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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 周崇熙(Chung-Hsi Chou) | |
| dc.contributor.author | Pai-Hsung Chen | en |
| dc.contributor.author | 陳百勳 | zh_TW |
| dc.date.accessioned | 2021-06-16T17:44:44Z | - |
| dc.date.available | 2017-08-17 | |
| dc.date.copyright | 2012-08-17 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-14 | |
| dc.identifier.citation | 農業委員會。農業統計年報。行政院農業委員會漁業署。2009。 http://www.coa.gov.tw/files/web_article_files/21938/12745.pdf
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64395 | - |
| dc.description.abstract | 沙門氏菌症是常見的動物產品媒介傳染病，其病原沙門氏菌廣泛存在於環境中，是全球公共衛生的重要課題，國外研究針對市售牡蠣食媒病的調查報告指出無論是市售或進口的牡蠣遭沙門氏菌污染的情形十分普遍。牡蠣在臺灣是十分受到歡迎的食材，然而對於國產或進口牡蠣中沙門氏菌的污染資料卻是欠缺。本研究即於臺灣北部地區一般傳統及超級市場調查已剝殼之國產生鮮牡蠣 (n=137) 和進口即食性生鮮牡蠣 (n=114) 共251件；其中進口牡蠣均無分離出沙門氏菌；而國產牡蠣則有80件出現沙門氏菌陽性，總分離率為58.4% (80/137)；傳統市場來源的牡蠣其分離率為58.1% (68/117)，超級市場來源的牡蠣其分離率為60% (12/20)。本次所分離出來的沙門氏菌概括11種血清型，檢出率最高的前三個血清型，分別為Saintpaul (26.4%)、Newport (21.9%) 及Infantis (13.2%)。以80件陽性樣本中所分離的91株沙門氏菌，進行藥物敏感性試驗，所分離出來的菌株對Tetracycline及Oxytetracycline的抗藥性最高 (n=12, 14.3%)。以PCR針對Integron與tet、PSE-1等抗藥基因進行檢測，檢測結果具有Integron的沙門氏菌，佔16.5%，tetA、tetB、PSE-1等基因的檢出率分別為26.4%、6.6%、22.0%。以販售型式來分，以泡水型式販賣的牡蠣污染率 (67.7%) 顯著高於非泡水型式 (50.7%) (P<0.05)；以統計方式分析菌株是否攜帶Integron與抗藥性的關係上，具Integron的菌株，其抗藥性和嵌入抗藥基因的比率上都顯著高於不具Integron的菌株；在具有tetA抗藥基因的菌株，對於Tetracycline、Oxytetracycline的抗藥性顯著高於不具tetA基因的菌株；而具有PSE-1基因的菌株，對於Ampicillin也呈現較高比例的抗藥性。根據本次研究調查顯示市售生鮮牡蠣仍具有食媒性沙門氏菌的傳播風險，其可能的汙染來源包括產地或加工過程，消費者於食材料理時仍應加強衛生習慣，以避免交叉汙染進而降低沙門氏菌的患病風險，且未來有必要進一步探究其可能之汙染來源與傳播模式。 | zh_TW |
| dc.description.abstract | Salmonellosis frequently causes food-borne illness in human, and poses a serious public health concern. Many of the salmonellosis outbreaks are associated with the consumption of oysters. The research about oyster in Taiwan is absent. Hence we had collect oysters from northern Taiwan’s retail market and supermarket, totally 137 samples. Import ready-to-eat oyster, totally 114 samples and screened for the presence of Salmonella. Isolates were characterized by serotyping and antibiotic resistant testing. None of imported oysters showed positive results. The domestic samples were 80 Salmonella-positive where 91 Salmonella strain were isolated and 11 Salmonella serovars were identified. The top three are Saintpaul (26.4%), Newport (21.9%) and Infantis (13.2%). The most frequent resistances were to Tetracycline and Oxytetracycline (n=12, 14.3%). The antibiotic related genes: Integron, tetA, tetB, PSE-1 were detected in 16.5%, 26.4%, 6.6%, 22% respectively. According to statistics result, the contamination level in oyster rearing location, Dongshih’s isolation rate (68.8%) is significantly higher than Budai (20.0%) and Wanggang (9.1%) (P<0.05). The presence of Salmonella isolation rate is highly associated with soaked-in-water sold type (P<0.05). The Integron-positive strains are highly associated with the presence of the antimicrobial resistance. The tetA-positive strain are highly associated with the presence of the Tetracycline and Oxytetracycline resistance. and PSE-1-positive strain are highly associated with the presence of the Ampicill in resistance. In our result shows market raw oyster are still have potential risk in foodborne disease. The hazard points include rearing enviroment and transportation procedures. Consumers should be noticed to avoid cross-infection. Further researches of contamination source and transmission route are needed. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T17:44:44Z (GMT). No. of bitstreams: 1 ntu-101-R97629039-1.pdf: 718847 bytes, checksum: 0ad1b10711e0403433e17e600035ea1f (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 目 錄
頁次 摘要 ..........…………………………………………………………… Ⅰ Abstract ……………………………………………………………… Ⅲ 目錄 …………………………………………………………………. Ⅴ 表次 …………………………………………………………………. Ⅶ 圖次 …………………………………………………………………... Ⅸ 第一章 緒言 ………………………………………………………….. 1 第二章 文獻探討 …………………………………………………….. 4 第一節 沙門氏菌簡介 ………………………………………… 4 第二節 沙門氏菌的分離與鑑定 ……………………………… 7 第三節 沙門氏菌之流行病學 ……………………………….. 11 第四節 沙門氏菌的抗藥性問題 ……………………………… 18 第五節 沙門氏菌抗藥基因的傳播 ………………………… 24 第三章 材料與方法 ………………………………………………… 29 第一節 採樣流程及方法 ……………………………………… 29 第二節 沙門氏菌之分離與生化學鑑定 ……………………… 30 第三節 沙門氏菌血清學鑑定 …………………………………. 32 第四節 沙門氏菌藥物感受性試驗 …………………………… 34 第五節 以聚合酵素鏈鎖反應檢測抗藥性基因 …………….... 35 第六節 統計分析 ………………………………………………. 38 第四章 結果 …………………………………………………………... 39 第一節 牡蠣中沙門氏菌之分離率 …………………………..... 39 第二節 沙門氏菌分離株血清型的分布 ……………………..... 42 第三節 沙門氏菌分離株之藥物感受性試驗結果 …………..... 44 第四節 沙門氏菌分離株之抗藥性基因偵測 ……………......... 46 第五章 討論 …………………………………………………………... 49 第一節 牡蠣沙門氏菌汙染率 ………………………………..... 