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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林俊彬(Chun-Pin Lin) | |
| dc.contributor.author | Yu-Chen Lu | en |
| dc.contributor.author | 盧育成 | zh_TW |
| dc.date.accessioned | 2021-06-16T08:05:23Z | - |
| dc.date.available | 2017-10-15 | |
| dc.date.copyright | 2014-10-15 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-06-25 | |
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J Periodontol 1993;64(5 Suppl):474-84. 66. Ganss C, Neutard L, von Hinckeldey J, Klimek J, Schlueter N. Efficacy of a tin/fluoride rinse: a randomized in situ trial on erosion. J Dent Res 2010;89(11):1214-8. 67. Kato MT, Bolanho A, Zarella BL, et al. Sodium fluoride inhibits MMP-2 and MMP-9. J Dent Res 2014;93(1):74-7. 68. Ganss C, Lussi A, Sommer N, Klimek J, Schlueter N. Efficacy of fluoride compounds and stannous chloride as erosion inhibitors in dentine. Caries Res 2010;44(3):248-52. 69. Sinija VR, Mishra HN. Green tea: Health benefits. Journal of Nutritional and Environmental Medicine 2008;17(4):232-42. 70. Jha A, Shah K, Verma RJ. Effects of sodium fluoride on DNA, RNA and protein contents in liver of mice and its amelioration by Camellia sinensis. Acta Pol Pharm 2012;69(3):551-5. 71. Milton P, Thanga P. Epigallocatechin gallate potentially ameliorates sodium fluoride-induced genotoxicity in rats; 2013. 72. Millward A, Shaw L, Harrington E, Smith AJ. Continuous monitoring of salivary flow rate and pH at the surface of the dentition following consumption of acidic beverages. Caries Res 1997;31(1):44-9. 73. Hannig C, Hannig M, Attin T. Enzymes in the acquired enamel pellicle. Eur J Oral Sci 2005;113(1):2-13. 74. Hannig M. Ultrastructural investigation of pellicle morphogenesis at two different intraoral sites during a 24-h period. Clin Oral Investig 1999;3(2):88-95. 75. Ganss C, Schlueter N, Klimek J. Retention of KOH-soluble fluoride on enamel and dentine under erosive conditions--A comparison of in vitro and in situ results. Arch Oral Biol 2007;52(1):9-14. 76. Hara K, Ohara M, Hayashi I, et al. The green tea polyphenol (-)-epigallocatechin gallate precipitates salivary proteins including alpha-amylase: biochemical implications for oral health. Eur J Oral Sci 2012;120(2):132-9. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58067 | - |
| dc.description.abstract | 目的
牙齒酸蝕是近年來越來越值得重視的一個牙齒問題，常見於大量飲用酸性軟性飲料的人群。本實驗的目的為以體外實驗的方法來探討氟化物及兒茶素對於降低軟性飲料所引起之牙釉質及牙本質齒酸蝕之效果。 材料與方法 本實驗使用市面上常見的碳酸軟性飲料來當作牙齒酸蝕之酸性來源。本實驗共使用了40個人類牙釉質樣本及40個人類牙本質樣本，將其各平均分成四組，事前分別以去離子水(DW)、0.5M氟化鈉溶液(F)、400μM兒茶素溶液(EGCG)、0.5M氯化鈉，及400μM兒茶素混合溶液(Mix)做事前處理4分鐘。之後以軟性飲料浸泡處理15分鐘及人工唾液浸泡處理1小時之循環4次。最後以雷射掃描共軛焦顯微鏡分析酸蝕後平均喪失高度、表面圖像及表面積變化，並使用維氏微小硬度計來測量酸蝕後表面硬度變化，以及使用掃瞄式電子掃描顯微鏡觀察表面影像。 結果 牙釉質樣本方面，和DW組相比，F組有顯著較高之表面硬度，但平均喪失高度部分和表面積變化則無顯著差異。EGCG組和Mix組在之表面硬度變化、平均喪失高度及表面積變化和DW組相比都有顯著較少之變化。其中，EGCG組在表面硬度方面有最高之表面硬度，優於F組及Mix組。 牙本質樣本方面，和DW組相比，F組相比有較高之表面硬度、較少之平均喪失高度，EGCG組及Mix組則是有高之表面硬度，表面積變化則無顯著差異。 結論 本實驗顯示，0.5M氟化鈉及400μM兒茶素及其混合溶液在體外實驗中皆能顯著抑制牙釉質及牙本質酸蝕，其中兒茶素也展示了抗牙釉質酸蝕之能力，氟化物也展示了抗牙本質酸蝕之能力。混合溶液之抑制效果非簡單之加成效果，可能的原因為兒茶素與氟化物之間可能有交互作用之存在，或是彼此的抑制途徑類似而有競爭效果，尚待進一步之研究去確認。 | zh_TW |
