Please use this identifier to cite or link to this item:
Language-related lateralization before/after antipsychotics treatment in first-episode schizophrenia: an fMRI study
|Publication Year :||2013|
Purpose: Language disorder is one of the core symptoms of schizophrenia. Previous studies have found the decrease of language-related lateralization in patients with schizophrenia. However, little is known whether the aberrant language-related lateralization could be reversed after treatment with antipsychotics for drug-naive first-episode patients. This study was aimed to observe changes of language-related lateralization, clinical symptoms, and language-related functions after antipsychotics treatment. Methods: Eleven drug-naive first-episode patients and eleven matched healthy controls were recruited. Before treatment, both groups received neuropsychological testing (NPT), and the patient group received additional clinical rating with the Positive and Negative Syndrome Scale (PANSS). Both groups also underwent the semantic judgment task within a magnetic resonance imaging (MRI) scanner. The patient group then received treatment with aripiprazole (averaged dose of 6.5 mg/day). At week 4, the patient group received NPT and PANSS again, and at week 6 the second semantic judgment task within MRI scanner. Brain images were collected and lateralization index in patients was calculated before/after treatment. Additionally, the magnitudes of brain activations were correlated with the behavioral performance, PANSS rating scores, and language-related NPT measures. Results: The direct comparison of before-treatment versus after-treatment produced significant activation in right inferior frontal gyrus (IFG) and right middle/inferior temporal gyrus (MTG/ITG) for the patient group. The lateralization index of the IFG and ITG was reversed after aripiprazole treatment due to less activation of right IFG and ITG. Moreover, the lateralization index of the ITG after treatment was positively correlated with before-treatment verbal-IQ items, and before-treatment/ after-treatment working memory. Two before-treatment measures (categorical verbal fluency and verbal-IQ items) were correlated with lower PANSS negative subscale scores after-treatment. Conclusion: Reversed language-related lateralization index could be observed in patients after treatment with aripiprazole. Better pre-treatment verbal-IQ scores were related to greater lateralization of ITG and lower negative subscale scores of the PANSS after-treatment. The findings suggest that the aberrant language-related lateralization could be reversed after treatment with antipsychotics, and that the change of lateralization was related to improved clinical symptoms.
|Appears in Collections:||腦與心智科學研究所|
Files in This Item:
|511.5 kB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.