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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鄭謙仁(Chian-Ren Jeng) | |
dc.contributor.author | Chuan-Hsing Chang | en |
dc.contributor.author | 張權星 | zh_TW |
dc.date.accessioned | 2021-06-16T06:51:31Z | - |
dc.date.available | 2016-11-21 | |
dc.date.copyright | 2014-07-29 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-07-23 | |
dc.identifier.citation | Argus, M.V., 1993. New paleontological excavation techniques. Journal of Paleontology
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Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Veterinary Microbiology 152, 235-246. Sinha, A., Shen, H.G., Schalk, S., Beach, N.M., Huang, Y.W., Halbur, P.G., Meng, X.J., Opriessnig, T., 2010. Porcine reproductive and respiratory syndrome virus infection at the time of porcine circovirus type 2 vaccination has no impact on vaccine efficacy. Clinical and Vaccine Immunology : CVI 17, 1940-1945. Sun, L., Li, Y., Liu, R., Wang, X., Gao, F., Lin, T., Huang, T., Yao, H., Tong, G., Fan, H., Wei, Z., Yuan, S., 2013. Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability. Virus research 171, 178-185. Sun, X.Z., Wertz, N., Lager, K.L., Tobin, G., Butler, J.E., 2012. Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS Virus display the same immune dysregulation seen in isolator piglets. Vaccine 30, 3646-3652. Thomas, B.S., Nishi | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57560 | - |
dc.description.abstract | 豬生殖與與呼吸道綜合症是全球養豬產業具有嚴重影響之豬隻傳染病,主要造成保育豬嚴重呼吸道臨床症狀,以及母豬流產與死產等繁殖障礙,並經常併發細性肺炎等疾病,造成豬隻衰弱與生長性狀不佳,進而產生巨額經濟損失。由於PRRSV減毒活毒疫苗會排毒及有回毒風險,以及無交叉保護效力。本實驗室賈敏原等人 (2011)於無特定病原豬隻 (SPF)口服免疫豬生殖與呼吸綜合症病毒ORF5與大腸桿菌熱溶解性腸毒素次單位B (LTB)之基因轉殖菸草次單位疫苗,以同源病毒株進行攻毒,結果顯示本疫苗能誘發體液免疫與黏膜免疫,以及能減少血清病毒量,達到免疫保護效果。本研究將該疫苗使用於田間豬場,觀察其對豬隻生長性狀之實際效益以及免疫保護效力之變化。將240頭保育豬隨機分為4個試驗豬群,分別為基因轉殖PRRSV GP5-LTB菸草次單位疫苗組 (GP5-LTB T)、正常菸草組 (W T)、商業化MLV減毒疫苗組 (MLV)與對照組 (C)。豬隻5、7、9週齡時餵飼轉殖菸草 50 g/頭 三次。商用疫苗PRRS MLV則於5週齡時,接種一次。相關生長性能以及免疫反應結果顯示,四組豬群試驗前後均為PRRSV陽性不穩定之感染狀態,然而,GP5-LTB T組豬群於生長性狀的整體表現,呈現最佳狀態,其終末平均體重可達59.07公斤,平均日增重達473.5公克/天,並且具有四組最佳之飼料效率1.9 ; 顯示基因轉殖PRRSV GP5-LTB菸草次單位疫苗對於陽性感染豬隻在生長性狀上,具有降低飼料成本與縮短上市時間等生產潛力。本田間試驗結果顯示,基因轉殖PRRSV GP5-LTB菸草次單位疫苗於田間陽性保育階段豬群之生長性狀呈現正向之生長效益,具有持續發展的良好潛力,期盼未來能有助於本病的防疫與控制。 | zh_TW |
