請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57055
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張上鎮(Shang-Tzen Chang) | |
dc.contributor.author | Bing-Ho Cheng | en |
dc.contributor.author | 鄭秉和 | zh_TW |
dc.date.accessioned | 2021-06-16T06:33:49Z | - |
dc.date.available | 2016-08-14 | |
dc.date.copyright | 2014-08-14 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-04 | |
dc.identifier.citation | 參考文獻
孔繁鐘(2007)DSM-IV-TR精神疾病診斷準則手册。合記圖書出版社。370頁。 任麗華(2011)影響精神障礙者就業之重要因素分析。中華心理衛生學刊24(1):1–23。 李漢中、鄭森松、劉如芸、張上鎮(2003)不同地理品系土肉桂葉部精油之化學多態性。中華林學季刊36(4):411–422。 林晴筠、杜明勳、薛光傑(2007)芳香治療在臨床醫學的運用新知。基層醫學 22(11):408–413。 楊聖信、許桂森、林君穎、張國治(1994)人體藥理學。藝軒出版社。第353–359頁。 陳品方、張上鎮、吳懷慧(2002)土肉桂葉精油及其成分之抗蟎活性。中華林學季刊 35(4):397–403。 吳季玲、徐鈺雯、劉如芸、張上鎮(2007)土肉桂葉子抽出物之抗氧化活性。摘葉成精−土肉桂優良品系鑑定、種源保存及其特殊成分應用論壇,2007年12月27號,台北,台灣。 許雅青、吳季玲、張惠婷、張上鎮(2007)樟屬植物葉精油及其成分應用於防黴紙之硏製。中華林學季刊 40(3):391–404。 鄭秉和、張育銘、黃玲瓏、張上鎮(2013)葉片解剖學特徵對伽羅木醇型土肉桂葉子精油萃取速率影響之探討。中華林學季刊 46(4):521–530。 鄭森松、林群雅、王亞男、許原瑞、張上鎮(2008)臺灣土肉桂種源庫之設置−葉子精油成分與化學多態性分析。臺大實驗林研究報告22(1):21–34。 劉如芸(2006)六種化學品系土肉桂葉子精油抗細菌、腐朽菌、病媒蚊幼蟲及室塵蟎活性。國立台灣大學森林環境暨資源學系碩士論文。79頁。 劉如芸、鄭森松、蕭英倫、張上鎮(2006)樟屬植物葉子精油對竹林天狗巢病原菌抑制效果之評估。中華林學季刊 39(3):377–388。 Adams, R. P. (2007) Identification of essential oil components by gas chromatography/quadrupole mass spectroscopy. Allured, Illinois, 804 pp. Alaoui-Ismaili, O., E. Vernet-Maury, A. Dittmar, G. Delhomme and J. Chanel (1997) Odor hedonics: connection with emotional response estimated by autonomic parameters. Chemical Senses 22: 237–248. Andersson, S., L. A. Nilsson, I. Groth and G. Bergstrom (2002) Floral scents in butterfly-pollinated plants: possible convergence in chemical composition. Botanical Journal of the Linnean Society 140(2): 129–153. Andrews, N. and S. E. File (1993) Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety. European Journal of Pharmacology 235: 109–112. Azuma, H., L. B. Thien and S. Kawano (1999) Floral scents, leaf volatiles and thermogenic flowers in Magnoliaceae. Plant Species Biology 14(2): 121–127. Beninger, R. J. (1983) The role of dopamine in locomotor-activity and learning. Bruin Research Reviews 6: 173–196. Bernheimer, H. W. Birkmayer, O. Hornykiewicz, K. Jellinger and F. Seitelberger (1973) Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations. Journal of the Neurological Sciences 20: 415–455. Chadha, A. and K. M. Madyastha (1984) Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. Xenobiotica 14: 365–374. Chang, S. T., P. F. Chen and S. C. Chang (2001) Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. Journal of Ethnopharmacology 77: 123–127. Chang, S. T. and S. S. Cheng (2002) Antitermitic activity of leaf essential oils and components from Cinnamomum osmophloeum. Journal of Agricultural and Food Chemistry 50(6): 1389–1392. Chang, C. W., W. L. Chang, S. T. Chang and S. S. Cheng (2008) Antibacterial activities of plant essential oils against Legionella pneumophila. Water Research 42: 278–286. Cheng, T. A. (1988) A community study of minor psychiatric morbidity in Taiwan. Psychological Medicine 18: 953–968. Cheng F. C., J. S.Kuo, Y. Shih, J. S. Lai, D. R. Ni and L. G. Chia (1993) Simultaneous measurement of serotonin, catecholamines and their metabolites in mouse-brain homogenates by high-performance liquid-chromatography with a microbore column and dual electrochemical detection. Journal