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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 嚴震東 | |
dc.contributor.author | Tzu-Hao Chao | en |
dc.contributor.author | 趙子豪 | zh_TW |
dc.date.accessioned | 2021-06-16T17:31:25Z | - |
dc.date.available | 2012-08-19 | |
dc.date.copyright | 2012-08-19 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-15 | |
dc.identifier.citation | Angenstein, F., E. Kammerer, et al. (2007). 'Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study.' NeuroImage 38(1): 150-163.
Antognini, J. F., X. W. Wang, et al. (1999). 'Quantitative and qualitative effects of isoflurane on movement occurring after noxious stimulation.' Anesthesiology 91(4): 1064. Austin, V., A. Blamire, et al. (2003). 'Differences in the BOLD fMRI response to direct and indirect cortical stimulation in the rat.' Magnetic Resonance in Medicine 49(5): 838-847. Bandettini, P. A., E. C. Wong, et al. (1992). 'Time course EPI of human brain function during task activation.' Magnetic Resonance in Medicine 25(2): 390-397. Bear, M. F., B. W. Connors, et al. (2007). Neuroscience: Exploring the brain, Lippincott Williams & Wilkins. Bock, C., H. Krep, et al. (1998). 'Brainmapping of α-chloralose anesthetized rats with T2*-weighted imaging: distinction between the representation of the forepaw and hindpaw in the somatosensory cortex.' NMR in Biomedicine 11(3): 115-119. Bogdanova, O. and I. Sil'kis (1999). 'The effects of high-frequency microstimulation of the cortex on interhemisphere synchronization in the rat motor cortex.' Neuroscience and behavioral physiology 29(5): 515-522. Bonvento, G., R. Charbonne, et al. (1994). 'Is [alpha]-chloralose plus halothane induction a suitable anesthetic regimen for cerebrovascular research?' Brain research 665(2): 213-221. Bruggemann, J., T. Shi, et al. (1994). 'Squirrel monkey lateral thalamus. II. Viscerosomatic convergent representation of urinary bladder, colon, and esophagus.' The Journal of neuroscience 14(11): 6796-6814. Canals, S., M. Beyerlein, et al. (2008). 'Electric stimulation fMRI of the perforant pathway to the rat hippocampus.' Magnetic resonance imaging 26(7): 978-986. Chapin, J. K., B. D. Waterhouse, et al. (1981). 'Differences in cutaneous sensory response properties of single somatosensory cortical neurons in awake and halothane anesthetized rats.' Brain Research Bulletin 6(1): 63-70. de Celis Alonso, B., T. Makarova, et al. (2011). 'On the use of α-chloralose for repeated BOLD fMRI measurements in rats.' Journal of Neuroscience Methods 195(2): 236-240. Detre, J. A., B. M. Ances, et al. (1998). 'Signal averaged laser Doppler measurements of activation–flow coupling in the rat forepaw somatosensory cortex.' Brain Res 796(1–2): 91-98. Duong, T. Q., D. S. Kim, et al. (2001). 'Localized cerebral blood flow response at submillimeter columnar resolution.' Proceedings of the National Academy of Sciences 98(19): 10904. Eger, E. I., L. J. Saidman, et al. (1965). 'Minimum alveolar anesthetic concentration: a standard of anesthetic potency.' Anesthesiology 26(6): 756. Foffani, G., M. Morales-Botello, et al. (2009). 'Spike timing, spike count, and temporal information for the discrimination of tactile stimuli in the rat ventrobasal complex.' The Journal of neuroscience 29(18): 5964-5973. Francis, J. T., S. Xu, et al. (2008). 'Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus.' Journal of neurophysiology 99(5): 2291-2304. Fueger, B. J., J. Czernin, et al. (2006). 'Impact of animal handling on the results of 18F-FDG PET studies in mice.' Journal of Nuclear Medicine 47(6): 999-1006. Fukuda, M., U. M. Rajagopalan, et al. (2005). 'Localization of Activity-dependent Changes in Blood Volume to Submillimeter-scale Functional Domains in Cat Visual Cortex.' Cerebral Cortex 15(6): 823-833. Gyngell, M. L., C. Bock, et al. (1996). 