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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 楊偉勛(Wei-Shiung Yang) | |
dc.contributor.author | Wei-Che chen | en |
dc.contributor.author | 陳偉哲 | zh_TW |
dc.date.accessioned | 2021-05-17T09:14:41Z | - |
dc.date.available | 2012-09-19 | |
dc.date.available | 2021-05-17T09:14:41Z | - |
dc.date.copyright | 2012-09-19 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-15 | |
dc.identifier.citation | 1. McPherron AC, Lawler AM, S.J. L. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997;387:83-90.
2. Joulia-Ekaza D, Cabello G. Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects. Exp Cell Res 2006;312:2401-14. 3. Zimmers TA, Davies MV, Koniaris LG, et al. Induction of cachexia in mice by systemically administered myostatin. Science 2002;296:1486-8. 4. Liu CM, Yang Z, Liu CW, et al. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther 2008;15:155-60. 5. Dasarathy S, Dodig M, Muc SM, Kalhan SC, McCullough AJ. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Am J Physiol Gastrointest Liver Physiol 2004;287:G1124-30. 6. Hosoyama T, Tachi C, Yamanouchi K, Nishihara M. Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum. Zoolog Sci 2005;22:229-36. 7. Ma K, Mallidis C, Bhasin S, et al. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab 2003;285:E363-71. 8. Shyu KG, Lu MJ, Wang BW, Sun HY, Chang H. Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. Eur J Clin Invest 2006;36:713-9. 9. Hayot M, Rodriguez J, Vernus B, et al. Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli. Mol Cell Endocrinol 2011;332:38-47. 10. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, et al. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A 1998;95:14938-43. 11. George I, Bish LT, Kamalakkannan G, et al. Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur J Heart Fail 2010;12:444-53. 12. Han DS, Chen YM, Lin SY, et al. Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis. Clin Endocrinol (Oxf) 2011;75:857-63. 13. Duyff RF, Bosch JV, Laman DM, Loon BJP, Linssen WHJP. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. Journal of neurology, neurosurgery, and psychiatry 2000;68:700-5. 14. Carlson CJ, Booth FW, Gordon SE. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. The American journal of physiology 1999;277:R601-6. 15. Sakuma K, Watanabe K, Sano M, Uramoto I, Totsuka T. Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles. Biochimica et biophysica acta 2000;1497:77-88. 16. Baumann AP, Ibebunjo C, Grasser WA, Paralkar VM. Myostatin expression in age and denervation-induced skeletal muscle atrophy. Journal of musculoskeletal & neuronal interactions 2003;3:8-16. 17. Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. Journal of cellular biochemistry 2010;111:1059-73. 18. Carneiro I, Castro-Piedras I, Munoz A, Labandeira-Garcia JL, Devesa J, Arce VM. Hypothyroidism is associated with increased myostatin expression in rats. Journal of endocrinological investigation 2008;31:773-8. 19. Iglesias P, Bayon C, Mendez J, Gancedo PG, Grande C, Diez JJ. Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. Thyroid : official journal of the American Thyroid Association 2001;11:1043-8. 20. Duyff RF, Van den Bosch J, Laman DM, van Loon BJ, Linssen WH. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. Journal of neurology, neurosurgery, and psychiatry 2000;68:750-5. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6558 | - |
dc.description.abstract | 甲狀腺功能失調是最常見的內分泌疾病,甲狀腺功能亢進及甲狀腺功能低下都會造成肌肉病變及臨床上肌力的減退。本研究在於找出是否myostatin、follistatin及IGF-1是否參與甲狀腺功能失調所引發的肌肉病變,以及經過治療後肌肉力量的改善中myostatin pathway是否也有扮演重要的角色。