of Chromatography Biomedical Applications 615(2): 225–236. Cheng, S. S., J. Y. Liu, K. H. Tsai, W. J. Chen and S. T. Chang (2004) Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. Journal of Agricultural and Food Chemistry 52: 4395–4400. Cheng, S. S., J. Y. Liu, Y. R. Hsui and S. T. Chang (2006) Chemical polymorphism of essential oils and their antifungal activities from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Bioresource Technology 97: 306–312. Cheng, S. S., J. Y. Liu, C. Y. Lin, Y. R. Hsui, M. C. Ju, W. J. Wu and S. T. Chang (2007) Terminating red imported fire ants using Cinnamomum osmophloeum leaf essential oil. Bioresource Technology 99(4): 889–893. Cheng, S. S., M. J. Chung, Y. J. Chen and S. T. Chang (2011) Antipathogenic activities and chemical composition of Cinnamomum osmophloeum and Cinnamomum zeylanicum leaf essential oils. Journal of Wood Chemistry and Technology 31: 73–87. Costall B., B. J. Jones, M. E. Kelly, R. J. Naylor and D. M. Tomkins (1989) Exploration of mice in a black and white test box: validation as a model of anxiety. Pharmacology Biochemistry and Behavior 32: 777–785. Crawley J. N. and F. K. Goodwin (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacology Biochemistry and Behavior 13: 167–170. Crusio, W. E. and R. T. Gerlai (1999) Handbook of Molecular - Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences), Elsevier, Amsterdam. pp. 739–749. Cseke, L. J., P. B. Kaufman and A. Kirakosyan (2007) The biology of essential oils in the pollination of flowers. Natural Product Communications 2(12): 1317–1336. Dauer, W. and S. Przedborski (2003) Parkinson’s disease: mechanisms and model. Neuron 39: 889–909. Dotterl, S., D. Burkhardt, B. Weissbecker, A. Jurgens, S. Schutz and A. Mosandl (2006) Linalool and lilac aldehyde/alcohol in flower scents - electrophysiological detection of lilac aldehyde stereoisomers by a moth. Journal of Chromatography 1113(1-2): 231–238. Elisabetsky, E., G. P. Coelho De Souza, M. A. C. Dos Santos, I. R. Siquieira and T. A. Amador (1995) Sedative properties of linalool. Fitoterapia 66: 407–414. Elisabetsky, E., L. F. Silva Brum and D. O. Souza (1999) Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine 6: 107–113. Ford, R. A., B. Domeyer, O. Easterday, K. Maier and J. Middleton (2000) Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 31: 166–181. File, S. E. (1990) Age and anxiety: increased anxiety, decreased anxiolytic, but enhanced sedative, response to chlordiazepoxide in old rats. Human Psychopharmacology 5: 169–173. Frank, C., A. Dietrich, U. Kremer and A. Mosandl (1995) GC-IRMS in the authenticity control of the essential oil of Coriandrum sativum. Journal of Agricultural and Food Chemistry 43: 1634–1637. Galdino, P. M., M. V. Nascimento, I. F. Florentino, R. C. Lino, J. O. Fajemiroye, B. A. Chaibub, J. R. de Paula, T. C. de Lima and E. A. Costa (2012) The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 38: 276–284. Gaydou, E. M., R. Randriamiharisoa and J. P. Bianchini (1986) Composition of the essential oil of ylang-ylang (Cananga odorata Hook Fil. et Thomson forma genuina) from Madagascar. Journal of Agricultural and Food Chemistry 34: 481–487. Hall, C. S. (1934) Emotional behavior in the rat: I. Defecationand urination as measures of individual differences in emotionality. Journal of