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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
dc.contributor.author | Hsiao-Chun Kuo | en |
dc.contributor.author | 郭筱君 | zh_TW |
dc.date.accessioned | 2021-06-16T02:34:11Z | - |
dc.date.available | 2016-07-30 | |
dc.date.copyright | 2015-07-30 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-07-28 | |
dc.identifier.citation | [1] P. V. Phan, M. Grzanna, J. Chu, A. Polotsky, A. E. Ghannam, D. V. Heerden, D. S. Hungerford and C. G. Frondoza, “The effect of silica-containing calcium-phosphate particles on human osteoblasts in vitro,” J. Biomed. Mater. Res., 67A 1001-1008 (2003)
[2] C. J. Damien and J. R. Parsons, “Bone graft and bone graft substitutes: A review of current technology and application,” J. Appl. Biomater., 2 187-208 (1991) [3] W. S. Pietrzak, “Calcium sulfate bone void filler: a review and a look ahead,” J. Craniofac. Surg., 11 327-333 (2000) [4] M. V. Thomas and D. A. Puleo, “Review calcium sulfate: properties and clinical applications,” J. Biomed. Mater. Res. B, 597-610 (2008) [5] L. L. Hench, “The story of Bioglass | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53943 | - |
dc.description.abstract | 硫酸鈣(CS)具有良好的生物相容性與生物可降解性,因此應用於骨替代生醫材料已行之有年。而含有Na2O-CaO-SiO2-P2O5特定組成的生物活性玻璃,能使材料與骨組織形成良好的鍵結,並刺激骨細胞分化與增殖,進而促進新生骨的形成。本實驗利用噴霧熱解法製備生物活性玻璃,以硫酸鈣為基材,添加1wt%至10wt%不同比例之生物活性玻璃作為燒結添加劑,探討硫酸鈣/生物活性玻璃複合材的燒結行為與生物降解行為。本實驗結果顯示,生物活性玻璃的添加會減緩硫酸鈣的緻密化速率。此外,由微結構觀察可發現到反應相的生成,此反應相會阻礙硫酸鈣的晶粒成長。相較於純硫酸鈣陶瓷,含有5wt%玻璃的硫酸鈣具有較高的抗壓強度。生物活性玻璃的添加亦降低硫酸鈣的降解速率,並維持降解溶液的pH 值接近中性。
整體而言,適當之生物活性玻璃的添加可有效改善硫酸鈣的機械性質與降解行為,故此複合材具有良好的潛力,能在骨替代生醫陶瓷領域上有進一步的應用。 | zh_TW |
dc.description.abstract | Calcium sulfate (CS) exhibits many desired properties to be used as a bone substitute. These properties include biocompatibility and biodegradability. Bioactive glass (BG) demonstrates excellent ability to bond to bone tissue and to stimulate the proliferation of osteoblasts. The combination of these two materials might be of interest. The aim of the present study is to investigate the sintering and biodegradation behavior of calcium
sulfate/bioactive glass composites. The bioactive glass is prepared using a spray pyrolysis (SP) process. The amount of glass in composites varies from 1wt% to 10wt%. The sintering was carried out at 600 | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T02:34:11Z (GMT). No. of bitstreams: 1 ntu-104-R02527050-1.pdf: 6579200 bytes, checksum: de5d7f4bce6ff9cbae0e5255717d0a59 (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | 致謝 .................................................. i
摘要 ................................................. ii ABSTRACT ............................................ iii CONTENTS ............................................. iv List of figures ..................................... vii List of tables ....................................... xi Chapter 1 Introduction ................................ 1 Chapter 2 Literature review ........................... 3 2.1 Basics of bones ................................... 3 2.2 Bioceramics and bone graft substitutes ............ 7 2.3 Use of calcium sulfate as bioceramics ............ 11 2.3.1 Chemical and physical properties of calcium sulfate ...................................................... 11 2.3.2 Biological properties and clinical applications of calcium sulfate ...................................... 14 2.4 Use of bioactive glass and glass-ceramics as bioceramics .......................................... 18 2.4.1 Properties of bioactive glass and glass-ceramics ...................................................... 18 2.4.2 Preparation techniques for bioactive glass ..... 22 2.5 Combination of calcium sulfate and bioactive glasses ...................................................... 26 2.6 The future of bioactive ceramics ................. 28 Chapter 3 Experimental procedures .................... 30 3.1 Calcium sulfate .................................. 30 3.2 58S bioactive glass .............................. 30 3.2.1 Starting material .............................. 30 3.2.2 Spray pyrolysis procedures ..................... 31 3.2.3 Heat treatment ................................. 33 3.2.4 Characterization................................ 33 3.3 Calcium sulfate/58S bioactive glass composite .... 35 3.3.1 Processing ..................................... 35 3.3.2 Characterization ............................... 36 Chapter 4 Results .................................... 41 4.1 58S bioactive glass .............................. 41 4.1.1 Microstructure observation...................... 41 4.1.2 TEM analysis ................................... 44 4.1.3 Phase identification ........................... 44 4.1.4 Bioactive test ................................. 46 4.2 Calcium sulfate/58S bioactive glass composite .....48 4.2.1 Wettability of 58S on calcium sulfate .......... 48 4.2.2 Density ........................................ 48 4.2.3 Phase identification ........................... 51 4.2.4 Microstructure observation ..................... 54 4.2.5 Mechanical properties .......................... 56 4.2.6 Degradation test ............................... 57 4.2.7 Washout behavior ............................... 73 Chapter 5 Discussion.................................. 75 5.1 58S bioactive glass .............................. 75 5.1.1 Microstructure observation ..................... 75 5.1.2 Phase identification ........................... 76 5.1.3 Bioactive test ................................. 77 5.2 Calcium sulfate/58S bioactive glass composite .... 79 5.2.1 Sintering behavior ............................. 79 5.2.2 Mechanical properties .......................... 85 5.2.3 Degradation behavior ........................... 87 5.2.4 Washout behavior ............................... 93 5.3 Comparison ....................................... 95 Chapter 6 Conclusions ................................ 98 Chapter 7 Future works ............................... 99 REFERENCE ........................................... 100 | |
dc.language.iso | en | |
dc.title | 硫酸鈣/生物活性玻璃複合材的生物降解行為探討 | zh_TW |
dc.title | Biodegradation Behavior of Calcium Sulfate/Bioactive Glass Composites | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 賴伯亮(Po-Liang Lai),施劭儒(Shao-Ju Shih) | |
dc.subject.keyword | 硫酸鈣,生物活性玻璃,噴霧熱解製程,燒結,生物降解, | zh_TW |
dc.subject.keyword | calcium sulfate,bioactive glass,spray pyrolysis,sintering,biodegradation, | en |
dc.relation.page | 110 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-07-28 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
顯示於系所單位: | 材料科學與工程學系 |
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