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標題: | 光敏樹脂暨生物支架之雙光子吸收光致聚合製作參數與特性分析 A parametric and characteristic analysis of two-photon polymerization resin and bio-scaffold |
作者: | Eric Dowkon Huang 黃道康 |
指導教授: | 單秋成(Chow-Shing Shin) |
關鍵字: | 雙光子吸收光致聚合,機械性質,楊氏係數,生物支架, Two-Photon absorption Polymerization (TPP),mechanical property(ies),Young’s Modulus,(bio-)scaffold, |
出版年 : | 2014 |
學位: | 碩士 |
摘要: | 雙光子吸收光致聚合(TPP)可被用於微製造。這種微製造可以精確地製造出微米或次微米等級,形狀複雜的三維立體微結構,是微機電系統製造的一個非常實用,且已經達到一定成熟度的技術。目前國內外這方面的研究大多集中在開發適當的光敏樹脂原料、雷射功能的控制、各種形狀複雜的微機械的可製作性,以及這些微(機械)結構的各式新穎的應用(如:微流道晶片和生物支架)。至於有關這些微結構的機械性質探討,則仍然十分缺乏。然而要進一步設計有實務應用能力的微(機械)結構,一個很重要前提是要能夠具體地掌握雙光子吸收光致聚合所製作出來的結構的機械性質。目前TPP產品的機械性質大多仰賴原廠商所提供原本樹脂的各項數據,但目前已經有研究顯示樹脂經過TPP製程之後,其機械性質可能有相當大的改變。然而,針對TPP結構的機械性質測試方法仍缺乏研究,因此各種製程參數對TPP結構的影響以及如何製作具有較佳性質結構的方法仍不是十分清楚。又因TPP所能製造的結構尺寸有其限制,所以無法使用傳統的機械性質測試方法(如拉伸試驗、斷裂測試等)來測量TPP結構的楊氏係數。有鑑於此,本研究的目的為嘗試量測樹脂經TPP製作後其結構的楊氏係數,並探討一些參數(如雷射聚焦點的重疊幅度、UV曝光時間)對楊氏係數的影響。而近年來TPP也常被用於製作生物支架來作為培養細胞相關的使用,然而對於生物支架的機械性質研究也仍缺乏,因此本研究的後半部則嘗試探討並使用有限元素法來分析生物支架的一些製程參數,並希望能作為之後製作生物支架時的參考準則。
關鍵詞:雙光子吸收光致聚合(TPP)、機械性質、楊氏係數、生物支架 Abstract Two-Photon absorption Polymerization (TPP) can be used for micro-structures’ production, which allows accurate manufacturing of complicated three-dimensional structures at the micron or sub-micron levels. It has become well developed enough to offer a reliable fabrication method for micro electro-mechanical systems. Previous researches on TPP were mainly concentrated on the development of photosensitive resins, control of fabrication laser beams, capability of the fabrication of complicated structures and possible new applications (ex. Micro-fluidic chips and bio-scaffolds) of TPP. On the other hand, as to the mechanical properties of the micro-structures, few researches had been done. However, to design a practical machine component with reasonable structural integrity, reliability and functional operability, the mechanical properties must be known. For now, mechanical properties for the resins rely much on the data given by the factory which produces the resins. However, there are researches indicate that after the TPP process, the mechanical properties of the resins might change a lot. Because TPP fabrication has its limitation on the size of the structure, which makes the conventional mechanical testing methods impossible to be applied, and the lacking of the researches about the mechanical properties, the objective of this research is to measure the Young’s Modulus of the structure after the TPP process, and to understand the relationships between Young’s Modulus and some parameters during the production. Moreover, recently TPP is also used for manufacturing the bio-scaffold for the cell culture, but the researches on the mechanical properties of the bio-scaffold are also not enough. So the other half of this research is trying to understand and analyze some mechanical behavior and parameters of the bio-scaffold by Finite Element Method (FEM), and hope to give some ideas to later the production of the bio-scaffold. Keywords: Two-Photon absorption Polymerization (TPP), mechanical property(ies), Young’s Modulus, (bio-)scaffold |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56741 |
全文授權: | 有償授權 |
顯示於系所單位: | 機械工程學系 |
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