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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 王儷穎(Li-Ying Wang) | |
dc.contributor.author | Pei-Yu Yang | en |
dc.contributor.author | 楊佩瑜 | zh_TW |
dc.date.accessioned | 2021-06-16T05:10:26Z | - |
dc.date.available | 2019-10-09 | |
dc.date.copyright | 2014-10-09 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-19 | |
dc.identifier.citation | Eatmon S. Cancer: An overview. In: Washington CM, Leaver D, editors. Principles and Practice of Radiation Therapy. 3rd ed. St. Louis (MO): Mosby Elsevier;2010:3-21.
2 衛生福利部國民健康署。中華民國100年癌症登記報告。2014。 3 Vonkadich AC. Overview of radiobiology. In: Washington CM, Leaver D, editors. Principles and Practice of Radiation Therapy. 3rd ed. St. Louis (MO): Mosby Elsevier;2010:57-85. 4 Ikushima H. Radiation therapy: State of the art and the future. J Med Invest 2010;57:1-11. 5 Purdy JA. Dose to normal tissues outside the radiation therapy patient's treated volume: A review of different radiation therapy techniques. Health Phys 2008;95:666-76. 6 Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: Therapeutic implications. Curr Med Chem 2009;16:130-43. 7 Khan MY. Radiation-induced changes in skeletal muscle. An electron microscopic study. J Neuropathol Exp Neurol 1974;33:42-57. 8 Schwenen M, Altman KI, Schroder W. Radiation-induced increase in the release of amino acids by isolated, perfused skeletal muscle. Int J Radiat Biol 1989;55:257-69. 9 Hsu HY, Chai CY, Lee MS. Radiation-induced muscle damage in rats after fractionated high-dose irradiation. Radiat Res 1998;149:482-6. 10 Lazarus C, Logemann JA, Pauloski BR, Rademaker AW, Helenowski IB, Vonesh EF, et al. Effects of radiotherapy with or without chemotherapy on tongue strength and swallowing in patients with oral cancer. Head Neck 2007;29:632-7. 11 林芸琤。放射治療對橫膈肌收縮功能之影響及相關機制之探討。臺灣大學物理治療研究所。碩士論文;2012。 12 Singer J, Yelin EH, Katz PP, Sanchez G, Iribarren C, Eisner MD, et al. Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: Impact on exercise capacity and lower extremity function. J Cardiopulm Rehabil Prev 2011;31:111-9. 13 Huang CH, Yang GG, Wu YT, Lee CW. Comparison of inspiratory muscle strength training effects between older subjects with and without chronic obstructive pulmonary disease. J Formos Med Assoc 2011;110:518-26. 14 Gallagher CG, Hof VI, Younes M. Effect of inspiratory muscle fatigue on breathing pattern. J Appl Physiol 1985;59:1152-8. 15 Cohen CA, Zagelbaum G, Gross D, Roussos C, Macklem PT. Clinical manifestations of inspiratory muscle fatigue. Am J Med 1982;73:308-16. 16 De Troyer A, Borenstein S, Cordier R. Analysis of lung volume restriction in patients with respiratory muscle weakness. Thorax 1980;35:603-10. 17 Stahl M, Budach W, Meyer HJ, Cervantes A. Esophageal cancer: Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21 Suppl 5:v46-9. 18 Uramoto H, Nakanishi R, Fujino Y, Imoto H, Takenoyama M, Yoshimatsu T, et al. Prediction of pulmonary complications after a lobectomy in patients with non-small cell lung cancer. Thorax 2001;56:59-61. 19 Gosselink R, De Vos J, van den Heuvel SP, Segers J, Decramer M, Kwakkel G. Impact of inspiratory muscle training in patients with COPD: What is the evidence? Eur Respir J 2011;37:416-25. 20 Keens TG, Chen V, Patel P, O'Brien P, Levison H, Ianuzzo CD. Cellular adaptations of the ventilatory muscles to a chronic increased respiratory load. J Appl Physiol 1978;44:905-8. 21 Tarasiuk A, Scharf SM, Miller MJ. Effect of chronic resistive loading on inspiratory muscles in rats. J Appl Physiol 1991;70:216-22. 