請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59994
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鄭尊仁(Tsun-Jen Cheng) | |
dc.contributor.author | Wan-Ru Zheng | en |
dc.contributor.author | 鄭琬儒 | zh_TW |
dc.date.accessioned | 2021-06-16T09:49:27Z | - |
dc.date.available | 2021-08-01 | |
dc.date.copyright | 2020-08-27 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-14 | |
dc.identifier.citation | Adar, S. D., L. Sheppard, S. Vedal, J. F. Polak, P. D. Sampson, A. V. D. Roux, M. Budoff, D. R. Jacobs Jr, R. G. Barr and K. Watson (2013). 'Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the multi-ethnic study of atherosclerosis and air pollution.' PLoS Med 10(4): e1001430. Adluru, N., D. J. Destiche, S. Y.-F. Lu, S. T. Doran, A. C. Birdsill, K. E. Melah, O. C. Okonkwo, A. L. Alexander, N. M. Dowling and S. C. Johnson (2014). 'White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease.' NeuroImage: Clinical 4: 730-742. Ailshire, J. A. and E. M. Crimmins (2014). 'Fine particulate matter air pollution and cognitive function among older US adults.' American journal of epidemiology 180(4): 359-366. Ajmani, G. S., H. H. Suh and J. M. Pinto (2016). 'Effects of ambient air pollution exposure on olfaction: a review.' Environmental health perspectives 124(11): 1683-1693. Akiyama, H. and P. McGeer (1990). 'Brain microglia constitutively express β-2 integrins.' Journal of neuroimmunology 30(1): 81-93. Allen, J. L., G. Oberdorster, K. Morris-Schaffer, C. Wong, C. Klocke, M. Sobolewski, K. Conrad, M. Mayer-Proschel and D. Cory-Slechta (2017). 'Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders.' Neurotoxicology 59: 140-154. Alves, G. S., V. Oertel Knöchel, C. Knöchel, A. F. Carvalho, J. Pantel, E. Engelhardt and J. Laks (2015). 'Integrating retrogenesis theory to Alzheimer’s disease pathology: insight from DTI-TBSS investigation of the white matter microstructural integrity.' BioMed research international 2015. Alzheimer’s Disease International. (2015). World Alzheimer Report 2015. The global impact of dementia: an analysis of prevalence, incidence, cost and trends, Alzheimer’s Disease International London. Amato, F., M. Pandolfi, A. Escrig, X. Querol, A. Alastuey, J. Pey, N. Perez and P. Hopke (2009). 'Quantifying road dust resuspension in urban environment by multilinear engine: a comparison with PMF2.' Atmospheric Environment 43(17): 2770-2780. Amlien, I. and A. Fjell (2014). 'Diffusion tensor imaging of white matter degeneration in Alzheimer’s disease and mild cognitive impairment.' Neuroscience 276: 206-215. Babadjouni, R., A. Patel, Q. Liu, K. Shkirkova, K. Lamorie-Foote, M. Connor, D. M. Hodis, H. Cheng, C. Sioutas and T. E. Morgan (2018). 'Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.' PloS one 13(11): e0206934. Bartzokis, G. (2011). 'Alzheimer's disease as homeostatic responses to age-related myelin breakdown.' Neurobiology of aging 32(8): 1341-1371. Bartzokis, G., P. H. Lu and J. Mintz (2007). 'Human brain myelination and amyloid beta deposition in Alzheimer’s disease.' Alzheimer's dementia 3(2): 122-125. Behrendt, G., K. Baer, A. Buffo, M. A. Curtis, R. L. Faull, M. I. Rees, M. Götz and L. Dimou (2013). 'Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men.' Glia 61(2): 273-286. Belis, C., F. Karagulian, B. R. Larsen and P. Hopke (2013). 'Critical review and meta-analysis of ambient particulate matter source apportionment using receptor models in Europe.' Atmospheric Environment 69: 94-108. Bennett, I. J. and D. J. Madden (2014). 'Disconnected aging: cerebral white matter integrity and age-related differences in cognition.' Neuroscience 276: 187-205. Bhatt, D. P., K. L. Puig, M. W. Gorr, L. E. Wold and C. K. Combs (2015). 'A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain.' PLoS One 10(5). Bigham, B., S. A. Zamanpour, F. Zemorshidi, F. Boroumand, H. Zare and A. s. D. N. Initiative (2020). 'Identification of Superficial White Matter Abnormalities in Alzheimer’s Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging.' Journal of Alzheimer's Disease Reports(Preprint): 1-11. Billings, L. M., S. Oddo, K. N. Green, J. L. McGaugh and F. M. LaFerla (2005). 'Intraneuronal Aβ causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice.' Neuron 45(5): 675-688. Block, M. L., A. Elder, R. L. Auten, S. D. Bilbo, H. Chen, J.-C. Chen, D. A. Cory-Slechta, D. Costa, D. Diaz-Sanchez and D. C. Dorman (2012). 