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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59748完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邱銘章(Ming-Jang, Chiu) | |
| dc.contributor.author | Boon-Lead Tee | en |
| dc.contributor.author | 鄭文立 | zh_TW |
| dc.date.accessioned | 2021-06-16T09:36:02Z | - |
| dc.date.available | 2017-03-01 | |
| dc.date.copyright | 2017-03-01 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-02-13 | |
| dc.identifier.citation | 參考文獻 References
1. Adebakin, A., J. Bradley, S. Gümüsgöz, E. J. Waters and C. B. Lawrence (2012). 'Impaired Satiation and Increased Feeding Behaviour in the Triple-Transgenic Alzheimer's Disease Mouse Model.' PLoS ONE 7(10): e45179. 2. Andreano, J. M., B. C. Dickerson and L. F. Barrett (2014). 'Sex differences in the persistence of the amygdala response to negative material.' Social Cognitive and Affective Neuroscience 9(9): 1388-1394. 3. Appelbaum, L., G. X. Wang, G. S. Maro, R. Mori, A. Tovin, W. Marin, T. Yokogawa, K. Kawakami, S. J. Smith, Y. Gothilf, E. Mignot and P. Mourrain (2009). 'Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish.' Proc Natl Acad Sci U S A 106(51): 21942-21947. 4. Arriagada, P. V., J. H. Growdon, E. T. Hedley-Whyte and B. T. Hyman (1992). 'Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease.' Neurology 42(3 Pt 1): 631-639. 5. Barrett-Connor, E., S. L. Edelstein, J. Corey-Bloom and W. C. Wiederholt (1996). 'Weight loss precedes dementia in community-dwelling older adults.' J Am Geriatr Soc 44(10): 1147-1152. 6. Berkhout, A. M., H. J. Cools and H. C. van Houwelingen (1998). 'The relationship between difficulties in feeding oneself and loss of weight in nursing-home patients with dementia.' Age Ageing 27(5): 637-641. 7. Bhagavati, S. (2008). 'Marked hyperphagia associated with total loss of satiety in Alzheimer's disease.' J Neuropsychiatry Clin Neurosci 20(2): 248-249. 8. Bonanni, E., M. Maestri, G. Tognoni, M. Fabbrini, B. Nucciarone, M. L. Manca, S. Gori, A. Iudice and L. Murri (2005). 'Daytime sleepiness in mild and moderate Alzheimer's disease and its relationship with cognitive impairment.' J Sleep Res 14(3): 311-317. 9. Brodaty, H., M. Heffernan, B. Draper, S. Reppermund, N. A. Kochan, M. J. Slavin, J. N. Trollor and P. S. Sachdev (2012). 'Neuropsychiatric symptoms in older people with and without cognitive impairment.' J Alzheimers Dis 31(2): 411-420. 10. Brookmeyer, R., E. Johnson, K. Ziegler-Graham and H. M. Arrighi (2007). 'Forecasting the global burden of Alzheimer's disease.' Alzheimers Dement 3(3): 186-191. 11. Buchman, A. S., R. S. Wilson, J. L. Bienias, R. C. Shah, D. A. Evans and D. A. Bennett (2005). 'Change in body mass index and risk of incident Alzheimer disease.' Neurology 65(6): 892-897. 12. Buckwalter, J. G., L. S. Schneider, T. W. Wilshire, M. E. Dunn and V. W. Henderson (1997). 'Body weight, estrogen and cognitive functioning in Alzheimer's disease: an analysis of the Tacrine Study Group data.' Arch Gerontol Geriatr 24(3): 261-267. 13. Callen, D. J., S. E. Black, F. Gao, C. B. Caldwell and J. P. Szalai (2001). 'Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD.' Neurology 57(9): 1669-1674. 14. Chan, W. C., L. C. Lam, C. W. Tam, V. W. Lui, S. S. Chan, W. M. Chan and H. F. Chiu (2010). 'Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-a population-based study.' Am J Geriatr Psychiatry 18(10): 948-954. 15. Chan, W. C., L. C. Lam, C. W. Tam, V. W. Lui, G. T. Leung, A. T. Lee, S. S. Chan, A. W. Fung, H. F. Chiu and W. M. Chan (2011). 'Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment.' Age Ageing 40(1): 30-35. 