'Variation of functional MRI signal in response to frequency of somatosensory stimulation in α‐chloralose anesthetized rats.' Magnetic Resonance in Medicine 36(1): 13-15. Hau, J. and S. J. Schapiro (2011). Handbook of laboratory animal science. Boca Raton, FL, CRC Press. Heeger, D. J. and D. Ress (2002). 'What does fMRI tell us about neuronal activity?' Nature Reviews Neuroscience 3(2): 142-151. Huettel, S. A., A. W. Song, et al. (2008). Functional magnetic resonance imaging. Sunderland, Mass., Sinauer Associates. Huupponen, E., A. Maksimow, et al. (2008). 'Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep.' Acta Anaesthesiologica Scandinavica 52(2): 289-294. Imas, O. A., K. M. Ropella, et al. (2005). 'Volatile Anesthetics Enhance Flash-induced γ Oscillations in Rat Visual Cortex.' Anesthesiology 102(5): 937-947. Kida, I., F. Hyder, et al. (2001). 'Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent.' Journal of Cerebral Blood Flow & Metabolism 21(5): 585-591. Kim, D. S., T. Q. Duong, et al. (2000). 'High-resolution mapping of iso-orientation columns by fMRI.' Nature neuroscience 3(2): 164-169. Kim, T., K. Masamoto, et al. (2010). 'Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats.' NeuroImage 52(1): 224-233. Kumar, A., D. Welti, et al. (1975). 'NMR Fourier zeugmatography.' Journal of Magnetic Resonance (1969) 18(1): 69-83. Kwong, K. K., J. W. Belliveau, et al. (1992). 'Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.' Proceedings of the National Academy of Sciences 89(12): 5675. Lauterbur, P. C. (1973). 'Image formation by induced local interactions: examples employing nuclear magnetic resonance.' Nature 242(5394): 190-191. Lee, J. G., J. J. Smith, et al. (1995). 'Laser-Doppler measurement of the effects of halothane and isoflurane on the cerebrovascular CO2 response in the rat.' Anesthesia & Analgesia 80(4): 696-702. Lee, S. P., A. C. Silva, et al. (1999). 'Diffusion-weighted spin-echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal changes.' Magnetic Resonance in Medicine 42(5): 919-928. Lin, J., S. Sun, et al. (2002). A fMRI study of the anterior cingulate cortex activations during direct electrical stimulation of the medial thalamus in rats. Lindauer, U., G. Royl, et al. (2001). 'No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation.' NeuroImage 13(6): 988-1001. Lindauer, U., A. Villringer, et al. (1993). 'Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics.' American Journal of Physiology-Heart and Circulatory Physiology 264(4): H1223-H1228. Logothetis, N. K., H. Guggenberger, et al. (1999). 'Functional imaging of the monkey brain.' Nature neuroscience 2(6): 555-562. Lu, H., S. Patel, et al. (2004). 'Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression.' Magnetic Resonance in Medicine 52(5): 1060-1068. Lukasik, V. M. and R. J. Gillies (2003). 'Animal anaesthesia for in vivo magnetic resonance.' NMR in Biomedicine 16(8): 459-467. Malonek, D. and A. Grinvald (1996). 'Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping.' Science 272(5261): 551-554. Mandeville, J. B., J. J. A. Marota, et al. (1998). 'Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.' Magnetic Resonance in Medicine 39(4): 615-624. Mansfield, P. (1977). 'Multi-planar image formation using NMR spin echoes.' Journal of Physics C: Solid State Physics 10: L55. Marota, J. J. A., C. Ayata, et al. (1999). 'Investigation of the early response to rat forepaw stimulation.' Magnetic Resonance in Medicine 41(2): 247-252. Martin, C., J. Martindale, et al. (2006). 'Investigating neural–hemodynamic coupling and the hemodynamic response function in the awake rat.' NeuroImage 32(1): 33-48. Masamoto, K., M. Fukuda, et al. (2009). 'Dose‐dependent effect of isoflurane on neurovascular coupling in rat cerebral cortex.' European Journal of Neuroscience 30(2): 242-250. Masamoto, K., T. Kim, et al. (2007). 