請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58669
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 杜裕康(Yu-Kang Tu) | |
dc.contributor.author | HUEI-JU CHANG | en |
dc.contributor.author | 張慧如 | zh_TW |
dc.date.accessioned | 2021-06-16T08:24:52Z | - |
dc.date.available | 2019-01-01 | |
dc.date.copyright | 2014-02-25 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-01-22 | |
dc.identifier.citation | 1. Whitehead, A., Meta-analysis of controlled clinical trials. 2003: Wiley. com.
2. Ades, A.E., et al., Bayesian methods for evidence synthesis in cost-effectiveness analysis. Pharmacoeconomics, 2006. 24(1): p. 1-19. 3. Sutton, A., et al., Use of indirect and mixed treatment comparisons for technology assessment. Pharmacoeconomics, 2008. 26(9): p. 753-767. 4. Lumley, T., Network meta‐analysis for indirect treatment comparisons. Statistics in medicine, 2002. 21(16): p. 2313-2324. 5. Psaty, B.M., et al., Health outcomes associated with various antihypertensive therapies used as first-line agents. JAMA: the journal of the American Medical Association, 2003. 289(19): p. 2534-2544. 6. Glenny, A.-M., et al., Indirect comparisons of competing interventions. 2005: Gray Publishing. 7. Hong, H., et al., Comparing Bayesian and frequentist approaches for multiple outcome mixed treatment comparisons. Med Decis Making, 2013. 33(5): p. 702-14. 8. Lu, G. and A.E. Ades, Combination of direct and indirect evidence in mixed treatment comparisons. Statistics in Medicine, 2004. 23(20): p. 3105-24. 9. Tu, Y.K., et al., A Bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies. Journal of Clinical Periodontology, 2012. 39(3): p. 303-14. 10. Preshaw, P.M., et al., Progression and treatment of chronic adult periodontitis. J Periodontol, 1999. 70(10): p. 1209-20. 11. Haffajee, A.D., S.S. Socransky, and J.C. Gunsolley, Systemic anti-infective periodontal therapy. A systematic review. Annals of Periodontology, 2003. 8(1): p. 115-181. 12. Klinge, B., M. Hultin, and T. Berglundh, Peri-implantitis. Dent Clin North Am, 2005. 49(3): p. 661-76, vii-viii. 13. Xajigeorgiou, C., et al., Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. Journal of clinical periodontology, 2006. 33(4): p. 254-264. 14. Guerrero, A., et al., Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol, 2005. 32(10): p. 1096-107. 15. Akincibay, H., et al., Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study. Quintessence international (Berlin, Germany: 1985), 2008. 39(2): p. e33. 16. Mestnik, M.J., et al., The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol, 2012. 39(10): p. 955-61. 17. Yek, E.C., et al., Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. J Periodontol, 2010. 81(7): p. 964-74. 18. Schwarz, F., et al., Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study. Clin Oral Implants Res, 2005. 16(1): p. 44-52. 19. Machtei, E.E., et al., Treatment of peri-implantitis using multiple applications of chlorhexidine chips: a double-blind, randomized multi-centre clinical trial. J Clin Periodontol, 2012. 39(12): p. 1198-205. 20. Renvert, S., et al., Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results. J Clin Periodontol, 2009. 36(7): p. 604-9. 21. Renvert, S., et al., Treatment of peri-implantitis using an Er:YAG laser or an air-abrasive device: a randomized clinical trial. J Clin Periodontol, 2011. 