請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59859
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江俊斌 | |
dc.contributor.author | I-Chang Chen | en |
dc.contributor.author | 陳義章 | zh_TW |
dc.date.accessioned | 2021-06-16T09:41:43Z | - |
dc.date.available | 2018-03-01 | |
dc.date.copyright | 2017-03-01 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-02-06 | |
dc.identifier.citation | Albuquerque RL Jr, Miguel MC, Costa AL, Souza LB. Correlation of c-erbB-2 and S-100 expression with the malignancy grading and anatomical site in oral squamous cell carcinoma. Int J Exp Pathol 2003;84:259-65.
Araújo CP, Gurgel CA, Ramos EA, Freitas VS, Barbosa Ade A Jr, Ramalho LM, dos Santos JN. Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis. J Mol Histol 2010;41:357-65. Barrett AW, Cruchley AT, Williams DM. Oral mucosal Langerhans’ cells. Crit Rev Oral Biol Med 1996;7:36-58. Barrett AW, Williams DM, Scott J. Effect of tobacco and alcohol consumption on the Langerhans cell population of human lingual epithelium determined using a monoclonal antibody against HLADR. J Oral Pathol Med 1991;20:49-52. Bettendorf O, Piffko J, Bankfalvi A. Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? Oral Oncol 2004;40:110-9. Birbeck MS, Breathnach AS, Everall JD. An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cells) in vitelligo. J Invest Dermatol 1961;37:51-64. Bondad-Palmario GG. Histological and immunochemical studies of oral leukoplakia: phenotype and distribution of immunocompetent cells. J Philipp Dent Assoc 1995;47:3-18. Cancer registry annual report in Taiwan area, 2013. Department of Health, The Executive Yuan, Taiwan, 2015. Chang HH, Chiang CP, Hung HC, Lin CY, Deng YT, Kuo MYP. Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients. Oral Oncol 2009;45:610-4. Chang HH, Kuo MYP, Cheng SJ, Chiang CP. Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. Oral Oncol 2009;45:589-93. Chang JYF, Lin MC, Chiang CP. High-risk human papillomaviruses may have an important role in non-oral habits-associated oral squamous cell carcinomas in Taiwan. Am J Clin Pathol 2003;120:909-16. Chattopadhyay A. Epidemiologic study of oral cancer in Eastern India. Indian J Dermatol 1989;4:59-65. Chen HH, Yu CH, Wang JT, Liu BY, Wang YP, Sun A, Tsai TC, Chiang CP. Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. Oral Oncol 2007;43:122-9. Chen HM, Kuo MYP, Lin KH, Lin CY, Chiang CP. Expression of cyclin A is related to progression of oral squamous cell carcinoma in Taiwan. Oral Oncol 2003;39:476-82 Chen YK, Huang HC, Lin LM, Lin CC. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncol 1999;35:173-9. Chen YS, Wang JT, Chang YF, Liu BY, Wang YP, Sun A, Chiang CP. Expression of hepatocyte growth factor and c-met protein is significantly associated with the progression of oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 2004;33:209-17. Cheng SJ, Kok SH, Lee JJ, Kuo MYP, Cheng SL, Huang YL, Chen HM, Chang HH, Chiang CP. Significant association of Src protein expression with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. Head Neck 2012;34:1340-5. Cheng SJ, Lee JJ, Cheng SL, Chen HM, Chang HH, Wang YP, Kok SH, Kuo MYP, Chiang CP. Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma. Oral Oncol 2012;48:424-8. Cheng SJ, Lee JJ, Kok SH, Chou CH, Chang HH, Chiang ML, Chen HM, Kuo MYP, Chiang CP. Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer. Head Neck 2010;32:1363-9. Cheng SJ, Liu YC, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MYP, Chiang CP. Expression of Gα12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 2013;42:565-9. Chiang CP, Huang JS, Wang JT, Liu BY, Kuo YS, Hahn LJ, Kuo MYP. Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking-associated oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 1999;28:72-6. Chiang CP, Kao CY, Liu BY, Wang JT, Lin SK, Kuo MYP. Reduction of Langerhans cell density in oral epithelium of patients with oral submucous fibrosis. Chin Dent J 1998;17:137-47. Chiang CP, Lang MJ, Liu BY, Wang JT, Leu JS, Hahn LJ, Kuo MYP. Expression of p53 protein in oral submucous fibrosis, oral epithelial hyperkeratosis and epithelial dysplasia. J Formos Med Assoc 2000;99:229-34. Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC. Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma. J Oral Pathol Med 2016;45:418-24. Daniels TE, Chou L, Greenspan JS, Grady DG, Hauck WW, Greene JC, Ernster VL. Reduction of Langerhans cells in smokeless tobacco-associated oral mucosal lesions. J Oral Pathol Med 1992;21:100-4. Devi M, Saraswathi TR, Ranganathan K, Vijayalakshmi D, Sreeja C, Fathima SS. Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study. J Pharm Bioallied Sci 2014;6(Suppl 1):S146-9. Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. N Engl J Med 2001;345:1890-900. Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK, Hoffman HT. Presentation, treatment, and outcome of oral cavity cancer: a national cancer data base report. Head Neck 2002;24:165-80. Girod SC, Kühnast T, Ulrich S, Krueger GR. Langerhans cells in epithelial tumors and benign lesions of the oropharynx. In Vivo 1994;8:543-7. Gomes JO, de Vasconcelos Carvalho M, Fonseca FP, Gondak RO, Lopes MA, Vargas PA. CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma. J Oral Pathol Med 2016;45:433-9. Gueiros LA, Gondak R, Jorge Júnior J, Coletta RD, Carvalho Ade A, Leão JC, de Almeida OP, Vargas PA. Increased number of Langerhans cells in oral lichen planus and oral lichenoid lesions. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:661-6. Gustafson J, Eklund C, Wallström M, Zellin G, Magnusson B, Hasséus B. Langerin-expressing and CD83-expressing cells in oral lichen planus lesions. Acta Odontol Scand 2007;65:156-61. Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med 2007;36:25-9. Hwang EYC, Yu CH, Cheng SJ, Chang JYF, Chen HM, Chiang CP. Decreased expression of Ep-CAM protein is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 2009;38:87-93. Kindt N, Descamps G, Seminerio I, Bellier J, Lechien JR, Pottier C, Larsimont D, Journé F, Delvenne P, Saussez S. Langerhans cell number is a strong and independent prognostic factor for head and neck squamous cell carcinomas. Oral Oncol 2016;62:1-10. Ko HH, Lee JJ, Chen HM, Kok SH, Kuo MYP, Cheng SJ, Chiang CP. Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinoma. J Formos Med Assoc 2015;114:605-11. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995;24:450-3. Kovesi G, Szende B. Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia. Oncol 2003;65:331-6. Kuo MYP, Hsu HY, Kok SH, Kuo RC, Yang H, Hahn LJ, et al. Prognostic role of p27Kip1 expression in oral squamous cell carcinoma in Taiwan. Oral Oncol 2002;38:172-8. Kuo MYP, Jeng JH, Chiang CP, Hahn LJ. Mutations of Ki-ras oncogenes codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 1994;23:70-4. Kuo MYP, Chang HH, Hahn LJ, Wang JT, Chiang CP. Elevated ras p21 expression in oral premalignant lesions and squamous cell carcinomas in Taiwan. J Oral Pathol Med 1995;24:255-60. Kuo MYP, Cheng SJ, Chen HM, Kok SH, Hahn LJ, Chiang CP. Expression of CD44s, CD44v5, CD44v6 and CD44v7-8 in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan. J Oral Pathol Med 1998;27:428-33. Kuo MYP, Lin CY, Hahn LJ, Chiang CP. Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 1999;28:165-9. Kuo MYP, Huang JS, Kok SH, Kuo YS, Chiang CP. Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 2002;31:16-22. Lin CY, Jeng YM, Chou HY, Hsu HC, Yuan RH, Chiang CP, Kuo MY. Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J Surg Oncol 2008;97:544-50. Lin PY, Yu CH, Wang JT, Chen HH, Cheng SJ, Kuo MYP, Chiang CP. Expression of hypoxia-inducible factor-1α is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 2008;37:18-25. Lo WL, Kao SY, Chi LY, Wong YK, Chang RCS. Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg 2003;61:751-8. Lu CF, Huang CS, Tjiud JW, Chiang CP. Infiltrating macrophage count: a significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan. Head Neck 2010;32:18-25. Massano J, Regateiro FS, Januario G, Ferreira A. Oral squamous cell carcinoma: Review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:67-76. Narayanan B, Narasimhan M. Langerhans cell expression in oral submucous fibrosis: An immunohistochemical analysis. J Clin Diagn Res 2015;9:ZC39-41. Neville BW, Damm DD, Allen CM, Chi AC. Epithelial Pathology. In: Neville BW, Damm DD, Allen CM, Chi AC, eds. Oral and Maxillofacial Pathology. 4th ed, Philadelphia: Sauders Elsevier. 2016:355-64. Öhman J, Magnusson B, Telemo E, Jontell M, Hasséus B. Langerhans cells and T cells sense cell dysplasia in oral leukoplakias and oral squamous cell carcinomas -- evidence for immunosurveillance. Scand J Immunol 2012;76:39-48. Pereira KM, Soares RC, Oliveira MC, Pinto LP, Costa Ade L. Immunohistochemical staining of Langerhans cells in HPV-positive and HPV-negative cases of oral squamous cell carcinoma. J Appl Oral Sci 2011;19:378-83. Shen WR, Wang YP, Chang JYF, Yu SY, Chen HM, Chiang CP. Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. J Oral Pathol Med 2014;43:258-64. Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Klan A, Seymour GJ, Bigby M. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med 2002;13:350-65. Thomas SJ, MacLennan R. Slaked lime and betel nut cancer in Papua New Guinea. Lancet 1992;340:577-8. Tsai TC, Yu CH, Cheng SJ, Liu BY, Chen HM, Chiang CP. Expression of RCAS1 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. Oral Oncol 2008;44:759-66. Upadhyay J, Rao NN, Upadhyay RB. A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a. J Cancer Res Ther 2012;8:591-7. Wang YP, Chen HM, Kuo RC, Yu CH, Sun A, Liu BY, et al. Oral verrucous hyperplasia: histological classification, prognosis and clinical implications. J Oral Pathol Med 2009;38:651-6. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45:309-16. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med 2007;36:575-80. Williams HK. Molecular pathogenesis of oral squamous carcinoma. J Clin Pathol: Mol Pathol 2000;53:165-72. Yen AM, Chen SC, Chang SH, Chen TH. The effect of betel quid and cigarette on multistate progression of oral pre-malignancy. J Oral Pathol Med 2008;37:417-22. Yen AM, Chen SC, Chen TH. Dose-response relationships of oral habits associated with the risk of oral pre-malignant lesions among men who chew betel quid. Oral Oncol 2007;43:634-8. Yu SY, Wang YP, Chang JYF, Shen WR, Chen HM, Chiang CP. Increased expression of MCM5 is significantly associated with aggressive progression and poor prognosis of oral squamous cell carcinoma. J Oral Pathol Med 2014;43:344-9. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59859 | - |