49 第二節 牡蠣沙門氏菌血清型之分布 ………………………..... 54 第三節 牡蠣沙門氏菌分離株之抗藥性 ……………………..... 58 第四節 牡蠣沙門氏菌分離株之抗藥性基因 ………………..... 63 第六章 結論與建議 ………………………………………………....... 69 第七章 參考文獻 ………………………………………………........... 71 表 次 頁次 Table 1. Reference inhibition zone for antimicrobial resistance test of each tested drug........................................................................................90 Table 2. Primers and annealing temperatures used in the PCR reactions..........91 Table 3. Salmonella isolation positive cases and positive rates in each area....92 Table 4. The relationship between the presence of Salmonella isolation rates and sold type (with/without water)..........................................92 Table 5. The relationship between the presence of Salmonella isolation rate and market type..........................................................................................93 Table 6. Salmonella serotypes isolated from the oyster in Dongshih, Budai, Wanggong and other places..............................................................94 Table 7. Occurrance of two different serotypes isolated from one sample in each area.........................................................................................95 Table 8. Antimicrobial resistance of 91 Salmonella isolates from raw oyster in northern Taiwan..............................................................................95 Table 9. Serotypes, market type, sold type information of Integron-positive Salmonellaes...................................................................................96 Table 10. Serotypes, market type, sold type information of tetA-positive Salmonellaes...................................................................................97 Table 11. Serotypes, market type, sold type information of tetB-positive Salmonellaes.....................................................................................98 Table 12. Serotypes, market type, sold type information of PSE-1-positive Salmonellaes.....................................................................................99 Table 13. The relationship between Integron-positive case and antimicrobial resistant gene.................................................................................100 Table 14. The relationship between Integron-positive case and antimicrobial resistance bacterial........................................................................100 Table 15. The relationship between tetA gene-positive case and Tetracycline resistance bacterial.........................................................................101 Table 16. The relationship between tetA gene-positive case and Oxytetracycline resistant bacterial............................................................................101 Table 17. The relationship between PSE-1 gene-positive case and Ampicillin resistant bacterial............................................................................102 Table 18. Antimicrobial resistant profiles of the 18 Salmonella isolates from oyster..............................................................................................103 圖 次 頁次 Fig 1. Number of different serotypes of the 91 Salmonella strains isolated from oyster…...............................................................................................104 Fig 2. Detection of class 1 integron gene in 91 Salmonella isolates………….......105 Fig 3. Detection of tetA gene in 91 Salmonella isolates........................................106 Fig 4. Detection of tetB gene in 91 Salmonella isolates........................................107 Fig 5. Detection of PSE-1 gene in 91 Salmonella isolates....................................108 | |
| dc.language.iso | zh-TW | |
| dc.subject | 整合子 | zh_TW |
| dc.subject | 沙門氏菌症 | zh_TW |
| dc.subject | 基因卡匣 | zh_TW |
| dc.subject | gene cassette | en |
| dc.subject | Salmonellosis | en |
| dc.subject | Integron | en |
| dc.title | 臺灣北部地區市售生鮮牡蠣(Crassostrea gigas)之沙門氏菌污染及抗藥特性調查 | zh_TW |
| dc.title | Isolation Rate and Antimicrobial Resistance of Salmonella in Market Raw Oysters (Crassostrea gigas) in Northern Taiwan | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡向榮(Hsiang-Jung Tsai),張紹光(Shao-Kuang Chang),陳億乘(Yi-Chen Chen),蔡宜倫(Yi-Lun Tsai) | |
| dc.subject.keyword | 沙門氏菌症,整合子,基因卡匣, | zh_TW |
| dc.subject.keyword | Salmonellosis,Integron,gene cassette, | en |
| dc.relation.page | 108 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-08-14 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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