請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65237完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 嚴震東(Chen-Tung Yen) | |
| dc.contributor.author | Chih-Yu Yang | en |
| dc.contributor.author | 楊智羽 | zh_TW |
| dc.date.accessioned | 2021-06-16T23:31:52Z | - |
| dc.date.available | 2015-08-01 | |
| dc.date.copyright | 2012-08-01 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-07-29 | |
| dc.identifier.citation | Reference
Alkire, M. T. and J. Miller (2005). 'General anesthesia and the neural correlates of consciousness.' Prog Brain Res 150: 229-44. Almeida, T. F., S. Roizenblatt, et al. (2004). 'Afferent pain pathways: a neuroanatomical review.' Brain Res 1000(1-2): 40-56. Andrew, D. and J. D. Greenspan (1999). 'Peripheral coding of tonic mechanical cutaneous pain: Comparison of nociceptor activity in rat and human psychophysics.' Journal of Neurophysiology 82(5): 2641-2648. Apkarian, A. V. and T. Shi (1994). 'Squirrel-monkey lateral thalamus .1. Somatic nociresponsive neurons and their relation to spinothalamic terminals.' Journal of Neuroscience14(11): 6779-6795. Barasi, S. and Strauch, R. (1980). 'Responses of thalamic neurons to noxious stimulation in the rat. ' Proc. physiol. Soc.306:23-24 Bester, H., V. Chapman, et al. (2000). 'Physiological properties of the lamina I spinoparabrachial neurons in the rat.' J Neurophysiol 83(4): 2239-59. Blake, D. T., S. S. Hsiao, et al. (1997). 'Neural coding mechanisms in tactile pattern recognition: The relative contributions of slowly and rapidly adapting mechanoreceptors to perceived roughness.' Journal of Neuroscience 17(19): 7480-7489. Bushnell, M. C., G. H. Duncan, et al. (1984). 'Activity of trigeminothalamic neurons in medullary dorsal horn of awake monkeys trained in a thermal discrimination task.' J Neurophysiol 52(1): 170-87. Bushnell, M. C., G. H. Duncan, et al. (1993). 'Thalamic VPM nucleus in the behaving monkey .1. Multimodal and discriminative properties of thermosensitive neurons.' Journal of Neurophysiology69(3): 739-752.. Chapin, J. K., B. D. Waterhouse, et al. (1981). 'Differences in cutaneous sensory response properties of single somatosensory corticol-neurons in awake and halothane anesthetized rats.' Brain Research Bulletin6(1): 63-70. Craig, A. D. and J. O. Dostrovsky (2001). 'Differential projections of thermoreceptive and nociceptive lamina I trigeminothalamic and spinothalamic neurons in the cat.' Journal of Neurophysiology 86(2): 856-870. Craig, A. D. and K. D. Kniffki (1985). 'Spinothalamic lumbosacral lamina I cells responsive to skin and muscle stimulation in the cat.' J Physiol 365: 197-221. Detsch, O., E. Kochs, et al. (2002). 'Differential effects of isoflurane on excitatory and inhibitory synaptic inputs to thalamic neurones in vivo.' British Journal of Anaesthesia 89(2): 294-300. Detsch, O., C. Vahle-Hinz, et al. (1999). 'Isoflurane induces dose-dependent changes of thalamic somatosensory information transfer.' Brain Res 829(1-2): 77-89. Domnick, C., M. Hauck, et al. (2009). 'C-fiber-related EEG-oscillations induced by laser radiant heat stimulation of capsaicin-treated skin.' J Pain Res 2: 49-56. Duncan, G. H., M. C. Bushnell, et al. (1993). 'Thalamic VPM nucleus in the behaving monkey .3. Effects of reversible inactivation by lidocaine on thermal and mechanical discrimination.' Journal of Neurophysiology70(5): 2086-2096. Fan, R. J., J. C. Kung, et al. (2009). 'Nocifensive behaviors components evoked by brief laser pulses are mediated by C fibers.' Physiology & Behavior 98(1-2): 108-117. Ferron, J. F., D. Kroeger, et al. (2009). 'Cortical Inhibition during Burst Suppression Induced with Isoflurane Anesthesia.' Journal of Neuroscience 29(31): 9850-9860. Foffani, G., M. L. Morales-Botello, et al. (2009). 