'The outdoor air pollution and brain health workshop.' Neurotoxicology 33(5): 972-984. Bosch, B., E. M. Arenaza-Urquijo, L. Rami, R. Sala-Llonch, C. Junqué, C. Solé-Padullés, C. Peña-Gómez, N. Bargalló, J. L. Molinuevo and D. Bartrés-Faz (2012). 'Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance.' Neurobiology of aging 33(1): 61-74. Brain, J. D., D. E. Knudson, S. P. Sorokin and M. A. Davis (1976). 'Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation.' Environmental research 11(1): 13-33. Burnett, R. T., C. A. Pope III, M. Ezzati, C. Olives, S. S. Lim, S. Mehta, H. H. Shin, G. Singh, B. Hubbell and M. Brauer (2014). 'An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure.' Environmental health perspectives 122(4): 397-403. Calderón-Garcidueñas, L., R. Engle, A. Mora-Tiscareño, M. Styner, G. Gómez-Garza, H. Zhu, V. Jewells, R. Torres-Jardón, L. Romero and M. E. Monroy-Acosta (2011). 'Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children.' Brain and cognition 77(3): 345-355. Calderón-Garcidueñas, L., A. C. Solt, C. Henríquez-Roldán, R. Torres-Jardón, B. Nuse, L. Herritt, R. Villarreal-Calderón, N. Osnaya, I. Stone and R. Garcia (2008). 'Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid β-42 and α-synuclein in children and young adults.' Toxicologic pathology 36(2): 289-310. Calderón-Garcidueñas, L., R. Reynoso-Robles, J. Vargas-Martínez, A. Gómez-Maqueo-Chew, B. Pérez-Guillé, P. S. Mukherjee, R. Torres-Jardón, G. Perry and A. Gónzalez-Maciel (2016). 'Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease.' Environmental research 146: 404-417. Calderón-Garcidueñas, L., M. Franco-Lira, C. Henríquez-Roldán, N. Osnaya, A. González-Maciel, R. Reynoso-Robles, R. Villarreal-Calderon, L. Herritt, D. Brooks and S. Keefe (2010). 'Olfactory dysfunction, olfactory bulb pathology and urban air pollution.' Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie 62(1): 91. Calderón-Garcidueñas, L., M. Franco-Lira, C. Henríquez-Roldán, N. Osnaya, A. González-Maciel, R. Reynoso-Robles, R. Villarreal-Calderon, L. Herritt, D. Brooks and S. Keefe (2010). 'Urban air pollution: influences on olfactory function and pathology in exposed children and young adults.' Experimental and Toxicologic Pathology 62(1): 91-102. Calderón-Garcidueñas, L., M. Franco-Lira, R. Torres-Jardón, C. Henriquez-Roldán, G. Barragán-Mejía, G. Valencia-Salazar, A. Gonzalez-Maciel, R. Reynoso-Robles, R. Villarreal-Calderón and W. Reed (2007). 'Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology.' Toxicologic pathology 35(1): 154-162. Calderon-Garciduenas, L., J. Avila-Ramirez, A. Calderon-Garciduenas, T. Gonzalez-Heredia, H. Acuna-Ayala, C.-k. Chao, C. Thompson, R. Ruiz-Ramos, V. Cortes-Gonzalez and L. Martinez-Martinez (2016). 'Cerebrospinal fluid biomarkers in highly exposed PM 2.5 urbanites: The risk of Alzheimer’s and Parkinson’s diseases in young Mexico City residents.' Journal of Alzheimer's Disease 54(2): 597-613. Calderon-Garciduenas, L., R. R. Maronpot, R. Torres-Jardon, C. Henriquez-Roldan, R. Schoonhoven, H. Acuna-Ayala, A. Villarreal-Calderon, J. Nakamura, R. Fernando and W. Reed (2003). 'DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration.' Toxicologic pathology 31(5): 524-538. Carroll, J. C., E. R. Rosario, S. Kreimer, A. Villamagna, E. Gentzschein, F. Z. Stanczyk and C. J. Pike (2010). 'Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.' Brain research 1366: 233-245. Casanova, R., X. Wang, J. Reyes, Y. Akita, M. L. Serre, W. Vizuete, H. C. Chui, I. Driscoll, S. M. Resnick and M. A. Espeland (2016). 'A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women.' Frontiers in human neuroscience 10: 495. Chang, S.-C., C. C.-K. Chou, C.-C. Chan and C.-T. Lee (2010). 'Temporal characteristics from continuous measurements of PM2. 5 and speciation at the Taipei Aerosol Supersite from 2002 to 2008.' Atmospheric Environment 44(8): 1088-1096. Chen, Jiu‐Chiuan, X. Wang, G. A. Wellenius, M. L. Serre, I. Driscoll, R. Casanova, J. J. McArdle, J. E. Manson, H. C. Chui and M. A. Espeland (2015). 'Ambient air pollution and neurotoxicity on brain structure: evidence from women's health initiative memory study.' Annals of neurology 78(3): 466-476. Chen, W.-N., Y.-C. Chen, C.-Y. Kuo, C.-H. Chou, C.-H. Cheng, C.-C. Huang, S.-Y. Chang, M. R. Raman, W.-L. Shang and T.-Y. Chuang (2014). 