| dc.description.abstract | Objectives
Dental erosion is a rising problem recently, and the frequently soft-drink consuming nowadays might be one of the reasonable attributions. The present study is aim to evaluate the effect of fluoride and EGCG against soft-drink-induced dental erosion in vitro. Materials and methods A soft drink is used as acid source of erosion in the present study. 40 enamel samples and 40 dentin samples, which were made of human extracted teeth, were distributed into 4 group and received pre-treatment by deionized water (DW), 0.5M NaF (F), 400μM EGCG (EGCG), and combination of 0.5M NaF and 400μM EGCG (Mix) in rinse for 4 minutes respectively. Afterwards, the samples were immersed in the soft drink for 15 minutes for 4 times with 60 minutes interval in artificial saliva. Then, the samples were analyzed of the change of average height, surface area changing, surface hardness and surface structure after erosion by confocal laser scanning microscope, Vickers’s hardness tester, and scanning electronic microscope. Results In enamel samples, the F group showed higher surface hardness in contrast to the DW group, but it made no difference in surface area change and average height. The EGCG group and the Mix group, in contrast to the DW group, showed higher surface hardness, less surface area change and lower average height. Besides, the EGCG group exhibited highest surface hardness of 4 groups. In dentin samples, compared to the DW group, the F group showed higher surface hardness and lower average height. In the other hand, the EGCG group and the Mix group exhibited higher surface compared to the DW group. As for surface area change, the outcomes were similar in all groups. Conclusion The present study demonstrated that all of 0.5M NaF, 400μM EGCG, and combination of both rinse could reduce the amount of soft-drink-induced dental erosion in vitro. EGCG demonstrated anti-enamel-erosion effect and fluoride showed anti-dentin-erosion effect. The inhibitory effect of Mix rinse was neither simply combination effect nor the best of all. There might be a interaction or competitive effect between NaF and EGCG, and it needs further studies to assure. