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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 駱尚廉(Shang-Ling Lo) | |
dc.contributor.author | Hern Lee | en |
dc.contributor.author | 李珩 | zh_TW |
dc.date.accessioned | 2021-06-16T04:05:55Z | - |
dc.date.available | 2017-08-03 | |
dc.date.copyright | 2015-08-03 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-07-30 | |
dc.identifier.citation | Alalm, M.G., Tawfik, A. and Ookawara, S. Degradation of four pharmaceuticals by solar photo-Fenton process: Kinetics and costs estimation. Journal of Environmental Chemical Engineering 2015, 3(1), 46-51.
Antoniou, M.G., Hey, G., Rodríguez Vega, S., Spiliotopoulou, A., Fick, J., Tysklind, M., la Cour Jansen, J. and Andersen, H.R. Required ozone doses for removing pharmaceuticals from wastewater effluents. Science of the Total Environment 2013 456–457(0), 42-49. Aronson, J.K. Meyler's side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Fifteenth Edition). Elsevier 2006. Asghar, A., Abdul Raman, A.A. and Wan Daud, W.M.A. Advanced oxidation processes for in-situ production of hydrogen peroxide/hydroxyl radical for textile wastewater treatment: a review. Journal of Cleaner Production 2015 87(0), 826-838. Atmaca, E. Treatment of landfill leachate by using electro-Fenton method. Journal of Hazard Matererials 2009 163(1), 109-114. Babuponnusami, A. and Muthukumar, K. A review on Fenton and improvements to the Fenton process for wastewater treatment. Journal of Environmental Chemical Engineering 2014 2(1), 557-572. Beetge, E., du Plessis, J., Müller, D.G., Goosen, C. and van Rensburg, F.J. The influence of the physicochemical characteristics and pharmacokinetic properties of selected NSAID’s on their transdermal absorption. International Journal of Pharmaceutics 2000 193(2), 261-264. Brillas, E., Casado, J. Aniline degradation by Electro-Fenton® and peroxi-coagulation processes using a flow reactor for wastewater treatment. Chemosphere 2002, 47(3), 241-248. Cabrera Reina, A., Santos-Juanes, L., García Sánchez, J.L., Casas López, J.L., Maldonado Rubio, M.I., Li Puma, G. and Sánchez Pérez, J.A. Modelling the photo-Fenton oxidation of the pharmaceutical paracetamol in water including the effect of photon absorption (VRPA). Applied Catalysis B: Environmental 2015, 166–167(0), 295-301. Cruz-González, K., Torres-López, O., García-León, A., Guzmán-Mar, J.L., Reyes, L.H., Hernández-Ramírez, A. and Peralta-Hernández, J.M. Determination of optimum operating parameters for Acid Yellow 36 decolorization by electro-Fenton process using BDD cathode. Chemical Engineering Journal 2010, 160(1), 199-206. Cruz-Morató, C., Lucas, D., Llorca, M., Rodriguez-Mozaz, S., Gorga, M., Petrovic, M., Barceló, D., Vicent, T., Sarrà, M. and Marco-Urrea, E. Hospital wastewater treatment by fungal bioreactor: Removal efficiency for pharmaceuticals and endocrine disruptor compounds. Science of the Total Environment 2014, 493(0), 365-376. Cuklev, F., Fick, J., Cvijovic, M., Kristiansson, E., Förlin, L. and Larsson, D.G.J. Does ketoprofen or diclofenac pose the lowest risk to fish? Journal of Hazard Matererials 2012, 229–230(0), 100-106. Diniz, M.S., Salgado, R., Pereira, V.J., Carvalho, G., Oehmen, A., Reis, M.A.M. and Noronha, J.P. Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio). Science of the Total Environment 2015, 505(0), 282-289. Domínguez, J.R., González, T., Palo, P. and Sánchez-Martín, J. Anodic oxidation of ketoprofen on boron-doped diamond (BDD) electrodes. Role of operative parameters. Chemical Engineering Journal 2010, 162(3), 1012-1018. Feng, L., van Hullebusch, E.D., Rodrigo, M.A., Esposito, G. and Oturan, M.A. Removal of residual anti-inflammatory and analgesic pharmaceuticals from aqueous systems by electrochemical advanced oxidation processes. A review. Chemical Engineering Journal 2013, 228(0), 944-964. Flox, C., Ammar, S., Arias, C., Brillas, E., Vargas-Zavala, A.V. and Abdelhedi, R. Electro-Fenton and photoelectro-Fenton degradation of indigo carmine in acidic aqueous medium. Applied Catalysis B: Environmental 2006, 67(1–2), 93-104. Fujishima, A., Rao, T.N. and Tryk, D.A. Titanium dioxide photocatalysis. Journal of Photochemistry and Photobiology C: Photochemistry Reviews 2000, 1(1), 1-21. Gros, M., Petrović, M., Ginebreda, A. and Barceló, D. Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environment International 2010, 36(1), 15-26. Guivarch, E., Trevin, S., Lahitte, C., Oturan, M. A. Degradation of azo dyes in water by electro-Fenton process. Environmental Chemistry Letters 2003, 1(1), 38-44. Huang, Y., Chen, C., Huang, G., Chou, S. Comparison of a novel electro-Fenton method with Fentons reagent intreating a highly contaminated wastewater. Water Science & Technology 2001, 43(2), 17-24. Illés, E., Szabó, E., Takács, E., Wojnárovits, L., Dombi, A. and Gajda-Schrantz, K. Ketoprofen removal by O3 and O3/UV processes: Kinetics, transformation products and ecotoxicity. Science of the Total Environment 2014, 472(0), 178-184. Illés, E., Takács, E., Dombi, A., Gajda-Schrantz, K., Gonter, K. and Wojnárovits, L. Radiation induced degradation of ketoprofen in dilute aqueous solution. Radiation Physics and Chemistry 2012, 81(9), 1479-1483. Kang, N., Lee, D.S. and Yoon, J. Kinetic modeling of Fenton oxidation of phenol and monochlorophenols. Chemosphere 2002, 47(9), 915-924. Kourdali, S., Badis, A. and Boucherit, A. Degradation of direct yellow 9 by electro-Fenton: Process study and optimization and, monitoring of treated water toxicity using catalase. Ecotoxicology and Environmental Safety 2014, 110(0), 110-120. Kümmerer, K. The presence of pharmaceuticals in the environment due to human use – present knowledge and future challenges. Journal of Environmental Management 2009, 90(8), 2354-2366. Wilderer, P. Treatise on Water Science. Elsevier, Oxford 2011. Landry, K.A., Sun, P., Huang, C.