'Relationship between Neural, Vascular, and BOLD Signals in Isoflurane-Anesthetized Rat Somatosensory Cortex.' Cerebral Cortex 17(4): 942-950. Matsuura, T. and I. Kanno (2001). 'Quantitative and temporal relationship between local cerebral blood flow and neuronal activation induced by somatosensory stimulation in rats.' Neuroscience research 40(3): 281-290. Nakao, Y., Y. Itoh, et al. (2001). 'Effects of anesthesia on functional activation of cerebral blood flow and metabolism.' Proceedings of the National Academy of Sciences 98(13): 7593. Nelson, L. E., J. Lu, et al. (2003). 'The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects.' Anesthesiology 98(2): 428-436. Ngai, A. C., M. A. Jolley, et al. (1999). 'Frequency-dependent changes in cerebral blood flow and evoked potentials during somatosensory stimulation in the rat.' Brain Res 837(1-2): 221-228. Nielsen, A. N. and M. Lauritzen (2001). 'Coupling and uncoupling of activity‐dependent increases of neuronal activity and blood flow in rat somatosensory cortex.' J Physiol 533(3): 773-785. Ogawa, S., T. Lee, et al. (1990). 'Brain magnetic resonance imaging with contrast dependent on blood oxygenation.' Proceedings of the National Academy of Sciences 87(24): 9868. Ogawa, S., D. W. Tank, et al. (1992). 'Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.' Proceedings of the National Academy of Sciences 89(13): 5951. Parker, J. and H. Adams (1978). 'The influence of chemical restraining agents on cardiovascular function: a review.' Laboratory animal science 28(5): 575. Pauling, L. and C. D. Coryell (1936). 'The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin.' Proceedings of the National Academy of Sciences of the United States of America 22(4): 210. Pawela, C. P., B. B. Biswal, et al. (2009). 'A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity.' NeuroImage 46(4): 1137-1147. Paxinos, G. and C. Watson (2007). The Rat Brain in Stereotaxic Coordinates: Hard Cover Edition, Academic press. Peeters, R., I. Tindemans, et al. (2001). 'Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation.' Magnetic resonance imaging 19(6): 821-826. Perlmutter, J. S. and J. W. Mink (2006). 'Deep brain stimulation.' Annu. Rev. Neurosci. 29: 229-257. Rabi, I., S. Millman, et al. (1938). 'The Molecular Beam Resonance Method for Measuring Nuclear Magnetic Moments.' Phys. Rev 53(495): 318. Rang, H. P. (2001). Pharmacology. New York, Churchill Livingstone. Riviere, J. E. and M. G. Papich (2009). Veterinary pharmacology and therapeutics, Blackwell Pub. Rosin, D. L., A. Robeva, et al. (1998). 'Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system.' The Journal of Comparative Neurology 401(2): 163-186. Roy, C. S. and C. Sherrington (1890). 'On the regulation of the blood-supply of the brain.' The Journal of physiology 11(1-2): 85. Salonen, J. (1989). 'Pharmacokinetics of medetomidine.' Acta veterinaria Scandinavica. Supplementum 85: 49. Sheth, S., M. Nemoto, et al. (2003). 'Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex.' NeuroImage 19(3): 884-894. Shyu, B. C., C. Y. Lin, et al. (2004). 'BOLD response to direct thalamic stimulation reveals a functional connection between the medial thalamus and the anterior cingulate cortex in the rat.' Magnetic Resonance in Medicine 52(1): 47-55. Sicard, K., Q. Shen, et al. (2003). 'Regional Cerebral Blood Flow and BOLD Responses in Conscious and Anesthetized Rats Under Basal and Hypercapnic Conditions: Implications for Functional MRI Studies.' Journal of Cerebral Blood Flow & Metabolism 23(4): 472-481. Sicard, K., Q. Shen, et al. (2003). 'Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies.' Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 23(4): 472-481. Silva, A. C. and S. G. Kim (1999). 'Pseudo-continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution.' Magnetic Resonance in Medicine 42(3): 425-429. Silva, A. C., S. P. Lee, et al. (1999). 