38(1): p. 65-73. 22. Sahm, N., et al., Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study. J Clin Periodontol, 2011. 38(9): p. 872-8. 23. Karring, E.S., et al., Treatment of peri-implantitis by the Vector system. Clin Oral Implants Res, 2005. 16(3): p. 288-93. 24. Buchter, A., et al., Sustained release of doxycycline for the treatment of peri-implantitis: randomised controlled trial. Br J Oral Maxillofac Surg, 2004. 42(5): p. 439-44. 25. 唐志辉、曹采方、沙月琴、林野、王兴, 超声洁治和局部用甲硝唑治疗轻、中度种植体周围炎. 中华口腔医学杂志第37卷第3期, 2002年5月: p. 173-175. 26. Renvert, S., et al., Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. J Periodontol, 2008. 79(5): p. 836-44. 27. Renvert, S., et al., Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial. J Clin Periodontol, 2006. 33(5): p. 362-9. 28. Bassetti, M., et al., Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res, 2013. 29. Schwarz, F., et al., Nonsurgical treatment of moderate and advanced periimplantitis lesions: a controlled clinical study. Clin Oral Investig, 2006. 10(4): p. 279-88. 30. Lu, G., et al., Meta-analysis of mixed treatment comparisons at multiple follow-up times. Statistics in Medicine, 2007. 26(20): p. 3681-3699. 31. DerSimonian R, L.N., Meta-analysis in clinical trials. PubMed, 1986. Sep;7(3):177-88. 32. Smith TC, S.D., Thomas A., Bayesian approaches to random-effects meta-analysis: a comparative study. Stat Med. , 1995 Dec 30. 14(24):2685-99. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58669 | - |
dc.description.abstract | 隨著實證醫學運動的興起,過去20年來,系統性回顧(Systematic reviews)與統合分析(Meta-Analysis)被廣泛運用在不同治療影響的比較,但在傳統的統合分析(Meta-Analysis),通常限制在評估兩種積極的治療方式,或是與安慰劑的比較,即使是有系統性文獻回顧的協助下,傳統的統合分析(Meta-Analysis)仍無法提供全面性的評估,因為大部分的疾病或症狀都有好幾種處置方法。近10年來,網絡統合分析(Network Meta-Analysis)的發展已能解決上述的一些限制,網絡統合分析(Network Meta-Analysis)可透過在缺乏充分直接比較下,以間接比較的方式來整合分析所有研究所獲得的資料並做出結論,使用貝氏統計方法(Bayesian Statistical Approach)運用在更複雜的數據結構裡,探討直接證據與間接證據一致性的評估,同質性與異質性間證據的使用等等。
本篇研究針對2000年後有關(1)成人牙周病使用全身性抗生素及(2)植牙體周圍炎治療方式比較之SCI文章進行蒐集,使用網絡統合分析(Network Meta-Analysis)模型,探討直接證據與間接證據的比較牙周囊袋探測深度(PPD)和臨床牙齦附著水平(CAL)。 從貝氏網絡統合分析(Bayesian network meta-analysis)顯示,(1)成人牙周病使用全身性抗生素比較的方面,就PPD的結果與控制組相比,抗生素MTZ的PPD減少幅度較多,高於控制組1.106公釐(mm) (95%信用區間 CRI:0.674 - 1.544)。其次則為同時使用抗生素MTZ/AMX高於控制組0.625公釐(mm) (95%信用區間 CRI:0.427 - 0.880),再來才是抗生素DOX組,僅高於控制組0.190公釐(mm) (95%信用區間 CRI:-0.162 - 0.554)。與控制組相比較,使用抗生素DOX那ㄧ組雖然PPD減少得多一點,但其信用區間包含0,似乎說明使用抗生素DOX組與控制組並沒有明顯治療較佳的結果。另外就CAL,與控制組相比,抗生素MTZ的CAL增加幅度較多,高於控制組0.717公釐(mm) (95%信用區間 CRI:0.042 - 1.390)。其次則為同時使用抗生素MTZ/AMX高於控制組0.305公釐(mm) (95%信用區間 CRI: 0.005 - 0.648),再來才是抗生素DOX組,僅高於控制組0.260公釐(mm) (95%信用區間 CRI:-0.255 - 0.821)。與控制組相比較,使用抗生素DOX那ㄧ組雖然CAL增加得多一點,但其信用區間包含0,似乎可說明使用抗生素DOX組與控制組並沒有明顯治療較佳的結果。(2)植牙體周圍炎治療方式比較方面,與控制組相比,所有非手術型植牙體周圍炎治療方式之平均牙周囊袋探測深度(pocket probing depth, PPD)減少幅度皆大於控制組之平均PPD減少幅度,但從信用區間(Credit Interval)皆包含0值來看,並沒有明顯治療較佳的結果。 | zh_TW |
dc.description.abstract | Background Network meta-analysis methods are increasingly popular as a tool for clinical trial data involving both direct and indirect treatment comparisons. We therefore did a network meta-analysis, which accounts for both direct and indirect comparisons, to assess the effects of 4 systemic antibiotics regimens for treatment of adult periodontitis and 8 non-surgical treatments on peri-implantitis.