22 Wijnhoven HJ, Heunks LM, Geraedts MC, Hafmans T, Vina JR, Dekhuijzen PN. Oxidative and nitrosative stress in the diaphragm of patients with COPD. Int J Chron Obstruct Pulmon Dis 2006;1:173-9. 23 Ariga H, Nemoto K, Miyazaki S, Yoshioka T, Ogawa Y, Sakayauchi T, et al. Prospective comparison of surgery alone and chemoradiotherapy with selective surgery in resectable squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 2009;75:348-56. 24 Tishelman C, Petersson LM, Degner LF, Sprangers MA. Symptom prevalence, intensity, and distress in patients with inoperable lung cancer in relation to time of death. J Clin Oncol 2007;25:5381-9. 25 Wilcox PG, Pardy RL. Diaphragmatic weakness and paralysis. Lung 1989;167:323-41. 26 Morano MT, Araujo AS, Nascimento FB, da Silva GF, Mesquita R, Pinto JS, et al. Preoperative pulmonary rehabilitation versus chest physical therapy in patients undergoing lung cancer resection: A pilot randomized controlled trial. Arch Phys Med Rehabil 2013;94:53-8. 27 Hulzebos EH, Helders PJ, Favie NJ, De Bie RA, Brutel de la Riviere A, Van Meeteren NL. Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery: A randomized clinical trial. JAMA 2006;296:1851-7. 28 Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005;104:1129-37. 29 Xia P, Xing L, Amol HI, Ling CC. Three-dimentional conformal radiotherapy and intensity-modulated radiotherapy. In: Hoppe RT, Phillips TL, Roach M, editors. Leibel and Phillips Textbook of Radiation Oncology. 3rd ed. Philadelphia: Saunders;2010:170-92. 30 Bentzen SM, Dorr W, Anscher MS, Denham JW, Hauer-Jensen M, Marks LB, et al. Normal tissue effects: Reporting and analysis. Semin Radiat Oncol 2003;13:189-202. 31 Dorr W, Hendry JH. Consequential late effects in normal tissues. Radiother Oncol 2001;61:223-31. 32 Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses. Radiat Res 2000;153:245-57. 33 Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. MAPK pathways in radiation responses. Oncogene 2003;22:5885-96. 34 Levendag PC, Teguh DN, Voet P, van der Est H, Noever I, de Kruijf WJ, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship. Radiother Oncol 2007;85:64-73. 35 Caiozzo VJ, Giedzinski E, Baker M, Suarez T, Izadi A, Lan M, et al. The radiosensitivity of satellite cells: Cell cycle regulation, apoptosis and oxidative stress. Radiat Res 2010;174:582-9. 36 Halliwell B, Gutteridge JMC. The chemistry of free radicals and related reactive species. In: Halliwell B, Gutteridge JMC, editors. Free Radicals in Biology and Medicine. 4th ed. Oxford (UK): Oxford University;2007:30-78. 37 Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 2004;279:49064-73. 38 Powers SK, Jackson MJ. Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production. Physiol Rev 2008;88:1243-76. 39 Suzuki K, Ohno H, Oh-ishi S, Kizaki T, Ookawara T, Fukii J, et al. Superoxide dismutases in exercise and disease. In: Sen CK, Parcker L, Hanninen O, editors. Handbook of Oxidants and Antioxidants in Exercise. 1st ed. Amsterdam: Elsevier;2000:243-95. 40 Nohl H, Hegner D. Do mitochondria produce oxygen radicals in vivo? Eur J Biochem 1978;82:563-7. 41 Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983;52:711-60. 42 Gomes EC, Silva AN, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev 2012;2012:756132. 43 Han D, Loukianoff S, McLaughlin L. Oxidative stress indices: Analytical aspects and significance. In: Sen CK, Parcker L, Hanninen O, editors. Handbook of Oxidants and Antioxidants in Exercise. 1st ed. Amsterdam: Elsevier;2000:433-83. 