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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 葉伯廷(Po-Ting Yeh),楊長豪(Chang-Hao Yang) | |
dc.contributor.author | Yung-Jen Lai | en |
dc.contributor.author | 賴勇仁 | zh_TW |
dc.date.accessioned | 2021-06-16T09:27:34Z | - |
dc.date.available | 2020-08-26 | |
dc.date.copyright | 2020-08-26 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-18 | |
dc.identifier.citation | Accorinti, M., Gilardi, M., Pirraglia, M. P., Amorelli, G. M., Nardella, C., Abicca, I., Pesci, F. R. (2014). Cytomegalovirus anterior uveitis: long-term follow-up of immunocompetent patients. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 252(11), 1817-1824. doi: 10.1007/s00417-014-2782-4 Anshu, A., Tan, D., Chee, S. P., Mehta, J. S., Htoon, H. M. (2017). Interventions for the management of CMV‐associated anterior segment inflammation. Cochrane Database of Systematic Reviews(8). doi: 10.1002/14651858.CD011908.pub2 Antoun, J., Willermain, F., Makhoul, D., Motulsky, E., Caspers, L., Relvas, L. J. (2017). Topical Ganciclovir in Cytomegalovirus Anterior Uveitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 33(4), 313-318. doi: 10.1089/jop.2016.0138 Chan, N. S.-W., Chee, S.-P., Caspers, L., Bodaghi, B. (2018). Clinical Features of CMV-Associated Anterior Uveitis. Ocular Immunology and Inflammation, 26(1), 107-115. doi: 10.1080/09273948.2017.1394471 Chee, S. P., Jap, A. (2010). Cytomegalovirus anterior uveitis: outcome of treatment. The British journal of ophthalmology, 94(12), 1648-1652. doi: 10.1136/bjo.2009.167767 Hwang, Y.-S., Lin, K.-K., Lee, J.-S., Chang, S. H. L., Chen, K.-J., Lai, C.-C., . . . Hsiao, C.-H. (2010). Intravitreal loading injection of ganciclovir with or without adjunctive oral valganciclovir for cytomegalovirus anterior uveitis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 248(2), 263-269. doi: 10.1007/s00417-009-1195-2 Joye, A., Gonzales, J. A. (2018). Ocular manifestations of cytomegalovirus in immunocompetent hosts. Current opinion in ophthalmology, 29(6), 535-542. doi: 10.1097/ICU.0000000000000521 Jprn, U. (2015). Topical 0.5% ganciclovir therapy for cytomegalovirus corneal endothelitis and iritis. http://www.who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000018977. Keorochana, N., Choontanom, R. (2017). Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis. BMJ open ophthalmology, 2(1), e000061-e000061. doi: 10.1136/bmjophth-2016-000061 Koizumi, N., Inatomi, T., Suzuki, T., Shiraishi, A., Ohashi, Y., Kandori, M., . . . Japan Corneal Endotheliitis Study, G. (2015). Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study. The British journal of ophthalmology, 99(1), 54-58. doi: 10.1136/bjophthalmol-2013-304625 Laboratories Thea: Virgan gel. Leleu, I., Jhanji, V., Touhami, S., Westcott, M., Angi, M., Titah, C., . . . Errera, M.-H. (2019). Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. Ocular Immunology and Inflammation, 1-9. doi: 10.1080/09273948.2019.1662059 Megaw, R., Agarwal, P. K. (2017). Posner-Schlossman syndrome. Surv Ophthalmol, 62(3), 277-285. doi: 10.1016/j.survophthal.2016.12.005 Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(7), e1000097. doi: 10.1371/journal.pmed.1000097 Neumann, R., Barequet, D., Rosenblatt, A., Amer, R., Ben-Arie-Weintrob, Y., Hareuveni-Blum, T., . . . Habot-Wilner, Z. (2019). Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. Ocular Immunology and Inflammation, 27(2), 211-218. doi: 10.1080/09273948.2018.1483521 Okumura, N., Tanaka, T., Fukui, Y., Koizumi, N. J. J. j. o. o. (2019). Stability, safety, and pharmacokinetics of ganciclovir eye drops prepared from ganciclovir for intravenous infusion. 63(3), 289-296. Relvas, L. J. M., Antoun, J., de Groot-Mijnes, J. D. F., Motulsky, E., Ten Dam-Van Loon, N. H., Makhoul, D., . . . Caspers, L. (2018). Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. Ocular Immunology and Inflammation, 26(1), 116-121. doi: 10.1080/09273948.2017.1411952 Roche Pharmaceuticals. Valganciclovir. from https://www.rochecanada.com/PMs/Valcyte/Valcyte_PM_E.pdf Shahrudin, N. A., Mohd Zahidin, A. Z., Md Noh, U. K., Wan Abdul Halim, W. H., Md Din, N. (2017). CMV endotheliitis: a cause for recurrent failed corneal transplant. GMS ophthalmology cases, 7, Doc31-Doc31. doi: 10.3205/oc000082 Su, C.-C., Hu, F.-R., Wang, T.-H., Huang, J.-Y., Yeh, P.-T., Lin, C.-P., Wang, I. J. (2014). Clinical outcomes in cytomegalovirus-positive Posner-Schlossman syndrome patients treated with topical ganciclovir therapy. American Journal of Ophthalmology, 158(5), 1024-1031.e1022. doi: 10.1016/j.ajo.2014.08.007 Tan, W. J., Poh, E. W., Wong, P.-Y., Ho, S.-L., Lim, W.