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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64048完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳永耀(Yung-Yaw Chen) | |
| dc.contributor.author | Ming-Hsien Tsai | en |
| dc.contributor.author | 蔡旻諴 | zh_TW |
| dc.date.accessioned | 2021-06-16T17:27:54Z | - |
| dc.date.available | 2017-08-17 | |
| dc.date.copyright | 2012-08-17 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-15 | |
| dc.identifier.citation | References
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[14] 'Introduction of audio gating to further reduce organ motion in breathing synchronized radiotherapy,' Medical Physics, vol. 29, p. 345, 2002. [15] Y. Seppenwoolde, H. Shirato, K. Kitamura, S. Shimizu, M. van Herk, J. V. Lebesque, and K. Miyasaka, 'Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy,' International Journal of Radiation Oncology*Biology*Physics, vol. 53, pp. 822-834, 2002. [16] K. Hynynen, A. Darkazanli, E. Unger, and J. F. Schenck, 'MRI-guided noninvasive ultrasound surgery,' Medical Physics, vol. 20, pp. 107-115, 1993. [17] F. Wu, Z.-B. Wang, H. Zhu, W.-Z. Chen, J.-Z. Zou, J. Bai, K.-Q. Li, C.-B. Jin, F.-L. Xie, and H.-B. Su, 'Feasibility of US-guided High-Intensity Focused Ultrasound Treatment in Patients with Advanced Pancreatic Cancer: Initial Experience1,' Radiology, vol. 236, pp. 1034-1040, September 1, 2005 2005. [18] B. D. de Senneville, C. Mougenot, and C. T. W. Moonen, 'Real-time adaptive methods for treatment of mobile organs by MRI-controlled high-intensity focused ultrasound,' Magnetic Resonance in Medicine, vol. 57, pp. 319-330, 2007. [19] F. M. Axel J. Krafft, Wolfhard Semmler, Michael Bock, 'A long arm for ultrasound: a combined robotic focused ultrasound setup for magnetic resonance-guided focused ultrasoud surgery.,' Med. Phys., vol. 37, p. 14, 2010. [20] F. Wu, Z.-B. Wang, W.-Z. Chen, J.-Z. Zou, J. Bai, H. Zhu, K.-Q. Li, F.-L. Xie, C.-B. Jin, H.-B. Su, and G.-W. Gao, 'Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience,' Ultrasound in Medicine & Biology, vol. 30, pp. 245-260, 2004. [21] O. Al-Bataineh, J. Jenne, and P. Huber, 'Clinical and future applications of high intensity focused ultrasound in cancer,' Cancer Treatment Reviews, vol. 38, pp. 346-353, 2012. [22] Y.-Y. Li, W.-H. Sha, Y.-J. Zhou, and Y.-Q. Nie, 'Short and long term efficacy of high intensity focused ultrasound therapy for advanced hepatocellular carcinoma,' Journal of Gastroenterology and Hepatology, vol. 22, pp. 2148-2154, 2007. [23] L. Zhang, H. Zhu, C. Jin, K. Zhou, K. Li, H. Su, W. Chen, J. Bai, and Z. Wang, 'High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins,' European Radiology, vol. 19, pp. 437-445, 2009. [24] C.-H. Ho, 'Tracking Platform Design and Implementation for Ultrasound-Guided Focused Ultrasound Treatment,' National Taiwan University, 2010. [25] Y.-C. Chen, 'Motion Estimation by Respiratory Surrogated Signals for Liver Tumor Tracking,' National Taiwan University, Taiwan, 2011. [26] Matrox Co. Available: http://www.matrox.com/ [27] MC Co. Available: http://www.mccdaq.com/ [28] 'National Instruments Co.' | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64048 | - |
| dc.description.abstract | 在近年的研究中，核磁共振影像導引的高強度聚焦型超音波熱療系統在治療靜態腫瘤中獲得不錯的治療效果。然而在治療動態腫瘤上，由於用於定位動態腫瘤的核磁共振影像成像速度只有7 Hz，無法達到即時的定位追蹤加熱治療，例如肝癌與肺癌。
本研究目標為建立一套由超音波影像導引的同步系統，將可應用於肝臟腫瘤的高強度聚焦型超音波加熱治療。超音波影像的成像速度高達17 Hz，足以即時的同步追蹤肝腫瘤，並具有低成本與無副作用等優點。然而超音波影像有厚度方向定位誤差與低解析度等缺點，因此本研究針對肝臟移動軌跡具有一個明顯移動主軸的特性，提出了一套超音波影像校正與同步的方法，以降低超音波影像的厚度定位誤差並與肝臟腫瘤的運動進行同步運動。為了實現本研究提出的方法，本論文建構了具有六個自由度的機械手臂，能實現超音波影像在厚度方向上校正所需的各種角度與進行三維空間的同步運動。在以直徑為10 mm的塑膠珠實驗中，超音波影像厚度校正平均誤差為1.2度與0.4 mm；同步的方均根誤差均小於1.24 mm。相信此研究對於將來在以超音波影像導引的超強度聚焦型超音波熱療肝腫瘤上有一定程度的貢獻。 | zh_TW |
| dc.description.abstract | In recent studies, magnetic resonance image-guided high intensity focused ultrasound thermotherapy system has been proposed for the static tumors such as breast tumors and uterine fibroid tumors. However, it is very difficult to achieve real-time tracking thermotherapy by magnetic resonance image in mobile tumors, such as liver tumors and lung tumors. It is because the frame rate of the magnetic resonance image is only 7 Hz, which is not sufficient for real-time tracking.
