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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 邱靜雯(Ching-Wen Chiu) | |
dc.contributor.author | Chia-Hsuan Lin | en |
dc.contributor.author | 林佳萱 | zh_TW |
dc.date.accessioned | 2021-06-16T23:20:53Z | - |
dc.date.available | 2021-02-22 | |
dc.date.copyright | 2021-02-22 | |
dc.date.issued | 2021 | |
dc.date.submitted | 2021-02-03 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65071 | - |
dc.description.abstract | 三配位硼化合物具有三角平面幾何形狀,硼中心的空p軌道,使其具有路易斯酸的性質。利用在分子中引入正電荷,進一步增加其酸性,形成硼陽離子。由於酸性的增加,硼陽離子對化學計量的轉化和催化作用引起了越來越多科學家的注意。近年來,分子掌性特質在醫學方面不斷被廣泛研究,硼催化劑在不對稱合成的應用也持續被開發中。本研究成功合成帶有噁唑啉衍生配體的手性三配位中性硼化合物及其相應的陽離子化合物。這些化合物已通過1H,11B,13C,2D(HMBC,HSQC,COSY)NMR光譜鑑定,並藉由X射線晶體學確認結構。除此之外,利用Gutmann-Beckett方法測定硼化合物的路易斯酸性,並探討合成的掌性硼化合物在不對稱反應中的應用。 | zh_TW |
dc.description.abstract | Tricoordinate boron compounds possess a trigonal planer geometry with a vacant p orbital allowing it to behave as a Lewis acid. In the case of boron cations, the Lewis acidity of boron center will be further increased by introducing a positive charge to the molecule. Thus, boron cation has drawn an increase interest in stoichiometric and catalytic transformations. Over the years, the importance of chirality of a molecule on its medicinal applications had been extensively investigated. The application of boron catalysts in asymmetric synthesis has also been explored. In this research, chiral three-coordinate neutral and cationic boron compounds bearing an oxazoline-derived ligand were prepared. These compounds have been fully characterized by 1H, 11B, 13C, and 2D (HMBC, HSQC, COSY) NMR spectroscopy, and X-ray crystallography. The Lewis acidity of the boron compounds was also determined by Gutmann-Beckett method. The application of the synthesized chiral boron compounds in asymmetric synthesis will also be discussed. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T23:20:53Z (GMT). No. of bitstreams: 1 U0001-0202202116155800.pdf: 3333041 bytes, checksum: 9264881d47122c31dc2691d0b90db49d (MD5) Previous issue date: 2021 | en |
dc.description.tableofcontents | 謝辭 i 摘要 ii Abstract iii Contents iv List of Figures vi List of Schemes vii List of Table ix 1.1 Lewis Acidic Character of Boranes 1 1.2 Boron Cations 2 1.3 The Importance of Chirality 3 1.4 Asymmetric Boron-Catalyzed Reactions 4 1.5 Chiral Oxazoline Ligands 6 1.6 Molecular design 8 Chapter 2. Results and Discussions 11 2.1 Syntheses and characterizations 11 2.1.1 Route one 11 2.1.1.1 Synthesis of Pyridine Borane Complex 1 11 2.1.1.2 Reaction of Pyridine Borane Complex 1 11 2.1.1.3 Reduction of Pyridine Borane Complex 1 12 2.1.1.4 Reaction of Pyridine Borane Complex 3 14 2.1.2 Route two 14 2.2 Acidity Measurement 27 Gutmann-Beckett Method 27 2.3 Reactivity Studies 27 Chapter 3. Conclusion 30 Chapter 4. Experimental Section 31 Chapter 5. Supporting Information 41 5.1 Crystal Data 41 5.2 NMR Data 58 5.3 References 91 | |
dc.language.iso | zh-TW | |
dc.title | 合成掌性硼陽離子衍生物 | zh_TW |
dc.title | Synthesis of Chiral Cationic Boron Derivatives | en |
dc.type | Thesis | |
dc.date.schoolyear | 109-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳榮傑(Rong-Jie Chein),林雅凡(Ya-Fan Lin) | |
dc.subject.keyword | 硼陽離子,噁唑啉,鏡像選擇性, | zh_TW |
dc.subject.keyword | boron cation,oxazoline,enantioselectivity, | en |
dc.relation.page | 94 | |
dc.identifier.doi | 10.6342/NTU202100396 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2021-02-04 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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