Methods We reviewed 5 randomized controlled trials (studies) from 2000 up to 2013, which compared systemic antibiotics for treatment of adult periodontitis. And we reviewed 11 randomized controlled trials (studies) which compared any of the following non-surgical treatment of peri-implantitis. The following clinical parameters were assessed at baseline and 6 months: Pocket Probing Depth (PPD) and Clinical Attachment Level (CAL). Findings A total of 5 and 11 studies were included in this review, and we found the results from the Bayesian network meta-analysis found a) Comparing systemic antibiotics for treatment of adult periodontitis: all of the Treatment groups were better then Control group. b) Comparing treatments for peri-implantitis: there were no significant difference. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T08:24:52Z (GMT). No. of bitstreams: 1 ntu-103-R00847039-1.pdf: 1128466 bytes, checksum: f97409cb5424274b2b8ed10e230efe9f (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 內文目錄/ Contents
謝辭/ Acknowledgement I 中文摘要及關鍵字/ Abstract II 英文摘要及關鍵字/ Abstract IV 第一章 導論/ Chapter 1 Introduction 1 一、實習單位簡介/ Practicum Unit Features and Brief Introduction 1 二、研究動機與目的/ Research Purpose and Research Problems 3 第二章 方法/ Chapter 2 Methods 4 一、相關文獻探討/ Literature Review 4 二、研究方法/ Methods 6 第三章 結果/ Chapter 3 Results 8 第一部份 全身性抗生素對於慢性成人(20歲以上)牙周病治療 8 第二部分 成人(20歲以上)非手術型治療植牙體周圍炎 18 第四章 討論/ Chapter 4 Discussion 26 一、貝氏網絡統合分析(Bayesian Network Meta-Analyses) 26 二、全身性抗生素對於慢性成人(20歲以上)牙周病治療 26 三、成人(20歲以上)非手術型治療植牙體周圍炎 27 四、實習心得與建議 28 參考文獻/References 30 附錄一/ Appendix I 貝氏統計法(Bayesian Approach) 34 附錄二/ Appendix II winBUGS程式模型 38 附錄三/ Appendix Ⅲ諮詢部分結果整理 40 | |
dc.language.iso | zh-TW | |
dc.title | 網絡統合分析應用:使用不同抗生素治療成人慢性牙周炎及成人植牙體周圍炎之治療效果的比較 | zh_TW |
dc.title | Applications of Network Meta-Analysis : Comparing the uses of systemic antibiotics for treatment of adult periodontitis and comparing treatments for peri-implantitis. | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃耀輝(Yaw-Huei Hwang),方啟泰(Chi-Tai Fang) | |
dc.subject.keyword | 植牙體周圍炎,非手術性治療,全身性抗生素,網絡統合分析,同質性,異質性,隨機效應, | zh_TW |
dc.subject.keyword | periodontitis,nonsurgical treatments,systemic antibiotics,network meta-analysis,homogeneous,heterogeneous,random effects model, | en |
dc.relation.page | 57 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-01-22 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 公共衛生碩士學位學程 | zh_TW |
顯示於系所單位: | 公共衛生碩士學位學程 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-103-1.pdf 目前未授權公開取用 | 1.1 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。