Therefore, this study is aimed at developing an ultrasound image-guided synchronization system. It can be applied to ultrasound image-guided high intensity focused ultrasound thermotherapy system for liver tumor. Compare to the magnetic resonance image, the ultrasound image has the advantage of high speed, low cost, and no harm to human body. However, ultrasound image has the shortage of slice thickness effect. This study bases on the characteristics of liver movement, and proposes the alignment and synchronization methods to reduce the slice thickness effect of ultrasound image. In order to realize the proposed alignment and synchronization methods, the six degree of freedom robot arm is built on the therapeutic system. The six degree of freedom robot arm is built based on the size and the movement of human liver. The alignment and synchronization experiments are done under the plastic ball experiments. The average alignment error is 1.2 degree and 0.4 mm. The synchronization errors are below 1.24 mm. It is believed that this study can apply to the real-time ultrasound image-guided high intensity focused ultrasound thermotherapy system for liver tumors. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T17:27:54Z (GMT). No. of bitstreams: 1 ntu-101-R99921057-1.pdf: 2152418 bytes, checksum: f0fa1cefddd1107c63d96aa05fccbb03 (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | Content
誌謝 i 中文摘要 ii Abstract iii List of Figures viii List of Tables xv Chapter 1 Introduction 1 1.1 Background 2 1.1.1 High Intensity Focused Ultrasound (HIFU) 2 1.1.2 The Characteristics of Liver Tumor 5 1.1.3 Gating and Tracking 6 1.2 Motivation 7 1.3 Thesis Overview 12 Chapter 2 Previous Work 14 2.1 Computed Tomography-guided High Intensity Focused Ultrasound Surgery 15 2.2 Magnetic Resonance Image-guided High Intensity Focused Ultrasound Surgery 17 2.3 Ultrasound Image-guided High Intensity Focused Ultrasound Surgery 20 2.4 Summary 23 Chapter 3 Design of Therapeutic System 25 3.1 Design Idea of The Therapeutic Platform 28 3.2 Design of Six Degree of Freedom Robot Arm 31 3.2.1 Design in X, Y, and Z Axes 32 3.2.2 Design in Roll, Pitch, and Yaw Axes 38 3.3 XPC System (Real-Time Operating System) 44 3.4 Summary 46 Chapter 4 Align Ultrasound Image with Liver Tumor Trajectory 49 4.1 Alignment Procedures 50 4.2 Test of Alignment System 57 4.2.1 Alignment Experiments Setup 58 4.2.2 Image Positioning in Alignment Experiments 59 4.2.3 Alignment Experiments Results 60 4.2.4 Verify Alignment Results 74 4.3 Summary 78 Chapter 5 Synchronization of Ultrasound Probe with Liver Tumor Motion 80 5.1 Synchronization Methods 80 5.2 Test of Synchronization System 82 5.2.1 Synchronization Experiments Setup 83 5.2.2 Synchronization Experiment Results 84 5.3 Summary 86 Chapter 6 Conclusions and Future Work 88 Appendix A 90 Appendix B 93 References 96 | |
| dc.language.iso | en | |
| dc.subject | 同步 | zh_TW |
| dc.subject | 超音波影像導引系統 | zh_TW |
| dc.subject | 肝腫瘤治療 | zh_TW |
| dc.subject | 校正 | zh_TW |
| dc.subject | alignment | en |
| dc.subject | liver tumor treatment | en |
| dc.subject | synchronization | en |
| dc.subject | ultrasound image-guided system | en |
| dc.title | 以超音波影像同步追蹤由呼吸導致之肝腫瘤運動 | zh_TW |
| dc.title | Synchronized Tracking of Respiration-Induced Liver Tumor Motion by Ultrasound Imaging | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林文澧(Win-Li Lin),連豊力,顏家鈺,何明志 | |
| dc.subject.keyword | 超音波影像導引系統,肝腫瘤治療,同步,校正, | zh_TW |
| dc.subject.keyword | ultrasound image-guided system,liver tumor treatment,synchronization,alignment, | en |
| dc.relation.page | 100 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-08-16 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 電機工程學研究所 | zh_TW |
| 顯示於系所單位： | 電機工程學系 | |
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