-H. and Boyer, T.H. Ion-exchange selectivity of diclofenac, ibuprofen, ketoprofen, and naproxen in ureolyzed human urine. Water Research 2015, 68(0), 510-521. Lin, H., Zhang, H., Wang, X., Wang, L. and Wu, J. Electro-Fenton removal of Orange II in a divided cell: Reaction mechanism, degradation pathway and toxicity evolution. Separation and Purification Technology 2014, 122(0), 533-540. Mackuľak, T., Mosný, M., Grabic, R., Golovko, O., Koba, O. and Birošová, L. Fenton-like reaction: A possible way to efficiently remove illicit drugs and pharmaceuticals from wastewater. Environmental Toxicology and Pharmacology 2015, 39(2), 483-488. Mansour, D., Fourcade, F., Soutrel, I., Hauchard, D., Bellakhal, N. and Amrane, A. Mineralization of synthetic and industrial pharmaceutical effluent containing trimethoprim by combining electro-Fenton and activated sludge treatment. Journal of the Taiwan Institute of Chemical Engineers 2015. Martínez, C., Vilariño, S., Fernández, M.I., Faria, J., L, M.C. and Santaballa, J.A. Mechanism of degradation of ketoprofen by heterogeneous photocatalysis in aqueous solution. Applied Catalysis B: Environmental 2013, 142–143(0), 633-646. Mohajeri, S., Aziz, H.A., Isa, M.H., Zahed, M.A. and Adlan, M.N. Statistical optimization of process parameters for landfill leachate treatment using electro-Fenton technique. Journal of Hazard Materials 2010, 176(1–3), 749-758. Molkenthin, M., Olmez-Hanci, T., Jekel, M.R. and Arslan-Alaton, I. Photo-Fenton-like treatment of BPA: Effect of UV light source and water matrix on toxicity and transformation products. Water Research 2013, 47(14), 5052-5064. Moreno, A. D., Frontana-Uribe, B. A., Zamora, R. R. Electro-Fenton as a feasible advanced treatment process to produce reclaimed water. Water Science & Technology 2004, 50(2), 83-90. Murugananthan, M., Latha, S.S., Bhaskar Raju, G. and Yoshihara, S. Anodic oxidation of ketoprofen—An anti-inflammatory drug using boron doped diamond and platinum electrodes. Journal of Hazard Materials 2010, 180(1–3), 753-758. Pajootan, E., Arami, M. and Rahimdokht, M. Discoloration of wastewater in a continuous electro-Fenton process using modified graphite electrode with multi-walled carbon nanotubes/surfactant. Separation and Purification Technology 2014, 130(0), 34-44. Pimentel, M., Oturan, N., Dezotti, M. and Oturan, M.A. Phenol degradation by advanced electrochemical oxidation process electro-Fenton using a carbon felt cathode. Applied Catalysis B: Environmental 2008, 83(1–2), 140-149. Radjenović, J., Petrović, M. and Barceló, D. Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Research 2009, 43(3), 831-841. Rosal, R., Rodríguez, A., Perdigón-Melón, J.A., Petre, A., García-Calvo, E., Gómez, M.J., Agüera, A. and Fernández-Alba, A.R. Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation. Water Research 2010, 44(2), 578-588. Sirés, I., Arias, C., Cabot, P.L., Centellas, F., Garrido, J.A., Rodríguez, R.M. and Brillas, E. Degradation of clofibric acid in acidic aqueous medium by electro-Fenton and photoelectro-Fenton. Chemosphere 2007, 66(9), 1660-1669. Sun, M., Chen, F., Qu, J., Liu, H. and Liu, R. Optimization and control of Electro-Fenton process by pH inflection points: A case of treating acrylic fiber manufacturing wastewater. Chemical Engineering Journal 2015, 269(0), 399-407. Taggart, M.A., Cuthbert, R., Das, D., Sashikumar, C., Pain, D.J., Green, R.E., Feltrer, Y., Shultz, S., Cunningham, A.A. and Meharg, A.A. Diclofenac disposition in Indian cow and goat with reference to Gyps vulture population declines. Environmental Pollution 2007, 147(1), 