'The real-time method of assessing the contribution of individual sources on visibility degradation in Taichung.' Science of the total environment 497: 219-228. Cheng, H., A. Saffari, C. Sioutas, H. J. Forman, T. E. Morgan and C. E. Finch (2016). 'Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain.' Environmental health perspectives 124(10): 1537-1546. Chiu, H.-F., S.-S. Tsai, H.-H. Weng and C.-Y. Yang (2013). 'Short-term effects of fine particulate air pollution on emergency room visits for cardiac arrhythmias: A case-crossover study in Taipei.' Journal of Toxicology and Environmental Health, Part A 76(10): 614-623. Choi, Y. Kyung, T. Maki, E. T. Mandeville, S.-H. Koh, K. Hayakawa, K. Arai, Y.-M. Kim, M. J. Whalen, C. Xing and X. Wang (2016). 'Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.' Nature medicine 22(11): 1335-1341. Choi, J., J. Y. Oh, Y. S. Lee, K. H. Min, G. Y. Hur, S. Y. Lee, K. H. Kang and J. J. Shim (2018). 'Harmful impact of air pollution on severe acute exacerbation of chronic obstructive pulmonary disease: particulate matter is hazardous.' International journal of chronic obstructive pulmonary disease 13: 1053. Chu, T.-H., K. Cummins, J. S. Sparling, S. Tsutsui, C. Brideau, K. P. R. Nilsson, J. T. Joseph and P. K. Stys (2017). 'Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord.' PLoS One 12(11): e0188218. Cole, T. B., J. Coburn, K. Dao, P. Roqué, Y.-C. Chang, V. Kalia, T. R. Guilarte, J. Dziedzic and L. G. Costa (2016). 'Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain.' Toxicology 374: 1-9. Conti, G. O., A. C. Molinari, S. S. Signorelli, M. Ruggieri, A. Grasso and M. Ferrante (2018). 'Neonatal systemic thrombosis: an updated overview.' Current vascular pharmacology 16(5): 499-509. Costa, L. G., T. B. Cole, J. Coburn, Y.-C. Chang, K. Dao and P. Roque (2014). 'Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain.' BioMed research international 2014. Dean, D. C., S. A. Hurley, S. R. Kecskemeti, J. P. O’Grady, C. Canda, N. J. Davenport-Sis, C. M. Carlsson, H. Zetterberg, K. Blennow and S. Asthana (2017). 'Association of amyloid pathology with myelin alteration in preclinical Alzheimer disease.' JAMA neurology 74(1): 41-49. Desai, M. K., B. J. Guercio, W. C. Narrow and W. J. Bowers (2011). 'An Alzheimer's disease‐relevant presenilin‐1 mutation augments amyloid‐beta‐induced oligodendrocyte dysfunction.' Glia 59(4): 627-640. Desai, M. K., M. A. Mastrangelo, D. A. Ryan, K. L. Sudol, W. C. Narrow and W. J. Bowers (2010). 'Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.' The American journal of pathology 177(3): 1422-1435. Desai, M. K., K. L. Sudol, M. C. Janelsins, M. A. Mastrangelo, M. E. Frazer and W. J. Bowers (2009). 'Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology.' Glia 57(1): 54-65. Elder, A., R. Gelein, V. Silva, T. Feikert, L. Opanashuk, J. Carter, R. Potter, A. Maynard, Y. Ito and J. Finkelstein (2006). 'Translocation of inhaled ultrafine manganese oxide particles to the central nervous system.' Environmental health perspectives 114(8): 1172-1178. Environmental Protection Administration, E. Y., Taiwan (2016). '臺北市民國105年各污染源行業別排放量分類統計表.' Erickson, L. D., S. D. Gale, J. E. Anderson, B. L. Brown and D. W. Hedges (2020). 'Association between Exposure to Air Pollution and Total Gray Matter and Total White Matter Volumes in Adults: A Cross-Sectional Study.' Brain Sciences 10(3): 164. European lung white book. (2013). 'The European Lung White Book.' from https://www.erswhitebook.org/chapters/outdoor-environment/. Fertan, E., A. A. Wong, N. A. Vienneau and R. E. Brown (2019). 'Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb–Williams maze.' Behavioural brain research 370: 111937. Fischer, F. U., D. Wolf, A. Scheurich, A. Fellgiebel and A. s. D. N. Initiative (2015). 'Altered whole-brain white matter networks in preclinical Alzheimer's disease.' NeuroImage: clinical 8: 660-666. Frisoni, G. B., N. C. Fox, C. R. Jack, P. Scheltens and P. M. Thompson (2010). 'The clinical use of structural MRI in Alzheimer disease.' Nature Reviews Neurology 6(2): 67-77. Gatto, N. M., V. W. Henderson, H. N. Hodis, J. A. S. John, F. Lurmann, J.-C. Chen and W. J. Mack (2014). 'Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles.' Neurotoxicology 40: 1-7. Girguis, M. S., M. J. Strickland, X. Hu, Y. Liu, H. H. Chang, I. Kloog, C. Belanoff, S. M. Bartell and V. M. Vieira (2018). 