16. Coogan, A. N., B. Schutova, S. Husung, K. Furczyk, B. T. Baune, P. Kropp, F. Hassler and J. Thome (2013). 'The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities.' Biol Psychiatry 74(5): 333-339. 17. Donaldson, K. E., W. H. Carpenter, M. J. Toth, M. I. Goran, P. Newhouse and E. T. Poehlman (1996). 'No evidence for a higher resting metabolic rate in noninstitutionalized Alzheimer's disease patients.' J Am Geriatr Soc 44(10): 1232-1234. 18. Eustache, P., F. Nemmi, L. Saint-Aubert, J. Pariente and P. Peran (2016). 'Multimodal Magnetic Resonance Imaging in Alzheimer's Disease Patients at Prodromal Stage.' J Alzheimers Dis 50(4): 1035-1050. 19. Fabris, C., B. Cozzi, A. Hay-Schmidt, B. Naver and M. Moller (2004). 'Demonstration of an orexinergic central innervation of the pineal gland of the pig.' J Comp Neurol 471(2): 113-127. 20. Ferrari, E., A. Arcaini, R. Gornati, L. Pelanconi, L. Cravello, M. Fioravanti, S. B. Solerte and F. Magri (2000). 'Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia.' Exp Gerontol 35(9-10): 1239-1250. 21. Fleming, K., S. H. Kim, M. Doo, G. Maguire and S. G. Potkin (2003). 'Memory for emotional stimuli in patients with Alzheimer's disease.' Am J Alzheimers Dis Other Demen 18(6): 340-342. 22. Fronczek, R., S. van Geest, M. Frolich, S. Overeem, F. W. Roelandse, G. J. Lammers and D. F. Swaab (2012). 'Hypocretin (orexin) loss in Alzheimer's disease.' Neurobiol Aging 33(8): 1642-1650. 23. Gahete, M. D., A. Rubio, J. Cordoba-Chacon, F. Gracia-Navarro, R. D. Kineman, J. Avila, R. M. Luque and J. P. Castano (2010). 'Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.' J Alzheimers Dis 22(3): 819-828. 24. Grant, W. B. (2016). 'Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease.' J Am Coll Nutr 35(5): 476-489. 25. Green, M. W. and P. J. Rogers (1995). 'Impaired cognitive functioning during spontaneous dieting.' Psychol Med 25(5): 1003-1010. 26. Green, M. W., P. J. Rogers, N. A. Elliman and S. J. Gatenby (1994). 'Impairment of cognitive performance associated with dieting and high levels of dietary restraint.' Physiol Behav 55(3): 447-452. 27. Hellstrom, L., H. Wahrenberg, K. Hruska, S. Reynisdottir and P. Arner (2000). 'Mechanisms behind gender differences in circulating leptin levels.' J Intern Med 247(4): 457-462. 28. Herzog, A. G. and T. L. Kemper (1980). 'Amygdaloid changes in aging and dementia.' Arch Neurol 37(10): 625-629. 29. Hwang, J. P., C. H. Yang, S. J. Tsai and K. M. Liu (1997). 'Behavioural disturbances in psychiatric inpatients with dementia of the Alzheimer's type in Taiwan.' Int J Geriatr Psychiatry 12(9): 902-906. 30. Ikeda, M., J. Brown, A. J. Holland, R. Fukuhara and J. R. Hodges (2002). 'Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease.' J Neurol Neurosurg Psychiatry 73(4): 371-376. 31. Ishii, M., G. Wang, G. Racchumi, J. P. Dyke and C. Iadecola (2014). 'Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.' J Neurosci 34(27): 9096-9106. 32. Ishii, M., G. Wang, G. Racchumi, J. P. Dyke and C. Iadecola (2014). 'Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons.' The Journal of Neuroscience 34(27): 9096-9106. 33. Jackson, H. M., I. Soto, L. C. Graham, G. W. Carter and G. R. Howell (2013). 'Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.' BMC Genomics 14: 831. 34. Johnson, D. K., C. H. Wilkins and J. C. Morris (2006). 'Accelerated weight loss may precede diagnosis in Alzheimer disease.' Arch Neurol 63(9): 1312-1317. 