60-65. Thirugnanasambandham, K. and Sivakumar, V. Optimization of treatment of grey wastewater using Electro-Fenton technique – Modeling and validation. Process Safety and Environmental Protection 2015, 95(0), 60-68. Umar, M., Roddick, F., Fan, L. and Aziz, H.A. Application of ozone for the removal of bisphenol A from water and wastewater – A review. Chemosphere 2013, 90(8), 2197-2207. Villaroel, E., Silva-Agredo, J., Petrier, C., Taborda, G. and Torres-Palma, R.A. Ultrasonic degradation of acetaminophen in water: Effect of sonochemical parameters and water matrix. Ultrason Sonochem 2014, 21(5), 1763-1769. Wang, Y., Liu, Y., Liu, T., Song, S., Gui, X., Liu, H. and Tsiakaras, P. Dimethyl phthalate degradation at novel and efficient electro-Fenton cathode. Applied Catalysis B: Environmental 2014, 156–157(0), 1-7. Xagoraraki, I. and Kuo, D. International Encyclopedia of Public Health. Academic Press, Oxford 2008, 539-550. Yuan, S., Tian, M., Cui, Y., Lin, L. and Lu, X. Treatment of nitrophenols by cathode reduction and electro-Fenton methods. Journal of Hazard Materials 2006, 137(1), 573-580. Zhang, H., Zhang, D., Zhou, J. Removal of COD from landfill leachate by electro-Fenton method. Journal of Hazardous Materials 2006, 135(1), 106-111. Zhao, H., Cao, J., Lv, H., Wang, Y. and Zhao, G. 3D nano-scale perovskite-based composite as Fenton-like system for efficient oxidative degradation of ketoprofen. Catalysis Communications 2013, 41(0), 87-90. 司洪濤、呂冠霖、黃香玫,「氧化技術在高濃度COD廢水處理之應用」,經濟部工業局 2008。 林正芳、林郁真、余宗賢,「新興污染物(抗生素與止痛藥)於特定污染源環境之流佈」,2008年持久性有機污染物(含戴奧辛)研討會 2008。 趙敏傑,「以電-芬頓程序法處理2,6-二甲基苯胺」,碩士論文,嘉南藥理科技大學環境工程與科學系 2008。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55499 | - |
dc.description.abstract | 酮洛芬(Ketoprofen) ,全名2-(3-benzoylphenyl)propanoic acid,2-(3苯甲醯基苯基)丙酸,是非類固醇消炎止痛藥(Non-Steroidal Anti-Inflammatory Drugs,NSAIDs)的其中一種,為被廣泛使用的消炎止痛藥之一,常作為坐骨神經痛或是關節炎等徵狀的處方藥,此類藥物的使用量正逐年增加,而非類固醇類消炎止痛藥在水體中,會透過生物累積的作用影響整個生態系統。
酮洛芬在汙水處理廠中無法被有效去除,必須增加高級氧化法(AOP)單元來去除之,常見的高級氧化法有臭氧、光催化、Fenton、Fenton-like或是複合多種處理等方式,利用反應產生自由基的強氧化能力來降解水中之酮洛芬。 本研究以電芬頓法(Electro-Fenton,EF)處理水中酮洛芬,利用高效液相層析儀(High-Performance Liquid Chromatography,HPLC)來檢測處理效率與各項參數,再將得到的數據整理並利用反應曲面法(Response Surface Methodology,RSM)來找出最佳的處理參數範圍。在電解法與芬頓法的背景實驗中,分別測試控制電流大小、pH值、過氧化氫以及鐵離子加藥量等變數,得知處理效率隨pH的降低而提升,隨著過氧化氫及鐵離子的加藥量上升而提升。在電芬頓法的實驗中,分別控制電流大小、pH值、過氧化氫以及鐵離子加藥量來探討對酮洛芬的處理效率,電流大小在加藥量充足時,對處理效率影響不大,pH值與過氧化氫加藥量的影響趨勢與芬頓法相似,而鐵離子加藥量在電芬頓法中因提供電場可促使其循環利用,相較於芬頓法,需求量較低。 在反應曲面法中央合成設計實驗中,將變數設定為pH(2~4)、過氧化氫加藥量(0.01~0.1 mM)、鐵離子加藥量(0.01~0.1 mM),透過批次實驗,可找出最佳的處理效率發生在pH=2,過氧化氫與鐵離子加藥量0.1 mM,對酮洛芬的處理效率可達96%,證明電芬頓法是一種可行的處理酮洛芬的方法。 | zh_TW |
dc.description.abstract | Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs widely provides analgesic (Pain-killing) and antipyretic (Fever-reducing) effects. Ketoprofen (KET), [2-(3-benzoylphenyl)propanoic acid] is one of the propionic acid class of NSAIDs. KET is mainly used for treatment of musculoskeletal pain. KET can also be used for treatment of some nerve pain such as sciatica. In recent years, the amount of use for NSAIDs is increasing rapidly in developed countries. Therefore, the presence of these pharmaceuticals in water system becomes a growing problem in these decades.
