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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
| dc.contributor.author | Yi-Chun Tsung | en |
| dc.contributor.author | 宗怡君 | zh_TW |
| dc.date.accessioned | 2021-06-16T13:20:51Z | - |
| dc.date.available | 2023-07-25 | |
| dc.date.copyright | 2013-07-31 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-07-25 | |
| dc.identifier.citation | [1] L. L. Hench and J. R. Jones, Biomaterials, Artificial Organs and Tissue Engineering, Woodhead Pub. Ltd., Cambridge, England (2005)
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61965 | - |
| dc.description.abstract | 硫酸鈣(CS)具有良好的生物相容性與可生物降解的特性，因此應用於骨替代生醫材料已行之有年。而含有SiO2-P2O5-CaO-Na2O組成結構的生物活性玻璃，能使材料與骨組織鍵結，具有刺激骨細胞分化增殖，促進新骨生成的能力。因此本實驗的目的為以硫酸鈣作基材，添加少量的燒結添加劑，如SiO2、P2O5、CaO、NaHCO3及Ag，探討其燒結行為與生物降解行為。除此之外。玻璃粉末亦當作添加劑，進一步對硫酸鈣進行改質。本實驗結果顯示，添加少量添加劑對硫酸鈣的燒結密度影響不大。此外，由微結構觀察可發現到反應相的生成，此反應相會阻礙硫酸鈣的晶粒成長。相對於未添加的純硫酸鈣陶瓷，含少量添加劑的硫酸鈣可具有較高的抗壓強度，且降解速率也有明顯的降低。整體而言，在適當的燒結環境之下，少量添加劑對於硫酸鈣的機械性質和降解行為皆有顯著的改善。故此複合材料具有良好的潛力，能在骨替代生醫陶瓷領域上有進一步的應用。 | zh_TW |
| dc.description.abstract | Calcium sulfate (CS) has been used as a bone graft substitute for more than 100 years. It exhibits many desired properties as a bone substitute. These properties include biocompatible and biodegradable. The aim of the present study is to investigate the sintering and biodegradation behavior of the calcium sulfate. A small amount of sintering additives was used to improve the sinterability of CS. These additives are SiO2, P2O5, CaO, NaHCO3 and Ag. The additives are added into CS and then sintered at 1100°C. Several SiO2–CaO–P2O5–Na2O bioactive glasses exhibit excellent proliferation and differentiation for osteoblasts. They are also potential substitutes to form new bone. The glass powders were also added into CS to modify its properties.
The results demonstrate that a small amount of additives or glass affects little on the density. A reaction phase is formed; it inhibits the growth of CS grains during the sintering. The compressive strength of the specimens is increased after adding the additives. The degradation rate is slower than that of the pure CS specimens. All these results suggest that by adding a small amount of additives can improve the properties of CS. The composites investigated in the present study could be used for further application as a bone substitute. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T13:20:51Z (GMT). No. of bitstreams: 1 ntu-102-R00527008-1.pdf: 16420971 bytes, checksum: ee22a2c348e54468648931f82b7b1ff9 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | Content
Chapter 1: Introduction 1 Chapter 2: Literature review 3 2-1 Basics of bones 3 2-2 Bioceramics and bone graft substitutes 6 2-3 Use of calcium sulfate as bioceramics 10 2-3-1 Chemical and physical properties of calcium sulfate 10 2-3-2 Biological properties and clinical applications of calcium sulfate 13 2-4 Use of bioactive glasses and glass-ceramics as bioceramics 17 2-4-1 Bioactive ceramics 17 2-4-2 Bioactive glasses and bioactive glass-ceramics 18 2-5 Combination of calcium sulfate and bioactive glasses 23 Chapter 3: Experimental procedures 26 3-1 CaSO4 with 1wt% SiO2 26 3-1-1 Materials 26 3-1-2 Processing 26 3-1-3 Characterization 28 3-1-3-1 Physical properties 28 3-1-3-2 Mechanical properties 29 3-1-3-3 Degradation test 30 3-2 CaSO4 with 1wt% multiple sintering additives 33 3-2-1 Materials 33 3-2-2 Processing 34 3-2-3 Characterization 36 3-3 CaSO4 with 1wt% glass 37 3-3-1 Materials 37 3-3-2 Processing 38 3-3-3 Characterization 39 Chapter 4: Results 40 4-1 CaSO4 with 1wt% SiO2 40 4-1-1 Density 40 4-1-2 Phase identification 42 4-1-3 Microstructure observation 44 4-1-4 Mechanical properties 50 4-1-5 Degradation test 51 4-1-5-1 pH value and weight loss 51 4-1-5-2 Ion release 55 4-1-5-3 Surface morphology 58 4-1-5-4 Phase identification 65 4-2 CaSO4 with 1wt% multiple sintering additives 68 4-2-1 Density 68 4-2-2 Phase identification 70 4-2-3 Microstructure observation 71 4-2-4 Mechanical properties 73 4-2-5 Degradation test 74 4-2-5-1 pH value and weight loss 74 4-2-5-2 Ion release 77 4-2-5-3 Surface morphology 80 4-2-5-4 Phase identification 85 4-3 CaSO4 with 1wt% glass 88 4-3-1 Density 88 4-3-2 Phase identification 91 4-3-3 Microstructure observation 94 4-3-4 Mechanical properties 95 4-3-5 Degradation test 96 4-3-5-1 pH value and weight loss 96 4-3-5-2 Ion release 99 4-3-5-3 Surface morphology 101 4-3-5-4 Phase identification 105 Chapter 5: Discussion 107 5-1 CaSO4 with 1wt% SiO2 107 5-1-1 Sintering behavior 107 5-1-2 Mechanical properties 113 5-1-3 Degradation behavior 115 5-2 CaSO4 with 1wt% multiple sintering additives 121 5-2-1 Sintering behavior 121 5-2-2 Mechanical properties 122 5-2-3 Degradation behavior 123 5-3 CaSO4 with 1wt% glass 127 5-3-1 Sintering behavior 127 5-3-2 Mechanical properties 128 5-3-3 Degradation behavior 129 5-4 Comparison 133 Chapter 6: Conclusions 136 Chapter 7: Future work 137 Reference 138 | |
| dc.language.iso | zh-TW | |
| dc.subject | 燒結 | zh_TW |
| dc.subject | 生物活性玻璃 | zh_TW |
| dc.subject | 二氧化矽 | zh_TW |
| dc.subject | 硫酸鈣 | zh_TW |
| dc.subject | 生物降解 | zh_TW |
| dc.subject | bioactive glass | en |
| dc.subject | calcium sulfate | en |
| dc.subject | silica | en |
| dc.subject | sintering | en |
| dc.subject | biodegradation | en |
| dc.title | 含少量添加物之硫酸鈣生醫陶瓷其燒結性質與生物降解行為的研究 | zh_TW |
| dc.title | Sintering and biodegradation behavior of calcium sulfate with a small amount of sintering additives | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 施劭儒(shao-Ju Shih),劉典謨(Dean-Mo Liu) | |
| dc.subject.keyword | 硫酸鈣,生物活性玻璃,二氧化矽,燒結,生物降解, | zh_TW |
| dc.subject.keyword | calcium sulfate,bioactive glass,silica,sintering,biodegradation, | en |
| dc.relation.page | 152 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-07-25 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 材料科學與工程學系 | |
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