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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭尊仁(Tsun-Jen Cheng) | |
| dc.contributor.author | Szu-Yuan Liu | en |
| dc.contributor.author | 劉思源 | zh_TW |
| dc.date.accessioned | 2021-06-16T05:37:54Z | - |
| dc.date.available | 2017-10-20 | |
| dc.date.copyright | 2014-10-20 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-12 | |
| dc.identifier.citation | 1. Agency, U.S.E.P., Air quality criteria for particulate matter. National Center for Environmental Assessment-RTP Office, 2004.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56614 | - |
| dc.description.abstract | 近年來空氣汙染造成的健康效應備受矚目。大氣懸浮微粒是空氣汙染中主要的汙染物，也被視為造成健康危害的元凶之一。過去大氣懸浮微粒健康效應之研究已有大量文獻，然而目前的研究對於細小粒徑之微粒(PM1、PM0.1)仍有待探討，尤其目前對於不同粒徑微粒之呼吸毒性及微粒造成過敏性免疫反應的相關研究仍有所缺乏，故本研究比較不同粒徑間以及微粒上成份造成之毒性進行探討。
本研究將蒐集於濾紙上之大氣懸浮微粒配製成懸浮溶液，以氣管灌注暴露方式，使健康小鼠暴露於大氣懸浮微粒，實驗分成五大組，分別為控制組、暴露超細懸浮微粒、暴露次微米懸浮微粒、暴露細懸浮微粒、暴露粗懸浮微粒並且依粒徑之不同分別暴露三種不同劑量之大氣懸浮微粒(1.75 mg/kg、5 mg/kg、12.5 mg/kg)。本研究於第二次暴露後進行連續二十四小時尿液採集，並且於四十八小時後進行呼吸道阻力測試，於七十二小時後進行動物犧牲。犧牲時進行血液樣本與肺泡灌洗液採集，並進行細胞計數、生化指標之分析。 本研究所採集之微粒特性，在粒徑較大者(PM1、PM2.5及PM10)其組成成分以硫酸根離子為主其餘為銨根離子與無機金屬離子。在最小微粒者(PM0.1)以有機碳與元素碳為主。於肺部發炎反應部分，微粒暴露後會造成肺泡灌洗液中嗜中性球、淋巴球之數量上升以及肺部發炎指標包含Th1 細胞相關激素TNF-α, IFN-γ及IL-6與總蛋白質含量及Th17之細胞激素IL-17A 之上升，過敏性免疫反應部份，指標包含嗜酸白血球，第二型輔助T細胞相關激素IL-5, IL-10及IL-13具有明顯上升，以整體趨勢而言皆以大粒徑之粗懸浮微粒(PM10)反應最為顯著。以成分而言，細菌內毒素以及海鹽相關離子Na+、Mg2+、Ca2+、Cl-與發炎反應、過敏性免疫反應具有高度相關性。 本研究提供不同粒徑微粒與微粒成分在呼吸毒理上的相關探討，並且對於未來在超細粒徑懸浮微粒毒理議題上提供相關資料。但毒性相關的微粒成份及微粒來源仍須後續深入研究。 | zh_TW |
| dc.description.abstract | Evidence suggests that particulate matter (PM) is associated with cardiopulmonary effect and exacerbation of asthma. However, it is unclear whether repeated exposure to PM would cause inflammatory and immunological effects.
The aim of this study is to evaluate the effects of size-fractioned PM on lung inflammation and immune responses in healthy BALB/c mice. We collected PM10, PM2.5, PM1 and PM0.1 from October 2012 to August 2013 at Gongguan, Taipei. These particles represented urban traffic pollution. Samples were extracted and sonicated with phosphate-buffered saline (PBS). Female BALB/c mice exposed to PM10, PM2.5, PM1, PM0.1 and PBS via intratracheal instillation with three doses of 1.75 mg/kg (35μg/per mice), 5mg/kg (100 μg/per mice), 12.5mg/kg (250 μg/per mice). After exposures, cellular profile of plasma and expression of inflammation biomarkers, immune cytokines in bronchoalveolar lavage fluid (BALF), and pulmonary responses were assessed. PM increased inflammatory responses including neutrophils, T helper 1 cell related cytokines, TNF-α, IFN-γ. Allergic immune responses including eosinophils, T helper 2 cell related cytokines, IL-5, IL-10, IL-13, IL-17A were also increased in BALF. These inflammatory and allergic immune markers were greater in PM10 high dose group.We also found that endotoxin, Na+, Mg2+, Ca2+ and Cl- were correlated with pulmonary inflammation and immune response. Our results indicated that exposure to particulate matter would cause allergy-like immune responses in healthy mice. However the components of PM suspension for these immune responses needs further study. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T05:37:54Z (GMT). No. of bitstreams: 1 ntu-103-R01841015-1.pdf: 6806815 bytes, checksum: 5323d7157142b6525804b8dcaa43a26b (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 目錄