Comparative Psychology 18(3): 385–403. Heuberger, E., T. Hongratanaworakit, C. Bohm, R. Weber and G. Buchbauer (2001) Effects of chiral fragrances on human autonomic nervous system parameters and self-evaluation. Chemical Senses 26: 281–292. Holla, M., E. Svajdlenka, J. Tekel, S. Vaverkova and E. Havranek (1997) Composition of the essential oil from Melissa officinalis L. cultivated in Slovak Republic. Journal of Essential Oil Research 9: 481–484. Hsieh, M. T., W. H. Peng and C. C. Hsieh (1994) Effects of DL-tetrahydropalmatine on motor activity and the brain monoamine concentration in rats. The Chinese Journal of Physiology 37: 79–82. Huang, T. C., H. Y. Fu, C. T. Ho, D. Tan, Y. T. Huang and M. H. Pan (2007) Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh. through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food Chemistry 103(2): 434–443. Jellinek, J. S. (1997) Psychodynamic odor effects and their mechanisms. Cosmetics and Toiletries 112: 61–71. Jenner, P. M., E. C. Hagan, J. M. Taylor, E. L. Cook and O. G. Fitzhugh (1964) Food flavorings and compounds of related structure I. Acute oral toxicity. Food and Chemical Toxicology 2: 327–343. Johnson, S. D., A. Ellis and S. Dotterl (2007) Specialization for pollination by beetles and wasps: the role of lollipop hairs and fragrance in Satyrium microrrhynchum (Orchidaceae). American Journal of Botany 94(1): 47–55. Jun, H. J., J. H. Lee, J. Kim, Y. Jia, K. H. Kim, K. Y. Hwang, E. J. Yun, K. R. Do and S. J. Lee (2014) Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. Journal of Lipid Research 55: 1098–1100. Kuroda, K., N. Inoue, Y. Ito, K. Kubota, A. Sugimoto and T. Kakuda (2005) Sedative effects of the jasmine tea odor and (R)-(−)-linalool, one of its major odor components, on autonomic nerve activity and mood states. European Journal of Applied Physiology 95: 107–114. Lapczynski A, C. S. Letizia and A. M. Api (2008) Fragrance material review on d-linalool. Food and Chemical Toxicology 46: S193–S194. Lapczynski A, C. S. Letizia and A. M. Api (2008) Fragrance material review on l-linalool. Food and Chemical Toxicology 46: S195–S196. Lee, H. C., S. S. Cheng and S. T. Chang (2005) Antifungal property of the essential oils and their constituents from Cinnamomum osmophloeum leaf against tree pathogenic fungi. Journal of the Science of Food and Agriculture 85(12): 2047–2053. Letizia, C. S., J. Cocchiara, J. Lalko and A.M. Api (2003) Fragrance material review on linalool. Food and Chemical Toxicology 41: 943–964. Lin, T. Y., J. W. Liao, S. T. Chang and S. Y. Wang (2011) Antidyslipidemic activity of hot-water extracts from leaves of Cinnamomum osmophloeum Kaneh. Phytotherapy Research 21: 1317–1322. Linck V. M., A. L. Silva, M. Figueiro, A. L. Piato, A. P. Herrmann, F. D. Birck, E. B. Caramao, D. S. Nunes, P. R. H. Moreno and E. Elisabetsky (2009) Inhaled linalool-induced sedation in mice. Phytomedicine 16: 303–307. Linck V. M., A. L. Silva, M. Figueiro, E. B. Caramao, P. R. H. Moreno and E. Elisabetsky (2010) Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice. Phytomedicine 17: 679–683. Lister, R. G. (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92: 180–185. Mondello, L., P. Dugo, K. D. Bartle , B. Frere and G. Dugo (1994) On-line high performance liquid chromatography coupled with high resolution gas chromatography