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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝之真(Chih-Chen Hsieh) | |
dc.contributor.author | Chia-Wei Hsu | en |
dc.contributor.author | 許家偉 | zh_TW |
dc.date.accessioned | 2021-06-16T03:42:25Z | - |
dc.date.available | 2015-03-13 | |
dc.date.copyright | 2015-03-13 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-02-11 | |
dc.identifier.citation | 1. Tsou, T.Y., H.Y. Chen, and C.C. Hsieh, Bihydrogel particles as free-standing mechanical pH microsensors. Applied Physics Letters, 2013. 102(3).
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Erickson, D., D. Sinton, and D.Q. Li, Joule heating and heat transfer in poly(dimethylsiloxane) microfluidic systems. Lab on a Chip, 2003. 3(3): p. 141-149. 10. Hsieh, C.C., A. Balducci, and P.S. Doyle, Ionic effects on the equilibrium dynamics of DNA confined in nanoslits. Nano Letters, 2008. 8(6): p. 1683-1688. 11. Dendukuri, D., et al., Stop-flow lithography in a microfluidic device. Lab on a Chip, 2007. 7(7): p. 818-828. 12. Suh, S.K., et al., Using Stop-Flow Lithography To Produce Opaque Microparticles: Synthesis and Modeling. Langmuir, 2011. 27(22): p. 13813-13819. 13. Jones, J.J., J.R.C. van der Maarel, and P.S. Doyle, Effect of Nanochannel Geometry on DNA Structure in the Presence of Macromolecular Crowding Agent. Nano Letters, 2011. 11(11): p. 5047-5053. 14. Peppas, N.A., et al., Hydrogels in biology and medicine: From molecular principles to bionanotechnology. Advanced Materials, 2006. 18(11): p. 1345-1360. 15. Chapin, S.C. and P.S. 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Bong, K.W., et al., Non-polydimethylsiloxane devices for oxygen-free flow lithography. Nature Communications, 2012. 3. 42. Xu, H.P., et al., UV-curable waterborne polyurethane-acrylate: preparation, characterization and properties. Progress in Organic Coatings, 2012. 73(1): p. 47-53. 43. Witte, R.P., et al., Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system. Journal of Biomedical Materials Research Part A, 2004. 71A(3): p. 508-518. 44. Richter, A., et al., Influence of volume phase transition phenomena on the behavior of hydrogel-based valves. Sensors and Actuators B-Chemical, 2004. 99(2-3): p. 451-458. 45. Dimitrov, I., et al., Thermosensitive water-soluble copolymers with doubly responsive reversibly interacting entities. Progress in Polymer Science, 2007. 32(11): p. 1275-1343. 46. Zhu, P.W. and D.H. Napper, Experimental-Observation of Coil-to-Globule Type Transitions at Interfaces. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54949 | - |
dc.description.abstract | 環境感應性水凝膠(Stimuli-responsive hydrogel)在外界環境發生改變時,水凝膠的體積能隨環境參數產生劇烈變化,近年來已有相當多的研究將此類材料應用在環境感測器上。
本實驗室先前曾參考雙金屬片(Bimetallic strip)在溫度變化下因為兩種金屬體積膨脹程度不同而使金屬片彎曲的概念,以pH感應性水凝膠─丙烯酸(acrylic acid),製作出pH雙相水凝膠感測器[1]。本研究延續此概念並以溫度感應性水凝膠─N-異丙基丙烯醯胺(NIPAAm),製作出溫度雙相水凝膠感測器以驗證此概念廣泛通用在各種感應性水凝膠材質上。我們以靜止流微影術(Stop-Flow Lithography)將溫度敏感性的NIPAAm與不具溫度敏感性的高分子材質聚乙二醇二丙烯酸(PEGDA)交聯聚合成溫度雙相水凝膠感測器。當環境溫度變化時,感測器兩相因對於溫度的敏感性不同而有不同的體積變化,使感測器粒子彎曲,再依其彎曲角度對應環境溫度關係以達到觀測之目的。我們也研究溫度感測器在環境溫度變化下粒子彎曲的反應時間,並應用感測器於測量施加電場下微流道因焦耳熱效應而造成的溫度變化。為了讓雙相水凝膠感測器更為方便使用,我們也對感測器的形狀做改變,將具不同環境敏感度的兩相水凝膠材質間隔開成H形,並在非環境敏感側加上刻度。相對於其他感測器,雙相水凝膠感測器製作成本低廉且易大量製造,又無需連接龐大的訊號處理器,使其非常適合用於量測難以深入的微小侷限環境的環境參數。 | zh_TW |
dc.description.abstract | Stimuli-sensitive hydrogels change dramatically in volume in response to alterations of certain environmental parameter. In recent years, this category of materials has attracted much attention in field of sensors.