誌謝 i 目錄 ii 表目錄 iv 圖目錄 v 中文摘要 1 ABSTRACT 2 第一章 前言與研究目的 3 第二章 背景介紹與文獻回顧 4 2.1 大氣懸浮微粒 4 2.2 微粒健康效應與流行病學研究 5 2.3 微粒粒徑毒性與成份毒性 6 2.4 超細粒徑大氣懸浮微粒毒性 8 2.5 過敏免疫反應與第二型輔助T細胞 9 2.6 過敏性呼吸道疾病 10 第三章 材料與方法 12 3.1 研究架構 12 3.2 研究流程 12 3.3 研究設計 13 3.4 實驗動物 13 3.5 微粒採集與成份特性分析 13 3.6 大氣微粒懸浮溶液製備 14 3.7 氣管灌注暴露 15 3.8 血液及肺泡灌洗液採集 15 3.9 肺部傷害與發炎指標 16 3.10 免疫反應評估 16 3.11 氣道過度反應測試 16 3.12 細菌內毒素測定 17 3.13 統計分析 17 第四章 結果.. 18 4.1 微粒特性與成分分析 18 4.2 氣道過度反應 19 4.3 肺部傷害與發炎指標 19 4.4 過敏免疫反應指標 20 4.5 微粒成份與發炎免疫指標相關性 20 4.6 內毒素測定 21 第五章 討論.. 22 5.1 微粒特性與成分分析 22 5.2 大氣懸浮微粒之肺部發炎損傷 23 5.2.1 粒徑成份對於肺部發炎損傷探討 24 5.3 大氣懸浮微粒與過敏性免疫反應 26 5.3.1 粒徑與成分對於過敏性免疫反應探討 28 5.3.2 過敏性免疫反應與呼吸道阻抗 29 第六章 結論與建議 30 參考文獻…… 31 表目錄 表 1大氣懸浮微粒肺部毒性動物研究 39 表 2大氣懸浮微粒與過敏性動物之毒性研究 40 表 3不同大氣懸浮微粒粒徑研究比較 41 表 4大氣懸浮微粒特性與化學成份 42 表 5大氣懸浮微粒暴露後之氣道過度反應測試結果 43 表 6呼吸道阻力Penh值相對增加倍數 44 表 7肺泡灌洗液中總細胞數、血球分類計數 45 表 8肺泡灌洗液中發炎相關細胞激素濃度 46 表 9血清中免疫球蛋白濃度與肺泡灌洗液中過敏性免疫相關細胞激素濃度 47 表 10發炎指標微粒成份相關性分析 48 表 11過敏性免疫指標微粒成份相關性分析 49 表 12微粒成份相關性分析 50 表 13等劑量濃度下內毒素活性濃度與各成份質量 51 圖目錄 圖 1秋季大氣懸浮微粒化學組成比例 52 圖 2綜合三季大氣懸浮微粒化學組成比例 53 圖 3 PM10與PM2.5 SEM結果 54 圖 4 PM1與PM0.1 SEM結果 55 圖 5 PM10、PM2.5與PM1 EDX成份分析結果 56 圖 6 PM0.1之呼吸道阻力Penh值相對增加比例 57 圖 7 PM1之呼吸道阻力Penh值相對增加比例 57 圖 8 PM2.5之呼吸道阻力Penh值相對增加比例 58 圖 9 PM10之呼吸道阻力Penh值相對增加比例 58 圖 10低劑量組之呼吸道阻力Penh值相對增加比例 59 圖 11中劑量組之呼吸道阻力Penh值相對增加比例 59 圖 12高劑量組之呼吸道阻力Penh值相對增加比例 60 圖 13嗜中性球於肺泡灌洗液中比率 61 圖 14嗜酸性球於肺泡灌洗液中比率 61 圖 15巨噬細胞於肺泡灌洗液中比率 62 圖 16淋巴球於肺泡灌洗液中比率 62 圖 17免疫球蛋白於血清中之濃度 63 圖 18 IL-6於血清中之濃度 63 圖 19 IFN-γ於肺泡灌洗液中之濃度 64 圖 20 TNF-α於肺泡灌洗液中之濃度 64 圖 21 IL-4於肺泡灌洗液中之濃度 65 圖 22 IL-5於肺泡灌洗液中之濃度 65 圖 23 IL-6於肺泡灌洗液中之濃度 66 圖 24 IL-10於肺泡灌洗液中之濃度 66 圖 25 IL-13於肺泡灌洗液中之濃度 67 圖 26 IL-17A於肺泡灌洗液中之濃度 67 圖 27懸浮溶液中內毒素活性濃度 68 | |
| dc.language.iso | zh-TW | |
| dc.subject | 空氣汙染 | zh_TW |
| dc.subject | 大氣懸浮微粒 | zh_TW |
| dc.subject | 肺部發炎 | zh_TW |
| dc.subject | 過敏性免疫反應 | zh_TW |
| dc.subject | Particulate matter | en |
| dc.subject | Lung inflammation | en |
| dc.subject | T helper 2 type immune response | en |
| dc.title | 大氣懸浮微粒粒徑對小鼠之呼吸毒理研究 | zh_TW |
| dc.title | Inhalation Toxicity of Size-Segregated Ambient Particulate Matter in BALB/c Mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 吳焜裕(Kuen-Yuh Wu),周崇光(Charles C.-K. Chou),李珍珍(Chen-Chen Lee) | |
| dc.subject.keyword | 空氣汙染,大氣懸浮微粒,肺部發炎,過敏性免疫反應, | zh_TW |
| dc.subject.keyword | Particulate matter,Lung inflammation,T helper 2 type immune response, | en |
| dc.relation.page | 68 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-08-12 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
| 顯示於系所單位： | 職業醫學與工業衛生研究所 | |
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