依診斷分為兩組::1.甲狀腺功能亢進之病患,甲狀腺功能亢進之定義為Free T4大於參考值及TSH小於參考值;2.對照組,甲狀腺功能正常,沒有排除條件者 於收案抽驗血液每次抽血量為10ml,檢驗Free T4、TSH。利用酵素免疫分析法(Enzyme-link immunosorbent assay, ELISA),來定量serum myostatin protein,及IGF-1。 實驗組中,甲狀腺功能亢進者接受口服抗甲狀腺藥物治療二十四週,甲狀腺功能亢進組以Carbimazole 每日5mg至30mg分一至三次使用,或Propylthiouracil每日50mg至300mg分一至三次使用。在試驗中持續使用,依患者狀況至少於每八週應抽血檢驗甲狀腺功能並回診,並依追蹤之血液free T4、TSH濃度調整劑量,完成試驗後應繼續治療。其間無禁止合併使用藥物。若治療24週未達成甲狀腺功能正常之個案可繼續進行抗甲狀腺口服藥物治療,或改以甲狀腺半全切除術(Subtotal thyroidectomy)治療,或放射碘治療。 對照組則在收案後完成抽血檢驗後結案。 檢驗項目:1.Myostatin及IGF-1需於接受治療前及接受治療後的第24週抽血時抽血檢驗;2. 於接受治療前及接受治療後的第24週抽血檢驗白蛋白(albumin)、天門冬胺酸轉胺酶(Aspartate aminotransferase, AST)、丙胺酸轉胺酶(Alanine amino-transferase ,ALT)與肌酸酐(Creatinine, Cre.)。 此研究包括24位甲狀腺機能亢進的患者以及31位對照組,對照組和實驗組以隨機的方式選取。甲狀腺機能亢進的患者相較甲狀腺正能的對照組血清的myostatin平均濃度沒有顯著差異但血清的IGF-1平均濃度增加。藥物治療二十四週後,血清的myostatin及IGF-1的平均濃度都沒有顯著改變。二十四個甲狀腺機能亢進的患者在藥物治療二十四週後,十一位個案血清的myostatin濃度減少而十三位個案為增加。 | zh_TW |
dc.description.abstract | Objectives: Myostatin, a negative regulator of skeletal muscle growth, may modulate muscle in myopathy after development.
Background: Both hypothyroidism and hyperthyroidism may cause signs and symptoms of neuromuscular dysfunction. We hypothesized that serum myostatin level might be related to myopathy in hyperthyroidism. Method: We measure serum myostatin level in patients with hyperthyroidism and normal control, and check serum myostatin again after anti-thyroid drugs used in patients with hyperthyroidism for 24 weeks. . Results There is no elevation of serum myostatin level but elevated serum IGF-1 level, compared to euthyroidism. After anti-thyroid medication for 24 weeks, no significant increase of serum myostatin protein levels was found and the serum IGF-1 level also had no obvious change. 11 of 24 patients have decrease of serum myostatin protein levels after medication for 24 weeks Conclusions: There are no changes in myostatin level before and after medication. Serum IGF-1 increase in patients with hyperthyroidism and no change after treatment. Advanced measurement of serum and muscle myostatin protein, myostatin mRNA, follistatin and other muscle related markers in more cases could be done. | en |
dc.description.provenance | Made available in DSpace on 2021-05-17T09:14:41Z (GMT). No. of bitstreams: 1 ntu-101-P99421009-1.pdf: 484511 bytes, checksum: 9d6a3c42b64aee073fcd2ee8adc7d17a (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 致謝 ………………………..………………………………………..……………….1
目錄 ……………….………...……………………………………………………….2 表目錄 …………….…….……………………………………………………………3 圖目錄 …………….…………………….………………..……………………….…4 第一章 中文摘要…….…….………………………………….……………………..5 第二章 緒論…………..………………………………………………….…….…….7 第一節 研究背景………………………………………………………….…7 第二節 研究目的………………………………………………………….…8 第三章 研究材料與方法………..………………………………………………......9 第四章 研究結果……………….……………………………...............................11 第五章 討論……………………...………………...............................................14 第六章 侷限與展望…………….…………………………..……….....................16 第七章 英文摘要..……….……………..………………………..........................18 第八章 參考文獻……………….…………………….........................................19 第九章 圖表………………………………….....................................................22 | |
dc.language.iso | zh-TW | |
dc.title | 血清中的肌肉生長抑制素於甲狀腺機能亢進的變化 | zh_TW |
dc.title | The Change of Serum Myostain in Patients with Hyperthyroidism | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳祈玲(Chi-Lin Chen),曾芬郁(Fen-Yu Tseng) | |
dc.subject.keyword | 肌肉生長抑制素,甲狀腺機能亢進, | zh_TW |
dc.subject.keyword | Myostatin,IGF-1,myopathy,hyperthyroidism, | en |
dc.relation.page | 28 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2012-08-15 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
顯示於系所單位: | 臨床醫學研究所 |
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