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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56312完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 趙福杉 | |
| dc.contributor.author | Wei-Yi Ho | en |
| dc.contributor.author | 何威毅 | zh_TW |
| dc.date.accessioned | 2021-06-16T05:22:59Z | - |
| dc.date.available | 2019-08-25 | |
| dc.date.copyright | 2014-08-25 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-14 | |
| dc.identifier.citation | [1] Mayo NE, Wood-Dauphinee S, Cote R, Durcan L, & Carlton J. Activity, Participation, and Quality of Life 6 Months Poststroke. Archives of Physical Medicine and Rehabilitation. 2002;83(8):1035-42.
[2] Facts and figures at a glance (2013) National Spinal Cord Injury Statistical Centre, University of Alabama at Birmingham website. Available at https://www.nscisc.uab.edu/PublicDocuments/fact_figures_docs/Facts%202013.pdf. Accessed 14th Feb. 2014. [3] Samar Hamid, & Ray Hayek. Role of electrical stimulation for rehabilitation and regeneration after spinal cord injury: an overview. European Spine Journal. 2008;17:1256–1269. [4] Barbara M. Doucet, Amy Lam, Lisa Griffin. Neuromuscular Electrical Stimulation for Skeletal Muscle Function. Yale Journal of Biology and Medicine. 2012;85:201-215. [5] Liberson W, Holmquest H, Scot D, & Dow M. Functional electrotherapy: stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients. Archives of Physical Medicine and Rehabilitation. 1961;42:101. [6] Kralj A, Bajd T, & Turk R. Use of functional electrical stimulation in the rehabilitation of patients with incomplete spinal injury. Journal of Biomedical Engineering. 1989;11(2):96–102. [7] Bijak M, Rakos M, Hofer C, Mayr W, Strohhofer M, & Raschka D. Stimulation parameter optimization for FES supported standing up and walking in SCI patients. Journal of Artificial Organs. 2005;29(3):220-223. [8] Davis R, Eckhouse J, & Patrick J. Computerised 22 channel stimulator for limb movement. Applied Neurophysiology. 1987;50:444–448. [9] G. B. Thrope, P. H. Peckham, & P. E. Crago. A computer-controlled multichannel stimulation system for laboratory use in functional neuromuscular stimulation. IEEE Transactions on Biomedical Engineering. 1985;32(6):363-370. [10] J. R. Buckett, P. H. Peckham, G. B. Thrope, S. D. Braswell, and M.W. Keith. A flexible, portable system for neuromuscular stimulation in the paralyzed upper extremity. IEEE Transactions on Biomedical Engineering. 1988;35:897-904. [11] Baker LL, Bowman BR, McNeal DR. Effects of waveform on comfort during neuromuscular electrical stimulation. Clinical Orthopaedics and Related Research. 1988;233:75-85. [12] Chih-Wei Peng, Shih-Ching Chen, Chien-Hung Lai, Chao-Jung Chen, Chien-Chih Chen, JosephMizrahi, & Yasunobu Handa. Review: Clinical Benefits of Functional Electrical Stimulation Cycling Exercise for Subjects with Central Neurological Impairments. Journal of Medical and Biological Engineering. 2011;31(1):1-11. [13] P. Hunter Peckham and David B . Gray. Functional neuromuscular stimulation. Journal of Rehabilitation Research and Development. 1996;33:2. [14] P. Hunter Peckham, & Jayme S. Knutson. Functional electrical stimulation for neuromuscular applications. Annual Review of Biomedical Engineering. 2005;7:327(60). [15] Xavier Navarro,Thilo B. Krueger, Natalia Lago, Silvestro Micera,Thomas Stieglitz, & Paolo Dario. A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems. Journal of the Peripheral Nervous System. 2005;10:229-258. [16] Han-Chang Wu, Shuenn-Tsong Young, & Te-Son Kuo. A Versatile multichannel direct-synthesized electrical stimulator for FES applications. IEEE Transactions on Instrumentation and measurement. 2002;5(1). [17] R. J. Weber. “Functional neuromuscular stimulation”, in Rehabilitation Medicine: Principles and Practice. Philadelphia, PA: Lippincott, 1993. [18] J. Millar, & T.G. Barnett. Isolated contant-current stimulation circuits for neuroscience applications. Journal of Neuroscience Methods. 1988;24:81-87. [19] J. Millar, T.G. Barnett, & S.J. Trout. The neurodyne: a simple mains-powered constant-current stimulus isolator. Journal of Neuroscience Methods. 1994;55:53-57. [20] Neil Zhao, Reem Malik, & Wenshuai Liao. Difference amplifier forms heart of precision current source. Analog Dialogue 43-09 Back Burner. 