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T08:05:23Z (GMT). No. of bitstreams: 1 ntu-103-R00422023-1.pdf: 23495496 bytes, checksum: 4e9afdcba95890871463eab08a0c3472 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書 i 中文摘要 ii ABSTRACT iii 目 錄 v 圖目錄 x 表目錄 xii 第1章 緒論 1 1.1 牙齒酸蝕 1 1.1.1 定義 1 1.1.2 成因 2 1.1.3 診斷 2 1.1.4 預防方法 2 1.2 軟性飲料 3 1.2.1 定義 3 1.2.2 與牙齒酸蝕之關係 3 1.3 牙釉質 3 1.3.1 結構 3 1.3.2 酸蝕過程 4 1.4 牙本質 5 1.4.1 結構 5 1.4.2 酸蝕過程 5 1.5 氟化物 6 1.5.1 與牙齒酸蝕之作用 6 1.6 兒茶素 7 1.6.1 與牙齒酸蝕之關係 8 1.7 唾液與人工唾液 8 1.7.1 與牙齒酸蝕之關係 8 1.7.2 人工唾液 9 第2章 實驗目的 10 第3章 實驗材料與方法 11 3.1 軟性飲料 11 3.2 測量pH值 11 3.2.1 pH計 11 3.2.2 校正步驟 11 3.2.3 測量步驟 12 3.3 牙齒樣本 12 3.3.1 樣本來源 12 3.3.2 牙齒樣本之製備 13 3.3.3 樣本分組 14 3.4 實驗溶液 14 3.5 人工唾液 15 3.5.1 成份 15 3.5.2 製備步驟 15 3.6 牙齒酸蝕過程 16 3.6.1 事前處理 16 3.6.2 酸蝕處理 16 3.6.3 事後處理 17 3.7 雷射掃描共軛焦顯微鏡 17 3.7.1 原理與特色 17 3.7.2 掃描樣本步驟: 18 3.7.3 分析影像步驟 18 3.8 維氏微小硬度計 19 3.8.1 原理 19 3.8.2 測量步驟 20 3.9 電子掃描顯微鏡 20 3.9.1 原理 20 3.9.2 測量項目 21 3.10 統計分析 21 第4章 實驗結果 22 4.1 各種溶液酸鹼值 22 4.2 雷射掃描共軛焦顯微鏡之影像 22 4.2.1 牙釉質 22 4.2.2 牙本質 22 4.3 電子掃描顯微鏡之影像 23 4.3.1 牙釉質 23 4.3.2 牙本質 23 4.4 表面硬度之變化 24 4.4.1 牙釉質 24 4.4.2 牙本質 24 4.5 平均喪失高度 24 4.5.1 牙釉質 24 4.5.2 牙本質 25 4.6 表面積之變化 25 4.6.1 牙釉質 25 4.6.2 牙本質 25 第5章 討論 26 5.1 氟化物對牙釉質之抗酸蝕效果 26 5.2 兒茶素對牙釉質之抗酸蝕效果 27 5.3 兒茶素對牙本質之抗酸蝕效果 28 5.4 氟化物對牙本質之抗酸蝕效果 29 5.5 混合溶液對牙釉質之抗酸蝕效果 30 5.6 混合溶液對牙本質之抗酸蝕效果 31 5.7 體外實驗及體內實驗之差異 32 第6章 結論 34 第7章 實驗未來展望 35 參考文獻 36 圖目錄 圖 1 pH計主要結構。 40 圖 2 硬組織研磨機 40 圖 3 超音波震盪器 41 圖 4 牙釉質樣本製備及各階段照片。 41 圖 5 酸蝕模型流程示意圖。 42 圖 6 雷射掃描共軛焦顯微鏡 43 圖 7 維氏微小硬度計 43 圖 8 維氏微小硬度計印痕示意圖及其計算式 44 圖 9 電子掃描顯微鏡。 44 圖 10 牙釉質DW組雷射顯微鏡影像及3D圖。 45 圖 11 牙釉質F組雷射顯微鏡影像及3D圖。 46 圖 12 牙釉質EGCG組雷射顯微鏡影像及3D圖。 47 圖 13 牙釉質Mix組雷射顯微鏡影像及3D圖。 48 圖 14 牙本質DW組雷射顯微鏡影像及3D圖。 49 圖 15 牙本質F組雷射顯微鏡影像及3D圖。 50 圖 16 牙本質EGCG組雷射顯微鏡影像及3D圖。 51 圖 17 牙本質Mix組雷射顯微鏡影像及3D圖。 52 圖 18 牙釉質DW組電子掃描顯微鏡影像。 53 圖 19 牙釉質F組電子掃描顯微鏡影像。 54 圖 20 牙釉質EGCG組電子掃描顯微鏡影像。 55 圖 21 牙釉質Mix組電子掃描顯微鏡影像。 56 圖 22 牙本質DW組電子掃描顯微鏡影像。 57 圖 23 牙本質F組電子掃描顯微鏡影像。 58 圖 24 牙本質EGCG組電子掃描顯微鏡影像。 59 圖 25 牙本質Mix組電子掃描顯微鏡影像。 60 圖 26 牙釉質各組在酸蝕後之表面硬度變化量(%)。 61 圖 27 牙釉質各組在酸蝕後之平均喪失高度(μm)。 61 圖 28 牙釉質各組在酸蝕後之表面積變化量(%)。 62 圖 29 牙本質各組在酸蝕後之表面硬度變化量(%)。 62 圖 30 牙本質各組在酸蝕後之平均喪失高度(μm)。 63 圖 31 牙本質各組在酸蝕後之表面積變化量(%)。 63 表目錄 表 1 人工唾液成分表 64 表 2 牙釉質樣本各組在表面硬度、平均喪失高度及表面積之變化 64 表 3 牙釉質樣本各組在表面硬度、平均喪失高度及表面積變化之統計分析 65 表 4 牙本質樣本各組在表面硬度、平均喪失高度及表面積之變化 65 表 5 牙本質樣本各組在表面硬度、平均喪失高度及表面積變化之統計分析 65 | |
| dc.language.iso | zh-TW | |
| dc.title | 兒茶素與氟化物對於降低軟性飲料引起之牙齒酸蝕之影響：體外實驗 | zh_TW |
| dc.title | Effect of EGCG and Fluoride against Soft-drink-induced Dental Erosion: an in vitro study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖運炫(Yunn-Shiuan Liao),朱瑾(Jinn Chu),張曉華(Hsiao-Hua Chang),張志涵(Chih-Han Chang) | |
| dc.subject.keyword | 牙齒酸蝕,軟性飲料,氟化物,兒茶素,牙釉質,牙本質, | zh_TW |
| dc.subject.keyword | dental erosion,soft drinks,fluoride,EGCG,enamel,dentin, | en |
| dc.relation.page | 65 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-06-25 | |
| dc.contributor.author-college | 牙醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-103-1.pdf 目前未授權公開取用 | 22.94 MB | Adobe PDF |
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