44 Sies H, Cadenas E. Oxidative stress: Damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci 1985;311:617-31. 45 Jones DP. Redefining oxidative stress. Antioxid Redox Signal 2006;8:1865-79. 46 Halliwell B, Gutteridge JMC. Measurement of reactive species. In: Halliwell B, Gutteridge JMC, editors. Free Radicals in Biology and Medicine. 4th ed. Oxford (UK): Oxford University;2007:268-340. 47 Reid MB, Khawli FA, Moody MR. Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle. J Appl Physiol 1993;75:1081-7. 48 Supinski G, Nethery D, Stofan D, Hirschfield W, DiMarco A. Diaphragmatic lipid peroxidation in chronically loaded rats. J Appl Physiol 1999;86:651-8. 49 Reid MB, Haack KE, Franchek KM, Valberg PA, Kobzik L, West MS. Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro. J Appl Physiol 1992;73:1797-804. 50 Vincent HK, Powers SK, Demirel HA, Coombes JS, Naito H. Exercise training protects against contraction-induced lipid peroxidation in the diaphragm. Eur J Appl Physiol Occup Physiol 1999;79:268-73. 51 Orhan H, van Holland B, Krab B, Moeken J, Vermeulen NP, Hollander P, et al. Evaluation of a multi-parameter biomarker set for oxidative damage in man: Increased urinary excretion of lipid, protein and DNA oxidation products after one hour of exercise. Free Radic Res 2004;38:1269-79. 52 Steinberg JG, Ba A, Bregeon F, Delliaux S, Jammes Y. Cytokine and oxidative responses to maximal cycling exercise in sedentary subjects. Med Sci Sports Exerc 2007;39:964-8. 53 Bloomer RJ, Davis PG, Consitt LA, Wideman L. Plasma protein carbonyl response to increasing exercise duration in aerobically trained men and women. Int J Sports Med 2007;28:21-5. 54 Reid WD, MacGowan NA. Respiratory muscle injury in animal models and humans. Mol Cell Biochem 1998;179:63-80. 55 NHLBI Workshop group. Respiratory muscle fatigue: Report of the Respiratory Muscle Fatigue Workshop Group. Am Rev Respir Dis 1990;142:474-80. 56 Barreiro E, de la Puente B, Minguella J, Corominas JM, Serrano S, Hussain SN, et al. Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;171:1116-24. 57 American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med 2002;166:518-624. 58 Mills GH, Kyroussis D, Hamnegard CH, Polkey MI, Green M, Moxham J. Bilateral magnetic stimulation of the phrenic nerves from an anterolateral approach. Am J Respir Crit Care Med 1996;154:1099-105. 59 Watson AC, Hughes PD, Louise Harris M, Hart N, Ware RJ, Wendon J, et al. Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the intensive care unit. Crit Care Med 2001;29:1325-31. 60 De Jonghe B, Bastuji-Garin S, Durand MC, Malissin I, Rodrigues P, Cerf C, et al. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med 2007;35:2007-15. 61 Hart N, Cramer D, Ward SP, Nickol AH, Moxham J, Polkey MI, et al. Effect of pattern and severity of respiratory muscle weakness on carbon monoxide gas transfer and lung volumes. Eur Respir J 2002;20:996-1002. 62 Gorini M, Misuri G, Corrado A, Duranti R, Iandelli I, De Paola E, et al. Breathing pattern and carbon dioxide retention in severe chronic obstructive pulmonary disease. Thorax 1996;51:677-83. 63 Mador MJ, Acevedo FA. Effect of respiratory muscle fatigue on breathing pattern during incremental exercise. Am Rev Respir Dis 1991;143:462-8. 64 Chua TP, Anker SD, Harrington D, Coats AJ. Inspiratory muscle strength is a determinant of maximum oxygen consumption in chronic heart failure. Br Heart J 1995;74:381-5. 65 Bruera E, Schmitz B, Pither J, Neumann CM, Hanson J. The frequency and correlates of dyspnea in patients with advanced cancer. J Pain Symptom Manage 2000;19:357-62. 