請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58219完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王水深(Shoei-Shen Wang) | |
| dc.contributor.author | Chen-Yen Chien | en |
| dc.contributor.author | 簡禎彥 | zh_TW |
| dc.date.accessioned | 2021-06-16T08:08:34Z | - |
| dc.date.available | 2016-10-15 | |
| dc.date.copyright | 2014-10-15 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-05-26 | |
| dc.identifier.citation | Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, et al. Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. Anesthesiology 2009;110:317-25.
Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome C release from mitochondria. Biochem J. 2000;345:271-8. Arnaud C, Joyeux M, Garrel C, Godin-Ribuot D, Demenge P, Ribuot C. Free-radical production triggered by hyperthermia contributes to heat stress- induced cardio protection in isolated rat hearts. Br J Pharmacol 2002;135:1776-1782 Baxter G, Yellon D. Temporal charterization of the “second window of protection”: prolonged anti-infarct effect after adenosine A1 receptor activation. Circulation (abstract) 1994;90(suppl):I-475. Calvert JW, Jha S, Gundewar S, Elrod JW, Ramachandran A, Pattillo CB, et al. Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res. 2009;105:365-74. Chandawarker, R.Y., et al. Exogenous heat shock protein 70 binds macrophage lipid raft microdomain and stimulates phagocytosis, processing, and MHC-II presentation of antigens. Blood. 2006;107:1636-42. Chen CF, Tsai SY, Ma MC, Wu MS. Hypoxic preconditioning enhances renal superoxide dismutase levels in rats. J Physiol. 2003;552:561-9. Chen DL, Chen TW, Chien CT, Li PC. Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via downregulation of endothelial H2O2, CX3CL1, intercellular adhesion molecule-1, and p53 expression. Transl Res 2011;157:306-19. Chen YC, Chow JM, Lin CW, Wu CY, Shen SC. Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Toxicol Appl Pharmacol 2006; 216: 263-73. Chien CT, Chang WT, Chen HW, Wang TD, Liou SY, Chen TJ, et al. Ascorbate supplement reduces oxidative stress in dyslipidemic patients undergoing apheresis. Arterioscler Thromb Vasc Biol 2004;24:1111-7. Chien CT, Lee PH, Chen CF, Ma MC, Lai MK, Hsu SM, et al. De novo demonstration and co-localization of free-radical production and apoptosis formation in rat kidney subjected to ischemia/reperfusion. J Am Soc Nephrol. 2001;12:973-82. Chien CT, Shyue SK, Lai MK. Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation. 2007;84:1183-90. Chien CY, Lin CH, Chen JW, Hsu RB Bloodstream Infection in Patients Undergoing Systematic Off Pump Coronary Artery Bypass: Incidence, Risk Factors, Outcome and Associated Pathogens. Surgical infections ( article in press) Chung SD, Lai TY, Chien CT, Yu HJ. Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney. PLoS One. 2012;7:e47299. Currie RW, Karmazyn M, Kloc M, Mailer K. Heat shock response is associated with enhanced postischemic ventricular recovery. Circ Res 1988;63:543–549. D’Ambra MN,Magrassi P, Lowenstein E, Kyo S, Austen WG, Buckley MJ, et al. Myocardial temperature variation: effect on regional function and coronary flow in dogs. Am J Physiol. 