Since the sewage treatment plant can’t eliminate the NSAIDs efficiently, the treatment which usually applied for the removal of NSAIDs is Advanced Oxidation Process (AOP). Advanced oxidation process such as Ozonation, Fenton/Fenton-like, Photocatalysis or Electrolysis all using the hydroxyl radical (•OH) to mineralized the target compounds in water. The goal of this research is to find out the removal efficiency of KET in water by using Electro-Fenton process (EF). Using HPLC to quantified the residual KET in water solution after the EF process. Applying response surface methodology (RSM) to approach the optimal operation conditions. In the background test of Electrolysis and Fenton reaction, four different operating parameters (current level, pH, hydrogen peroxide [H2O2] and iron [Fe2+] dosage) were tested. The removal efficiency increased with the decreasing pH and increasing H2O2 and Fe2+ dosage. In the EF batch experiments, four operating parameters, current level, pH, H2O2 and Fe2+ dosage were tested. The removal efficiency increased with pH decreasing and increasing H2O2 dosage, which followed the same patterns as Fenton experiment. However, the reduction reaction in cathode contributed to less Fe2+ required for Electro-Fenton process. The Fe3+ was converted to Fe2+ in this reduction process. The current level didn’t affect the removal efficiency significantly when applying enough H2O2 and Fe2+. By choosing pH range from 2 to 4, H2O2 and Fe2+ dosage from 0.01 to 0.1 mM as the varieties in the response surface methodology, tested a sequence of the design experiments. The removal efficiency can reach 96% at pH=2, H2O2=0.1 mM and Fe2+=0.1 mM. In conclusion, the EF process is a decent method for the elimination of KET. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T04:05:55Z (GMT). No. of bitstreams: 1 ntu-104-R02541119-1.pdf: 1762426 bytes, checksum: 2f61244fd12501a37c507b3a8193b84c (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | 中文摘要 I
Abstarct II 總目錄 IV 表目錄 VII 圖目錄 VIII 第一章 緒論 1 1.1 前言 1 1.2 研究目的 2 1.3 研究內容 3 第二章 文獻回顧 4 2.1 非類固醇類消炎止痛藥─酮洛芬性質及應用 4 2.2 酮洛芬對環境生態的影響 7 2.3 酮洛芬可行的處理方法 8 2.3.1 Ozone 臭氧 10 2.3.2 Ultrasonic Oxidation 超聲波氧化 11 2.3.3 Fenton/Fenton-like Oxidation 芬頓/類芬頓氧化 11 2.3.4 Photocatalysis 光催化法 14 2.3.5 Photo-Fenton 光芬頓法 15 2.3.6 Elcetrochemical 電化學法 16 2.3.6.1 Anodic Oxidation 陽極氧化法 16 2.3.6.2 Electro-Fenton電芬頓法 17 2.3.7 Electro-Fenton Parameters 電芬頓法操作參數 19 2.3.7.1電流密度的影響 19 2.3.7.2 pH值的影響 19 2.3.7.3鐵離子濃度的影響 20 2.3.7.4過氧化氫濃度的影響 21 第三章 實驗方法與材料 24 3.1 實驗架構 24 3.2藥品與設備 26 3.2.1藥品 26 3.2.2設備 26 3.3 實驗分析方法 27 3.3.1 HPLC高效液相層析儀與PDA detector光電二極體陣列檢測器 27 3.3.2 反應曲面法(Response Surface Methodology,RSM) 29 3.4實驗流程 30 3.4.1溶液配製 30 3.4.2實驗反應步驟 30 3.4.3設定HPLC及PDA detector儀器 32 3.4.4 實驗參數選擇以及反應曲面法 33 第四章 結果與討論 35 4.1實驗前置準備 35 4.1.1檢量線與查核樣品 35 4.1.2儀器偵測極限 36 4.2 Electrolysis電解法(陽極氧化法) 38 4.3 Fenton芬頓法 40 4.3.1 控制過氧化氫H2O2濃度 40 4.3.2 控制亞鐵離子Fe2+濃度 42 4.3.3 控制pH值 43 4.4 Electro-Fenton電芬頓法 44 4.4.1 控制電流大小 44 4.4.2 控制過氧化氫H2O2濃度 46 4.4.3 控制亞鐵離子Fe2+濃度 47 4.4.4 控制pH值 49 4.5 RSM反應曲面法 49 第五章 結論與建議 50 5.1 結論 59 5.2 建議 60 參考文獻 61 附錄 68 | |
dc.language.iso | zh-TW | |
dc.title | 以電芬頓法去除水中酮洛芬之研究 | zh_TW |
dc.title | Removal of Ketoprofen from Water by the Electro-Fenton Treatment Process | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林正芳(Cheng-Fang Lin),張慶源(Ching-Yuan Chang) | |
dc.subject.keyword | 酮洛芬,非類固醇消炎止痛藥,電芬頓法,液相層析儀,反應曲面法, | zh_TW |
dc.subject.keyword | Ketoprofen,Nonsteroidal anti-inflammatory drugs,Electro-Fenton process,High-performance liquid chromatography,Response surface methodology, | en |
dc.relation.page | 71 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-07-31 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 環境工程學研究所 | zh_TW |
顯示於系所單位: | 環境工程學研究所 |
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