66 Dudgeon DJ, Lertzman M, Askew GR. Physiological changes and clinical correlations of dyspnea in cancer outpatients. J Pain Symptom Manage 2001;21:373-9. 67 Travers J, Dudgeon DJ, Amjadi K, McBride I, Dillon K, Laveneziana P, et al. Mechanisms of exertional dyspnea in patients with cancer. J Appl Physiol 2008;104:57-66. 68 England R, Maddocks M, Manderson C, Wilcock A. Factors influencing exercise performance in thoracic cancer. Respir Med 2012;106:294-9. 69 Mohan A, Singh P, Singh S, Goyal A, Pathak A, Mohan C, et al. Quality of life in lung cancer patients: Impact of baseline clinical profile and respiratory status. Eur J Cancer Care (Engl) 2007;16:268-76. 70 McArdle A, Pattwell D, Vasilaki A, Griffiths RD, Jackson MJ. Contractile activity-induced oxidative stress: Cellular origin and adaptive responses. Am J Physiol Cell Physiol 2001;280:C621-7. 71 Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology 2003;189:41-54. 72 Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Res 2004;94:478-86. 73 Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys 2002;397:342-4. 74 Espinosa A, Leiva A, Pena M, Muller M, Debandi A, Hidalgo C, et al. Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes. J Cell Physiol 2006;209:379-88. 75 Javesghani D, Magder SA, Barreiro E, Quinn MT, Hussain SN. Molecular characterization of a superoxide-generating NAD(P)H oxidase in the ventilatory muscles. Am J Respir Crit Care Med 2002;165:412-8. 76 Smith MA, Reid MB. Redox modulation of contractile function in respiratory and limb skeletal muscle. Respir Physiol Neurobiol 2006;151:229-41. 77 Lawler JM, Cline CC, Hu Z, Coast JR. Effect of oxidant challenge on contractile function of the aging rat diaphragm. Am J Physiol 1997;272:E201-7. 78 Khawli FA, Reid MB. N-acetylcysteine depresses contractile function and inhibits fatigue of diaphragm in vitro. J Appl Physiol 1994;77:317-24. 79 Travaline JM, Sudarshan S, Roy BG, Cordova F, Leyenson V, Criner GJ. Effect of N-acetylcysteine on human diaphragm strength and fatigability. Am J Respir Crit Care Med 1997;156:1567-71. 80 Lawler JM, Powers SK, Van Dijk H, Visser T, Kordus MJ, Ji LL. Metabolic and antioxidant enzyme activities in the diaphragm: Effects of acute exercise. Respir Physiol 1994;96:139-49. 81 De Lisio M, Kaczor JJ, Phan N, Tarnopolsky MA, Boreham DR, Parise G. Exercise training enhances the skeletal muscle response to radiation-induced oxidative stress. Muscle Nerve 2011;43:58-64. 82 Powers SK, Criswell D, Lawler J, Martin D, Ji LL, Herb RA, et al. Regional training-induced alterations in diaphragmatic oxidative and antioxidant enzymes. Respir Physiol 1994;95:227-37. 83 Oh-ishi S, Kizaki T, Ookawara T, Sakurai T, Izawa T, Nagata N, et al. Endurance training improves the resistance of rat diaphragm to exercise-induced oxidative stress. Am J Respir Crit Care Med 1997;156:1579-85. 84 Vincent HK, Powers SK, Stewart DJ, Demirel HA, Shanely RA, Naito H. Short-term exercise training improves diaphragm antioxidant capacity and endurance. Eur J Appl Physiol 2000;81:67-74. 85 Gomez-Cabrera MC, Borras C, Pallardo FV, Sastre J, Ji LL, Vina J. Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 2005;567:113-20. 86 Hollander J, Fiebig R, Gore M, Ookawara T, Ohno H, Ji LL. Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle. Pflugers Arch 2001;442:426-34. 87 Ji LL, Gomez-Cabrera MC, Vina J. Exercise and hormesis: Activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci 2006;1067:425-35. 