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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳億乘(Yi-Chen Chen) | |
| dc.contributor.author | Chaung-Sung Chang | en |
| dc.contributor.author | 張壯嵩 | zh_TW |
| dc.date.accessioned | 2021-06-16T05:10:15Z | - |
| dc.date.available | 2019-09-02 | |
| dc.date.copyright | 2014-09-02 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-19 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55891 | - |
| dc.description.abstract | 根據行政院衛福部統計資料顯示，國人脂肪肝盛行率高達26-34%，因此如何減緩脂肪肝成了近年來重要的研究課題。前人研究結果指出，動脈粥狀硬化小鼠補充左旋肉鹼（L-carnitine, CNT）可以有效減少心臟及肝臟中的脂質過氧化物；且於乙醯氨酚(acetaminophen)誘導之急性肝損傷小鼠中，亦能展現其抗氧化能力及對肝臟的保護功效。本研究目標為探討CNT補充於高脂飲食C57BL/6小鼠模式下調節脂質平衡及抗氧化的功效。30隻雄性C57BL/6小鼠隨機分至以下組別：（1）Control組：一般飼糧+蒸餾水；（2）HFD組：高脂飼糧+蒸餾水；（3）CNTL組：高脂飼糧+低劑量CNT (500 mg CNT/kg BW)；（4） CNTH組：高脂飼糧+高劑量CNT (1500mg CNT/kg BW)。動物試驗結果顯示：CNT補充能改善（p<0.05）血脂組成（膽固醇、三酸甘油酯、高密度脂蛋白膽固醇及低密度脂蛋白膽固醇）及減少肝臟脂質堆積。而上述脂質調節效果可能來自於調降（p<0.05）脂質生合成基因表現（Acc, Me, Srebp-2, and Hmgr）及提升（p<0.05）脂肪的β氧化（Pparα, Rxrα, Cpt-1, and Ucp-2）與血清中膽固醇清除（Ldlr）與肝臟中膽固醇代謝（Cyp7a1）基因表現。此外，CNT亦可提高（p<0.05）脂肪β氧化（CPT-1）及能量耗損（UCP-2）之蛋白質表現。補充CNT亦能提高（p<0.05）血中總抗氧化力及提高（p<0.05）肝臟中麩胱甘肽含量及麩胱甘肽過氧化酶活性。此外亦能降低（p<0.05）肝臟中細胞激素（TNF-α）含量藉此達到抗發炎效果。綜觀上述研究結果，於高脂飲食下補充CNT具有抗氧化、調節脂質恆定及抗發炎的效果，對於調降血脂及減緩高脂飲食下導致脂肪肝具有顯著的保健功效。 | zh_TW |
| dc.description.abstract | Liver is an organ where lipid metabolism occurs, so under this condition it’s likely to cause the burden of the liver. About 26-34% people suffer non-alcoholic fatty liver disease (NAFLD) in Taiwan, so how to reduce the prevalence of NAFLD is the most important topic nowadays. Literatures showed that L-carnitine (CNT) could reduce lipid peroxidants in atherosclerotic rats and provide a hepatoprotective effect against acute acetaminophen toxicity in mice.
