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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳立仁 | |
dc.contributor.author | Hsueh-Wen Tseng | en |
dc.contributor.author | 曾學文 | zh_TW |
dc.date.accessioned | 2021-06-16T13:08:15Z | - |
dc.date.available | 2016-09-01 | |
dc.date.copyright | 2013-08-08 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-01 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61643 | - |
dc.description.abstract | 本研究主要分成兩部分,第一部分探討界面活性劑Pluronics形成混合微胞的機制與熱力學性質,第二部分探討聚電解質/界面活性劑系統中的交互作用情形。
在第一部分中,藉由高感度微分掃描式熱卡計和粒徑分析儀觀察不同Pluronics系統形成混合微胞的過程機制。Pluronics是一系列結構為聚氧乙烯-聚氧丙烯-聚氧乙烯的界面活性劑。實驗探討的混合系統包含Pluronic L92 + F68 / F88 / F98 / F108和Pluronic L92 + P84 / F87 / F88;其中,L92 單成份系統在溫度高於臨界微胞溫度(critical micelle temperature, CMT)之後形成層板狀的聚集,其他的Pluronics皆是形成球形的微胞。Pluronic F68、F88、F98和F108這四種Pluronics分子具有相同的親水/疏水片段比例,但分子鏈長不同,實驗結果發現雙成份系統中F108、F98的疏水片段較L92疏水片段長或相同,可以主導形成混合微胞的過程,將L92包覆在內形成球形的混合微胞。L92 + F88系統受L92濃度影響會有不同的混合微胞形成機制;L92 + F68系統因兩成份鏈長以及CMT相差較大,會在系統中分別形成各自的微胞。 P84、F87和F88則是分子中具有相同分子量的疏水片段,但有不同的親水片段鏈長,此系列探討不同比例的親疏水片段對系統的影響,實驗結果發現親疏水片段比例對於系統形成混合微胞的影響沒有明顯的趨勢,但三系統所形成的混合微胞皆受L92的主導,不夠穩定,可能不足以當作藥物釋放的載體。 第二部分中,利用核磁共振儀、恆溫滴定熱卡計和表面張力儀觀察聚電解質Poly acrylic acid (PAA)與非離子型界面活性劑Tetraethylene glycol monooctyl ether (C8E4)、Pentaethylene glycol monooctyl ether (C8E5)之間的交互作用情形,以了解微胞形成的機制與熱力學性質分析。實驗結果發現,將界面活性劑C8E4或C8E5加入PAA溶液後,當濃度超過臨界聚集濃度 (critical aggregation concentration, CA)後,C8E4 (C8E5)會開始附著到PAA分子鏈上,同時也會開始形成自由微胞,此與一般認為界面活性劑會先被吸附至PAA長碳鏈上,直到PAA長碳鏈達到飽和後界面活性劑才會開始形成自由微胞的現象不同,因為C8E4和C8E5屬於非離子型的界面活性劑,和陰離子型的聚電解質PAA之間沒有強烈的靜電吸引力,而是藉由疏水作用力而產生較弱的交互作用。 | zh_TW |
dc.description.abstract | The first part of this work, we study mixed-micelle formed mechanism and thermodynamic properties of the binary Pluronics system by differential scanning calorimeter (DSC) and Particle Size Analyzer. Pluronics are copolymers which have poly (ethylene oxide) – poly (propylene oxide) – poly (ethylene oxide) (PEO-PPO-PPO) structure. We investigate several mixed-systems including Pluronic L92 + F68 / F88 / F98 / F108 and Pluronic L92 + P84 / F87 / F88. In individual system, L92 forms lamellar aggregation when temperature is higher than its critical micelle temperature (CMT), and other Pluronics form spherical micelles.