dc.description.abstract | Porcine reproductive and respiratory syndrome (PRRS) is a highly infectious and economically important viral disease in swine industry worldwide. The disease causes severe respiratory clinical signs in nursery pigs and induces reproductive disorder, including abortion and still borne in sows. Additionally, it commonly complicates with bacterial pneumonia and causes weaken and poor growth performance in the herd resulting in huge economic loss. Due to commercial live attenuated vaccine shows long shedding period and risk of virulent reversion with poor cross-protection against various strains. Chia et al., 2011 demonstrated an oral administration of transgenic PRRSV ORF5-LTB tobacco subunit vaccine was able to induce humoral and mucosal immunity; in addition, it also reduced the serum viral load after homologous virus challenging. In the present study, the transgenic PRRSV ORF5-LTB subunit tobacco vaccine was tested in the field to estimate the growth performance and immune protectivity. 240 nursery pigs were randomly assigned to 4 groups, including transgenic PRRSV ORF5-LTB subunit tobacco vaccine (GP5-LTB T), wild tobacco leaves (W T), IngelvacR PRRS MLV (MLV) and non-treatment control (C). In the GP5-LTB T, group transgenic tobacco leaves was oral fed 50 g per pig for three times at 5, 7 and 9 weeks old. Commercial MLV vaccine was injected at 5 weeks old in the group of V. The result showed PRRSV infectious status belonging to positive unstable condition before and after the trial. The group of GP5-LTB T demonstrated the best growth performance including its final average body weight achieved 59.07 Kg, its average daily weight gain was 473.5 g/day, and especially, its feed conversion ratio was 1.9. In conclusion, transgenic PRRSV subunit plant vaccine has the great potential to be a competitor for PRRS control in the future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T06:51:31Z (GMT). No. of bitstreams: 1 ntu-103-R00644005-1.pdf: 7758257 bytes, checksum: 1864ec71ad94b0863e70a897c96282cb (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 誌謝 i
中文摘要 iii ABSTRACT iv 目錄 v 圖次 ix 表次 x 附錄 xi 第一章 序言 1 第二章 文獻回顧 2 第一節 豬生殖與呼吸道綜合症 (PRRS) 2 2.1.1 豬生殖與呼吸道綜合症之歷史背景與對養豬產業之經濟影響 2 2.1.2 豬生殖與呼吸道綜合症病毒之病毒學 3 2.1.2.1豬生殖與呼吸道綜合症病毒結構蛋白 4 2.1.2.2豬生殖與呼吸道綜合症病毒非結構蛋白 6 2.1.3 豬生殖與呼吸道綜合症之流行病學回顧 7 2.1.3.1 PRRS病毒之quasispecies特性 7 2.1.3.2 PRRS病毒之分子流行病學 8 2.1.3.3 減毒活毒豬生殖與呼吸道綜合症疫苗病毒株 11 2.1.4 豬生殖與呼吸道綜合症之臨床症狀、病理變化 11 2.1.4.1 豬生殖與呼吸道綜合症於豬隻之病理變化 11 2.1.4.2 豬生殖與呼吸道綜合症於仔豬與肉豬之臨床症狀 12 2.1.5 豬生殖與呼吸道綜合症病毒之致病機轉、免疫反應與致病劑量 12 2.1.5.1 個體豬隻之致病機轉與免疫反應 12 2.1.5.2 致病劑量 15 2.1.6 豬生殖與呼吸道綜合症病毒之傳染途徑與現場之混和感染 16 2.1.7 台灣豬生殖與呼吸道綜合症現況 18 