The objectives of this study were to clarify the lipid ameliorative effect and the anti-oxidative capacity of CNT on high-fat-diet fed mice. Thirty male C57BL/6 mice were randomly divided to four groups: 1) control group (CON group): normal diet + ddH2O, 2) high-fat diet group (HFD group: high-fat diet + ddH2O, 3) low-dosage-CNT group (CNTL group): high-fat diet + 500 mg CNT/kg BW, and 4) high-dosage-CNT group (CNTH group): high-fat diet + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplement reduced (p<0.05) serum triglyceride (TG), cholesterol (TC) and lipoprotein ratio (LDLC/HDLC), as well as (p<0.05) liver TG contents. Those improvements might be due to a down-regulation (p<0.05) of lipogenesis (Acc, Me, Srebp-2, and Hmgr), and up-regulations of energy expenditure (Pparα, Rxrα, Cpt-1, and Ucp-2) and cholesterol clearance (Ldlr) and catabolism (Cyp7a1). In addition, CNT supplementation also increased (p<0.05) the protein expressions of CPT-1 and UCP-2 expressions, which related to fatty acid β-oxidation and energy expenditure, respectively. Serum trolox equivalent antioxidants capacity (TEAC) level, and liver glutathione (GSH) content and the activity of glutathione peroxidase (GPx) of high-fat-diet fed mice were also increased (p<0.05) by CNT supplementation. Besides, TNF-α contents in livers of high-fat-diet fed mice were also decreased (p<0.05) by CNT supplementation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T05:10:15Z (GMT). No. of bitstreams: 1 ntu-103-R01626001-1.pdf: 8117131 bytes, checksum: 4031a0a996196cc33677f79b9e5013a5 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | TABLE OF CONTENTS
Page Chinese abstract…………………………………………………………….. 1 English abstract……………………………………………………………... 2 I. Introduction…………………………………………………......... 4 II. Literature review…………………………………………………. 6 2.1. Lipid dysfunction and oxidative stress in high-fat dietary habit…. 6 2.1.1. The statistics related to obesity between other countries and Taiwan……………………………………………………………. 6 2.1.2. Lipid homeostasis………………………………………………... 10 2.1.3. Diet-induced fatty liver disease………………………………… 27 2.1.4. The oxidative stress and inflamatory responses induced by a high-fat dietary habit……………………………………………... 30 2.1.5. Antioxidative mechanism in the mammalian……………………. 34 2.2. L-carnitine summary……………………………………………... 38 2.2.1 L-carnitine biosynthesis and L-carnitine content in foods……..… 38 2.2.2 L-carnitine physical functions……………………………………. 43 2.2.3 L-carnitine anti-oxidative, anti-inflammatory, and anti-fibrosis abilities…………………………………………………………… 46 III. Materials and Methods...…………………………………………. 51 3.1. Experimental design……………………………………………… 51 3.2. Experimental materials…………………………………………... 52 3.3. Animals and diets………………………………………………… 52 3.4. Sample collection………………………………………………… 53 3.5. Lipid profile analyses...................................................................... 56 3.6. Preparation of liver filtrates............................................................ 57 3.7. Analyses of antioxidant capacity.................................................... 58 3.8. Serum liver damage indices............................................................ 63 3.9. Liver inflammatory cytokines analysis........................................... 63 3.10. mRNA expression analyses.......................................................... 64 3.11. Histological analysis....................................................................... 67 3.12. 3.13. Western blotting.............................................................................. Statistical analysis........................................................................... 68 70 IV. Results and Discussion................................................................... 71 4.1 Growth performance....................................................................... 71 4.2 Lipid profile of experimental mice................................................. 72 4.3. Histological analysis....................................................................... 75 4.4. 4.5. Relative gene expressions related to lipid metabolism................... Protein expressions in hepatic energy expenditure......................... 76 80 4.6. Antioxidative capacity.................................................................... 81 4.7. 4.8. Liver inflammatory analysis........................................................... Dosage comparison......................................................................... 83 85 V. Conclusion……………………………………………………….. 101 VI. References………………………………………………………... 104 VII. Appendix…………………………………………………………. 128 | |
| dc.language.iso | zh-TW | |
| dc.title | 探討左旋肉鹼於高脂飲食下肝臟保護功效 | zh_TW |
| dc.title | The lipid lowering effects of L-carnitine in a high-fat dietary habit | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 楊國泰(Kuo-Tai Yang),邱志賢(Chih-Hsien Chiu),周崇熙(Chung-Hsi Chou),謝淑貞(Shu-Chen Hsieh) | |
| dc.subject.keyword | 脂肪肝,高脂飼糧,脂質恆定,左旋肉鹼,抗氧化能力, | zh_TW |
| dc.subject.keyword | non-alcoholic fatty liver disease,high-fat diet,lipid homeostasis,L-carnitine,anti-oxidative effect, | en |
| dc.relation.page | 128 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-08-19 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
| 顯示於系所單位： | 動物科學技術學系 | |
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