35. Ju, Y. E., J. S. McLeland, C. D. Toedebusch, C. Xiong, A. M. Fagan, S. P. Duntley, J. C. Morris and D. M. Holtzman (2013). 'Sleep quality and preclinical Alzheimer disease.' JAMA Neurol 70(5): 587-593. 36. Khachiyants, N., D. Trinkle, S. J. Son and K. Y. Kim (2011). 'Sundown syndrome in persons with dementia: an update.' Psychiatry Investig 8(4): 275-287. 37. Kile, S. J., W. G. Ellis, J. M. Olichney, S. Farias and C. DeCarli (2009). 'Alzheimer abnormalities of the amygdala with Kluver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease.' Arch Neurol 66(1): 125-129. 38. Knight, E. M., A. Verkhratsky, S. M. Luckman, S. M. Allan and C. B. Lawrence (2012). 'Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease.' Neurobiol Aging 33(1): 187-193. 39. Kromer Vogt, L. J., B. T. Hyman, G. W. Van Hoesen and A. R. Damasio (1990). 'Pathological alterations in the amygdala in Alzheimer's disease.' Neuroscience 37(2): 377-385. 40. Lahiri, D. K. (1999). 'Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types.' J Pineal Res 26(3): 137-146. 41. Laxton, A. W., D. F. Tang-Wai, M. P. McAndrews, D. Zumsteg, R. Wennberg, R. Keren, J. Wherrett, G. Naglie, C. Hamani, G. S. Smith and A. M. Lozano (2010). 'A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease.' Ann Neurol 68(4): 521-534. 42. Lee, E. B. (2011). 'Obesity, leptin, and Alzheimer's disease.' Ann N Y Acad Sci 1243: 15-29. 43. Lee, J. H., D. L. Bliwise, F. P. Ansari, F. C. Goldstein, J. S. Cellar, J. J. Lah and A. I. Levey (2007). 'Daytime sleepiness and functional impairment in Alzheimer disease.' Am J Geriatr Psychiatry 15(7): 620-626. 44. Lee, Y. M., J. M. Park, B. D. Lee, E. Moon, H. J. Jeong, Y. I. Chung, J. H. Kim, H. J. Kim, C. W. Mun, T. H. Kim and Y. H. Kim (2016). 'Gray matter volumes and treatment response of psychotic symptoms to risperidone in antipsychotic-naive Alzheimer's disease patients.' J Clin Psychiatry 77(1): e8-13. 45. Leibowitz, S. F. and K. E. Wortley (2004). 'Hypothalamic control of energy balance: different peptides, different functions.' Peptides 25(3): 473-504. 46. Lieb, W., A. S. Beiser, R. S. Vasan, Z. S. Tan, R. Au, T. B. Harris, R. Roubenoff, S. Auerbach, C. DeCarli, P. A. Wolf and S. Seshadri (2009). 'Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.' Jama 302(23): 2565-2572. 47. Lim, A. S., B. A. Ellison, J. L. Wang, L. Yu, J. A. Schneider, A. S. Buchman, D. A. Bennett and C. B. Saper (2014). 'Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease.' Brain 137(Pt 10): 2847-2861. 48. Lim, A. S., M. Kowgier, L. Yu, A. S. Buchman and D. A. Bennett (2013). 'Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons.' Sleep 36(7): 1027-1032. 49. Lim, A. S., L. Yu, M. Kowgier, J. A. Schneider, A. S. Buchman and D. A. Bennett (2013). 'Modification of the relationship of the apolipoprotein E epsilon4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep.' JAMA Neurol 70(12): 1544-1551. 50. Lin, T. W., Y. F. Liu, Y. H. Shih, S. J. Chen, T. Y. Huang, C. Y. Chang, C. H. Lien, L. Yu, S. H. Chen and Y. M. Kuo (2015). 'Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer's Disease.' Curr Alzheimer Res 12(10): 951-963. 51. Liu, R. Y., J. N. Zhou, J. van Heerikhuize, M. A. Hofman and D. F. Swaab (1999). 'Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.' J Clin Endocrinol Metab 84(1): 323-327. 