and mass spectrometry (HPLC-HRGC-MS) for the analysis of complex mixtures containing highly volatile compounds. Chromatographia 39: 529–538. Montgomery, K. C. (1955) The relation between fear induced by novelty stimulation and exploratory behaviour. Journal of Comparative and Physiological Psychology 48(4): 254–260. Mukherjee P. K., V. Kumar, M. Mal and P. J. Houghton (2007) Acorus calamus: Scientific validation of Ayurvedic tradition from natural resources. Pharmaceutical Biology 45: 651–666. Northover, B. J. and J. Verghese (1962) Pharmacology of certain terpene alcohols and oxides. Journal of Scientific and Industrial Research 21: 342–345. Parke, D.V., K. H. M. Q. Rahman and R. Walker (1974) The absorption, distribution and excretion of linalool in the rat. Biochemical Society Transactions 2: 612–615. Peana, A. T. and M. D. L. Moretti (2002) Pharmacological activities and applications of Salvia sclarea and Salvia desoleana essential oils. Studies in Natural Products Chemistry 26: 391–423. Pellow, S., P. Chopin, S. E. File and M. Briley (1985) Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14: 149–167. Pollard, G. T. and J. L. Howard (1990) Effects of drugs on punished behavior: pre-clinical test for anxiolytics. Pharmacology and Therapeutics 45(3): 403–424. Raguso, R. A. and E. Pichersky (1999) New perspectives in pollination biology: floral fragrances. A day in the life of a linalool molecule: chemical communication in a plant-pollinator system. Part 1: Linalool biosynthesis in flowering plants. Plant Species Biology 14(2): 95–120. Rao, B. R. R., P. N. Kaul, G. R. Mallavarapu and S. Ramesh (1996) Effect of seasonal climatic changes on biomass yield and terpenoid composition of rose-scented geranium (Pelargonium species). Biochemical Systematics and Ecology 24: 627–635. Reaven, G. M. (1993) Role of insulin resistance in human disease (syndrome X): an expanded definition. Annual Review of Medicine 44: 121–131. Rickels, K., R. Downing, E. Schweizer and H. Hassman (1993) Antidepressants for the treatment of generalized anxiety disorder: a placebo-controlled comparison of imipramine, trazodone, and diazepam. Archives of General Psychiatry 50 (11): 884–895. RIFM (Research Institute for Fragrance Materials Inc.) (1967) Acute Toxicity, Eye and Skin Irritation Tests on Aromatic Compounds. Unpublished report from Hoffmann-LaRoche, 20 September. Report number 30642. (RIFM, Woodcliff Lake, NJ, USA). RIFM (Research Institute for Fragrance Materials Inc.) (1984) A 14-Day Single Dose Subacute Toxicity Study in the Rat. Unpublished report from Lorillard Tobacco Company, 12 January. Report number 36660. (RIFM, Woodcliff Lake, NJ, USA). RIFM (Research Institute for Fragrance Materials Inc.) (1992) Linalool and Dehydrolinalool. Acute Toxicity and Local Tolerance. Submission to EPA by Rhone-Poulenc, Inc., 11 September. Document number 23272. (RIFM, Woodcliff Lake, NJ, USA). RIFM (Research Institute for Fragrance Materials Inc.) (2001) Micronucleus Test in Bone Marrow Cells of the Mouse with Linalool. Unpublished report from Hoffmann-LaRoche, 18 November. Report number 38577. (RIFM, Woodcliff Lake, NJ, USA). Romeo, F. V., S. De Luca, A. Piscopo and M. Poiana (2008) Antimicrobial effect of some essential oils. Journal of Essential Oil Research 20(4): 