1987;252:H448-55. Das DK, Maulik N, Sato M, Ray PS. Reactive oxygen species function as second messenger during ischemic preconditioning of heart. Mol Cell Biochem 1999;196:59–67. Eisen A, Fisman EZ, Rubenfire M, Freimark D, McKechnie R, Tenenbaum A, Motro M, Adler Y. Ischemic preconditioning: nearly two decades of reaearch. Atherosclerosis 2004;172:201-210. Falk E. Thrombosis in unstable angina: pathologic aspects, In: Mehta JL, Conti CR, editors. Thrombosis and platelets in myocardial ischemia.Philadelphia: F. A. Davis Publishers; 1987. p. 137-49. Fernandez L, Carrasco-Chaumel E, Serafin A, Xaus C, Grande L, Rimola A, Rosello-Catafau J, Peralta C. Is ischemic preonditioing a useful strategy in steatotic liver transplantation? Am J Transplant 2004;4:888-899. Fisher, M. and R. Zipser, Increased excretion of immunoreactive thromboxane B2 in cerebral ischemia. Stroke, 1985. 16(1): p. 10-4. Garrouste-Orgeas M, Timsit JF, Tafflet M, et al. Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections : a reappraisal. Clin Infect Dis 2006;42:1118-26 Goto M, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res 1995;77:611–621. Gross A, Jockel J,Wei MC, Korsmeyer SJ. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 1998;17: 3878-85. Huang SC, Tsai YF, Cheng YS, Liu KH, Li PC, Chien CT. Vascular protection with less activation evoked by progressive thermal preconditioning in adrenergic receptor-mediated hypertension and tachycardia. Chin J Physiol 2009;52:419-25. Halliwell B. The antioxidant paradox. Lancet. 2000;355:1179-80. Ikonomidis JS, Shirai T, Weisel RD, Derylo B, Rao V, Whiteside CI, Mickle DAG, Karck M, Tanaka S, Bolling SF, Simon A, Su TP, Oeltgen PR, et al. Myocardial protection by ischemic preconditioning and delta-opioid receptor activation in the isolated working rat heart. J Thorac Cardiovasc Surg. 2001;122: 986-92. Kaszala K, Vegh A, Papp JG, Parratt JR. Time course of the protection against ischemia and reperfusion-induced ventricular arrhythmias resulting from brief periods of cardiac pacing. J Mol Cell Cardiol 1996;28:2085–2095. Kato H, Liu Y, Kogure K, Kato K. Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance. Brain Res. 1994;634(2):235-244. Kataoka Y, Yoshida F. The change of hemodynamics and heart rate variability on bathing by the gap of water temperature. Biomed Pharmacother 2005;59:S92-9. Kollocassides KG, Seymor AM, Galinanes M, Hearse DJ. Paradoxical effect of ischemic preconditioning on ischemic contracture? NMR studies of energy metabolism and intracellular pH in the rat heart. J Mol Cell Cardiol 1996;28:1045–1057. Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, et al. Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome: an attractive target for the NF-B-specific inhibitor DHMEQ. Ann N Y Acad Sci 2009;1173:137-45. Kuzuya T, Hoshida S, Yamashita N, Fuji H, Oe H, Hori M, Kamada T, Tada M. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circulation 1993;72:1293-1299. Légaré JF, Oxner A, Heimrath O, Myers T, Currie RW. Heat shock treatment results in increased recruitment of labeled PMN following myocardial infarction. Am J Physiol Heart Circ Physiol 2007; 293:H3210-5. Li RK. Preconditioning cultured human pediatric myocytes requires adenosine and protein kinase C. Am J Physiol 1997;272:H1220–1230. Li PC, Yang CC, Hsu SP, Chien CT. Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling. J Vasc Surg. 2012;56:159-70. Li Y, Cai M, Xu Y, Swartz HM, He G. Late phase ischemic preconditioning preserves mitochondrial oxygen metabolism and attenuates post-ischemic myocardial tissue hyperoxygenation. Life Sci. 2011;88:57-64. Lin HY, Shen SC, Chen YC. Anti-inflammatory effect of heme oxygenase1: glycosylation and nitric oxide inhibition in macrophages. J Cell Physiol 2005;202:579-90. Marber MS, Latchman DS, Walker JM, Yellon DM. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 1993;88:1264-1272 McCormick PH, Chen G, Tlerney S, Kelly CJ, Bouchier-Hayes DJ. Clinically relevant thermal preconditioning attenuates ischemia-reperfusion injury. J Surg Res 2003;109:24-30. Miyamae M, Fujiwara H, Kida M, et al. Preconditioning improves energy metabolism during reperfusion but does not attenuate myocardial stunning in porcine hearts. Circulation 1993;88:223–34. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-1136. Murry CE, Richard VJ, Jennings RB, Reimer KA. Myocardial protection is lost before contractile function recovers from ischemic preconditioning. Am J Physiol 1991;260:H796-804. Nakabe N, Kokura S, Shimozawa M, Katada K, Sakamoto N, Ishikawa T, et al. Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells. Int J Hyperthermia 2007;23:217-24 Neschis DG, Safford SD, Raghunath PN, Langer DJ, David ML, Hanna AK, et al. Thermal preconditioning before rat arterial balloon injury: limitation of injury and sustained reduction of intimal thickening. Arterioscler Thromb Vasc Biol 1998;18:120-6. Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, Kurose H. Gαi and Gαo are target proteins of reactive oxygen species. Nature 2000;408:492–425. Okada M, Hasebe N, Aizawa Y, Izawa K, Kawabe J, Kikuchi K. Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Circulation 2004;109:1763-8. Pain T, Yang XM, Critz SD, et al. Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 2000;87:460–466. Peralta C, Hotter G, Closa D, Gelpi E, Bulbena O, Rosello-Catafau. Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: role of nitric oxide and adenosine. Hepatology 1997;25:934-937. Presley T, Vedam K, Druhan LJ, Ilangovan G. Hyperthermia-induced Hsp90•eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating glut-1 and up-regulating G6PD activity. J Biol Chem 2010;285:38194-203. Qian H, Yang Y,Wang X. Curcumin enhanced Adriamycin-induced human liverderived hepatoma G2 cell death through activation of mitochondria-mediated apoptosis and autophagy. Eur J Pharm Sci. 2011;43:125-31. Ravagnan L, Gurbuxani S, Susin SA, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat. Cell. Biol., 3, 839–843. Ritossa F A new puffing pattern induced by temperature shock and DNP in drosophila'. Cellular and Molecular Life Sciences (CMLS) 1962 ;18: 571–573 Sanada S, Kitakaze M, Asanuma H, et al. Role of mitochondrial and sarcolemmal KATP channels in ischemic preconditioning of the canine heart. Am J Physiol Heart Circ Physiol 2001;280:H256–263. Sandhu R, Diaz RJ, Mao GD, Wilson GJ. Ischemic preconditioning-difference in protection and susceptibility to blockade with single cycle versus multicycle transient ischemia. Circulation 1997;96:984–995. Santoro MG. Heat shock factors and the control of the stress response. Biochemical pharmacology 2000;59: 55–63 Schäfer A, Schulz C, Fraccarollo D, Tas P, Leutke M, Eigenthaler M, et al. The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions. Arterioscler Thromb Vasc Biol 2007;27:55-62. Schlecht-Bauer D, Antier D, Machet MC, Hyvelin JM. Short- and long-term cardioprotective effect of darbepoetin-alpha: role of Bcl-2 family proteins. J Cardiovasc Pharmacol. 2009;54:223-31. Schulz R, Post H, Vahlhaus C, Heusch G. Ischemic preconditioning in pigs: a graded phenomenon. Its relation to adenosine and bradykinin. Circulation1998;98:1022–1029. Schwartz LM, Jennings RB, Reimer KA. Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs. Basic Res Cardiol 1997;92:106–114. Seet, R.C., et al., Oxidative damage in ischemic stroke revealed using multiple biomarkers. Stroke, 2011. 