'Exposure to acute air pollution and risk of bronchiolitis and otitis media for preterm and term infants.' Journal of exposure science environmental epidemiology 28(4): 348. Han, F., R. J. Perrin, Q. Wang, Y. Wang, J. S. Perlmutter, J. C. Morris, T. L. Benzinger and J. Xu (2019). 'Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study.' Parkinson’s Disease 2019. Harris, M. H., D. R. Gold, S. L. Rifas-Shiman, S. J. Melly, A. Zanobetti, B. A. Coull, J. D. Schwartz, A. Gryparis, I. Kloog and P. Koutrakis (2015). 'Prenatal and childhood traffic-related pollution exposure and childhood cognition in the project viva cohort (Massachusetts, USA).' Environmental health perspectives 123(10): 1072-1078. Hartz, A. M., D. S. Miller and B. Bauer (2010). 'Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-β in a mouse model of Alzheimer's disease.' Molecular pharmacology 77(5): 715-723. Horiuchi, M., I. Maezawa, A. Itoh, K. Wakayama, L.-W. Jin, T. Itoh and C. DeCarli (2012). 'Amyloid β1–42 oligomer inhibits myelin sheet formation in vitro.' Neurobiology of aging 33(3): 499-509. Huber, C. M., C. Yee, T. May, A. Dhanala and C. S. Mitchell (2018). 'Cognitive decline in preclinical Alzheimer’s disease: amyloid-beta versus tauopathy.' Journal of Alzheimer's Disease 61(1): 265-281. International Agency for Research on Cancer. and W. H. Organization (2013). 'IARC: Outdoor air pollution a leading environmental cause of cancer deaths. No. 221.' World Health Organization. Juda-Rezler, K., M. Reizer and J.-P. Oudinet (2011). 'Determination and analysis of PM10 source apportionment during episodes of air pollution in Central Eastern European urban areas: The case of wintertime 2006.' Atmospheric Environment 45(36): 6557-6566. Jung, C.-R., Y.-T. Lin and B.-F. Hwang (2015). 'Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.' Journal of Alzheimer's Disease 44(2): 573-584. Kane, A. E., S. Shin, A. A. Wong, E. Fertan, N. S. Faustova, S. E. Howlett and R. E. Brown (2018). 'Sex differences in healthspan predict lifespan in the 3xTg-AD mouse model of Alzheimer’s disease.' Frontiers in aging neuroscience 10: 172. Karagulian, F., C. A. Belis, C. F. C. Dora, A. M. Prüss-Ustün, S. Bonjour, H. Adair-Rohani and M. Amann (2015). 'Contributions to cities' ambient particulate matter (PM): A systematic review of local source contributions at global level.' Atmospheric environment 120: 475-483. Kavroulakis, E., P. G. Simos, G. Kalaitzakis, T. G. Maris, D. Karageorgou, I. Zaganas, S. Panagiotakis, M. Basta, A. Vgontzas and E. Papadaki (2018). 'Myelin content changes in probable Alzheimer's disease and mild cognitive impairment: associations with age and severity of neuropsychiatric impairment.' Journal of Magnetic Resonance Imaging 47(5): 1359-1372. Kicinski, M., G. Vermeir, N. Van Larebeke, E. Den Hond, G. Schoeters, L. Bruckers, I. Sioen, E. Bijnens, H. A. Roels and W. Baeyens (2015). 'Neurobehavioral performance in adolescents is inversely associated with traffic exposure.' Environment international 75: 136-143. Kioumourtzoglou, M.-A., J. D. Schwartz, M. G. Weisskopf, S. J. Melly, Y. Wang, F. Dominici and A. Zanobetti (2016). 'Long-term PM2. 5 exposure and neurological hospital admissions in the northeastern United States.' Environmental health perspectives 124(1): 23-29. Klocke, C., J. L. Allen, M. Sobolewski, J. L. Blum, J. T. Zelikoff and D. A. Cory-Slechta (2018). 'Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination.' Neurotoxicology 65: 196-206. Ku, T., M. Chen, B. Li, Y. Yun, G. Li and N. Sang (2017). 'Synergistic effects of particulate matter (PM2. 5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.' Toxicology research 6(1): 7-16. Löndahl, J., A. Massling, J. Pagels, E. Swietlicki, E. Vaclavik and S. Loft (2007). 'Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise.' Inhalation toxicology 19(2): 109-116. Lee, S.-H., J.-P. Coutu, P. Wilkens, A. Yendiki, H. D. Rosas, D. H. Salat and A. s. d. N. Initiative (2015). 'Tract-based analysis of white matter degeneration in Alzheimer’s disease.' Neuroscience 301: 79-89. Lewis, J., G. Bench, O. Myers, B. Tinner, W. Staines, E. Barr, K. Divine, W. Barrington and J. Karlsson (2005). 'Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice.' Neurotoxicology 26(1): 113-123. Li, J., P. Pan, R. Huang and H. Shang (2012). 'A meta-analysis of voxel-based morphometry studies of white matter volume alterations in Alzheimer's disease.' Neuroscience Biobehavioral Reviews 36(2): 757-763. Li, X.-y., Z.-c. Tang, Y. Sun, J. Tian, Z.-y. Liu and Y. Han (2016). 