'Simultaneous blood oxygenation level-dependent and cerebral blood flow functional magnetic resonance imaging during forepaw stimulation in the rat.' Journal of Cerebral Blood Flow & Metabolism 19(8): 871-879. Silverman, J. and W. Muir 3rd (1993). 'A review of laboratory animal anesthesia with chloral hydrate and chloralose.' Laboratory animal science 43(3): 210. Sinclair, M. D. (2003). 'A review of the physiological effects of α2-agonists related to the clinical use of medetomidine in small animal practice.' The Canadian Veterinary Journal 44(11): 885. Sokoloff, L. (1981). Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Southworth, R., C. R. Parry, et al. (2003). 'Tissue‐specific differences in 2‐fluoro‐2‐deoxyglucose metabolism beyond FDG‐6‐P: a 19F NMR spectroscopy study in the rat.' NMR in Biomedicine 16(8): 494-502. Strafella, A. P. and T. Paus (2001). 'Cerebral Blood-Flow Changes Induced by Paired-Pulse Transcranial Magnetic Stimulation of the Primary Motor Cortex.' Journal of neurophysiology 85(6): 2624-2629. Treves, S. (2007). 'Pediatric nuclear medicine/pet.' Recherche 67: 02. Ueki, M., F. Linn, et al. (1988). 'Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain.' Journal of Cerebral Blood Flow & Metabolism 8(4): 486-494. Ureshi, M., T. Matsuura, et al. (2004). 'Stimulus frequency dependence of the linear relationship between local cerebral blood flow and field potential evoked by activation of rat somatosensory cortex.' Neuroscience research 48(2): 147-153. Wang, K., M. van Meer, et al. (2011). 'Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level‐dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia.' NMR in Biomedicine 24(1): 61-67. Weber, R., P. Ramos-Cabrer, et al. (2006). 'A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat.' NeuroImage 29(4): 1303-1310. Yang, X., F. Hyder, et al. (1996). 'Activation of single whisker barrel in rat brain localized by functional magnetic resonance imaging.' Proceedings of the National Academy of Sciences 93(1): 475. Yang, X., F. Hyder, et al. (1997). 'Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels.' Magnetic Resonance in Medicine 38(6): 874-877. Zhao, F., T. Jin, et al. (2007). 'Isoflurane anesthesia effect in functional imaging studies.' NeuroImage 38(1): 3-4. Zhao, F., T. Zhao, et al. (2008). 'BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat.' NeuroImage 39(1): 248-260. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64133 | - |
dc.description.abstract | 功能性磁振造影(fMRI)是腦功能研究中甚佳的檢驗工具,其優越性在於闡明大腦中神經活動的空間分布。在囓齒動物的fMRI研究中,為避免動物不必要的壓力及掙扎,適當的麻醉是必須的。α-氯醛糖(α-chloralose)為動物fMRI中最常用的麻藥,因為這種麻藥可以很好的保留大腦中神經與血管間的耦合反應。然而,α-chloralose對於動物有害,因此並不建議用於長期追蹤研究。
最近有人提出以A2-腎上腺素受體的刺激劑medetomidine作為鎮定劑來進行動物fMRI,並在五天的間隔中經由周邊刺激獲得穩定的血氧濃度變化。在本實驗中,我們更進一步的結合這個方法與長期埋入MRI相容的刺激電極,試圖長期追蹤鼠腦中的視丘皮質迴路。 利用medetomidine進行麻醉,我們得以在長達幾週之間重複掃描直接電刺激腹外側視丘。我們在同側的初級感覺皮質獲得可重現的刺激強度與頻率依賴性血氧濃度反應,伴隨著高度保守性表現在其反應強度(兩次測試階段間的correlation coefficient = 0.8677, P < 0.001)、反應區域的大小(第二次測試階段為第一次的92.41-96.99%)以及位置(61.3-80.02% 的重疊率)。該反應的分布模式與在α-chloralose麻醉下所獲得的反應近乎相同,但反應強度較小。 我們也利用正子造影在S1發現了刺激強度依賴性的葡萄糖代謝變化。其S1中葡萄糖代謝變化量與血氧濃度反應強度呈現高度相關(correlation coefficient = 0.9001, P < 0.001)。這個新的方法將促使我們得以利用動物fMRI和PET來研究特定腦神經迴路於正常運作或疾病狀態下的長期可塑性變化。 | zh_TW |
dc.description.abstract | Functional magnetic resonance imaging (fMRI) provides an excellent tool for the examination of brain function, especially for revealing the global spatial activation pattern in the brain. For rodent fMRI, to prevent the undesired stress and motion artifacts, suitable anesthesia is needed. Alpha-chloralose is the most commonly used anesthetic in rodent fMRI, since it preserve well the neurovascular coupling response in the brain. However, α-chloralose is very harmful to the animal, and is not recommended for longitudinal study.