'Spike timing, spike count, and temporal information for the discrimination of tactile stimuli in the rat ventrobasal complex.' J Neurosci 29(18): 5964-73. Francis, J. T., S. Xu, et al. (2008). 'Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus.' J Neurophysiol 99(5): 2291-304. Gauriau, C. and J. F. Bernard (2004). 'A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain.' Journal of Comparative Neurology 468(1): 24-56. Guilbaud, G., K. J. Berkley, et al. (1993). 'Responses of neurons in thalamic ventrobasal complex of rats to graded distension of uterus and vagina and to uterine suprafusion with bradykinin and prostaglandin F2 alpha.' Brain Res 614(1-2): 285-90. Guilbaud, G., M. Peschanski, et al. (1980). 'Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat.' Pain 8(3): 303-18. Gybels, J., H. O. Handwerker, et al. (1979). 'A comparison between the discharges of human nociceptive nerve fibres and the subject's ratings of his sensations.' J Physiol 292: 193-206. Handwerker, H. O., C. Forster, et al. (1991). 'Discharge patterns of human C-fibers induced by itching and burning stimuli.' J Neurophysiol 66(1): 307-15. Hubbard, S. J. (1958). 'A study of rapid mechanical events in a mechanoreceptor.' J Physiol 141(2): 198-218. Iannetti, G. D., M. Leandri, et al. (2004). 'Adelta nociceptor response to laser stimuli: selective effect of stimulus duration on skin temperature, brain potentials and pain perception.' Clin Neurophysiol 115(11): 2629-37. Johnson, K. O. (1974). 'Reconstruction of population response to a vibratory stimulus in quickly adapting mechanoreceptive afferent fiber population innervating glabrous skin of monkey.' Journal of Neurophysiology37(1): 48-72. Kenshalo, D. R., K. Iwata, et al. (2000). 'Response properties and organization of nociceptive neurons in area 1 of monkey primary somatosensory cortex.' J Neurophysiol 84(2): 719-29. Khasabov, S. G., S. D. Rogers, et al. (2002). 'Spinal neurons that possess the substance P receptor are required for the development of central sensitization.' J Neurosci 22(20): 9086-98. Kobayashi, K., J. Winberry, et al. (2009). 'A Painful Cutaneous Laser Stimulus Evokes Responses From Single Neurons in the Human Thalamic Principal Somatic Sensory Nucleus Ventral Caudal (Vc).' Journal of Neurophysiology 101(5): 2210-2217. Kress, M., M. Koltzenburg, et al. (1992). 'Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro.' J Neurophysiol 68(2): 581-95. Lee, J. I., P. M. Dougherty, et al. (1999). 'Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range.' Journal of Comparative Neurology 410(4): 541-555. Light, A. R., D. L. Trevino, et al. (1979). 'Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn.' Journal of Comparative Neurology186(2): 151-171. Luo, F. and J. Y. Wang (2009). 'Neuronal nociceptive responses in thalamocortical pathways.' Neurosci Bull 25(5): 289-95. Martin, W. J., Y. Cao, et al. (2004). 'Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo.' J Neurophysiol 91(5): 1945-54. Montagne-Clavel, J. and J. L. Oliveras (1995). 'Does barbiturate anesthesia modify the neuronal properties of the somatosensory thalamus? A single-unit study related to nociception in the awake-pentobarbital-treated rat.' Neurosci Lett 196(1-2): 69-72. Muniak, M. A., S. Ray, et al. (2007). 'The neural coding of stimulus intensity: Linking the population response of mechanoreceptive Afferents with psychophysical Behavior.' Journal of Neuroscience 27(43): 11687-11699. Palecek, J., V. Paleckova, et al. (1992). 'Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy.' J Neurophysiol 67(6): 1562-73. Peschanski, M., G. Guilbaud, et al. (1980). 'Encoding of noxious heat messages in neurons of the ventrobasal thalamic complex of the rat.' Brain Research197(2): 401-413. Rausell, E. and E. G. Jones (1991). 