-K., Teoh, S. C. (2013). Trends in patterns of anterior uveitis in a tertiary institution in singapore. Ocular Immunology and Inflammation, 21(4), 270-275. doi: 10.3109/09273948.2013.779725 Touhami, S., Qu, L., Angi, M., Bojanova, M., Touitou, V., Lehoang, P., . . . Bodaghi, B. (2018). Cytomegalovirus Anterior Uveitis: Clinical Characteristics and Long-term Outcomes in a French Series. American Journal of Ophthalmology, 194, 134-142. doi: 10.1016/j.ajo.2018.07.021 Wong, J. X. H., Agrawal, R., Wong, E. P. Y., Teoh, S. C. (2016). Efficacy and safety of topical ganciclovir in the management of cytomegalovirus (CMV)-related anterior uveitis. Journal of ophthalmic inflammation and infection, 6(1), 10-10. doi: 10.1186/s12348-016-0078-z Wong, V. W., Chan, C. K., Leung, D. Y., Lai, T. Y. (2012). Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection. Clinical ophthalmology (Auckland, N.Z.), 6, 595-600. doi: 10.2147/OPTH.S30476 Zandi, S., Bodaghi, B., Garweg, J. G. (2018). Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective. Ocular Immunology and Inflammation, 26(7), 1135-1142. doi: 10.1080/09273948.2018.1498109 Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. A. (2016). Intraocular inflammation: Springer. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59550 | - |
dc.description.abstract | 背景: 巨細胞病毒前葡萄膜炎可能以急性、反覆發作的青光眼睫狀體炎危象或是慢性虹彩炎來表現,也有部分角膜內皮炎案例與巨細胞病毒感染有關。根據先前案例報告研究,系統性或局部性抗病毒藥物治療可以有效治療前房發炎。然而,對於巨細胞病毒前葡萄膜炎,尚未有標準治療。 此篇統合分析主要是為整合與評估不同路徑的抗病毒藥物療法對於巨細胞病毒前葡萄膜炎之結果影響。並計畫以此設計臨床試驗以解決相關問題。 方法: 本研究於西元2019年11月15日於資料庫進行文獻搜尋,並以前房發炎反應緩解作為主要療效指標,復發次數與復發時間等做為次要療效指標。 結果: 有四篇回溯性、非隨機分派的觀察性研究符合納入標準而進行後續統合分析,文獻中皆描述可緩解巨細胞病毒前葡萄膜炎的前房發炎反應,但因無對照組資料可供比較驗證主要療效指標。然而次要療效指標中復發次數,可藉由以抗病毒藥物介入前的資料做為對照組,無論是系統性或局部性抗病毒藥物,使用後皆可顯著降低復發次數(p<0.00001) 臨床試驗: 局部抗病毒藥物(2%西美芬液)使用對於巨細胞病毒前葡萄膜炎治療之結果影響: 臨床試驗計畫書 | zh_TW |
dc.description.abstract | Background: Patients with cytomegalovirus (CMV) anterior uveitis may have acute relapsing hypertensive uveitis (Posner-Schlossman syndrome) or present as chronic uveitis as Fuchs uveitis syndrome. Besides, some cases of corneal endotheliitis are related to CMV infection. Anti-CMV treatment are reported effective for resolution of CMV anterior infection, regardless of systemic, topical or intraocular treatment. However, there is no standard guideline for treatment of CMV anterior uveitis yet. Objective: The aim of this meta-analysis was to assess and summarize the updated evidence on the outcomes of treatment with any route of anti-CMV treatment for CMV anterior uveitis. And plan to design further clinical trial to conduct unsolved problem in the treatment of CMV anterior uveitis. Materials and methods: We conducted a systematic search on November 15, 2019, of electronic databases (PubMED, and The Cochrane Library) and clinical trial registers. The primary outcome was uveitis resolution as measured by SUN criteria, while the secondary outcomes included number of recurrences, time to recurrence, and etc. A meta-analysis was conducted on selected studies with appropriate clinical and methodological homogeneity. Results: Nine studies were included and reviewed at first. Four retrospective nonrandomized clinical trials were eligible for meta-analysis. All studies illustrated effective for inflammation resolution, but no comparable data could be pooled for further quantitative synthesis. In addition, anti-CMV therapy, either systemic or topical route, is effective for recurrence reduction of uveitis flares up while comparing to the status prior to anti-CMV therapy. (p<0.00001) Protocol design: Outcomes of treatment with topical 2% ganciclovir for cytomegalovirus (CMV) anterior uveitis: Protocol We plan to conduct the trial to confirm the efficacy of topical 2% ganciclovir for CMV anterior uveitis via randomized, placebo-controlled trail. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T09:27:34Z (GMT). No. of bitstreams: 1 U0001-1408202000373000.pdf: 1647295 bytes, checksum: f90746b768934c631609bb17c18682d2 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS v LIST OF FIGURES vi LIST OF TABLES vii Chapter 1 Meta-analysis 1 Chapter 2 Protocol 11 Chapter 3 Figures 45 Chapter 4 Tables 49 REFERENCE 51 | |
dc.language.iso | en | |
dc.title | 抗病毒藥物使用對於巨細胞病毒前葡萄膜炎治療之結果影響: 統合分析與臨床試驗計畫書 | zh_TW |
dc.title | Outcomes of treatment with antiviral agents for cytomegalovirus (CMV) anterior uveitis: a meta-analysis and protocol | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳祈玲(Chi-Ling Chen) | |
dc.subject.keyword | 巨細胞病毒前葡萄膜炎,青光眼睫狀體炎危象,巨細胞病毒角膜內皮炎,西美芬,克毒癒, | zh_TW |
dc.subject.keyword | cytomegalovirus anterior uveitis,Posner-Schlossman syndrome,cytomegalovirus endotheliitis,ganciclovir,valganciclovir, | en |
dc.relation.page | 56 | |
dc.identifier.doi | 10.6342/NTU202003351 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-18 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
顯示於系所單位: | 臨床醫學研究所 |
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