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標題: | 頻域光學同調斷層掃瞄系統建立及其於侷域表面電漿子共振感應之光熱效應量測應用 Construction of a Spectral-domain Optical Coherence Tomography System and Its Application to the Measurement of the Photothermal Effect Induced by Localized Surface Plasmon Resonance |
作者: | Chen-Chin Liao 廖展勤 |
指導教授: | 楊志忠 |
關鍵字: | 光學同調斷層掃描,侷域表面電漿子, Optical coherence tomography,Localized surface plasmon, |
出版年 : | 2013 |
學位: | 碩士 |
摘要: | 在本論文中,我們利用兩套不同工作波長光學同調斷層掃瞄系統來掃瞄含有金奈米環以及無金奈米環之洋菜凍假體,取得散射和光熱影像來比較。本實驗金奈米環之侷域表面電漿子共振波長為1320奈米,在工作波長1310奈米之光學同調斷層掃瞄系統下可藉由此金奈米環提升同調散射而獲得清楚光學同調斷層掃瞄之影像。在操作波長分別為800及1310奈米之兩光學同調斷層掃瞄系統下使用一調變式激發雷射時,可藉由侷域表面電漿子之共振吸收得到一清楚光熱影像。為增加背景散射,我們將洋菜凍混入豆漿,並利用工作波長800奈米之光學同調斷層掃瞄系統掃瞄,發現雖然散射訊號較弱,但其光熱訊號相當強。當光學同調斷層掃瞄工作波長落在金奈米環侷域表面電漿子共振頻譜之外,其光熱訊號會隨著背景散射訊號增強而提升。實際在追蹤金奈米環應用的觀點上,同時獲得一清楚之光學同調斷層掃瞄影像和光熱影像更能讓我們準確地辦認金奈米環的分佈,然而為了達到此目標,侷域表面電漿子共振波長和光學同調斷層掃描工作波長需要匹配,使得金奈米環的選擇彈性變低。 In this research, the intensity and photothermal images of optical coherence tomography (OCT) scanning of agar phantoms with and without the mixture of Au nanorings (NRIs) based on two OCT systems of different operation wavelengths are compared. The Au NRIs have the localized surface plasmon (LSP) resonance peak at ~1320 nm, leading to enhanced coherent scattering for producing clear OCT intensity images with the OCT system of 1310 nm in operation wavelength. Also, the LSP resonance induced absorption results in clear photothermal images through phase signal calibration of OCT scanning with the 1310-nm OCT system and another OCT system of 800 nm in central operation wavelength when a modulated excitation laser is applied. It is found that although the intensity image signal is weak with the 800-nm OCT system, its photothermal signal is quite strong, particularly when bean milk is mixed with agar for enhancing background scattering. The photothermal signal level increases with increasing background scattering when the OCT operation wavelength is located outside the spectral range of LSP resonance of Au NRI. In the viewpoint of practical application of Au nanoparticle (NP) tracking, simultaneous acquirement of clear OCT intensity and photothermal images can help in more precisely identifying the distribution of Au NPs. However, to this goal, the required matching of LSP resonance wavelength and OCT operation wavelength results in lower flexibility of choosing the used Au NP. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61831 |
全文授權: | 有償授權 |
顯示於系所單位: | 光電工程學研究所 |
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