[4]車輪交環烷的自組裝合成研究

Abstract

本實驗室先前發現，利用鈉離子作為模板，可引導大環分子對單一寡聚乙二醇或尿素單元進行辨識，並以穿透後封鎖或夾鎖法合成相對應的[2]交環烷與[2]車輪烷作為證明，成功地在內鎖分子領域加入新的辨識系統與合成內鎖分子的方法。 在本研究中，我們延伸、結合前人的工作，希望藉由鈉離子模板來引導[4]車輪交環烷的自組裝合成。

Recently, we demonstrated that the threading of oligo(ethylene glyco) and urea units into bis-para-xylyl[26]crown-6 (BPX26C6) via Na+ ion template is possible. Herein, we reported a single urea functionality in a dumbbell-shaped guest can be “clipped” by macrocycle generated from a diamine and two dialdehydes through the templating effect of a Na+ ion to self-assembly of a [4]rotacatenane. The resulting imine-containing rotacatenane can be reduced to allow isolation of stable amine-based rotacatenane.