373-379. Sanchez, C. (1995) Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box. Pharmacology and Toxicology 77(1): 71–78. Shackelford, C., G. Long, J. Wolf, C. Okerberg and R. Herbert (2002) Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies. Toxicologic Pathology 30: 93–96. Shen, J., A. Niijima, M. Tanida, Y. Horii, K. Maeda and K. Nagai (2005) Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats. Neuroscience Letters 383: 188–193. Siani, A. S., M. R. Tappin, M. F. Ramos, J. L. Mazzei, M. C. Ramos, F. R. De Aquino Neto and N. Frighetto (2002) Linalool from Lippia alba: study of the reproducibility of the essential oil profile and the enantiomeric purity. Journal of Agricultural and Food Chemistry 12: 3518–3521. Stahl, S. M. (2000) Essential psychopharmacology Neuroscientific basis and practial applications. Cambrige University press, New York. USA. pp. 167–215. Thiebot, M. H., P. Soubrie, M. Hamon and P. Simon (1984) Evidence against the involvement of serotonergic neurons in the anti-punishment activity of diazepam in the rat. Psychopharmacology 82: 355–359. Troy, W. R. (1977) The comparative respiratory irritation potential of fourteen fragrance raw materials. Doctoral dissertation, Private communication to RIFM. Report number 9011. Tschiggerl, C. and B. Franz, (2010) Volatile fraction of lavender and bitter fennel infusion extracts. Natural Product Communications 5(9): 1431–1436. Tung, Y. T., P. L. Yen, C. Y. Lin and S. T. Chang (2010) Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharmaceutical Biology 48(10): 1130–1136. Vander, A. J., J. H. Sherman and D. S. Luciano (2001) Human physiology the mechanisms of body function. Mc Graw-Hill, USA. p. 800. Verzera, A., G. Lamonica, L. Mondello, A. Trozzi and G. Dugo (1996) The composition of bergamot oil. Perfumer & Flavorist 21: 19–34. Vogel, J. R., B. Beer and D. E. Clody (1971) A simple and reliable conflict procedure for testing anti-anxiety agents. Psychopharmacologia 21: 1–7. Wang, S. Y., C. W. Yang, J. W. Liao, W. W. Zhen, F. H. Chu and S. T. Chang (2008) Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice. Phytomedicine 15(11): 940–945. William, N. S. (2009) Essential oils and anxiolytic aromatherapy. Natural Product Communications 4: 1305–1316. Woode, E., E. Boakye-Gyasi, N. Amidu and M. Duwiejua (2010) Anxiolytic and antidepressant effects of a leaf extract of Palisota hirsuta K. Schum. (commelinaceae) in mice. International Journal of Pharmacology 6: 1–17. Yoshiaki, S., H. Chihiro, T. Keiko, F. Tamotsu, N. Ken-ichi, M. Tsutomu and A. Tadashi (1998) Sedative effect on humans of inhalation of essential oil of linalool: Sensory evaluation and physiological measurements using optically active linalools. Analytica Chimica Acta 365: 293–299. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57055 | - |
dc.description.abstract | 伽羅木醇型土肉桂(Cinnamomum osmophloeum Kaneh. ct. linalool)為臺灣特有的土肉桂6種化學品系之一,本研究探討不同植株、不同採收季節及不同成熟度對精油收率、成分和含量的影響。試驗以水蒸餾法萃取伽羅木醇型土肉桂葉子精油,再以氣相層析−質譜儀(GC-MS)分析其成分,並以火焰離子偵測器氣相層析儀(GC-FID)配合異構物管柱確定成分之絕對立體組態及定量成分;另外,本研究也評估不同萃取時間(1 h、2 h、6 h和10 h)對精油收率和成分的影響。試驗結果發現,12株伽羅木醇型土肉桂葉子精油收率之平均值為3.7%,平均Linalool含量為90%,其絕對立體組態為S-(+)-Linalool,在每克絕乾成熟葉子含量平均為31.0 mg。此外,伽羅木醇型土肉桂葉子精油收率和S-(+)-Linalool含量並不會隨著季節氣候的變化而有大幅動的變動,其含量相當穩定,又比較不同成熟度的葉子時,以成熟葉含量較為豐富。同時從不同萃取時間證實,以水蒸餾法萃取精油,只需要1 h即可獲得全部精油及純的S-(+)-Linalool。