2009. [21] 林家名。骨痂延長術與肌腱、韌帶力量量測系統。臺灣大學醫學工程學研究所碩士論文。2002。 [22] Wikipedia. Rheobase. Available at http://en.wikipedia.org/wiki/Rheobase. Accessed 1st Apr. 2014. [23] Binder-Macleod SA, Lee SC, Russ DW, & Kucharski LJ. Effects of activation pattern on human skeletal muscle fatigue. Muscle Nerve. 1998;21(9):1145-1152. [24] L Diaz Rodriguez, M Varga, J K Wolter, & U Pliquett. Impedance as guidance for electrode placement in intraoperative monitoring of nerve fibers.Journal of Physics: Conference Series 434 012025. 2013. [25] Z. P. Fang, & J. T. Mortimer. Selective activation of small motor axons by quasitrapezoidal current pulses. IEEE Transactions on Rehabilitation Engineering. 1991;38:168-172. [26] William F. Agnew, Douglas B. McCreery, Ted G.H. Yuen, & Leo A. Bullara. Histologic and physiologic evaluation of electrically stimulated peripheral nerve: considerations for the selection of parameters. Annals of Biomedical Engineering. 1989;17:39-60. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56312 | - |
| dc.description.abstract | 脊髓損傷(Spinal Cord Injury)造成肌肉癱瘓而使傷者無法完成坐到站(Sit-to-stand)，此為日常生活中最常使用到的動作之一。周邊神經電刺激(Peripheral Nerve Stimulation, PNS)可被用以改善及恢復肌肉的功能，可使肌肉達到最大收縮(Maximal Contraction) – 完成坐到站之前提，然而，其安全性及電刺激參數和肌肉收縮力量之關係尚不清楚。本研究實現一可程式化神經電刺激器，藉由可任意調整參數如電流強度、頻率、Pulse Duration及Burst Duration之特性，以及結合微小化的力感測裝置計算肌肉收縮力量，在牛蛙動物實驗中，找到一組最低能量電刺激參數使肌肉達到最大收縮(Maximal Contraction, MC)，此參數為1 Hz，0.327 mA，6 ms Burst Duration，1 ms Pulse Duration，448.54 μJ。 | zh_TW |
| dc.description.abstract | Patients with spinal cord injuries lose their motor control and cannot transfer from sit to stand motion, which is of great importance for mobility and independence in daily life. To assist transfer, maximal contraction of lower limb muscles are necessary and can be achieved by peripheral nerve stimulation. However, the relation between stimulating parameters and force of contraction is not known. In our research, a programmable electrical nerve stimulator with a bi-phasic, constant-current output and a miniaturized force measurement device are implemented. Parameters such as current amplitude, frequency, burst duration, and pulse duration can be adjusted arbitrarily. In animal experiment of bullfrogs, a set of stimulating parameters, 1 Hz, 0.327 mA, 6 pulses with pulse duration of 1 ms, and 448.54 μJ, is found to achieve maximal contraction of gastrocnemius with minimal energy delivery. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T05:22:59Z (GMT). No. of bitstreams: 1 ntu-103-R01548005-1.pdf: 2347159 bytes, checksum: 5d2259879a717ddd1c72e21650a854ab (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 致謝 i
摘要 ii Abstract iii 目錄 iv 圖目錄 vi 表目錄 vii 一、前言 1 二、研究目的 3 三、實驗設計 4 3.1 可程式化神經電刺激系統 4 3.1.1 電刺激系統考量 4 3.1.2 電刺激系統架構 5 3.1.2.1 Altera DE2 5 3.1.2.2 數位類比轉換介面 5 3.1.2.3 光隔離介面 7 3.1.2.4 定電流源輸出介面 8 3.1.2.5 Neural Interface 9 3.2 力量量測系統 10 3.3 動物實驗設計 13 3.3.1 實驗動物準備 13 3.3.2 實驗步驟 13 四、結果 15 4.1 電刺激系統 15 4.1.1 電刺激系統參數定義 16 4.1.2 電刺激系統校正 18 4.2 力量量測系統校正 19 4.3 動物實驗 20 4.3.1 刺激電流之選擇 20 4.3.2 Maximal Contraction之定義 21 4.3.3 Strength Duration Curves with different percentages of MC 22 4.3.4 Energy Duration Curves with different percentages of MC 23 五、討論 25 5.1 電刺激系統 25 5.2 動物實驗 27 六、結論 28 七、未來展望 29 參考文獻 30 | |
| dc.language.iso | zh-TW | |
| dc.subject | 最小能量傳遞 | zh_TW |
| dc.subject | 脊髓損傷 | zh_TW |
| dc.subject | 坐到站 | zh_TW |
| dc.subject | 周邊神經電刺激 | zh_TW |
| dc.subject | 最大收縮 | zh_TW |
| dc.subject | Minimal energy delivery | en |
| dc.subject | Sit-to-stand | en |
| dc.subject | Peripheral nerve stimulation | en |
| dc.subject | Maximal contraction | en |
| dc.subject | Spinal cord injury | en |
| dc.title | 可程式化神經電刺激器-最小能量傳遞達到最大收縮 | zh_TW |
| dc.title | Programmable electrical nerve stimulator for maximal contraction with minimal energy delivery | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭德盛,黃基礎,謝建興,曾乙立,廖文劍 | |
| dc.subject.keyword | 脊髓損傷,坐到站,周邊神經電刺激,最大收縮,最小能量傳遞, | zh_TW |
| dc.subject.keyword | Spinal cord injury,Sit-to-stand,Peripheral nerve stimulation,Maximal contraction,Minimal energy delivery, | en |
| dc.relation.page | 33 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-08-15 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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