88 Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radic Biol Med 2008;44:126-31. 89 Radak Z, Chung HY, Goto S. Exercise and hormesis: Oxidative stress-related adaptation for successful aging. Biogerontology 2005;6:71-5. 90 Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008;44:153-9. 91 Leith DE, Bradley M. Ventilatory muscle strength and endurance training. J Appl Physiol 1976;41:508-16. 92 Ramirez-Sarmiento A, Orozco-Levi M, Guell R, Barreiro E, Hernandez N, Mota S, et al. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: Structural adaptation and physiologic outcomes. Am J Respir Crit Care Med 2002;166:1491-7. 93 Sanchez Riera H, Montemayor Rubio T, Ortega Ruiz F, Cejudo Ramos P, Del Castillo Otero D, Elias Hernandez T, et al. Inspiratory muscle training in patients with COPD: Effect on dyspnea, exercise performance, and quality of life. Chest 2001;120:748-56. 94 Shoemaker MJ, Donker S, Lapoe A. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: The state of the evidence. Cardiopulm Phys Ther J 2009;20:5-15. 95 Holland AE, Hill CJ, Rasekaba T, Lee A, Naughton MT, McDonald CF. Updating the minimal important difference for six-minute walk distance in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil 2010;91:221-5. 96 Nomori H, Kobayashi R, Fuyuno G, Morinaga S, Yashima H. Preoperative respiratory muscle training. Assessment in thoracic surgery patients with special reference to postoperative pulmonary complications. Chest 1994;105:1782-8. 97 Sekine Y, Chiyo M, Iwata T, Yasufuku K, Furukawa S, Amada Y, et al. Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Surg 2005;53:237-43. 98 Inoue J, Ono R, Makiura D, Kashiwa-Motoyama M, Miura Y, Usami M, et al. Prevention of postoperative pulmonary complications through intensive preoperative respiratory rehabilitation in patients with esophageal cancer. Dis Esophagus 2013;26:68-74. 99 Prezant DJ, Aldrich TK, Richner B, Gentry EI, Valentine DE, Nagashima H, et al. Effects of long-term continuous respiratory resistive loading on rat diaphragm function and structure. J Appl Physiol 1993;74:1212-9. 100 Bisschop A, Gayan-Ramirez G, Rollier H, Gosselink R, Dom R, de Bock V, et al. Intermittent inspiratory muscle training induces fiber hypertrophy in rat diaphragm. Am J Respir Crit Care Med 1997;155:1583-9. 101 Rollier H, Bisschop A, Gayan-Ramirez G, Gosselink R, Decramer M. Low load inspiratory muscle training increases diaphragmatic fiber dimensions in rats. Am J Respir Crit Care Med 1998;157:833-9. 102 Lewis MI, Zhan WZ, Sieck GC. Adaptations of the diaphragm in emphysema. J Appl Physiol 1992;72:934-43. 103 Levine S, Bashir MH, Clanton TL, Powers SK, Singhal S. COPD elicits remodeling of the diaphragm and vastus lateralis muscles in humans. J Appl Physiol 2013;114:1235-45. 104 Gaertner DJ, Hallman TM, Hankenson FC, Batchelder MA. Anesthesia and analgesia for laboratory rodents. In: Fish RE, Brown MJ, Danneman PJ, Karas AZ, editors. Anesthesia and Analgesia in Laboratory Animals. 2nd ed. Boston: Academic Press;2008:239-97. 105 Oishi PE, Cholsiripunlert S, Gong W, Baker AJ, Bernstein HS. Myo-mechanical analysis of isolated skeletal muscle. J Vis Exp 2011;22:2582. 106 Crapo JD, McCord JM, Fridovich I. Preparation and assay of superioxide dismutases. Methods Enzymol 1978;53:382-93. 107 Pinlaor S, Prakobwong S, Hiraku Y, Kaewsamut B, Dechakhamphu S, Boonmars T, et al. Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: An indirect effect after praziquantel treatment. Am J Trop Med Hyg 2008;78:564-73. 108 Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464-78. 