'White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study.' Oncotarget 7(34): 54405. Li, X., S. Huang, A. Jiao, X. Yang, J. Yun, Y. Wang, X. Xue, Y. Chu, F. Liu and Y. Liu (2017). 'Association between ambient fine particulate matter and preterm birth or term low birth weight: an updated systematic review and meta-analysis.' Environmental Pollution 227: 596-605. Ling, Z., Y. Zhu, C. wai Tong, J. A. Snyder, J. W. Lipton and P. M. Carvey (2006). 'Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally.' Experimental neurology 199(2): 499-512. Liu, J. and G. Lewis (2014). 'Environmental toxicity and poor cognitive outcomes in children and adults.' Journal of environmental health 76(6): 130. Loop, M. S., S. T. Kent, M. Z. Al-Hamdan, W. L. Crosson, S. M. Estes, M. G. Estes Jr, D. A. Quattrochi, S. N. Hemmings, V. G. Wadley and L. A. McClure (2013). 'Fine particulate matter and incident cognitive impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.' PloS one 8(9). Mayo, C. D., M. A. Garcia-Barrera, E. L. Mazerolle, L. J. Ritchie, J. D. Fisk, J. R. Gawryluk and A. s. D. N. Initiative (2019). 'Relationship between DTI metrics and cognitive function in Alzheimer’s disease.' Frontiers in aging neuroscience 10: 436. McGeer, P. L., E. McGeer and K. Yasojima (2000). Alzheimer disease and neuroinflammation. Advances in Dementia Research, Springer: 53-57. Mills, N. L., K. Donaldson, P. W. Hadoke, N. A. Boon, W. MacNee, F. R. Cassee, T. Sandström, A. Blomberg and D. E. Newby (2009). 'Adverse cardiovascular effects of air pollution.' Nature clinical practice Cardiovascular medicine 6(1): 36-44. Mumaw, C. L., S. Levesque, C. McGraw, S. Robertson, S. Lucas, J. E. Stafflinger, M. J. Campen, P. Hall, J. P. Norenberg and T. Anderson (2016). 'Microglial priming through the lung—brain axis: the role of air pollution‐induced circulating factors.' The FASEB Journal 30(5): 1880-1891. Mustafic, H., P. Jabre, C. Caussin, M. H. Murad, S. Escolano, M. Tafflet, M.-C. Périer, E. Marijon, D. Vernerey and J.-P. Empana (2012). 'Main air pollutants and myocardial infarction.' a systematic review and meta-analysis 2012: 307. Nasrabady, S. E., B. Rizvi, J. E. Goldman and A. M. Brickman (2018). 'White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes.' Acta neuropathologica communications 6(1): 1-10. Nishioka, C., C. Poh, S.-W. Sun and A. s. D. N. Initiative (2015). 'Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer's disease.' Journal of Alzheimer's Disease 45(1): 97-107. Oddo, S., A. Caccamo, J. D. Shepherd, M. P. Murphy, T. E. Golde, R. Kayed, R. Metherate, M. P. Mattson, Y. Akbari and F. M. LaFerla (2003). 'Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction.' Neuron 39(3): 409-421. Perry, V. H., C. Cunningham and C. Holmes (2007). 'Systemic infections and inflammation affect chronic neurodegeneration.' Nature Reviews Immunology 7(2): 161-167. Peters, A., B. Veronesi, L. Calderón-Garcidueñas, P. Gehr, L. C. Chen, M. Geiser, W. Reed, B. Rothen-Rutishauser, S. Schürch and H. Schulz (2006). 'Translocation and potential neurological effects of fine and ultrafine particles a critical update.' Particle and fibre toxicology 3(1): 13. Peters, J. M., T. Hummel, T. Kratzsch, J. Lötsch, C. Skarke and L. Frölich (2003). 'Olfactory function in mild cognitive impairment and Alzheimer’s disease: an investigation using psychophysical and electrophysiological techniques.' American journal of psychiatry 160(11): 1995-2002. Phillips, O. R., S. H. Joshi, F. Piras, M. D. Orfei, M. Iorio, K. L. Narr, D. W. Shattuck, C. Caltagirone, G. Spalletta and M. Di Paola (2016). 'The superficial white matter in Alzheimer's disease.' Human brain mapping 37(4): 1321-1334. Power, M. C., M. G. Weisskopf, S. E. Alexeeff, B. A. Coull, A. Spiro III and J. Schwartz (2011). 'Traffic-related air pollution and cognitive function in a cohort of older men.' Environmental health perspectives 119(5): 682-687. Qin, L., X. Wu, M. L. Block, Y. Liu, G. R. Breese, J. S. Hong, D. J. Knapp and F. T. Crews (2007). 'Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.' Glia 55(5): 453-462. Rae, E. A. and R. E. Brown (2015). 'The problem of genotype and sex differences in life expectancy in transgenic AD mice.' Neuroscience Biobehavioral Reviews 57: 238-251. Ranft, U., T. Schikowski, D. Sugiri, J. Krutmann and U. Krämer (2009). 'Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly.' Environmental research 109(8): 1004-1011. Reginold, W., A. C. Luedke, J. Itorralba, J. Fernandez-Ruiz, O. Islam and A. Garcia (2016). 