本研究進一步以焦慮症動物模式(開放場地試驗、光暗試驗及高腳十字迷宮試驗)評估伽羅木醇型土肉桂葉子精油及其主成分S-(+)-Linalool之抗焦慮活性。將4週齡大的ICR小白鼠,利用口服灌餵高低劑量(500及250 mg/kg)伽羅木醇型土肉桂葉子精油、500 mg/kg S-(+)-Linalool、500 mg/kg R-(−)-Linalool及市售抗焦慮藥物Trazodone hydrochloride(75 mg/kg),連續餵食及記錄體重變化率14天後,進行焦慮症動物模式。動物模式後犧牲小鼠,並立即分析腦組織(大腦皮質前區、海馬迴和紋狀體)神經傳導物質含量及檢測血液中血糖、總膽固醇、三酸甘油酯、Aspartate aminotransferase(AST)和Alanine aminotransferase(ALT)含量差異。試驗結果顯示,伽羅木醇型土肉桂葉子精油及其主成分S-(+)-Linalool,具有降低小鼠在開放場地試驗、光暗試驗及高腳十字迷宮試驗的焦慮情緒,並且不會影響其活動力,而降低焦慮之功效主要源自於小鼠腦組織(大腦前區皮質和海馬迴)的單胺類神經傳遞物質濃度降低;另外,從紋狀體的多巴胺(Dopamine)的濃度增加,可知道伽羅木醇型土肉桂葉子精油及其主成分S-(+)-Linalool具有開發成為改善帕金森氏症病症的潛力。此外餵食S-(+)-Linalool小鼠體重增加率從第9天開始較控制組減少35%及其血液中三酸甘油酯值較控制組下降26%,同時不會增加肝臟、腎臟和脾臟負擔也無臟器病變的發生。綜合上述結果顯示,伽羅木醇型土肉桂葉子精油來源、成分及含量穩定,且具有優良抗焦慮功效,因此具有發展為低成本、低副作用及高品質的抗焦慮食品及保健產品之潛力。 | zh_TW |
dc.description.abstract | Cinnamomum osmophloeum Kaneh. ct. linalool is one chemotype of the indigenous cinnamon in Taiwan. In this study, hydrodistillation was used for extracting the leaf essential oil (LEO) of C. osmophloeum ct. linalool collected from various plants and seasons, and GC-MS and GC-FID were used to examine variations and contents of chemical composition in LEOs. Moreover, the absolute configuration of the main constituent and its content of LEO were illustrated by GC-FID with chiral column. In addition, we also investigated the effect of the extraction time (1 h, 2 h, 6 h, and 10 h) on the yield of LEO and the content of main constituents. Results from this study revealed that the average LEO yield of 12 plants was 3.7%, and there were more than 90% linalool in them. The linalool in the LEO was proved to be pure S-(+)-linalool and its average content in 12 plants is 31.0 mg. Furthermore, there were no obvious differences in LEO yield and S-(+)-linalool content from various plants and seasons, and the mature leaves have more S-(+)-linalool content. On the other hand, we also identified that LEO and S-(+)-linalool from C. osmophloeum ct. linalool leaves can be completely extracted out by 1 h hydrodistillation.
This study recorded the rate of weight changes in mice, and examined the anxiolytic potency of LEO from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice by using the following animal models, including open field test (OFT), light-dark test (LDT) and elevated plus maze test (EPT). After oral administrations of LEO (250 mg/kg and 500 mg/kg), S-(+)-linalool (500 mg/kg), R-(−)-linalool (500 mg/kg) and trazodone hydrochloride (75 mg/kg) for 14 days, their anxiolytic effects on mice behavior were evaluated, and rate of weight changes were recorded. Brain tissue and blood of the mice were collected after sacrifice for analyses. And then, monoamines in brain tissue sample (frontal cortex, hippocampus and striatum) were measured and blood biochemical values (Glucose, Total cholesterol, Triglyceride, Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT)) in mice blood were also assessed. The results showed that LEO from C. osmophloeum ct. linalool and S-(+)-linalool can significantly increase time spending in the center area of OFT, illuminated area of LDT and open arms of EPT without side effects on locomotor activity, indicating excellent anxiolytic responses. It was also found that the levels of the neurotransmitters (serotonin, dopamine and norepinephrine) decreased in frontal cortex and hippocampus, which could result in the anxiolytic effects in