denervation study on muscle, atrophy is one well known phenomena and issue. We then asked whether sweat gland atrophy occurred after denervation. Two weeks after sciatic nerve transection, the wall thickness of sweat gland coils was significantly reduced (0.215 ± 0.015 vs. 0.163 ± 0.004 μm, p = 0.032). Accordingly, the ratio of the lumen to the diameter of the sweat gland coil was increased (0.160 ± 0.005 v.s. 0.270 ± 0.025 μm, p = 0.013). These observations indicated nerve transection-induced targeted atrophy due to increase of sweat gland coil lumen. We, to investigate the molecular mechanism of denervation, further explored molecular candidates of sudomotor denervation. pERK-immunoreactivity was co-localized with protein gene product 9.5 (PGP9.5) but reduced after nerve transection. However, c-fos-immunoreactivity was increased in sweat gland coils after denervation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T00:13:56Z (GMT). No. of bitstreams: 1 ntu-101-R99446002-1.pdf: 1383403 bytes, checksum: bbc5628e08d758cc82d2ac5827e0b397 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 謝誌 I
中文摘要 II Abstract III Introduction 1 Material and Methods 5 Animal surgery 5 Immunohistochemistry of footpads 5 Neurophysiology of motor nerves 6 Semi-thin sections of sciatic nerve 6 Area-based morphometry of sweat gland innervation 7 Modification of SGII in rodent model 7 Quantification of epidermal innervation 8 Paraffin embedding and serious sections preparation 8 Quantification method of sweat gland atrophy 9 Statistical analysis 9 Results 11 Model of complete nerve degeneration, sciatic nerve transection 11 Sweat gland denervation in footpad of transection model 11 Sweat gland innervations index (SGII) and intra-epidermal nerve fiber density (IENFD) 12 Atrophy study of sweat gland 12 Reduction of pERK1/2 in denervated footpad 13 Colocalization of pERK1/2 and PGP9.5 in footpad of transection model 13 Increased colocalization of c-fos and NKCC1 in denervated footpad 14 Induced c-fos in cytoplasm of sweat gland cell 14 Discussion 15 References 20 Figures 29 | |
dc.language.iso | en | |
dc.title | 於囓齒類神經損傷時之汗腺神經退化研究 | zh_TW |
dc.title | Sweat gland denervation in rodent models of nerve injury | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江皓郁,曾拓榮,謝侑霖 | |
dc.subject.keyword | 汗腺,神經損傷,神經退化,萎縮,腳掌, | zh_TW |
dc.subject.keyword | Sweat gland,nerve injury,denervation,atrophy,footpad, | en |
dc.relation.page | 42 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-07-09 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
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