'Altered superficial white matter on tractography MRI in Alzheimer's disease.' Dementia and geriatric cognitive disorders extra 6(2): 233-241. Roqué, P. J., K. Dao and L. G. Costa (2016). 'Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms.' Neurotoxicology 56: 204-214. Schikowski, T., M. Vossoughi, A. Vierkötter, T. Schulte, T. Teichert, D. Sugiri, K. Fehsel, L. Tzivian, I.-s. Bae and U. Ranft (2015). 'Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women.' Environmental research 142: 10-16. Schuff, N., D. Tosun, P. S. Insel, G. C. Chiang, D. Truran, P. S. Aisen, C. R. Jack Jr, M. W. Weiner and A. s. D. N. Initiative (2012). 'Nonlinear time course of brain volume loss in cognitively normal and impaired elders.' Neurobiology of aging 33(5): 845-855. Seinfeld, J. H. and S. N. Pandis (2016). Atmospheric chemistry and physics: from air pollution to climate change, John Wiley Sons. Selnes, P., A. M. Fjell, L. Gjerstad, A. Bjørnerud, A. Wallin, P. Due-Tønnessen, R. Grambaite, V. Stenset and T. Fladby (2012). 'White matter imaging changes in subjective and mild cognitive impairment.' Alzheimer's dementia 8: S112-S121. Sexton, C. E., U. G. Kalu, N. Filippini, C. E. Mackay and K. P. Ebmeier (2011). 'A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease.' Neurobiology of aging 32(12): 2322. e2325-2322. e2318. Shahsavani, A., K. Naddafi, N. J. Haghighifard, A. Mesdaghinia, M. Yunesian, R. Nabizadeh, M. Arahami, M. Sowlat, M. Yarahmadi and H. Saki (2012). 'The evaluation of PM10, PM2. 5, and PM1 concentrations during the Middle Eastern Dust (MED) events in Ahvaz, Iran, from april through september 2010.' Journal of arid environments 77: 72-83. Song, C., J. He, L. Wu, T. Jin, X. Chen, R. Li, P. Ren, L. Zhang and H. Mao (2017). 'Health burden attributable to ambient PM2. 5 in China.' Environmental pollution 223: 575-586. Spangenberg, E. E. and K. N. Green (2017). 'Inflammation in Alzheimer’s disease: lessons learned from microglia-depletion models.' Brain, behavior, and immunity 61: 1-11. Sperling, R. A., P. S. Aisen, L. A. Beckett, D. A. Bennett, S. Craft, A. M. Fagan, T. Iwatsubo, C. R. Jack Jr, J. Kaye and T. J. Montine (2011). 'Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.' Alzheimer's dementia 7(3): 280-292. Sterniczuk, R., M. C. Antle, F. M. LaFerla and R. H. Dyck (2010). 'Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes.' Brain research 1348: 149-155. Sterniczuk, R., R. H. Dyck, F. M. LaFerla and M. C. Antle (2010). 'Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes.' Brain research 1348: 139-148. Stimmell, A. C., D. Baglietto-Vargas, S. C. Moseley, V. Lapointe, L. M. Thompson, F. M. LaFerla, B. L. McNaughton and A. A. Wilber (2019). 'Impaired spatial reorientation in the 3xTg-AD mouse model of Alzheimer’s disease.' Scientific reports 9(1): 1-12. Stoub, T. R., L. deToledo-Morrell and B. C. Dickerson (2014). 'Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults.' Neurobiology of aging 35(8): 1855-1861. Stover, K. R., M. A. Campbell, C. M. Van Winssen and R. E. Brown (2015). 'Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease.' Behavioural Brain Research 289: 29-38. Tonne, C., A. Elbaz, S. Beevers and A. Singh-Manoux (2014). 'Traffic-related air pollution in relation to cognitive function in older adults.' Epidemiology (Cambridge, Mass.) 25(5): 674. Traiffort, E., A. Kassoussi, A. Zahaf and Y. Laouarem (2020). 'Astrocytes and microglia as major players of myelin production in normal and pathological conditions.' Frontiers in Cellular Neuroscience 14: 79. Tyler, C. R., S. Noor, T. L. Young, V. Rivero, B. Sanchez, S. Lucas, K. K. Caldwell, E. D. Milligan and M. J. Campen (2018). 'Aging exacerbates neuroinflammatory outcomes induced by acute ozone exposure.' Toxicological Sciences 163(1): 123-139. Vernooij, M. W., B. Jasperse, R. Steketee, M. Koek, H. Vrooman, M. A. Ikram, J. Papma, A. van der Lugt, M. Smits and W. J. Niessen (2018). 'Automatic normative quantification of brain tissue volume to support the diagnosis of dementia: a clinical evaluation of diagnostic accuracy.' NeuroImage: Clinical 20: 374-379. Wang, B., W. Y. Feng, M. Wang, J. W. Shi, F. Zhang, H. Ouyang, Y. L. Zhao, Z. F. Chai, Y. Y. Huang and Y. N. Xie (2007). 