42(8): p. 2326-9. Snoeckx LH, Cornelussen RN, Van Nieuwenhoven FA, et al. Heat shock proteins and cardiovascular pathophysiology. Physiol Rev. 2001;81:1461-1597. Sorrentino SA, Doerries C, Manes C, Speer T, Dessy C, Lobysheva I, et al. Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional b1-blockade. J Am Coll Cardiol. 2011;57:601-11. Srivastava, P. K., et al. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2002;2: 185-94. Stirone C, Boroujerdi A, Duckles SP, Krause DN. Estrogen receptor activation of phosphoinositide-3 kinase, Akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol Pharmacol 2005;67:105-13. Sung Yeong Yik Heat Shock Proteins: An Alternative to Control Disease in Aquatic Organism J Marine Sci Res Dev 2014, 4:1 Sztajzel, J., Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly, 2004. 134(35-36): p. 514-22. Takano H, Manchikalapudi S, Tang XL, Qiu Y, Rizvi A, Jadoon AK, Zhang Q, Bolli R. Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. Circulation 1998;98:441–449. Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, et al. Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res 2009;82:484-92. Williams, T.J. and M.J. Peck, Role of prostaglandin-mediated vasodilatation in inflammation. Nature, 1977. 270(5637): p. 530-2. Yang XM, Sato H, Downey JM, Cohen MV. Protection of ischemic preconditioning is dependent upon a critical timing sequence of protein kinase C activation. J Mol Cell Cardiol 1997;29:991–999. Yeh CH, Hsu SP, Yang CC, Chien CT, Wang NP. Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy. Life Sci 2010;86:115-23. Yeh YC, Wang MJ, Lin CP, Fan SZ, Tsai JC, Sun WZ, et al. Enoxaparin sodium prevents intestinal microcirculatory dysfunction in endotoxemic rats. Crit Care. 2012;16:R59. Yellon DM, Baxter GF. A “second window of protection” or delayed preconditioning phenomenon: future horizons for myocardial protection? J Mol Cell Cardiol 1995;27:1023-1034 Yellon DM, Pasini E, Cargnoni A, Marber MS, Latchman DS, Ferrari R. The protective role of heat stress in the ischaemic and reperfused rabbit myocardium. J Mol Cell Cardiol 1992;24:895-907. Zhou J, Schmid T, Frank R, Brüne B. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHLindependent degradation. J Biol Chem 2004;279:13506-13. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58219 | - |
| dc.description.abstract | 目標：比起全身熱療，漸進式熱前置處理（PTP）因引起較少的血行動力變化、內質網（ER）壓力和氧化刺激而對血管提供較佳之保護。我們認為PTP亦可能可有效地減少因心肌缺血/再灌注所誘導的細胞凋亡和自噬。
方法：將67隻雄性Wistar老鼠隨機分為非PTP控制組，和在一個週期或是連續3個週期進行42℃水浴的PTP 後24及72小時（1-24，1-72，3-24和3-72組）共5組。我們測量在左冠狀動脈前降支結紮3小時與再灌注2小時後體內產生的心肌負氧離子含量。另外由微循環、心電圖和心肌梗塞面積來決定心肌功能和受損程度。PTP因結抗煙酰胺腺嘌呤二核苷酸磷酸氧化酶gp91媒介的氧化刺激，內質網壓力和細胞凋亡及自噬產生的保護作用，則採用Western blot和免疫組化來檢驗。 結果：冠狀動脈缺血/再灌注在控制組及PTP的老鼠上均能抑制心肌的微循環，誘發心電圖ST段部位升高，並增加心肌梗塞之面積。缺血/再灌注會透過加強煙酰胺腺嘌呤二核苷酸磷酸氧化酶gp91的表現、胞漿細胞色素C釋放和降低粒腺體Bcl-2的含量而增加心肌負氧離子。因心肌受傷而被激活的ER壓力-78-kDa的葡萄糖調節蛋白的表現增加了Bax/Bcl-2比值，切割後caspase3的表現和聚（ADP-核糖）聚合酶的片段則導致細胞凋亡的形成﹔並藉由促進LC3-II的表達，進而導致細胞自噬。PTP治療會在老鼠的心臟中升高熱休克蛋白70、熱休克蛋白32和Bcl-2、Bcl-xL與錳超氧化物歧化酶，尤以3-72組量最高。PTP治療能顯著恢復心肌微循環、降低氧化刺激、ER壓力、細胞凋亡、細胞自噬和梗塞面積。 結論：PTP能透過加強抗氧化、抗凋亡和抗細胞自噬機制顯著降低心臟缺血/再灌注之損傷。 | zh_TW |
| dc.description.abstract | Objectives: Progressive thermal preconditioning (PTP) provides vascular protection with less hemodynamic fluctuations, endoplasmic reticulum (ER), and oxidative stress compared with whole body hyperthermia. We suggest PTP might efficiently diminish cardiac ischemia/reperfusion-induced apoptosis and autophagy injury.