Recently, a noninvasive rat fMRI protocol using the A2-adrenoreceptor agonist medetomidine as sedative has been proposed, and the peripheral evoked BOLD response was observed reproducibly over 5 days. In the current study, we further combine this protocol with chronic implantation of MRI compatible stimulation electrode, and seek to longitudinally trace the thalamocortical circuit in the rat brain. By using medetomidine anesthesia, we were able to repetitively scan direct ventroposterior (VP) thalamus electrical stimulation over weeks. We found reproducible stimulus frequency and amplitude dependent BOLD response within ipsilateral S1, with highly conserved in amplitude (the correlation coefficient between two sessions = 0.8677, P < 0.001), area size (the second session was 92.41-96.99% to the first session) and location (61.3-80.02% overlapping). The pattern of the response was comparable to that under α-chloralose anesthesia, but the response amplitude was weaker. We also found stimulus amplitude dependent change of glucose consumption (CMRglu) in S1 by Positron Emission Tomography (PET). The change of CMRglu was highly correlated with the amplitude of BOLD response in S1, with the correlation coefficient of 0.9001 (P < 0.001). Thus this new protocol will enable us to study long-term plasticity of specific circuitry of the brain in normal function and in disease states by rodent fMRI and PET. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T17:31:25Z (GMT). No. of bitstreams: 1 ntu-101-R99b41004-1.pdf: 1814971 bytes, checksum: 745b359ca421f40a2c2c9d26d039f0e3 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 致謝 3
摘要 4 Abstract 5 Introduction 6 Magnetic resonance imaging 6 BOLD-fMRI 8 Positron emission tomography 10 FDG-PET 11 Anesthetic used in animal brain imaging 12 The somatosensory thalamocortical pathway from ventroposterior nucleus to primary somatosensory cortex 15 Purpose of current study 16 Materials and methods: 18 Animal preparation 18 Thalamic stimulus paradigms 19 BOLD-fMRI acquisition 19 BOLD-fMRI data processing and analysis 22 FDG-PET acquisition 22 FDG-PET data processing and analysis 24 Result 26 Tungsten electrode caused limited MR distortion 26 High reproducibility can be achieve in fMRI study under dexmedetomidine anesthesia 27 Comparison of the BOLD response under dexmedetomidine and α-chloralose anesthesia 28 Low reproducibility under isoflurane- based anesthesia fMRI 28 Glucose metabolic change evoked by VP stimulation under dexmedetomidine anesthesia 29 Glucose metabolic change evoked by VP stimulation under isoflurane anesthesia 30 Comparison between BOLD-fMRI and FDG-PET under dexmedetomidine anesthesia 31 Discussion 32 Longitudinal rodent fMRI 32 Dexmedetomidine anesthesia 33 Isoflurane anesthesia in fMRI 35 Deep brain stimulation in fMRI 36 Significance 38 Reference 39 Figures 46 | |
dc.language.iso | en | |
dc.title | 穩定長期使用功能性磁振造影與正子斷層攝影術探討大鼠腦部深層腦刺激的反應 | zh_TW |
dc.title | A Stable Protocol for Longitudinal Studies of BOLD-fMRI and FDG-PET Imaging DBS Response in the Rat Brain | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張程,陳志宏,徐百川,曾凱元 | |
dc.subject.keyword | 功能性磁振造影,正子斷層攝影,深層腦刺激,血氧濃度,氟-18去氧葡萄糖, | zh_TW |
dc.subject.keyword | BOLD,fMRI,FDG,PET,DBS,deep brain stimulation,longitudinal, | en |
dc.relation.page | 63 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-08-15 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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