F68, F88, F98 and F108 have the same ratio of hydrophilic segments to hydrophobic segments, but different chain lengths. Then we can identify the influence of molecule chain length on mixed-micellization. F108 has larger hydrophobic segment than L92. The L92 + F108 system is dominated by F108 to form spherical mixed – micelles, as well as the L92 + F98 system. The mechanism of L92 + F88 system is affected by L92 concentration. In L92 + F68 system, they form individual micelles. P84, F87 and F88 have same chain length of hydrophobic segments, but different chain lengths of hydrophilic segments. Compare the three different systems (L92 + P84 / F87 / F88), we can analyze the effect of different ratios of hydrophilic segments to hydrophobic segments on the micelle formation mechanism. However there is no significant trend according to these three different ratios. In these three systems, the micelle formation mechanism is still dominated by L92. The mix-micelles are too unstable to be applied as drug release carriers. In the second part of this work, we use nuclear magnetic resonance (NMR), isothermal titration calorimeter (ITC) and tensiometer to explore the interaction between nonionic surfactant and anionic polyelectrolyte. Two systems tetraethylene glycol monooctyl ether (C8E4) + poly acrylic acid (PAA) and Pentaethylene glycol monooctyl ether (C8E5) + poly acrylic acid (PAA) are examined. It is found the interaction mechanism of these two systems is different from that of cationic surfactant + anionic polyelectrolyte system. There is no strong electrostatic attraction between C8Ej and PAA. When the surfactant C8Ej starts to bind to PAA chain, C8E4 molecules also simultaneously form free micelles. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T13:08:15Z (GMT). No. of bitstreams: 1 ntu-102-R00524034-1.pdf: 3313916 bytes, checksum: 80600235b45a2cbb767b6ba2a835e3ab (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 摘要 I
Abstract III 目錄 V 表目錄 VIII 圖目錄 IX 第一章 緒論 1 第二章 文獻回顧 9 2-1界面活性劑與微胞 9 2-1.1界面活性劑形成微胞之機制 9 2-1.2 Pluronics形成微胞之機制 10 2-1.3臨界微胞溫度和臨界微胞濃度 11 2-1.4影響微胞化過程的因素 12 2-2 微胞化過程之熱力學模型 14 2-2.1相變模型 14 2-2.2質量作用模式 16 2-2.3由ITC實驗分析微胞化過程 17 2-3 雙成份Pluronics系統 19 2-4聚電解質之溶液特性 20 2-5聚電解質/界面活性劑系統 21 2-5.2帶相反電性之聚電解質/界面活性劑系統 25 2-5.3帶相同電性之聚電解質/界面活性劑系統 25 2-5.4聚電解質/非離子型界面活性劑系統 25 2-6表面張力之探討 26 第三章 實驗設備及方法 33 3-1實驗設備 33 3-2實驗藥品 35 3-3儀器測量原理 36 3-3.1高感度微分掃描式熱卡計 36 3-3.2動態光散射粒徑分析儀 36 3-3.3恆溫滴定熱卡計 37 3-3.4表面張力儀 38 3-4實驗方法 38 3-4.1實驗用具清洗與藥品配製 38 3-4.2高感度微分掃描式熱卡計 39 3-4.3動態光散射粒徑分析儀 40 3-4.4恆溫滴定熱卡計 40 3-4.5表面張力儀 42 第四章 結果與討論-混合Pluronics系統 49 4-1高感度微分掃描式熱卡計數據處理方法 49 4-1.1臨界微胞溫度的定義 49 4-1.2 DSC數據積分基線的決定 50 4-2動態光散射粒徑分析儀數據處理方法 50 4-3 Pluronics鏈長對混合微胞化過程的影響 50 4-3.1 L92 + F108和L92 + F98混合系統結果討論 51 4-3.2 L92 + F88混合系統結果討論 52 4-3.3 L92 + F68混合系統結果討論 54 4-3.4綜合結果討論 55 4-4 Pluronics親疏水片段比例對微胞化過程的影響 56 4-4.1 L92 + F88 / F87混合系統結果討論 56 4-4.2 L92 + P84混合系統結果討論 57 4-4.3綜合結果討論 58 4-5雙成份Pluronics系統結果統整 59 第五章 結果與討論- PAA+C8E4/C8E5系統 75 5-1核磁共振儀(NMR)數據處理方法 75 5-2恆溫滴定熱卡計(ITC)數據處理方法 76 5-2.1 ITC積分基線的決定 76 5-2.2微胞化過程之特徵濃度和∆Hm的決定 77 5-2.3 PAA + C8E4 / C8E5交互作用探討與∆Had計算方法 78 5-3表面張力數據處理方法 79 5-4 PAA + C8E4 / C8E5系統結果討論 79 5-4.1 PAA + C8E4系統NMR結果討論 80 5-4.2 PAA + C8E4 / C8E5系統ITC結果討論 82 5-4.2 PAA + C8E4 / C8E5系統表面張力結果討論 83 5-4.2 PAA + C8E4系統混濁度結果討論 84 5-5 PAA + C8E4 / C8E5系統結果統整 85 第六章 結論 111 參考文獻 113 附錄Ⅰ 粒徑分析儀原始實驗數據 119 附錄Ⅱ 混合Pluronics系統微胞化過程機制示意圖 128 附錄Ⅲ C8E4+PAA系統微胞化過程機制示意圖 131 | |
dc.language.iso | zh-TW | |
dc.title | 界面活性劑微胞化過程之機制與熱力學性質探討 | zh_TW |
dc.title | A Study on the Mechanisms and Thermodynamic Properties of Micellization of Surfactants | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳炳宏,林析右,蔡瑞瑩 | |
dc.subject.keyword | 界面活性劑,聚電解質,微胞,混合微胞,混微胞複合物,微分掃描式熱卡計,恆溫滴定熱卡計, | zh_TW |
dc.subject.keyword | surfactant,pluronic,C8E4,C8E5,polyelectrolyte,poly(acrylic acid),PAA,mixed micelle,polyelectrolyte-surfactant complexes,differential scanning calorimeter,DSC,isothermal titration calorimetry,ITC, | en |
dc.relation.page | 131 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-01 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
顯示於系所單位: | 化學工程學系 |
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