Methods: A total of 67 male Wistar rats were divided into a non-PTP control group, 24 or 72 hours after a single cycle or 3 consecutive cycles of PTP in a 42℃ water bath (1-24, 1-72, 3-24, and 3-72 groups). We measured the cardiac O2‾ amount in vivo in response to left anterior descending coronary artery ligation for 2 hours and reperfusion for 3 hours. Cardiac function and injury were determined by microcirculation, electrocardiography, and infarct size. The PTP-induced protective effects on nicotinamide adenine dinucleotide phosphate oxidase gp91-mediated oxidative stress, ER stress, and apoptosis- and autophagy-related mechanisms were examined using Western blot and immunohistochemistry. Results: Coronary arterial ischemia/reperfusion depressed cardiac microcirculation, induced ST-segment elevation and increased infarct size in non-PTP and PTP rats. Ischemia/reperfusion enhanced the cardiac O2‾ levels by enhanced nicotinamide adenine dinucleotide phosphate oxidase gp91 expression, cytosolic cytochrome C release, and decreased mitochondrial Bcl-2 expression. Cardiac injury activated ER stress–78-kDa glucose-regulated protein expression, increased the Bax/Bcl-2 ratio, cleaved caspase 3 expression and poly-(ADP-ribose)-polymerase fragments, leading to apoptosis formation, and promoted LC3-II expression, resulting in autophagy formation. PTP treatment elevated heat shock protein 70, heat shock protein 32, Bcl-2, Bcl-xL, and manganese superoxide dismutase in the rat heart, especially in the 3-72 group. PTP treatment significantly restored cardiac microcirculation, decreased oxidative stress, ER stress, apoptosis, autophagy, and infarct size. Conclusions: PTP significantly reduced cardiac ischemia/reperfusion injury by upregulating antioxidant, anti-apoptotic, and anti-autophagic mechanisms. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T08:08:34Z (GMT). No. of bitstreams: 1 ntu-103-D92421101-1.pdf: 1736937 bytes, checksum: 895081098fffebe57cfc025307633fad (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 口試委員會審定書…………………………………………………… i
誌謝………………………………………………………………… ii 中文摘要…………………………………………………………… iii 英文摘要…………………………………………………………… iv 博士論文內容 第一章 緒論………………………………………………… 1 第一節 背景…………………………………………… 1 第二節 前置處理…………………………………… 3 第三節 前置處理之機轉…………………………… 5 第四節 熱前置處理及熱休克蛋白之角色……… .... 8 第五節 設計最適當之熱前置處理：漸進式熱前置處理. 12 第六節 動機：漸進式熱前置處理對心肌保護的另一可能機轉 15 第七節 欲研究的問題…………………………………………… 17 第二章 研究方法與材料………………………….…………… 18 第三章 結果…………………………………………… …………… 22 第四章 討論..............................................24 第五章 展望………………………………………………… ……… 30 第一節 臨床可能之應用...............................30 第二節 未來的臨床實驗...............................33 論文英文簡述............................................ 41 參考文獻.................................................54 表目錄 表1......................................................64 圖目錄 圖1………………………………………………………………….… 65 圖2……………………………………………………………………. 66 圖3………………………………………………………………….….67 圖4……………………………………………………………………..68 圖5……………………………………………………………………..69 圖6…………………………………………………………………… .70 圖7……………………………………………………………………..71 圖8……………………………………………………………………..72 附錄.....................................................73 | |
| dc.language.iso | zh-TW | |
| dc.subject | 漸進式熱前置處理 | zh_TW |
| dc.subject | 抗氧化 | zh_TW |
| dc.subject | 抗凋亡 | zh_TW |
| dc.subject | 抗細胞自噬 | zh_TW |
| dc.subject | 心臟缺血/再灌注損傷 | zh_TW |
| dc.subject | 老鼠 | zh_TW |
| dc.subject | Progressive thermal preconditioning | en |
| dc.subject | Antioxidant | en |
| dc.subject | Apoptosis | en |
| dc.subject | Autophagy | en |
| dc.subject | Cardiac ischemia/reperfusion | en |
| dc.subject | Rat | en |
| dc.title | 漸進式熱前置處理與熱休克蛋白在心肌保護作用之角色 | zh_TW |
| dc.title | The Role of Progressive Thermal Preconditioning and Heat Shock Protein in Myocardium Protection | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.coadvisor | 何奕倫(Yi-Lwun Ho),鄭劍廷(Chiang-Ting Chien) | |
| dc.contributor.oralexamcommittee | 陳益祥(Yih-Sharng Chen),吳懿哲(Yih-Jer Wu) | |
| dc.subject.keyword | 漸進式熱前置處理,抗氧化,抗凋亡,抗細胞自噬,心臟缺血/再灌注損傷,老鼠, | zh_TW |
| dc.subject.keyword | Progressive thermal preconditioning,Antioxidant,Apoptosis,Autophagy,Cardiac ischemia/reperfusion,Rat, | en |
| dc.relation.page | 73 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-05-26 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-103-1.pdf 未授權公開取用 | 1.7 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。