'Transport of intranasally instilled fine Fe 2 O 3 particles into the brain: micro-distribution, chemical states, and histopathological observation.' Biological trace element research 118(3): 233-243. Wang, J., Y. Liu, F. Jiao, F. Lao, W. Li, Y. Gu, Y. Li, C. Ge, G. Zhou and B. Li (2008). 'Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles.' Toxicology 254(1-2): 82-90. Wellenius, G. A., L. D. Boyle, B. A. Coull, W. P. Milberg, A. Gryparis, J. Schwartz, M. A. Mittleman and L. A. Lipsitz (2012). 'Residential proximity to nearest major roadway and cognitive function in community‐dwelling seniors: results from the MOBILIZE boston study.' Journal of the American Geriatrics Society 60(11): 2075-2080. Weuve, J., R. C. Puett, J. Schwartz, J. D. Yanosky, F. Laden and F. Grodstein (2012). 'Exposure to particulate air pollution and cognitive decline in older women.' Archives of internal medicine 172(3): 219-227. Whitwell, J. L. (2010). 'The protective role of brain size in Alzheimer’s disease.' Expert review of neurotherapeutics 10(12): 1799-1801. Wilker, E. H., S. R. Preis, A. S. Beiser, P. A. Wolf, R. Au, I. Kloog, W. Li, J. Schwartz, P. Koutrakis and C. DeCarli (2015). 'Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure.' Stroke 46(5): 1161-1166. Woodward, N. C., P. Pakbin, A. Saffari, F. Shirmohammadi, A. Haghani, C. Sioutas, M. Cacciottolo, T. E. Morgan and C. E. Finch (2017). 'Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons.' Neurobiology of aging 53: 48-58. World Health Organization. (2014). 'Burden of Disease from Ambient Air Pollution.' Glob. Health Obs. Data. World Health Organization. (2018). '9 out of 10 people worldwide breathe polluted air, but more countries are taking action.' from https://www.who.int/news-room/detail/02-05-2018-9-out-of-10-people-worldwide-breathe-polluted-air-but-more-countries-are-taking-action. World Health Organization. (2018). 'The top 10 causes of death.' Wu, Y. C., Y. C. Lin, H. L. Yu, J. H. Chen, T. F. Chen, Y. Sun, L. L. Wen, P. K. Yip, Y. M. Chu and Y. C. Chen (2015). 'Association between air pollutants and dementia risk in the elderly.' Alzheimer's Dementia: Diagnosis, Assessment Disease Monitoring 1(2): 220-228. Zhan, X., G. C. C Jickling, B. P Ander, D. Liu, B. Stamova, C. Cox, L.-W. Jin, C. DeCarli and F. R Sharp (2014). 'Myelin injury and degraded myelin vesicles in Alzheimer’s disease.' Current Alzheimer Research 11(3): 232-238. Zhang, Q., Q. Li, J. Ma and Y. Zhao (2018). 'PM2. 5 impairs neurobehavior by oxidative stress and myelin sheaths injury of brain in the rat.' Environmental Pollution 242: 994-1001. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59994 | - |
dc.description.abstract | 過去許多研究指出空氣中懸浮微粒(particulate matter,PM)會對呼吸系統、心血管系統產生危害,近年更是發現可能對中樞神經系統(central nervous system,CNS)產生不良影響,進而引起神經退化性疾病,其中阿茲海默症(Alzheimer’s disease,AD)因高盛行率備受各界關注。近年利用神經影像學對大腦白質(white matter,WM)纖維微結構變化的研究顯示,AD患者普遍存在廣泛的WM損傷,其可能透過如髓鞘變性、寡突細胞損傷或是神經軸突損失等因素,加重AD的風險及疾病進程。 人類流行病學研究發現居住高汙染地區的民眾,顯示白質高張訊號(white matter hyperintensities)、白質體積減小等變化,動物研究也顯示,暴露微粒會減少髓鞘數量或改變髓鞘型態。但是迄今為止,調查PM2.5與WM變化之間關聯的研究有限,現有研究證據大多來自觀察居住高濃度空氣污染地區民眾的研究,其PM2.5濃度高於WHO所建議標準,或使用濃縮暴露系統進行動物實驗,故本研究的目的是想探討長期暴露於非濃縮的環境PM2.5,是否會加速AD動物模式的WM病理。 本研究選用6個月大雌性阿茲海默症三基因轉殖小鼠(3xTg-AD mice),該品系可發展出與人類相似之阿茲海默症病徵,並使用台北空氣汙染暴露系統(TAPES)模擬真實人類暴露之大氣環境,將小鼠放置其中進行5個月(2018年11月26日開始) 全身連續性呼吸暴露。犧牲後先進行小鼠全腦核磁共振成像(magnetic resonance imaging,MRI)了解其腦部體積變化,及擴散張量成像(diffusion tensor imaging,DTI) 量化WM微結構的變化。之後取腦組織包含皮質(又稱灰質)、髓質(又稱白質),以西方墨點法(western blot)測定阿茲海默症病徵Aβ42、P-tau、髓鞘鹼性蛋白(myelin basic protein,MBP)以及微膠細胞活化指標CD11b之蛋白表現量。於組織病理染色分析,使用Luxol fast blue stain以定量髓鞘之密度、Nissl stain以進行神經元細胞計數。 研究期間暴露總微粒PM2.5濃度為13.85 μg/m3,MRI影像結果顯示暴露組的全腦體積顯著小於對照組(462.15 ± 5.69 mm3;490.24 ± 13.93 mm3,p<0.05),但胼胝體(corpus callosum,CC)體積兩組間並無顯著差異。DTI結果顯示暴露組的胼胝體、前連合體(anterior commissure)、穹窿(fimbria)、視神經束(optic tract,OpT)及嗅神經束(olfactory tract)的擴散不等向性(fractional anisotropy)降低,CC的軸向擴散率(axial diffusivity)降低,OpT的徑向擴散率(radial diffusivity)和平均擴散率(mean diffusivity)增加(所有p<0.05)。另外,我們發現暴露組相較控制組WM組織中的MBP表現量顯著降低(1.28 ± 0.33;2.2 ± 0.59,p<0.05),但在皮質並未發現MBP表現量有明顯變化,Aβ42、P-tau及CD11b在兩個腦區皆無顯著差異。由染色的結果顯示,暴露組CC中髓鞘密度顯著降低(0.48 ± 0.09;1.00 ± 0.45,p<0.05),暴露組的皮質神經元數量相較對照組顯著減少(487.00 ± 30.26;560.60 ± 37.62,p <0.05)。 就我們所知,本研究是第一篇使用AD動物模型有系統地、完整地探討暴露PM2.5與WM變化的研究。我們的結果表明,長期暴露於環境水平的PM2.5會加速AD小鼠中樞神經系統WM病理學的惡化,之後可能會影響神經元減少,導致較差的認知能力,並可能在未來進一步發展為AD。由於在我們研究暴露的過程中有老鼠死亡的情形,這可能使我們的結果低估,未來期望能使用轉殖更多AD基因的小鼠,以提前相關病徵出現的時間,來更加釐清PM對中樞神經的影響,並且探討暴露微粒造成白質變化的可能機制。 | zh_TW |