52. Lupton, M. K., L. Strike, N. K. Hansell, W. Wen, K. A. Mather, N. J. Armstrong, A. Thalamuthu, K. L. McMahon, G. I. de Zubicaray, A. A. Assareh, A. Simmons, P. Proitsi, J. F. Powell, G. W. Montgomery, D. P. Hibar, E. Westman, M. Tsolaki, I. Kloszewska, H. Soininen, P. Mecocci, B. Velas, S. Lovestone, H. Brodaty, D. Ames, J. N. Trollor, N. G. Martin, P. M. Thompson, P. S. Sachdev and M. J. Wright (2016). 'The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.' Neurobiol Aging 40: 68-77. 53. Makovey, J., V. Naganathan, M. Seibel and P. Sambrook (2007). 'Gender differences in plasma ghrelin and its relations to body composition and bone - an opposite-sex twin study.' Clin Endocrinol (Oxf) 66(4): 530-537. 54. Mikkelsen, J. D., F. Hauser, L. deLecea, J. G. Sutcliffe, T. S. Kilduff, C. Calgari, P. Pevet and V. Simonneaux (2001). 'Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin.' Eur J Neurosci 14(3): 419-425. 55. Morris, J. C. (2005). 'Early-stage and preclinical Alzheimer disease.' Alzheimer Dis Assoc Disord 19(3): 163-165. 56. Morrison, C. D. (2009). 'Leptin signaling in brain: A link between nutrition and cognition?' Biochim Biophys Acta 1792(5): 401-408. 57. Naharci, M. I. (2015). 'Is Weight Loss an Outcome of or a Contributory Factor for Vascular Dementia in Frail Elderly People?' Medical Principles and Practice 24(3): 298-298. 58. Oddo, S., A. Caccamo, J. D. Shepherd, M. P. Murphy, T. E. Golde, R. Kayed, R. Metherate, M. P. Mattson, Y. Akbari and F. M. LaFerla (2003). 'Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.' Neuron 39(3): 409-421. 59. Ohashi, Y., N. Okamoto, K. Uchida, M. Iyo, N. Mori and Y. Morita (1999). 'Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type.' Biol Psychiatry 45(12): 1646-1652. 60. Orsi, G., G. Perlaki, N. Kovacs, M. Aradi, Z. Papp, K. Karadi, C. Szalay, Z. Karadi, L. Lenard, T. Tenyi, E. Plozer, R. Gabriel, F. Nagy, T. Doczi, S. Komoly, H. Jokeit, A. Schwarcz and J. Janszky (2011). 'Body weight and the reward system: the volume of the right amygdala may be associated with body mass index in young overweight men.' Brain Imaging Behav 5(2): 149-157. 61. Osorio, R. S., E. Pirraglia, L. F. Aguera-Ortiz, E. H. During, H. Sacks, I. Ayappa, J. Walsleben, A. Mooney, A. Hussain, L. Glodzik, B. Frangione, P. Martinez-Martin and M. J. de Leon (2011). 'Greater risk of Alzheimer's disease in older adults with insomnia.' J Am Geriatr Soc 59(3): 559-562. 62. Pappolla, M., P. Bozner, C. Soto, H. Shao, N. K. Robakis, M. Zagorski, B. Frangione and J. Ghiso (1998). 'Inhibition of Alzheimer beta-fibrillogenesis by melatonin.' J Biol Chem 273(13): 7185-7188. 63. Patel, N. V., M. N. Gordon, K. E. Connor, R. A. Good, R. W. Engelman, J. Mason, D. G. Morgan, T. E. Morgan and C. E. Finch (2005). 'Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models.' Neurobiol Aging 26(7): 995-1000. 64. Peng, Y., J. Liu, Y. Tang, J. Liu, T. Han, S. Han, H. Li, C. Hou, J. Liu and J. Long (2014). 'High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice.' Frontiers in Cellular Neuroscience 8: 225. 65. Peters, M. E., P. B. Rosenberg, M. Steinberg, J. T. Tschanz, M. C. Norton, K. A. Welsh-Bohmer, K. M. Hayden, J. C. Breitner and C. G. Lyketsos (2012). 'Prevalence of neuropsychiatric symptoms in CIND and its subtypes: the Cache County Study.' Am J Geriatr Psychiatry 20(5): 416-424. 66. Petrovich, G. D. and M. Gallagher (2003). 'Amygdala subsystems and control of feeding behavior by learned cues.' Ann N Y Acad Sci 985: 251-262. 67. Petrovich, G. D., P. C. Holland and M. Gallagher (2005). 'Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating.' J Neurosci 25(36): 8295-8302. 