We proposed a pH microsensor consisting of two parallel phases of pH-sensitive hydrogel, acrylic acid, and insensitive hydrogel, PEGDA[1]. Working similarly to bimetallic strip, this type of sensor can bend to different degree on the corresponding environmental parameter and therefore was named bihydrogel microsensers. To demonstrate this general idea is also workable for microsensors sensitive to environmental parameters other than pH value, we use temperature-sensitive hydrogel, NIPAAm, and PEGDA to form temperature bihydrogel microsensors. We measure the response time of the temperature bihydrogel microsensors, and also apply them to measure the temperature rise caused by Joule heating in microchannel. Besides we also propose H-shaped pH and temperature bihydrogel microsensors with two separate phases of stimuli-sensitive and insensitive hydrogels. With marked graduations on the phase of stimuli-insensitive hydrogel, the measurements of the environmental parameters are more direct and convenient. These freestanding bihydrogel particles are low-cost and easy to manufacture by stop-flow lithography printing technique in PDMS microchannel. They are particularly suitable for use in confined environment where most sensors are unable to fit in. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T03:42:25Z (GMT). No. of bitstreams: 1 ntu-104-R01524075-1.pdf: 5384190 bytes, checksum: ca0e07a69dfacbeaa73d310f98e4b10a (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | 致謝 II
摘要 III Abstract IV 目錄 V 圖目錄 VIII 表目錄 XII 符號表 XIII 希臘符號表 XIII 第1章 緒論 1 1.1 前言 1 1.2 研究目的與動機 2 第2章 文獻回顧 4 2.1 水凝膠高分子 (Hydrogel) 4 2.1.1 水凝膠高分子基本性質 5 2.2 感應性水凝膠 6 2.2.1 pH感應性水凝膠 7 2.2.2 溫度感應性水凝膠 8 2.2.3 其他感應性水凝膠 10 2.2.3.1 光感應性水凝膠 11 2.2.3.2 電場感應性水凝膠 12 2.3 凝膠在感應器上的應用 13 2.3.1 體積變化轉為光強度變化 13 2.3.2 體積變化轉為力學變化 14 2.4 雙相水凝膠感應器 16 2.5 流體微影術 19 2.5.1 連續流微影術 19 2.5.2 靜止流微影術 21 2.5.3 流體微影術成果介紹 26 2.6 研究構想 35 2.6.1 溫度雙相水凝膠感測器 35 2.6.2 H形pH雙相水凝膠感測器 36 第3章 實驗步驟與方法 38 3.1 儀器設備 38 3.2 實驗藥品 39 3.3 實驗方法 41 3.3.1 軟微影製程技術 41 3.3.2 軟微影製程結果 44 3.3.3 微流道製作 46 3.3.4 前驅物溶液與靜止流微影術儀器架設 48 3.3.4.1 前驅物溶液成分 48 3.3.4.2 靜止流微影術儀器架設 54 3.3.5 水凝膠感測器粒子收集、清洗及敏感性優化 55 3.3.5.1 感測器粒子收集及清洗 55 3.3.5.2 感測器敏感性優化 56 3.3.6 環境參數感測 57 3.3.6.1 溫度雙相水凝膠感測器的彎曲角度與環境溫度關係 57 3.3.6.2 溫度感測器粒子反應時間測量 58 3.3.6.3 以溫度感測器粒子量測流道中因焦耳熱變化(Joule Heating)造成之溫度變化 58 3.3.6.4 pH雙相水凝膠感測器的彎曲角度與環境pH值關係 59 3.3.7 感測器粒子角度測量 59 第4章 實驗結果與討論 68 4.1 溫度雙相水凝膠感測器 68 4.1.1 製造溫度感測器過程 68 4.1.2 溫度感測器與溫度關係 73 4.1.3 溫度感測器的再現性 75 4.1.4 溫度感測器的反應時間 77 4.1.5 以溫度感測器粒子量測流道中因焦耳熱造成之溫度變化 83 4.2 H形感測器 87 4.2.1 H形pH值感測器與環境酸鹼值關係 87 4.2.2 H形溫度感測器與環境溫度關係 93 第5章 結論與未來展望 96 第6章 參考文獻 97 | |
dc.language.iso | zh-TW | |
dc.title | 以雙相水凝膠顆粒作為微型pH及溫度感測器之研究 | zh_TW |
dc.title | Research of Bihydrogel Particles as pH and Thermal Microsensor | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 曹恆光(Heng-Kuang Tsao),諶玉真(Yu-Chen Chen),趙玲(Chso Ling) | |
dc.subject.keyword | 雙相水凝膠,感應性水凝膠,溫度感測器, | zh_TW |
dc.subject.keyword | bihydrogel,stimuli-sensitive hydrogel,thermal sensor, | en |
dc.relation.page | 100 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-02-12 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
顯示於系所單位: | 化學工程學系 |
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