第二節 回顧豬生殖與呼吸道綜合症病毒之疫苗發展 20 2.2.1 豬生殖與呼吸道綜合症病毒減毒活毒疫苗 21 2.2.2 豬生殖與呼吸道綜合症病毒死毒疫苗 23 2.2.3 豬生殖與呼吸道綜合症病毒次單位疫苗 24 2.2.4 豬生殖與呼吸道綜合症病毒DNA疫苗 26 第三節 基因轉殖植物次單位疫苗 28 2.3.1 基因轉殖植物疫苗於獸醫領域之應用與效益 28 2.3.2 基因轉殖植物蛋白表現系統 30 2.3.2.1 基因轉殖植物細胞核表現系統 31 2.3.2.2 基因轉殖植物葉綠體表現系統 31 2.3.3 共同黏膜免疫系統與豬隻口服耐受性回顧 32 2.3.3.1 豬隻口服投予基因轉殖植物次單位疫苗之共同黏膜免疫反應 32 2.3.3.2 豬隻口服耐受性 35 2.3.4 基因轉殖豬生殖與呼吸道綜合症病毒次單位蛋白之免疫效力 36 2.3.4.1 基因轉殖菸草葉之豬生殖與呼吸道綜合症病毒次單位蛋白 36 2.3.4.2 基因轉殖香蕉葉之豬生殖與呼吸道綜合症病毒次單位蛋白 40 2.3.4.3 基因轉殖馬鈴薯之豬生殖與呼吸道綜合症病毒次單位蛋白 41 2.3.4.4 基因轉殖黃豆種子之豬生殖與呼吸道綜合症病毒次單位蛋白 42 2.3.4.5 基因轉殖玉米之豬生殖與呼吸道綜合症病毒次單位蛋白 44 2.3.5 基因轉殖植物次單位疫苗之佐劑回顧 45 2.3.5.1 動物相關之口服疫苗之黏膜免疫佐劑 45 2.3.5.2 豬生殖與呼吸道綜合症病毒疫苗佐劑 48 2.3.6 基因轉殖植物疫苗之優點 48 2.3.7 基因轉殖植物疫苗發展之限制與我國基因轉殖作物相關法規 49 第四節 豬用疫苗之田間試驗 51 2.4.1 以生產醫學評估田間豬隻健康狀態之方法 51 2.4.1.1 田間試驗分組原則 51 2.4.2 豬生殖與呼吸道綜合症對於豬隻生長性狀影響 52 第三章 材料與方法 55 第一節 實驗設計 55 第二節 實驗材料 57 3.2.1 田間實驗豬場與豬隻 57 3.2.2 基因轉殖PRRSV GP5-LTB菸草次單位疫苗 58 3.2.3 無基因轉殖菸草 58 3.2.4 商品化豬生殖與呼吸道綜合症病毒減毒疫苗 58 第三節 實驗方法 60 3.3.1 樣本採集與處理 60 3.3.1.1 血清樣本 60 3.3.1.2 唾液樣本 60 3.3.2 豬隻族群健康狀態與死亡率 60 3.3.2.1 血清中之PRRS病毒RNA萃取 61 3.3.2.2 PRRS病毒RNA轉綠cDNA之製備 61 3.3.2.3 以SYBR Green進行單一及及時聚合酶鏈鎖反應 (RT-PCR) 61 3.3.3 生長性能效益評估 62 3.3.3.1 平均日增重 62 3.3.3.2 整齊度 63 3.3.3.3 平均日採食量 63 3.3.3.4 飼料換肉率 63 3.3.3.5 死亡率 63 3.3.4 豬隻對豬生殖與呼吸道綜合症病毒之免疫效力分析 64 3.3.4.1 血清中PRRS病毒ORF5相關特異性IgG抗體反應測定 64 3.3.4.2 唾液中PRRS病毒ORF5相關特異性IgA抗體反應測定 64 3.3.5 統計分析 65 第四章 結果 66 第一節 田間試驗豬群PRRSV感染狀態 66 第二節 生長性能效益結果評估 68 4.2.1 平均日增重 68 4.2.2 整齊度 68 4.2.3 平均日採食量 69 4.2.4 飼料換肉率 69 4.2.5 死亡率 69 第三節 豬隻對豬生殖與呼吸道綜合症病毒之免疫效力分析 74 4.3.1 血清中PRRS病毒ORF5相關特異性IgG抗體反應 74 4.3.2 唾液中PRRS病毒ORF5相關特異性IgA抗體反應 74 第五章 討論 77 第六章 參考文獻 83 | |
dc.language.iso | zh-TW | |
dc.title | 豬生殖與呼吸綜合症病毒ORF5與大腸桿菌熱溶解性腸毒素次單位B (LTB)之基因轉殖菸草次單位疫苗田間保護效力之研究 | zh_TW |
dc.title | Protective Assessment of a Transgenic Tobacco Vaccine co-expressing Procine Reproductive and Respiratory Syndrome Virus GP5 and E.coli LTB in the Field | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 龐飛(Victor Fei Pang) | |
dc.contributor.oralexamcommittee | 劉涓(Jiuan Liu),張志成(Chih-Cheng Chang),張惠雯(Hui-Wen Chang),黃有良(Yu-Liang Huang) | |
dc.subject.keyword | 基因轉殖PRRSV GP5-LTB菸草次單位疫苗,田間試驗,生長性狀, | zh_TW |
dc.subject.keyword | Transgenic PRRS tobacco vaccine,Field trial,Growth performance, | en |
dc.relation.page | 103 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-07-24 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 分子暨比較病理生物學研究所 | zh_TW |
顯示於系所單位: | 分子暨比較病理生物學研究所 |
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