'Chemically distinct compartments of the thalamic VPM nucleus in monkeys relay principal and spinal trigeminal pathways to different layers of the somatosensory cortex.' J Neurosci 11(1): 226-37. Schmidt, R., M. Schmelz, et al. (2000). 'Mechano-insensitive nociceptors encode pain evoked by tonic pressure to human skin.' Neuroscience 98(4): 793-800. Simone, D. A., X. J. Zhang, et al. (2004). 'Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.' Journal of Neurophysiology 91(1): 213-222. Slugg, R. M., J. N. Campbell, et al. (2004). 'The population response of A- and C-fiber nociceptors in monkey encodes high-intensity mechanical stimuli.' Journal of Neuroscience 24(19): 4649-4656. Slugg, R. M., R. A. Meyer, et al. (2000). 'Response of cutaneous A- and C-fiber nociceptors in the monkey to controlled-force stimuli.' Journal of Neurophysiology 83(4): 2179-2191. Taguchi, T., H. Ota, et al. 'Cutaneous C-fiber nociceptor responses and nociceptive behaviors in aged Sprague-Dawley rats.' Pain 151(3): 771-82. Treede, R. D. (2002). 'Spinothalamic and thalamocortical nociceptive pathways.' Journal of Pain 3(2): 109-112. Treede, R. D., R. A. Meyer, et al. (1995). 'Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin.' J Physiol 483 ( Pt 3): 747-58. Vahle-Hinz, C., O. Detsch, et al. (2007). 'Corresponding minimum alveolar concentrations of isoflurane and isoflurane/nitrous oxide have divergent effects on thalamic nociceptive signalling.' British Journal of Anaesthesia 98(2): 228-235. Vahle-Hinz, C., O. Detsch, et al. (2007). 'Contributions of GABAergic and glutamatergic mechanisms to isoflurane-induced suppression of thalamic somatosensory information transfer.' Experimental Brain Research 176(1): 159-172. Vahle-Hinz, C., O. Detsch, et al. (2001). 'Local GABA(A) receptor blockade reverses isoflurane's suppressive effects on thalamic neurons in vivo.' Anesth Analg 92(6): 1578-84. Vahle-Hinz, C., T. P. Hicks, et al. (1994). 'Amino acids modify thalamo-cortical response transformation expressed by neurons of the ventrobasal complex.' Brain Res 637(1-2): 139-55. Van Hees, J. and J. Gybels (1981). 'C nociceptor activity in human nerve during painful and non painful skin stimulation.' J Neurol Neurosurg Psychiatry 44(7): 600-7. Walk, D., N. Sehgal, et al. (2009). 'Quantitative Sensory Testing and Mapping A Review of Nonautomated Quantitative Methods for Examination of the Patient With Neuropathic Pain.' Clinical Journal of Pain 25(7): 632-640. Wang, J. Y., H. T. Zhang, et al. (2004). 'Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study.' Brain Research 1014(1-2): 197-208. Willis, W. D., X. J. Zhang, et al. (2002). 'A critical review of the role of the proposed VMpo nucleus in pain.' Journal of Pain 3(2): 79-94. Yen, C. T. and F. Z. Shaw (2003). 'Reticular thalamic responses to nociceptive inputs in anesthetized rats.' Brain Research 968(2): 179-191. Zhang, X. and G. J. Giesler, Jr. (2005). 'Response characterstics of spinothalamic tract neurons that project to the posterior thalamus in rats.' J Neurophysiol 93(5): 2552-64. Zhang, X. J., S. Davidson, et al. (2006). 'Thermally identified subgroups of marginal zone neurons project to distinct regions of the ventral posterior lateral nucleus in rats.' Journal of Neuroscience 26(19): 5215-5223. Zhang, X. J., H. N. Wenk, et al. (2000). 'Locations of spinothalamic tract axons in cervical and thoracic spinal cord white matter in monkeys.' Journal of Neurophysiology 83(5): 2869-2880. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65237 | - |
| dc.description.abstract | 大鼠視丘腹尾外側核（VPL）主要接收來自於mediolemniscus (ML)和脊髓丘腦束（STT tract）的訊息並將體感覺忠實的傳遞至大腦體感覺皮質區。之前研究已在麻醉下的動物(大鼠，貓和猴子)中分辨出低閾值機械性受體（LTM）、廣動力型神經元（WDR）和疼痛傳導特定型神經元（NS）。然而痛覺只有在清醒的狀態下才可以被辨別的，因此，本篇研究的主要目的在比較這些在麻醉下所定義出的VPL神經元在清醒時對於觸覺及痛覺刺激的反應為何。此實驗經由長期記錄單一神經元（SU）的方法並使用不同強度的機械性von Frey filaments和雷射熱痛刺激，在不同的腦狀態下去測試同一神經元的反應。SR slope結果顯示，VPL中的神經元在麻醉下具有顯著性較差的反應。除此之外，LTM，WDR和NS神經元在清醒的狀態下會有功能性相似的表現。因此，我們認為在麻醉的狀態下，視丘對於感覺訊息的傳遞會有所改變。 | zh_TW |