dc.description.abstract | Accumulating evidence have shown that PM2.5 may cause central nervous system (CNS) diseases, including Alzheimer’s disease (AD). White matter (WM) is observed in the early stage of AD and seen as an early marker of AD. To date, there are still few studies investigating associations between PM2.5 and WM change. The purpose of my study is to determine whether long-term exposure to non-concentrated ambient PM2.5 accelerates the WM pathology in AD animal model. In this study, we assessed the change of WM following chronic PM2.5 exposure in 6-month-old female triple-transgenic AD (3xTg-AD) mice using the Taipei Air Pollution Exposure System (TAPES). The treated mice were whole-bodily and continuously exposed to real world and non-concentrated PM2.5 for 5 months, while the control mice inhaled filtered air. The magnetic resonance imaging (MRI) was used to observe the brain structures. The diffusion tensor imaging (DTI) method was used to quantify changes in WM microstructure. We used the western blot to determine the level of the myelin basic protein (MBP), and the Luxol fast blue stain was used to assess the myelin or myelinated axons. The number of neuronal cells was scored on the histological preparation with Nissl staining. The average PM2.5 concentration in our study was 13.85 μg/m3. The exposure group has smaller total cerebral brain volumes than the control group by MRI (p < 0.05). The DTI demonstrated a decreased fractional anisotropy in corpus callosum (CC), anterior commissure, fimbria, optic tract (OpT), and olfactory tract; a decreased axial diffusivity in the CC; an increased radial diffusivity and mean diffusivity in the OpT in the exposure group (all p < 0.05). We found both MBP level in WM tissue and the density of stained myelin in CC were decreased (p<0.05) in the exposure group. Neuron number in cortex was decreased (p<0.05) in the exposure group compared to the control group. To the best of our knowledge, this is the first study to use AD animal models to systematically and comprehensively describe changes in WM. Our results indicate that chronic exposure to environmental level PM2.5 may accelerate the deterioration of WM pathology in the CNS of AD mice. It may subsequently affect neuron, which may lead to poor cognitive ability and may develop into AD in the future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T09:49:27Z (GMT). No. of bitstreams: 1 U0001-1308202015155500.pdf: 2925321 bytes, checksum: 04a04b61c6744e02671d098142a19c6a (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 致謝 i 摘要 ii Abstract iv 第一章 前言與研究目的 1 1.1 前言 1 1.2 研究目的 2 第二章 文獻回顧 3 2.1 空氣汙染物中的細懸浮微粒 3 2.2 細懸浮微粒之健康效應 5 2.3 細懸浮微粒之中樞神經毒性 6 2.3.1 微粒影響中樞神經的途徑 6 2.3.2 微粒暴露與神經發炎機制 8 2.4 阿茲海默症(Alzheimer’s disease,AD) 9 2.4.1 阿茲海默症與大腦白質病變 10 2.4.2 阿茲海默症與神經影像學技術 11 2.5 阿茲海默症三基因轉殖小鼠 13 第三章 材料與方法 15 3.1 實驗流程與架構 15 3.2 實驗動物 16 3.3 大氣細懸浮微粒暴露 17 3.3.1 台北空氣汙染暴露系統(TAPES) 17 3.3.2 大氣微粒濃度監測 17 3.3.3 大氣微粒成分分析 18 3.4 動物犧牲與組織處理 19 3.5 神經影像學分析 20 3.5.1 核磁共振成像(MRI) 20 3.5.2 擴散張量成像(DTI) 21 3.6 組織病理切片 24 3.6.1 Luxol fast blue染色 24 3.6.2 尼氏染色(Nissl Stain) 24 3.6.3 半定量分析 24 3.7 西方墨點法(Western Blot) 26 3.7.1 蛋白質萃取 26 3.7.2 總蛋白質定量 27 3.7.3 西方墨點法流程 27 3.7.4 半定量分析 29 3.8 統計方法 31 第四章 結果 32 4.1 暴露期間微粒濃度與成分組成 32 4.1.1 暴露期間微粒濃度 32 4.1.2 暴露期間微粒成分組成 32 4.2 實驗動物體重變化及死亡情形描述 34 4.3 神經影像學分析 35 4.3.1 MRI 35 4.3.2 DTI 35 4.4 組織病理切片 36 4.4.1 Luxol fast blue stain 36 4.4.2 Nissl stain 36 4.5 阿茲海默症相關病徵蛋白表現 37 4.5.1 白質阿茲海默症相關蛋白表現量 37 4.5.2 灰質阿茲海默症相關蛋白表現量 37 第五章 討論 38 5.1 全身性呼吸暴露 39 5.2 PM2.5濃度及組成特性 40 5.3 暴露微粒對微膠細胞活化之影響 42 5.4 暴露微粒對腦部體積之影響 43 5.5 暴露微粒對大腦白質微結構之影響 45 5.6 暴露微粒對髓鞘數量之影響 48 5.7 暴露微粒對白質與灰質的變化 50 5.8 研究限制及建議 51 第六章 結論 52 第七章 參考資料 53 | |
dc.language.iso | zh-TW | |
dc.title | 慢性暴露大氣懸浮微粒對阿茲海默症三基因轉殖小鼠腦白質病理學之影響 | zh_TW |
dc.title | Effects of chronic exposure to ambient particles on white matter pathology in 3xTg-AD mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林靖愉(Ching-Yu Lin),陳達夫(Ta-Fu Chen),莊校奇(Hsiao-Chi Chuang) | |
dc.subject.keyword | 大氣細懸浮微粒,阿茲海默症,白質病理變化,脫髓鞘,核磁共振成像,擴散張量成像, | zh_TW |
dc.subject.keyword | PM2.5,Alzheimer's disease,White matter changes,Demyelination,Magnetic resonance imaging,Diffusion tensor imaging, | en |
dc.relation.page | 98 | |
dc.identifier.doi | 10.6342/NTU202003264 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-14 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
顯示於系所單位: | 環境與職業健康科學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
U0001-1308202015155500.pdf 目前未授權公開取用 | 2.86 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。