68. Poeggeler, B., L. Miravalle, M. G. Zagorski, T. Wisniewski, Y. J. Chyan, Y. Zhang, H. Shao, T. Bryant-Thomas, R. Vidal, B. Frangione, J. Ghiso and M. A. Pappolla (2001). 'Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.' Biochemistry 40(49): 14995-15001. 69. Poehlman, E. T., M. J. Toth, M. I. Goran, W. H. Carpenter, P. Newhouse and C. J. Rosen (1997). 'Daily energy expenditure in free-living non-institutionalized Alzheimer's patients: a doubly labeled water study.' Neurology 48(4): 997-1002. 70. Poulin, S. P., R. Dautoff, J. C. Morris, L. F. Barrett and B. C. Dickerson (2011). 'Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity.' Psychiatry research 194(1): 7-13. 71. Prasher, V. P., T. Metseagharun and S. Haque (2004). 'Weight loss in adults with Down syndrome and with dementia in Alzheimer's disease.' Res Dev Disabil 25(1): 1-7. 72. Prinz, P. N., E. R. Peskind, P. P. Vitaliano, M. A. Raskind, C. Eisdorfer, N. Zemcuznikov and C. J. Gerber (1982). 'Changes in the sleep and waking EEGs of nondemented and demented elderly subjects.' J Am Geriatr Soc 30(2): 86-93. 73. Pueschel, S. M., K. J. Rothman and J. D. Ogilby (1976). 'Birth weight of children with Down's syndrome.' Am J Ment Defic 80(4): 442-445. 74. Richards, M., R. Hardy, D. Kuh and M. E. Wadsworth (2002). 'Birthweight, postnatal growth and cognitive function in a national UK birth cohort.' International Journal of Epidemiology 31(2): 342-348. 75. Rosenberg, P. B., M. M. Mielke, B. Appleby, E. Oh, J. M. Leoutsakos and C. G. Lyketsos (2011). 'Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction.' Int J Geriatr Psychiatry 26(4): 364-372. 76. Saper, C. B. and D. C. German (1987). 'Hypothalamic pathology in Alzheimer's disease.' Neurosci Lett 74(3): 364-370. 77. Savaskan, E., M. A. Ayoub, R. Ravid, D. Angeloni, F. Fraschini, F. Meier, A. Eckert, F. Muller-Spahn and R. Jockers (2005). 'Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease.' J Pineal Res 38(1): 10-16. 78. Savaskan, E., G. Olivieri, F. Meier, L. Brydon, R. Jockers, R. Ravid, A. Wirz-Justice and F. Muller-Spahn (2002). 'Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.' J Pineal Res 32(1): 59-62. 79. Schlosser Covell, G. E., P. S. Dhawan, J. K. Lee Iannotti, C. R. Hoffman-Snyder, K. E. Wellik, R. J. Caselli, B. K. Woodruff, D. M. Wingerchuk and B. M. Demaerschalk (2012). 'Disrupted daytime activity and altered sleep-wake patterns may predict transition to mild cognitive impairment or dementia: a critically appraised topic.' Neurologist 18(6): 426-429. 80. Scott, S. A., S. T. DeKosky and S. W. Scheff (1991). 'Volumetric atrophy of the amygdala in Alzheimer's disease: quantitative serial reconstruction.' Neurology 41(3): 351-356. 81. Scott, S. A., S. T. DeKosky, D. L. Sparks, C. A. Knox and S. W. Scheff (1992). 'Amygdala cell loss and atrophy in Alzheimer's disease.' Ann Neurol 32(4): 555-563. 82. Sergi, G., M. De Rui, A. Coin, E. M. Inelmen and E. Manzato (2013). 'Weight loss and Alzheimer's disease: temporal and aetiologic connections.' Proc Nutr Soc 72(1): 160-165. 83. Shatenstein, B., M. J. Kergoat and I. Reid (2007). 'Poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage Alzheimer dementia compared to cognitively intact matched controls.' J Am Diet Assoc 107(12): 2091-2099. 84. Solomon, M. B., K. Jones, B. A. Packard and J. P. Herman (2010). 'The medial amygdala modulates body weight but not neuroendocrine responses to chronic stress.' J Neuroendocrinol 22(1): 13-23. 85. Song, Y., G. A. Dowling, M. I. Wallhagen, K. A. Lee and W. J. Strawbridge (2010). 