| dc.description.abstract | Ventroposterior lateral nucleus (VPL) is a first-order thalamic nucleus which receives somatosensory information from mediolemniscus and spinothalamic tract, and relays inputs of the body to somatosensory cortex. Previous studies identify low-threshold (LTM), wide-dynamic range (WDR), and noxious-specific (NS) neurons in anesthetized rat, cat and monkey. However, pain sensation can only be discriminated under conscious state. Thus, the main purpose of the present study was to compare the somatosensory response of the different types of VPL neurons under conscious and anesthetized states in the rat. VPL single-unit activities were recorded by chronically implanted microwire electrodes. Mechanical von Frey filaments and laser heat stimulations applied to the paws were used for quantitative stimulations. Stimulus-response slope results showed that VPL neurons had significantly lower response under anesthetized state. In addition, LTM, WDR and NS neurons became functionally alike neurons in the conscious state. Therefore, we concluded that anesthesia altered sensory transmission in the thalamus. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T23:31:52Z (GMT). No. of bitstreams: 1 ntu-101-R98b41012-1.pdf: 3387684 bytes, checksum: 4e751237a838fcdcf9886ab47b6fe9da (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | Table of Content
INTRODUCTION 1 SENSORY RESPONDING PROPERTIES OF PRIMARY AFFERENTS 1 SENSORY RESPONDING PROPERTIES OF DORSAL HORN NEURONS 3 FUNCTIONAL ROLE OF THE VPL 5 THERMOSENSITIVITY OF SPINOTHALAMIC NEURONS 6 ANESTHETIC EFFECT OF ISOFLURANE 7 PURPOSE OF THE STUDY 8 GOAL OF THE STUDY 9 MATERIAL AND METHOD 11 ANIMALS 11 ELECTRODES PREPARATION 11 CHRONIC ELECTRODES IMPLANT SURGERY 12 EXPERIMENT 1. EVOKED-RESPONSE OF SAME NEURONS UNDER ANESTHESIA IN THE CONSCIOUS STATE 13 EXTRACELLULAR SINGLE-UNIT RECORDING 13 GENERAL 13 PROCEDURES OF MECHANICAL STIMULI 14 PROCEDURES OF LASER HEAT STIMULI 14 EXPERIMENT 2. RECORDING AND CLASSIFY NEURON TYPES IN THE ANESTHETIZED STATE 15 GENERAL 15 PROCEDURES OF MECHANICAL STIMULI 15 PROCEDURES OF THERMAL STIMULI 15 DATA ACQUISITION AND ANALYSIS 16 HISTOLOGY 18 RESULT 19 MECHANICAL CLASSIFICATION OF VPL NEURONS 19 MECHANICAL CODING ABILITIES UNDER ANESTHETIZED STATE 20 MECHANICAL CODING ABILITIES UNDER CONSCIOUS AND ANESTHETIZED STATE 22 MECHANICAL CODING ABILITIES UNDER CONSCIOUS STATE 24 LASER HEAT RESPONSIBILITY OF VPL NEURONS 25 LASER HEAT RESPONSIBILITY OF VPL NEURONS UNDER ANESTHETIZED AND CONSCIOUS STATE 26 LASER HEAT RESPONSIBILITY OF VPL NEURONS UNDER CONSCIOUS STATE 27 RECEPTIVE FIELD EXPANSION UNDER THE CONSCIOUS STATE 28 HISTOLOGY 29 DISCUSSION 30 MECHANICAL-EVOKED RESPONSES 30 LASER HEAT EVOKED RESPONSES 33 EQUALLY DISTRIBUTION OF LH SENSITIVE AFFERENTS AMONG THE VPL NEURONS 36 CONCLUSION AND PERSPECTIVES 38 REFERENCE 40 TABLES AND FIGURES 47 | |
| dc.language.iso | en | |
| dc.title | 大鼠視丘腹尾外側核神經元在清醒與麻醉下對於觸覺與痛刺激反應之比較 | zh_TW |
| dc.title | Comparison Response to Tactile and Noxious Stimulation of the Ventral Posterolateral Nuclei under Anesthetized and Conscious State of Rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蕭富仁(Fu-Zen Shaw),徐百川(Bai-Chuang Shyu),蔡孟利(Meng-Li Tsai),謝松蒼(Sung-Tsang Hsieh) | |
| dc.subject.keyword | 大鼠,視丘腹尾外側核,痛覺,單一神經元, | zh_TW |
| dc.subject.keyword | Rat,Ventroposterior lateral nucleus (VPL),nociception,single unit, | en |
| dc.relation.page | 82 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-07-30 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-101-1.pdf 目前未授權公開取用 | 3.31 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。