animal models. In addition, mice administrated LEO from C. osmophloeum ct. linalool and S-(+)-linalool have increased the level of dopamine in striatum, indicating that LEO from C. osmophloeum ct. linalool and S-(+)-linalool could be used in Parkinson's disease treatment. We also found that body weight and triglyceride levels of mice after oral administration of S-(+)-linalool was less than control group. The injuries of liver and organ in mice were not observed in this study. The finding obtained suggested that LEO from C. osmophloeum ct. linalool and its major compound, S-(+)-linalool, possess anxiolytic properties without any side effects and thus support their potential uses as cheap and safe additives and health products with anxiolytic effects. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T06:33:49Z (GMT). No. of bitstreams: 1 ntu-103-R98625038-1.pdf: 4261780 bytes, checksum: 82815be529423e52ebe470890df6e3eb (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 目 錄 I
表目錄 V 圖目錄 VIII 摘 要 XIII Abstract XV 壹、前言 1 貳、文獻回顧 4 一、伽羅木醇 4 (一)伽羅木醇之基本資料 4 (二)伽羅木醇在植物中的功能 8 (三)伽羅木醇之生物活性 9 1. 鎮靜活性 9 2. 抗驚厥活性 10 3. 誘導睡眠活性 10 (四)伽羅木醇於動物體中之代謝 10 (五)伽羅木醇之毒理學 11 1. 口服急毒性 11 2. 皮膚急毒性 12 3. 腹腔注射急毒性 12 4. 其他急毒性 13 (六)R-form和S-form伽羅木醇對人生理與心理影響之差異 14 二、焦慮症 17 (一)焦慮症分類 17 1. 恐慌性焦慮症 18 2. 強迫症型焦慮症 18 3. 廣泛性焦慮症 18 4. 創傷後壓力症 18 5. 畏懼性焦慮症 19 (二)焦慮症治療方法 19 (三)評估焦慮之動物模式 19 1. 開放場地試驗 19 2. 蓋勒–賽福德衝突試驗 20 3. 社會互動試驗 21 4. 光暗試驗 21 5. 高腳十字迷宮試驗 22 6. 渴鼠衝突試驗 23 參、材料與方法 24 一、試驗材料 24 (一)伽羅木醇型土肉桂 24 (二)藥品化合物 25 (三)試驗動物 26 二、試驗方法 26 (一)精油萃取 26 (二)伽羅木醇型土肉桂葉子精油成分之鑑定 27 (三)伽羅木醇絕對立體組態之鑑定 27 1. 火焰離子偵測器氣相層析儀分析 27 2. 旋光光度儀測定 28 (四)伽羅木醇型土肉桂葉子精油成分之分離及純化 28 (五)伽羅木醇型土肉桂葉子精油中S-(+)-Linalool之定量 29 (六)動物試驗 29 1. 動物分組 29 2. 開放場地試驗 30 3. 光暗試驗 30 4. 高腳十字迷宮試驗 30 5. 小鼠犧牲 31 6. 腦部神經傳導物質含量分析 31 (1)腦組織中單胺物質之萃取 31 (2)單胺類神經傳導物質之分析 32 7. 血液生化分析 32 8. 臟器組織切片之檢查 33 三、統計分析 35 肆、結果與討論 36 一、伽羅木醇型土肉桂葉子精油之化學分析 36 (一)伽羅木醇型土肉桂葉子精油中伽羅木醇之絕對立體組態鑑定 36 (二)12株伽羅木醇型土肉桂葉子精油收率及其主成分分析 38 (三)不同季節採收之伽羅木醇型土肉桂葉子精油收率及成分分析 42 (四)萃取時間對伽羅木醇型土肉桂葉子精油成分含量之影響 44 (五)萃取次數對伽羅木醇型土肉桂葉子精油成分含量之影響 48 (六)葉片成熟度對伽羅木醇型土肉桂葉子精油成分含量之影響 52 二、伽羅木醇型土肉桂葉子精油對小鼠心理及生理之影響 56 (一)伽羅木醇型土肉桂葉子精油對小鼠焦慮之影響 56 1. 伽羅木醇型土肉桂葉子精油對小鼠自發行為之影響(開放場地試驗) 56 2. 伽羅木醇型土肉桂葉子精油對小鼠焦慮之影響(光暗試驗) 59 3. 伽羅木醇型土肉桂葉子精油對小鼠焦慮之影響(高腳十字迷宮試驗) 61 4. 伽羅木醇型土肉桂葉子精油對小鼠腦神經傳導物質之影響 63 (二)伽羅木醇型土肉桂葉子精油對小鼠生理變化之影響 67 1. 伽羅木醇型土肉桂葉子精油對小鼠體重變化之影響 67 2. 伽羅木醇型土肉桂葉子精油對小鼠總膽固醇、三酸甘油酯、血糖及血清肝指數變化之影響 69 3. 伽羅木醇型土肉桂葉子精油對小鼠肝臟、腎臟和脾臟之影響 72 伍、結論 79 陸、參考文獻 81 附錄 1 植物中的伽羅木醇 93 附錄 2 個別小鼠之組織病理變化 97 | |
dc.language.iso | zh-TW | |
dc.title | 伽羅木醇型土肉桂葉子精油之抗焦慮活性 | zh_TW |
dc.title | Anxiolytic Activity of Leaf Essential Oil
from Cinnamomum osmophloeum ct. linalool | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蘇裕昌(Yu-Chang Su),王升陽(Sheng-Yang Wang),何政坤(Cheng-Kuen Ho),沈立言(Lee-Yan Sheen) | |
dc.subject.keyword | 絕對立體組態鑑定,抗焦慮活性,伽羅木醇型土肉桂,保健產品,葉子精油,S-(+)-Linalool,單胺類神經傳導物質, | zh_TW |
dc.subject.keyword | Absolute configuration,Anxiolytics,Cinnamomum osmophloeum Kaneh. ct. linalool,Health products,Leaf essential oil,S-(+)-Linalool,Neurotransmitters, | en |
dc.relation.page | 98 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-08-04 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 森林環境暨資源學研究所 | zh_TW |
顯示於系所單位: | 森林環境暨資源學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-103-1.pdf 目前未授權公開取用 | 4.16 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。