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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林俊彬(Chun-Pin Lin) | |
dc.contributor.author | Wan-Chen Chao | en |
dc.contributor.author | 趙婉真 | zh_TW |
dc.date.accessioned | 2021-06-16T10:25:05Z | - |
dc.date.available | 2015-09-24 | |
dc.date.copyright | 2013-09-24 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-15 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60660 | - |
dc.description.abstract | 牙髓為具有修復與再生能力之組織,在治療具可回復性的牙髓傷害時,藉由適當的覆髓材料與生長因子,可以誘導牙本質牙髓複合體的再生,形成牙本質橋之屏障阻擋外界刺激並保護剩餘健康的牙髓以保留牙髓的活性。然而目前並沒有一種材料能夠有效地攜帶生長因子,達到理想的覆髓結果。
聚麩胺酸(poly-γ-glumatic acid, γ-PGA)為生物相容性良好之高分子聚合物,適合作為藥物之載體,而transforming growth factor -β1 (TGF-β1)具有誘導牙髓細胞分化之能力。而鈣矽材料能提供覆髓材料必要的機械強度與密封能力。本團隊所研發的鈣矽陶瓷材料partial stabilized cement 91 (PSC91)有良好的機械性質及生物活性本實驗將以γ-PGA攜帶TGF-β1,並結合PSC91鈣矽材料,作為覆髓之材料。 本實驗γ-PGA加入PSC91 (PSC91/γ-PGA),以X光繞射分析、硬化時間、抗壓強度、表面微硬度檢測材料性質,並進行體外生物活性、細胞生物相容性與牙髓細胞鹼性磷酸酶檢測,最後以狗作為模型進行動物實驗,觀察micro–computed tomography (μ-CT)影像及組織學切片。 結果顯示加入γ-PGA水膠後不太影響PSC91 的水合過程,材料性質在初始硬化時間與抗壓強度的表現皆獲得改善。WST-1 與LDH的結果顯示材料的生物相容性良好,而加入TGF-β1可以促進鹼性磷酸酶的表現。以γ-PGA水膠作為攜帶TGF-β1 的載體在動物實驗中也有優異的表現,其牙本質橋形成的速度較其他組別快。 含有γ-PGA之PSC91 結合了鈣矽材料與高分子材料的良好性質,並且具有攜帶藥物之功能。因此含γ-PGA攜帶TGF-β1 之鈣矽覆髓材料相當具有潛力作為活髓治療的材料。 | zh_TW |
dc.description.abstract | Dental pulp is able to repair and regenerate itself. To treat the inflamed pulp with healthy pulp tissue inside, incorporating growth factors with appropriate capping materials used in vital pulp therapy can induce dentin-pulp complex regeneration and dentin bridge formation. Therefore, maintaining the vitality of the pulp not only preserves the pulp tissue but blocks out the stimulations from the environment. However, there is no capping materials that can carry growth factors efficiently.
With excellent biocompatibility and highly adjustability, poly-γ-glumatic acid (γ-PGA) is suitable candidate for drug carrier. And TGF-β1 is well-known for its ability to induce differentiation of dental pulp. Chemical and mechanical property as well as excellent sealing ability make calcium silicate a well-known capping material. The partial stabilized cement 91 (PSC91) we developed before demonstrated optimal physical properties and bioactivity. The aim of this study was to develop a novel calcium silicate capping material with γ-PGA carrying TGF-β1. Combination of γ-PGA and a modified calcium silicate cement (PSC91/γ-PGA) was tested for hydration, setting time, compressive strength and microhardness. In vitro biocompatibility and bioactivity of PSC91/γ-PGA carrying TGF-β1 were performed, and ALP activity was tested with human dental pulp cells. Moreover, in vivo evaluation was done using a dog animal model by micro-CT radiographic and histological analysis. The results showed that initial setting time and compressive strength were improved by adding γ-PGA hydrogel. Results of WST-1 and LDH revealed that PSC91/γ-PGA containing TGF-β1 was highly biocompatible. Pulp cells treated with PSC91/γ-PGA carrying TGF-β1 showed increased level of ALP activity. In addition, earlier formation of dentin bridge was noted with PSC91/γ-PGA containing TGF-β1 in animal study. We concluded that the novel calcium silicate with γ-PGA carrying TGF-β1 has strong potential as a capping material. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T10:25:05Z (GMT). No. of bitstreams: 1 ntu-102-R99422003-1.pdf: 7305573 bytes, checksum: 109c78d402dc6a8520fd6f9813d787be (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 謝 誌 i