109 Alway SE, Cutlip RG. Resistance loading and signaling assays for oxidative stress in rodent skeletal muscle. Methods Mol Biol 2012;798:185-211. 110 Eisen EJ. Results of growth curve analyses in mice and rats. J Anim Sci 1976;42:1008-23. 111 Reid WD, Dechman G. Considerations when testing and training the respiratory muscles. Phys Ther 1995;75:971-82. 112 Sheel AW. Respiratory muscle training in healthy individuals: Physiological rationale and implications for exercise performance. Sports Med 2002;32:567-81. 113 Lieber RL. Skeletal muscle physiology. In: Lieber RL, editor. Skeletal Muscle Structure, Function, and Plasticity: The Physiological Basis of Rehabilitation. 3rd ed. Baltimore: Lippincott Williams & Wilkins;2010:41-92. 114 Schiaffino S, Reggiani C. Fiber types in mammalian skeletal muscles. Physiol Rev 2011;91:1447-531. 115 Harridge SD, Bottinelli R, Canepari M, Pellegrino MA, Reggiani C, Esbjornsson M, et al. Whole-muscle and single-fibre contractile properties and myosin heavy chain isoforms in humans. Pflugers Arch 1996;432:913-20. 116 Simunic B, Degens H, Rittweger J, Narici M, Mekjavic IB, Pisot R. Noninvasive estimation of myosin heavy chain composition in human skeletal muscle. Med Sci Sports Exerc 2011;43:1619-25. 117 Chin ER. Intracellular Ca2+ signaling in skeletal muscle: Decoding a complex message. Exerc Sport Sci Rev 2010;38:76-85. 118 Rassier DE, Tubman LA, MacIntosh BR. Inhibition of Ca2+ release in rat atrophied gastrocnemius muscle. Exp Physiol 1997;82:665-76. 119 Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev 2008;7:34-42. 120 Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR. Phosphorylation of c-jun mediated by MAP kinases. Nature 1991;353:670-4. 121 Miao L, St Clair DK. Regulation of superoxide dismutase genes: Implications in disease. Free Radic Biol Med 2009;47:344-56. 122 Beyzadeoglu M, Ozyigit G, Ebruli C. Radiobiology. In: Beyzadeoglu M, Ozyigit G, Ebruli C, editors. Basic Radiation Oncology. 1st ed. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg 2010:71-144. 123 Barreiro E, Gea J, Di Falco M, Kriazhev L, James S, Hussain SN. Protein carbonyl formation in the diaphragm. Am J Respir Cell Mol Biol 2005;32:9-17. 124 Schlattner U, Tokarska-Schlattner M, Wallimann T. Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta 2006;1762:164-80. 125 Dominguez R, Holmes KC. Actin structure and function. Annu Rev Biophys 2011;40:169-86. 126 Sag CM, Wolff HA, Neumann K, Opiela MK, Zhang J, Steuer F, et al. Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII. Basic Res Cardiol 2013;108:385. 127 Crick F. Central dogma of molecular biology. Nature 1970;227:561-3. 128 Oberley LW, St Clair DK, Autor AP, Oberley TD. Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch Biochem Biophys 1987;254:69-80. 129 Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med 2008;44:142-52. 130 Huang XJ, Song CX, Zhong CQ, Wang FS. Research progress in the radioprotective effect of superoxide dismutase. Drug Discov Ther 2012;6:169-77. 131 Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, et al. Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol 2006;81:196-205. 132 Nagler RM, Reznick AZ, Slavin S, Nagler A. Partial protection of rat parotid glands from irradiation-induced hyposalivation by manganese superoxide dismutase. Arch Oral Biol 2000;45:741-7. 133 Hosoki A, Yonekura S, Zhao QL, Wei ZL, Takasaki I, Tabuchi Y, et al. Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells. J Radiat Res 2012;53:58-71. 