'Sleep in older adults with Alzheimer's disease.' J Neurosci Nurs 42(4): 190-198; quiz 199-200. 86. Sperling, R. A., P. S. Aisen, L. A. Beckett, D. A. Bennett, S. Craft, A. M. Fagan, T. Iwatsubo, C. R. Jack, Jr., J. Kaye, T. J. Montine, D. C. Park, E. M. Reiman, C. C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M. C. Carrillo, B. Thies, M. Morrison-Bogorad, M. V. Wagster and C. H. Phelps (2011). 'Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.' Alzheimers Dement 7(3): 280-292. 87. Spira, A. P., A. A. Gamaldo, Y. An, M. N. Wu, E. M. Simonsick, M. Bilgel, Y. Zhou, D. F. Wong, L. Ferrucci and S. M. Resnick (2013). 'Self-reported sleep and beta-amyloid deposition in community-dwelling older adults.' JAMA Neurol 70(12): 1537-1543. 88. Srinivasan, V., S. R. Pandi-Perumal, D. P. Cardinali, B. Poeggeler and R. Hardeland (2006). 'Melatonin in Alzheimer's disease and other neurodegenerative disorders.' Behav Brain Funct 2: 15. 89. Standaert, D. G., V. M. Lee, B. D. Greenberg, D. E. Lowery and J. Q. Trojanowski (1991). 'Molecular features of hypothalamic plaques in Alzheimer's disease.' Am J Pathol 139(3): 681-691. 90. Stewart, R., K. Masaki, Q. L. Xue, R. Peila, H. Petrovitch, L. R. White and L. J. Launer (2005). 'A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study.' Arch Neurol 62(1): 55-60. 91. Stopa, E. G., L. Volicer, V. Kuo-Leblanc, D. Harper, D. Lathi, B. Tate and A. Satlin (1999). 'Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia.' J Neuropathol Exp Neurol 58(1): 29-39. 92. Swaab, D. F., E. Fliers and T. S. Partiman (1985). 'The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia.' Brain Res 342(1): 37-44. 93. Swaab, D. F., I. Grundke-Iqbal, K. Iqbal, H. P. Kremer, R. Ravid and J. A. van de Nes (1992). 'Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease.' Brain Res 590(1-2): 239-249. 94. Tranah, G. J., T. Blackwell, K. L. Stone, S. Ancoli-Israel, M. L. Paudel, K. E. Ensrud, J. A. Cauley, S. Redline, T. A. Hillier, S. R. Cummings and K. Yaffe (2011). 'Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.' Ann Neurol 70(5): 722-732. 95. Tsuchiya, K. and K. Kosaka (1990). 'Neuropathological study of the amygdala in presenile Alzheimer's disease.' J Neurol Sci 100(1-2): 165-173. 96. Vitiello, M. V., P. N. Prinz, D. E. Williams, M. S. Frommlet and R. K. Ries (1990). 'Sleep disturbances in patients with mild-stage Alzheimer's disease.' J Gerontol 45(4): M131-138. 97. Vloeberghs, E., D. Van Dam, F. Franck, J. Serroyen, M. Geert, M. Staufenbiel and P. P. De Deyn (2008). 'Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model.' Behav Neurosci 122(3): 491-497. 98. Wang, Z., M. Zhang, Y. Han, H. Song, R. Guo and K. Li (2016). 'Differentially disrupted functional connectivity of the subregions of the amygdala in Alzheimer's disease.' J Xray Sci Technol 24(2): 329-342. 99. Weingarten, H. P. (1984). 'Meal initiation controlled by learned cues: basic behavioral properties.' Appetite 5(2): 147-158. 100. Weldemichael, D. A. and G. T. Grossberg (2010). 'Circadian rhythm disturbances in patients with Alzheimer's disease: a review.' Int J Alzheimers Dis 2010. 101. White, H., C. Pieper and K. Schmader (1998). 'The association of weight change in Alzheimer's disease with severity of disease and mortality: a longitudinal analysis.' J Am Geriatr Soc 46(10): 1223-1227. 102. Wolf-Klein, G. P., F. A. Silverstone, S. C. Lansey, D. Tesi, C. Ciampaglia, M. O'Donnell, J. Galkowski, A. Jaeger, S. Wallenstein and N. S. Leleiko (1995). 