中文摘要 ii Abstract iii 第一章 前言 1 第二章 文獻回顧 2 2.1 保存牙髓之重要性 2 2.1.1 牙髓之構造與功能 2 2.1.2 保留牙髓於臨床治療的意義 3 2.2 活髓治療(Vital Pulp Therapy) 4 2.2.1 活髓治療之介紹 4 2.3 TGF-β1 4 2.4 聚麩胺酸 (Poly-γ-glumatic acid, γ-PGA) 6 2.5 明膠 (Gelatin) 6 2.6 鈣矽生醫陶瓷(calcium silicate ceramics) 7 2.7 本研究團隊研發之鈣矽生醫陶瓷 9 2.8 活髓治療材料之研究與評估 9 2.8.1 生物相容性(Biocompatibility)之評估 10 2.8.2 生物活性(Bioactivity)之評估 11 2.8.3 鹼性磷酸酶與礦化(mineralization)之關係 12 第三章 動機與目的 14 第四章 材料與方法 16 4.1 實驗材料之製備與評估 16 4.1.1 材料製備 16 4.1.2 X光繞射分析評估材料粉末 16 4.2 水合產物分析 17 4.2.1 測試樣本製備 17 4.2.2 X光繞射分析評估材料粉末 17 4.3 硬化時間測試 17 4.3.1 測試樣本備製 17 4.3.2 測試方法 17 4.3.3 資料分析 18 4.4 抗壓強度測試 18 4.4.1 測試樣本備製 18 4.4.2 抗壓強度測試 18 4.4.3 實驗過程及記錄 18 4.4.4 結果分析 19 4.5 表面微硬度測試 19 4.5.1 測試樣本製備 19 4.5.2 微硬度儀器規格 19 4.5.3 測試方法 20 4.5.4 資料分析 20 4.6 體外生物活性測試 20 4.6.1 模擬體液溶液SBF之備製 20 4.6.2 測試樣本備製 21 4.6.3 掃描式電子顯微鏡(SEM)觀察 21 4.6.4 SBF溶液酸鹼值變化觀察(pH value) 22 4.7 生長因子釋放測試 22 4.8 材料生物相容性評估 22 4.8.1 人類牙髓細胞 (human pulp cell)之初級培養(primary culture) 22 4.8.2 萃取液備製 22 4.8.3 WST-1 23 4.8.4 LDH 23 4.9 鹼性磷酸酶(Alkaline phosphatase, ALPase)定性染色分析 24 4.9.1 Stock substrate solution配置 24 4.9.2 實驗步驟 25 4.10 鹼性磷酸酶(Alkaline phosphatase, ALPase)定量分析 25 4.10.1 實驗步驟 25 4.11 動物實驗 26 4.11.1 實驗步驟 26 4.11.2 動物灌流 27 4.11.3 標本備置 28 4.11.4 μ-CT照射 28 4.11.5 組織學切片標本備置 28 4.11.6 組織學評分標準 29 第五章 結果 30 5.1 材料粉末之X光繞射分析 30 5.2 水和產物分析 30 5.2.1 X 光繞射分析評估材料粉末 30 5.3 硬化時間測試 30 5.4 抗壓強度測試 31 5.5 表面微硬度測試 31 5.6 體外生物活性測試 32 5.6.1 掃描式電子顯微鏡(SEM)觀察 32 5.6.2 SBF溶液酸鹼值變化觀察(pH value) 32 5.7 生長因子釋放測試 32 5.8 材料生物相容性評估 33 5.8.1 WST-1 33 5.8.2 LDH 33 5.9 鹼性磷酸酶(Alkaline phosphatase, ALPase)定性染色分析 33 5.10 鹼性磷酸酶(Alkaline phosphatase, ALPase)定量分析 33 5.11 動物實驗 34 5.11.1 μ-CT影像分析 34 5.11.2 組織學切片觀察 34 第六章 討論 36 6.1 添加γ-PGA水膠對鈣矽材料水和反應之影響 36 6.2 添加γ-PGA水膠對鈣矽材料機械性質之影響 38 6.3 探討加入含TGF-β1之γ-PGA 水膠對材料PSC91其生物活性與生物相容性之影響 ……………………………………………………………………………………………………………………40 6.4 探討加入含TGF-β1之γ-PGA水膠對材料PSC91 其礦化能力與活體之整體表現 ……………………………………………………………………………………………………………………42 第七章 結論 44 第八章 未來研究方向 46 參考資料 47 | |
dc.language.iso | zh-TW | |
dc.title | 研發含聚麩胺酸攜帶TGF-β1之鈣矽覆髓材料–材料性質、生物活性及動物實驗 | zh_TW |
dc.title | Development of Calcium Silicate with γ-PGA Carrying TGF-β1 as a Pulp Capping Material - Material Property, Bioactivity and Animal Study | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 林?輝(Feng-Huei Lin) | |
dc.contributor.oralexamcommittee | 章浩宏,林弘萍 | |
dc.subject.keyword | 鈣矽陶瓷,活髓治療,TGF-β1,γ-PGA,動物實驗, | zh_TW |
dc.subject.keyword | calcium silicate ceramics,vital pulp therapy,TGF-β1,γ-PGA,animal study, | en |
dc.relation.page | 97 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-15 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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