134 Salganik RI. The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr 2001;20:464S-472S. 135 Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 1992;11:121-39. 136 Bairati I, Meyer F, Gelinas M, Fortin A, Nabid A, Brochet F, et al. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 2005;97:481-8. 137 Meyer F, Bairati I, Fortin A, Gelinas M, Nabid A, Brochet F, et al. Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: A randomized trial among head and neck cancer patients. Int J Cancer 2008;122:1679-83. 138 Bairati I, Meyer F, Jobin E, Gelinas M, Fortin A, Nabid A, et al. Antioxidant vitamins supplementation and mortality: A randomized trial in head and neck cancer patients. Int J Cancer 2006;119:2221-4. 139 Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008;100:773-83. 140 Jones DA. High-and low-frequency fatigue revisited. Acta Physiol Scand 1996;156:265-70. 141 Binder-Macleod SA. Variable-frequency stimulation patterns for the optimization of force during muscle fatigue. In: Pierce PA, Enoka RM, Gandevia SC, McComas AJ, Stuart DG, Thomas CK, editors. Fatigue: Neural and Muscular Mechanisms. 1st ed. New York: Plenum Press;1995:227-40. 142 Aldrich TK, Appel D. Diaphragm fatigue induced by inspiratory resistive loading in spontaneously breathing rabbits. J Appl Physiol 1985;59:1527-32. 143 Keeton RB, Binder-Macleod SA. Low-frequency fatigue. Phys Ther 2006;86:1146-50. 144 Bruton JD, Place N, Yamada T, Silva JP, Andrade FH, Dahlstedt AJ, et al. Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice. J Physiol 2008;586:175-84. 145 Andrade FH, Reid MB, Westerblad H. Contractile response of skeletal muscle to low peroxide concentrations: Myofibrillar calcium sensitivity as a likely target for redox-modulation. FASEB J 2001;15:309-11. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55900 | - |
dc.description.abstract | 研究背景:過去動物實驗證實,放射照射會造成急性橫膈肌收縮功能異常。吸氣肌訓練在臨床與動物實驗均已被證實可以增進吸氣肌收縮功能,然而前置性吸氣肌訓練是否可以降低因放射照射所引起的橫膈肌收縮功能異常則需進一步探討。研究目的:以動物模式探討:1)大鼠橫膈肌收縮功能、抗氧化能力及氧化傷害在1週阻力呼吸訓練後之改變;及2)此前置性訓練是否可降低放射照射引起的橫膈肌收縮功能異常及其相關機制之初探。研究方法:本研究分兩階段進行。第一階段將Sprague-Dawley(SD)大鼠隨機分配至阻力呼吸訓練(TG, n=7)與假訓練組(SG, n=6),TG以氣道限制方式進行為期1週之阻力呼吸訓練,SG則接受假手術。兩組大鼠在訓練1週後犧牲並取下橫膈肌進行收縮功能測試、抗氧化能力與氧化傷害分析。第二階段將大鼠隨機分配至訓練後+放射(TR, n=6)與假訓練後+放射組(SR, n=6)。訓練同第一階段。訓練後,兩組大鼠之橫膈肌均接受5 Gy單次放射照射,並於照射後24小時犧牲取下橫膈肌進行收縮功能測試、抗氧化能力與氧化傷害分析。抗氧化能力以總SOD活性、CuZnSOD與MnSOD mRNA表現量分析,而氧化傷害則以蛋白質羰基及8-OHdG濃度來分析。以廣義估計或線性廣義方程式分析相關測試參數在組間與組內之差異,統計顯著水平為0.05。結果:氣道限制法提供平均1.6倍之呼吸阻力。第一階段結果顯示,1週的阻力呼吸訓練可增加大鼠橫膈肌之收縮力(p<0.05)、總SOD活性(p=0.004)、及MnSOD mRNA表現量(p=0.03),但蛋白質羰基濃度也會顯著上升(p<0.001)。第二階段結果顯示,先訓練再接受放射照射後,TR大鼠橫膈肌之收縮力顯著大於SR(p<0.05),疲勞指數(p=0.002)與蛋白質羰基濃度(p<0.001)則顯著小於SR。TR之相對張力-頻率曲線相較於SR在30-50 Hz間有顯著向下偏移之情形。TR之CuZnSOD與MnSOD mRNA表現皆顯著大於SR(p均<0.05)。結論:本研究結果顯示1週之阻力呼吸訓練可增加橫膈肌之收縮功能,並藉由正調控其抗氧化能力來減少放射照射引起之橫膈肌功能異常。 | zh_TW |
dc.description.abstract | Background: Radiotherapy (RT) had shown to induce acute diaphragm contractile dysfunction. Inspiratory muscle training (IMT) have proven to be effective in enhancing contractile function of the muscle; however, whether IMT prior to RT could ameliorate RT-related contractile dysfunction remains to be determined. Purposes: The purposes of this study were to investigate: 1) the effect of 1-week resistive breathing training on contractile function, antioxidant capacity and oxidative injury of the diaphragm; and 2) the effect of this training on RT-induced diaphragm contractile dysfunction and exploring the potential underlying mechanism in animal model. Methods: This study included two phases. In phase I, Sprague-Dawley (SD) rats were randomized into training (TG, n=7) or sham training (SG, n=6) group. TG received resistive breathing training using tracheal banding method for 1-week and SG received sham operation. Upon the completion of training, rats in both groups were sacrificed and the diaphragms were removed en bloc for contractile function assessment, antioxidant capacity and oxidative injury analysis. Antioxidant capacity analysis included total SOD activity, CuZnSOD and MnSOD mRNA expression. Oxidative injury was analyzed using protein carbonyl and 8-OHdG. In phase II, SD rats were randomized into training then RT (TR, n=6) or sham training then RT (SR, n=6) group. Training method was identical to that of phase I. After the completion of training, rats in both groups received one-shot 5 Gy RT to the diaphragm region. Twenty-four hours following RT, all rats were sacrificed and the diaphragms were removed for all the analyses as described in phase I. Generalized Estimated Equation and Generalized Linear Model were used to detect differences of variables between and within groups when suitable. Significant α level was set at 0.05. Results: Tracheal banding provided an average of 1.6 times increases in airway resistance. After 1-week of training, contractility (p<0.05), total SOD activity (p=0.004), and MnSOD mRNA expression (p=0.03) of the diaphragm were significantly higher in TG than those of SG. However, protein carbonyl level of the diaphragm were also increased after training (p<0.001). In phase II, contractility of the diaphragm were significantly higher (p<0.05), while fatigue index (p=0.002) and protein carbonyl level (p<0.001) were lower in TR than those of SR. Compared to SR, relative force-frequency curve showed significant downward shift between 30-50 Hz in TR. mRNA expression of CuZnSOD and MnSOD were significant higher in TR than those of SR (both p<0.05). Conclusions: This study showed that 1-week resistive breathing training could enhance diaphragm contractile function and thus reducing RT-induced its dysfunction through training related upregulation of antioxidant capacity of the diaphragm. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T05:10:26Z (GMT). No. of bitstreams: 1 ntu-103-R00428009-1.pdf: 1392484 bytes, checksum: b32e2c2cbd8e0cd636481221d5c8eae5 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 口試委員會審定書 I
致謝 II 中文摘要 IV Abstract VI 第一章、前言 1 第一節、研究背景與目的 1 第二節、研究假說 2 第三節、研究重要性 2 第二章、文獻回顧 4 第一節、放射治療與放射照射對組織的傷害 4 第二節、活性氧化物、氧化壓力與其生物標記 6 第三節、呼吸肌收縮功能損傷的表現與評估 8 第四節、活性氧化物與肌肉收縮功能之關係 12 第五節、全身性運動對肌肉內ROS的影響 14 第六節、阻力呼吸訓練與橫膈肌收縮功能及ROS的關係 16 第三章、研究方法 20 第一節、研究設計 20 第二節、研究動物 20 第三節、樣本數估計 20 第四節、實驗流程 21 第五節、氣道限制手術 23 第六節、食道壓測試 24 第七節、放射照射參數 24 第八節、研究工具與方法 24 第九節、研究變項 35 第十節、資料分析 36 第四章、研究結果 37 第一節、第一階段實驗結果 37 第二節、第二階段實驗結果 44 第五章、討論 50 第一節、阻力呼吸訓練之訓練效果 50 第二節、放射照射產生之橫膈肌氧化傷害與前置性阻力呼吸訓練產生之保護效益 53 第六章、結論與臨床應用 58 參考文獻 59 | |
dc.language.iso | zh-TW | |
dc.title | 以動物模式探討阻力呼吸訓練對降低放射照射引起之橫膈肌收縮功能異常之成效 | zh_TW |
dc.title | Effect of Resistive Breathing Training on Radiation-Induced Diaphragm Contractile Dysfunction – Animal Study | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳惠東(Huey-Dong Wu),陳裕仁(Yu-Jen Chen),謝忱希(Chen-Hsi Hsieh) | |
dc.subject.keyword | 阻力呼吸訓練,橫膈肌收縮功能,抗氧化能力,氧化傷害,放射治療, | zh_TW |
dc.subject.keyword | Resistive breathing training,Diaphragm contractile function,Antioxidant capacity,Oxidative injury,Radiotherapy, | en |
dc.relation.page | 69 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-08-19 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 物理治療學研究所 | zh_TW |
顯示於系所單位: | 物理治療學系所 |
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