dc.description.abstract | 背景:蘭格罕氏細胞是由骨髓來之抗原呈現細胞,口腔病變中較高之蘭格罕氏細胞數目,表示口腔病變患者對該病變之免疫監視能力有明顯增加。口腔上皮變異是一種癌前病變,它可能轉變成口腔癌。
方法:本研究利用免疫組織化學染色法,探討58例口腔上皮變異(21例輕度,18例中度,19例重度上皮變異)和10例正常口腔黏膜之上皮及上皮下方結締組織中之蘭格罕氏細胞數目。 結果:我們發現於上皮中之平均蘭格罕氏細胞數目,從正常口腔黏膜之14 ± 3細胞/高倍視域,至輕度口腔上皮變異之32 ± 12細胞/高倍視域,中度口腔上皮變異之40 ± 12細胞/高倍視域,至重度口腔上皮變異之49 ± 13細胞/高倍視域,有隨著上皮變異程度的增加,而呈現統計學上有意義增加的情形 (P < 0.001)。統計分析的結果也顯示,上皮下方結締組織中之平均蘭格罕氏細胞數目,從正常口腔黏膜之5 ± 2細胞/高倍視域,至輕度口腔上皮變異之24 ± 12細胞/高倍視域,中度口腔上皮變異之33 ± 12細胞/高倍視域,至重度口腔上皮變異之47 ± 17細胞/高倍視域,亦有隨著上皮變異程度的增加,而呈現統計學上有意義增加的情形 (P < 0.001)。另外上皮中之平均蘭格罕氏細胞數目,也隨著口腔上皮變異病變中上皮層厚度及上皮下方結締組織中發炎帶寬度之增加而增加。另外上皮下方結締組織中之平均蘭格罕氏細胞數目,也隨著口腔上皮變異病變中上皮下方結締組織中發炎帶寬度之增加而增加。我們也發現9例有惡性轉變口腔上皮變異病變(包括5例重度,3例中度及1例輕度口腔上皮變異病變),比49例無惡性轉變口腔上皮變異病變,其上皮及上皮下方結締組織中平均蘭格罕氏細胞數目明顯較低。 結論:蘭格罕氏細胞數目從正常口腔黏膜經由輕度和中度口腔上皮變異至重度口腔上皮變異,呈現有意義之逐漸增加,此表示口腔上皮變異患者之免疫監視能力於口腔癌生成之早期即有明顯增加。口腔上皮變異中較低之蘭格罕氏細胞數目,可能表示口腔上皮變異患者對變異細胞部分喪失免疫監視能力,此情況下有利於口腔上皮變異病變進一步惡性轉變成口腔癌。 | zh_TW |
dc.description.abstract | BACKGROUND: Langerhans cells (LCs) are bone marrow-derived antigen presenting cells. The high LC number in oral lesion may suggest an increase in immunosurveillance ability in patients with that oral disease. Oral epithelial dysplasia (OED) is a precancerous lesion that may develop into an oral cancer.
METHODS: This study examined the LC counts in the epithelium and in the subepithelial connective tissue of 58 specimens of OED (21 mild, 18 moderate, and 19 severe OED cases), and 10 specimens of normal oral mucosa (NOM) by immunohistochemistry. RESULTS: We found that the mean LC counts in the epithelia increased significantly from NOM (14 ± 3 cells/high-power field [HPF]) through mild OED (32 ± 12 cells/HPF) and moderate OED (40 ± 12 cells/HPF) to severe OED samples (49 ± 13 cells/HPF, P < 0.001). Moreover, the mean LC counts in the subepithelial connective tissues also increased significantly from NOM (5 ± 2 cells/HPF) through mild OED (24 ± 12 cells/HPF) and moderate OED (33 ± 12 cells/HPF) to severe OED samples (47 ± 17 cells/HPF, P < 0.001). In addition, a significant correlation was found between the higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (P < 0.001) or wider inflammatory zones (P < 0.001) as well as between the higher mean LC counts in the subepithelial connective tissues of OED samples and OED lesions with wider inflammatory zones (P < 0.001). Moreover, the 9 OED lesions (including 5 severe, 3 moderate and one mild OED lesions) with malignant transformation had a significantly lower mean LC count in the dysplastic epithelia or subepithelial connective tissues than 49 OED lesions without malignant transformation. CONCLUSIONS: The significant and gradual elevation in LC count from NOM through mild and moderate OED to severe OED lesions suggests an upregulation of immunosuveillance ability in OED patients during the early oral carcinogenesis process. The low LC count in OED lesions may suggest the partial loss of immunosurveillance ability against the dysplastic cells; this in turn favors the malignant transformation of an OED lesion into an OSCC lesion. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T09:41:43Z (GMT). No. of bitstreams: 1 ntu-106-R01422034-1.pdf: 1471176 bytes, checksum: ebba7456891f44ed7e5430a500e0d4ab (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 目 錄