'Energy requirements in Alzheimer's disease patients.' Nutrition 11(3): 264-268. 103. Wu, Y. H., M. G. Feenstra, J. N. Zhou, R. Y. Liu, J. S. Torano, H. J. Van Kan, D. F. Fischer, R. Ravid and D. F. Swaab (2003). 'Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages.' J Clin Endocrinol Metab 88(12): 5898-5906. 104. Wu, Y. H. and D. F. Swaab (2005). 'The human pineal gland and melatonin in aging and Alzheimer's disease.' J Pineal Res 38(3): 145-152. 105. Xie, L., H. Kang, Q. Xu, M. J. Chen, Y. Liao, M. Thiyagarajan, J. O'Donnell, D. J. Christensen, C. Nicholson, J. J. Iliff, T. Takano, R. Deane and M. Nedergaard (2013). 'Sleep drives metabolite clearance from the adult brain.' Science 342(6156): 373-377. 106. Xu, P., X. Cao, Y. He, L. Zhu, Y. Yang, K. Saito, C. Wang, X. Yan, A. O. Hinton, Jr., F. Zou, H. Ding, Y. Xia, C. Yan, G. Shu, S. P. Wu, B. Yang, Y. Feng, D. J. Clegg, R. DeMarchi, S. A. Khan, S. Y. Tsai, F. J. DeMayo, Q. Wu, Q. Tong and Y. Xu (2015). 'Estrogen receptor-alpha in medial amygdala neurons regulates body weight.' J Clin Invest 125(7): 2861-2876. 107. Yong-Hong, L., P. Xiao-Dong, H. Chang-Quan, Y. Bo and L. Qing-Xiu (2013). 'Hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD).' J Investig Med 61(3): 578-581. 108. Zhang, G., J. Li, S. Purkayastha, Y. Tang, H. Zhang, Y. Yin, B. Li, G. Liu and D. Cai (2013). 'Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH.' Nature 497(7448): 211-216. 109. Zhdanova, I. V. (2011). 'Sleep and its regulation in zebrafish.' Rev Neurosci 22(1): 27-36. 110. Zhou, J. N., R. Y. Liu, W. Kamphorst, M. A. Hofman and D. F. Swaab (2003). 'Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels.' J Pineal Res 35(2): 125-130. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59748 | - |
| dc.description.abstract | 背景：阿兹海默病是一種神經退行性疾病並以認知功能退化著稱。然而越來越多證據顯示阿兹海默症也會表現非認知功能的症狀，例如體重改變，睡眠和精神症狀。此外，研究者發現這些非認知功能的症狀會出現於阿茲海默症的早期，甚至會早於認知功能惡化前出現。以腦部各區塊的功能性考量，與這些非認知症狀相關的部位包含了下丘腦和杏仁體。從病理學而言，典型的阿兹海默症病理學表現主要以神經原纖維纏結和澱粉樣斑塊組成。這意味著阿兹海默症的病理生理學中tau蛋白和類澱粉蛋白扮演了重要的角色。三轉基因阿茲海默症老鼠具有tau蛋白和類澱粉蛋白的基因變化，是病理上與人類阿茲海默症最相似的老鼠模型。因此透過觀察三轉基因阿茲海默症老鼠，我們希望可以更了解阿茲海默症的非認知症狀，並探討這些非認知症狀與神經病理學之間的關聯。
研究方法：首先我們監測三轉基因阿茲海默症老鼠從4週齡至40週齡的體重、食物和水攝入量。透過間接測熱量儀，獲取代謝速率和活動量的數據。最後分批犧牲小鼠以完成澱粉樣蛋白病理學的免疫組織化學。 結果：三轉基因阿茲海默症雌性小鼠於4週齡時體重較輕，然而牠們體重增加的速度較快，於40週齡時反而超過對照小鼠，比對照小鼠的體重更重。三轉基因阿茲海默症雌性小鼠表現出更高的食物攝入量及較低的活動量，這可間接解釋為何三轉基因阿茲海默症雌性小鼠的體重上升較快。除此之外，病理染色分析發現體重和攝食量與三轉基因阿茲海默症雌性小鼠的杏仁核中的凋亡神經元數呈高度正相關（ρ分別0.86,0.88）。 結論：這項研究演示了三轉基因阿茲海默症雌性小鼠中的體重增加的過程，這可能歸因於相對性的食慾過盛和較低的身體活動量。此一體重增長和攝食量上升的行為可能與杏仁核病理學的變化相關。 | zh_TW |
| dc.description.abstract | Background: Alzheimer’s disease (AD) is a neurodegenerative disease well recognized for its cognitive decline features. Yet increasing evidence has indicated that AD also developed noncognitive symptoms such as body weight alterations, sleep and psychiatric symptoms. Furthermore, researches suggest that these noncognitive symptoms occurs early in the clinical course of AD and may even precede the cognitive deterioration of AD. Candidate brain regions responsible for these noncognitive symptoms includes hypothalamus and amygdala. Typical AD pathology mainly composed of neurofibrillary tangles and amyloid plaques which implied a combined role of taupathy and amyloidogenesis in the pathophysiology of AD. Using triple transgenic mice of Alzheimer’s disease that possess both taupathy and amyloidogenesis characteristic, we aim to decipher the noncognitive symptoms in early AD and attempt to correlate these noncognitive symptoms with neuropathological findings.
