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  1. NTU Theses and Dissertations Repository
  2. 工學院
  3. 醫學工程學研究所
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61514
完整後設資料紀錄
DC 欄位值語言
dc.contributor.advisor林啟萬(Chii-Wann Lin)
dc.contributor.authorTso-Jui Linen
dc.contributor.author林佐叡zh_TW
dc.date.accessioned2021-06-16T13:04:42Z-
dc.date.available2018-08-07
dc.date.copyright2013-08-07
dc.date.issued2013
dc.date.submitted2013-08-05
dc.identifier.citation1. Jon S. Wilson, Sensor Technology HANDBOOK, Butterworth-Heinemann, 2004.
2. David A. Armbruster and Terry Pry, “Limit of blank, limit of detection and limit of quantutation”, The Clinical Biochemist Reviews, Vol. 29, p. S49–S52, 2008.
3. David R. Walt, “Optical methods for single molecule detection and analysis”, Analytical Chenistry, vol. 85, p. 1258−1263, 2013.
4. James J. Collins, Carson C. Chow, and Thomas T. Imhoff, “Aperiodic stochastic resonance in excitable systems”. Physical Review E, Vol. 52, p. R3321-3324, 1995.
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17. Ahmad S. Asdi, and Ahmad H. Tewfik, ” Detection of weak signal using adaptive stochastic resonance”, Acoustics, Speech and Signal Processing, vol 2, p. 1332-1335, 1995.
18. Hamamatsu, “The H9306/H9307 series photosensor modules”
19. P. Pattnaik, “Surface plasmon resonance: applications in understanding receptor-ligand interaction”, Applied Biochemistry and Biotechnology, vol. 126, p. 79-92, 2005.
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dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61514-
dc.description.abstract隨機共振理論是描述在非線性的環境中,外加隨機訊號的擾動可以增強微小訊號或增強訊號中所挾帶的訊息。在最佳的雜訊強度下可以增強系統訊號,顛覆傳統中增加雜訊強度只會降低系統的量測能力。隨機共振現象出現的條件必須在非線性系統中而不會出現在嚴謹的線性系統中,在線性系統中加入雜訊只會有降低系統效能的效果。非線性系統可以將雜訊的能量轉移到訊號上,經過非連續性的系統擷取後,增強訊號的頻率成份等有意義的訊息。
  在程式及真實的感測器中驗證隨機共振機制的存在,接著利用自製的表面電漿共振系統驗證在訊號非常微小的情況下,雜訊對於訊號的影響。其中外加的光雜訊是利用被訊號產生器產生的雜訊所驅動的發光二極體加入,探討在真實的感測系統中隨機共振的效果。本實驗的結果證明外加光雜訊可以增加微小訊號的頻率成份,搭配鎖相放大器可以使直流輸出的振幅增加。這種隨機共振的非線性系統可能存在於光電倍增管的二次發射極對光電子的聚焦,在有最佳的雜訊強度中,光電子聚焦在發射極的基數較大且有較高的輸出訊號。
  本研究結合隨機共振與鎖相放大器,提出一個針對微小訊號的量測方式,實驗結果證明雜訊在特定條件下不只有降低系統效能的影響,若以更適合的非線性條件和微小訊號的條件下,隨機共振的機制應可以增強整體系統的感測效果。並且可以嘗試使用隨機共振法量測單分子,相較表面電漿共振系統更微小的訊號。
zh_TW
dc.description.abstractStochastic resonance is a nonlinear phenomenon whereby the addition of a random interference can enhance the detection of weak stimuli of a signal. An optimal amount of added noise results in the maximum enhancement, whereas further increases in the noise intensity only degrade detectability or information content. The phenomenon does not occur in strictly linear systems, where the addition of noise to either the system or the stimulus only degrades the measures of signal quality.
In this research, this research verified stochastic resonance in program and real sensor. Then applied stochastic resonance mechanism to surface plasmon resonance detection system using the second LED which is driven by function generator white noise. According to our result, the amplitude of weak signal from lock-in amplifier will be improved by adding noise. This effect may be caused because stochastic resonance mechanism appear in photocathode of photomultiplier.
This research developed a novel detection method for improving amplitude of weak signal. Stochastic resonance using noise to enhance signal with non-linear system. This method may be applied to weak signal detection such as single molecule detection.
en
dc.description.provenanceMade available in DSpace on 2021-06-16T13:04:42Z (GMT). No. of bitstreams: 1
ntu-102-R00548024-1.pdf: 10826202 bytes, checksum: 2fcef97b9925e13b617a29878ab21494 (MD5)
Previous issue date: 2013
en
dc.description.tableofcontents第一章 緒論 1
1.1 前言 1
1.2 研究動機與目的 2
1.3 論文架構 3
第二章 文獻回顧 4
2.1 隨機共振理論 4
2.1.1 隨機共振 4
2.1.2 隨機共振程式模擬 13
2.1.3 隨機共振硬體模擬 18
2.2 表面電漿共振 23
2.2.1 表面電漿共振原理 23
2.2.2 表面電漿共振激發方式 24
2.2.3 表面電漿共振量測方式比較 26
2.3 鎖相放大器 27
第三章 研究材料與方法 30
3.1 表面電漿共振系統架設 30
3.2 鎖相放大器 33
3.2.1 鎖相放大器系統架構 33
3.2.2 鎖相放大器軟體與流程 34
3.3 隨機共振光路設計 36
3.3.1 非線性系統 36
3.3.2 雜訊光路架構 37
第四章 實驗結果 39
4.1 表面電漿共振系統效能評估 39
4.1.1 樣品訊號量測 39
4.1.2 系統效能分析 41
4.2 鎖相放大器於表面電漿共振系統效能評估 45
4.3 隨機共振於表面電漿共振系統之影響 47
第五章 結論與未來展望 53
dc.language.isozh-TW
dc.title以隨機共振理論增強反射式表面電漿共振系統之研究zh_TW
dc.titleSurface Plasmon Resonance System Enhancement Using Stochastic Resonance Theoryen
dc.typeThesis
dc.date.schoolyear101-2
dc.description.degree碩士
dc.contributor.oralexamcommittee蕭子健(Tzu-Chien Hsiao),彭盛裕(Sheng-Yu Peng)
dc.subject.keyword隨機共振,表面電漿共振,鎖相放大器,微小訊號量測,非線性系統,zh_TW
dc.subject.keywordstochastic resonance,SPR,lock-in amplifier,weak signal detection,nonlinear system,en
dc.relation.page57
dc.rights.note有償授權
dc.date.accepted2013-08-05
dc.contributor.author-college工學院zh_TW
dc.contributor.author-dept醫學工程學研究所zh_TW
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