中文摘要 6 Abstract 7 Introduction 8 Background 10 Purposes of this study 12 Literature review 13 Part 1: Langerhans cell 13 (i) Introduction of Langerhans cell 13 (ii) Ultrastructure of Langerhans cell 14 (iii) Histochemistry for identification of Langerhans cell 14 (iv) Immunohistochemistry for identification of Langerhans cell 15 (v) Methodological considerations for studies of Langerhans cell 15 (vi) Regional differences for oral mucosal Langerhans cells 16 (vii) The evidence that Langerhans cell presents antigen 16 Part 2: Langerhans cell-related studies on oral potentially malignant disorders and oral squamous cell carcinomas 18 (i) Increased Langerhans cell number in oral potentially malignant disorders and oral squamous cell carcinomas 18 (ii) Decreased Langerhans cell number in oral potentially malignant disorders and oral squamous cell carcinomas 21 Part 3: Oral squamous cell carcinomas and oral potentially malignant disorders 25 (i) Oral squamous cell carcinomas 25 (ii) Oral potentially malignant disorders 26 (iii) Our previous studies on oral squamous cell carcinomas and oral potentially malignant disorders 28 Materials and Methods Part 1: Patients and specimens 40 Part 2: Immunohistochemical staining for Langerhans cells 40 Part 3: Statistical analysis 42 Results Part 1: LCs in NOM and OED samples 43 Part 2: Correlation between LC counts in OED samples and clinicopathological parameters of OED patients 43 Discussion 45 Conclusions 51 References 52 Tables 60 Figures 64 Tables Table1. The mean Langerhans cell (LC) counts in the normal and dysplastic epithelia of normal oral mucosa (NOM) and oral epithelial dysplasia (OED) samples 60 Table 2. The mean Langerhans cell (LC) counts in the subepithelial connective tissues of normal oral mucosa (NOM) and oral epithelial dysplasia (OED) samples 61 Table 3. Correlation between the LC counts in the dysplastic epithelia of oral epithelial dysplasia (OED) samples and clinicopathological parameters of OED patients . 62 Table 4. Correlation between the LC counts in the subepithelial connective tissues of oral epithelial dysplasia (OED) samples and clinicopathological parameters of OED patients 63 Figures Figure 1. Immunostaining microphotographs for Langerhans cells (LCs) in the normal and dysplastic epithelia of normal oral mucosa (NOM) and oral epithelial dysplasia (OED) specimens 64 Figure 2. Immunostaining microphotographs for Langerhans cells (LCs) in the subepithelial connective tissues of normal oral mucosa (NOM) and oral epithelial dysplasia (OED) specimens . 66 | |
dc.language.iso | en | |
dc.title | 口腔上皮變異中蘭格罕氏細胞數量及其與臨床病理參數之相關性 | zh_TW |
dc.title | Langerhans cell counts in oral epithelial dysplasia and their correlations to clinocopathological parameters | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張龍昌,林弘斌 | |
dc.subject.keyword | 蘭格罕氏細胞,口腔上皮變異,口腔癌生成,免疫監視能力, | zh_TW |
dc.subject.keyword | Langerhans cell,oral epithelial dysplasia,oral carcinogenesis,immunosurveillance, | en |
dc.relation.page | 68 | |
dc.identifier.doi | 10.6342/NTU201700360 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-02-06 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-106-1.pdf 目前未授權公開取用 | 1.44 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。