Methods: Body weight, food and water intake were repeatedly measured in triple transgenic mice of Alzheimer’s disease (3xTg AD mice) and non-transgenic control mice from 4 to 4o week-old. Metabolic rate and physical activity data was obtained via indirect calorimetry. Mice were then sacrificed for immunohistochemistry stain on amyloid pathology. Results: 3xTg AD female mice weighs lighter at 4 week-old but gain weight at a faster pace and weigh heavier than non-Tg control mice at 40 week-old. A higher intake amount and lower physical activity was noted in 3xTg AD female mice. Body weight and amount of food intake were found to be well correlated with number of pyknotic cells in amygdala (ρ= 0.86, 0.88 respectively). Lower physical activity was moderately correlated with number of amyloid cells in secondary motor cortex (ρ=0.64). Conclusion: This study demonstrated a gradual weight gain process in 3xTg AD female mice and is possibly attributed to relative hyperphagia and lower physical activity. This body weight alteration and hyperphagia behavior may be associated with amygdala pathology. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T09:36:02Z (GMT). No. of bitstreams: 1 ntu-106-P03421001-1.pdf: 3524726 bytes, checksum: 43d2e449d375df56e385a8f973bf3b2e (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書………………………………………… I 誌謝………………………………………………………… II 中文摘要…………………………………………………… III 英文摘要…………………………………………………… IV 碩士論文內容 第一章 緒論 Introduction 1.1 Overview of Alzheimer’s disease ………………… 1 1.2 Preclinical Alzheimer’s disease ………………… 1 1.3 Noncognitive symptoms of Alzheimer’s disease… 1 1.3.1 Body weight…………………………………………… 2 1.3.2 Altered eating behaviors ………………………… 3 1.3.3 Sleep…………………………………………………… 4 1.4 Neuroanatomy associated with noncognitive symptoms of AD…………………………………………………………… 5 1.4.1 Hypothalamus…………………………………………… 5 1.4.2 Amygdala ………………………………………………… 9 第二章 研究方法與材料 Materials and methods 2.1 Animal……………………………………………………… 11 2.2 Body weight, food and water intake measurement… 11 2.3 Wheel running activity………………………………… 12 2.4 Immunohistochemistry stain for amyloid β pathology…………………………………………………… 12 2.5 ELISA masurement of Aβ………………………………… 13 2.6 Data analysis……………………………………………… 13 第三章 結果 Results 3.1 Body weight, food intake and water intake ……… 15 3.2 Metabolic rate analysis ……………………………… 15 3.3 Wheel running activity ………………………………… 15 3.4 Immunohistochemistry staining for amyloid pathology ……………………………………………………16 3.5 ELISA measurement of Aβ40 and Aβ42 ……………… 17 第四章 討論 Discussion 4.1 Gender difference in metabolism and eating behavior …………………………………………………… 18 4.2 Triple transgenic Alzheimer’s female mice with lower body weight early in life……………………………… 19 4.3 Metabolism in female mice of triple transgenic Alzheimer’s mice model………………………………… 20 4.4 Physical activities in female triple transgenic Alzheimer’s mice model ……………………………… 20 4.5 Amygdala role in eating behavior and body weight ……………………………………………………… 20 4.6 Study limitation………………………………………… 22 第五章 展望 Future perspective…………………………… 23 第六章 參考文獻 Reference…………………………………… 24 第七章 圖表 Figures and Charts…………………………… 32 | |
| dc.language.iso | en | |
| dc.subject | 杏仁核 | zh_TW |
| dc.subject | 阿?海默症 | zh_TW |
| dc.subject | 體重 | zh_TW |
| dc.subject | 代謝 | zh_TW |
| dc.subject | 阿?海默症 | zh_TW |
| dc.subject | 代謝 | zh_TW |
| dc.subject | 體重 | zh_TW |
| dc.subject | 杏仁核 | zh_TW |
| dc.subject | Metabolism | en |
| dc.subject | Alzheimer’s disease | en |
| dc.subject | Metabolism | en |
| dc.subject | Body weight | en |
| dc.subject | Amygdala | en |
| dc.subject | Alzheimer’s disease | en |
| dc.subject | Body weight | en |
| dc.subject | Amygdala | en |
| dc.title | 三重轉基因阿茲海默氏症小鼠的體重、行為、代謝及病理變化 | zh_TW |
| dc.title | Weight, behavior, metabolism and amyloid pathology in triple transgenic Alzheimer’s mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 105-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 謝松蒼(Sung-Tsang Hsieh),楊偉勛(Wei-Shiung, Yang) | |
| dc.subject.keyword | 阿?海默症,代謝,體重,杏仁核, | zh_TW |
| dc.subject.keyword | Alzheimer’s disease,Metabolism,Body weight,Amygdala, | en |
| dc.relation.page | 50 | |
| dc.identifier.doi | 10.6342/NTU201700442 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2017-02-13 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床醫學研究所 | |
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