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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林琬琬 | |
dc.contributor.author | Ching-An Wu | en |
dc.contributor.author | 巫清安 | zh_TW |
dc.date.accessioned | 2021-05-15T17:57:16Z | - |
dc.date.available | 2020-03-12 | |
dc.date.available | 2021-05-15T17:57:16Z | - |
dc.date.copyright | 2015-03-12 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-10-22 | |
dc.identifier.citation | Armstrong, J.S., Whiteman, M., Yang, H., Jones, D.P., and Sternberg, P., Jr. (2004). Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 45, 4183-4189.
Arsikin, K., Kravic-Stevovic, T., Jovanovic, M., Ristic, B., Tovilovic, G., Zogovic, N., Bumbasirevic, V., Trajkovic, V., and Harhaji-Trajkovic, L. (2012). Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells. Biochim Biophys Acta 1822, 1826-1836. Averous, J., Gabillard, J.C., Seiliez, I., and Dardevet, D. (2012). Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation. Exp Cell Res 318, 217-227. Baird, S.D., Turcotte, M., Korneluk, R.G., and Holcik, M. (2006). Searching for IRES. RNA 12, 1755-1785. Baumann, F., Leukel, P., Doerfelt, A., Beier, C.P., Dettmer, K., Oefner, P.J., Kastenberger, M., Kreutz, M., Nickl-Jockschat, T., Bogdahn, U., et al. (2009). Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol 11, 368-380. Bennett, A.M., Hausdorff, S.F., O'Reilly, A.M., Freeman, R.M., and Neel, B.G. (1996). Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol Cell Biol 16, 1189-1202. Bor, Y.C., Swartz, J., Morrison, A., Rekosh, D., Ladomery, M., and Hammarskjold, M.L. (2006). The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron. Genes Dev 20, 1597-1608. Brahimi-Horn, M.C., Chiche, J., and Pouyssegur, J. (2007). Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol 19, 223-229. Braun, F., Bertin-Ciftci, J., Gallouet, A.S., Millour, J., and Juin, P. (2011). Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. PLoS One 6, e23577. Bushell, M., Stoneley, M., Kong, Y.W., Hamilton, T.L., Spriggs, K.A., Dobbyn, H.C., Qin, X., Sarnow, P., and Willis, A.E. (2006). Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Mol Cell 23, 401-412. Carling, D. (2004). The AMP-activated protein kinase cascade--a unifying system for energy control. Trends Biochem Sci 29, 18-24. Carling, D., Clarke, P.R., Zammit, V.A., and Hardie, D.G. (1989). Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. Eur J Biochem 186, 129-136. Chang, M.Y., Ho, F.M., Wang, J.S., Kang, H.C., Chang, Y., Ye, Z.X., and Lin, W.W. (2010). AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway. Biochem Pharmacol 80, 1210-1220. Christofk, H.R., Vander Heiden, M.G., Harris, M.H., Ramanathan, A., Gerszten, R.E., Wei, R., Fleming, M.D., Schreiber, S.L., and Cantley, L.C. (2008a). The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233. Christofk, H.R., Vander Heiden, M.G., Wu, N., Asara, J.M., and Cantley, L.C. (2008b). Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452, 181-186. Damiano, F., Rochira, A., Tocci, R., Alemanno, S., Gnoni, A., and Siculella, L. (2013). hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress. Biochem J 449, 543-553. De Flora, S., Izzotti, A., D'Agostini, F., and Balansky, R.M. (2001). Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22, 999-1013. Depre, C., Rider, M.H., and Hue, L. (1998). Mechanisms of control of heart glycolysis. Eur J Biochem 258, 277-290. Dewhirst, M.W. (2007). Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res 67, 854-855. Diebold, I., Petry, A., Djordjevic, T., Belaiba, R.S., Fineman, J., Black, S., Schreiber, C., Fratz, S., Hess, J., Kietzmann, T., et al. (2010). Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal 13, 399-412. Drogat, B., Bouchecareilh, M., North, S., Petibois, C., Deleris, G., Chevet, E., Bikfalvi, A., and Moenner, M. (2007). Acute L-glutamine deprivation compromises VEGF-a upregulation in A549/8 human carcinoma cells. J Cell Physiol 212, 463-472. Droge, W. (2005). Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci 360, 2355-2372. Farfariello, V., Amantini, C., and Santoni, G. (2012). Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways. J Leukoc Biol 92, 421-431. Ferreira, J.V., Fofo, H., Bejarano, E., Bento, C.F., Ramalho, J.S., Girao, H., and Pereira, P. (2013). STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy 9, 1349-1366. Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007). Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819. Frede, S., Freitag, P., Otto, T., Heilmaier, C., and Fandrey, J. (2005). The proinflammatory cytokine interleukin 1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells through hypoxia inducible factor 1 activation. Cancer Res 65, 4690-4697. Galban, S., Kuwano, Y., Pullmann, R., Jr., Martindale, J.L., Kim, H.H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J.O., et al. (2008). RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol 28, 93-107. Garcia-Navas, R., Munder, M., and Mollinedo, F. (2012). Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy 8, 1557-1576. Giaccia, A., Siim, B.G., and Johnson, R.S. (2003). HIF-1 as a target for drug development. Nat Rev Drug Discov 2, 803-811. Goetze, K., Walenta, S., Ksiazkiewicz, M., Kunz-Schughart, L.A., and Mueller-Klieser, W. (2011). Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 39, 453-463. Gonzalez, C.D., Lee, M.S., Marchetti, P., Pietropaolo, M., Towns, R., Vaccaro, M.I., Watada, H., and Wiley, J.W. (2011). The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 7, 2-11. Gottfried, E., Kunz-Schughart, L.A., Ebner, S., Mueller-Klieser, W., Hoves, S., Andreesen, R., Mackensen, A., and Kreutz, M. (2006). Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107, 2013-2021. Grishchuk, Y., Ginet, V., Truttmann, A.C., Clarke, P.G., and Puyal, J. (2011). Beclin 1-independent autophagy contributes to apoptosis in cortical neurons. Autophagy 7, 1115-1131. Groussard, C., Morel, I., Chevanne, M., Monnier, M., Cillard, J., and Delamarche, A. (2000). Free radical scavenging and antioxidant effects of lactate ion: an in vitro study. J Appl Physiol (1985) 89, 169-175. Grover, R., Ray, P.S., and Das, S. (2008). Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms. Cell Cycle 7, 2189-2198. Hardie, D.G. (2003). Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144, 5179-5183. Hardie, D.G. (2004). The AMP-activated protein kinase pathway--new players upstream and downstream. J Cell Sci 117, 5479-5487. Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Makela, T.P., Alessi, D.R., and Hardie, D.G. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2, 28. Herrera, B., Alvarez, A.M., Sanchez, A., Fernandez, M., Roncero, C., Benito, M., and Fabregat, I. (2001). Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J 15, 741-751. Higgins, G.C., Beart, P.M., Shin, Y.S., Chen, M.J., Cheung, N.S., and Nagley, P. (2010). Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury. J Alzheimers Dis 20 Suppl 2, S453-473. Hubbi, M.E., Hu, H., Kshitiz, Ahmed, I., Levchenko, A., and Semenza, G.L. (2013). Chaperone-mediated autophagy targets hypoxia-inducible factor-1alpha (HIF-1alpha) for lysosomal degradation. J Biol Chem 288, 10703-10714. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S., and Kaelin, W.G., Jr. (2001). HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-468. Jaakkola, P., Mole, D.R., Tian, Y.M., Wilson, M.I., Gielbert, J., Gaskell, S.J., von Kriegsheim, A., Hebestreit, H.F., Mukherji, M., Schofield, C.J., et al. (2001). Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472. Jin, S., and White, E. (2007). Role of autophagy in cancer: management of metabolic stress. Autophagy 3, 28-31. Jo, O.D., Martin, J., Bernath, A., Masri, J., Lichtenstein, A., and Gera, J. (2008). Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. J Biol Chem 283, 23274-23287. Jorgensen, S.B., and Rose, A.J. (2008). How is AMPK activity regulated in skeletal muscles during exercise? Front Biosci 13, 5589-5604. Juenemann, K., and Reits, E.A. (2012). Alternative macroautophagic pathways. Int J Cell Biol 2012, 189794. Jung, S.N., Yang, W.K., Kim, J., Kim, H.S., Kim, E.J., Yun, H., Park, H., Kim, S.S., Choe, W., Kang, I., et al. (2008). Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis 29, 713-721. Kalaany, N.Y., and Sabatini, D.M. (2009). Tumours with PI3K activation are resistant to dietary restriction. Nature 458, 725-731. Kim, J.W., and Dang, C.V. (2006). Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66, 8927-8930. Kim, J.W., Tchernyshyov, I., Semenza, G.L., and Dang, C.V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3, 177-185. Kim, S.H., Hwang, J.T., Park, H.S., Kwon, D.Y., and Kim, M.S. (2013). Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway. Biochem Biophys Res Commun 439, 66-70. Kim, Y.K., Hahm, B., and Jang, S.K. (2000). Polypyrimidine tract-binding protein inhibits translation of bip mRNA. J Mol Biol 304, 119-133. Klionsky, D.J., Cregg, J.M., Dunn, W.A., Jr., Emr, S.D., Sakai, Y., Sandoval, I.V., Sibirny, A., Subramani, S., Thumm, M., Veenhuis, M., et al. (2003). A unified nomenclature for yeast autophagy-related genes. Dev Cell 5, 539-545. Klionsky, D.J., and Emr, S.D. (2000). Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721. Knoechel, T.R., Tucker, A.D., Robinson, C.M., Phillips, C., Taylor, W., Bungay, P.J., Kasten, S.A., Roche, T.E., and Brown, D.G. (2006). Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry 45, 402-415. Komar, A.A., and Hatzoglou, M. (2011). Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states. Cell Cycle 10, 229-240. Komar, A.A., Mazumder, B., and Merrick, W.C. (2012). A new framework for understanding IRES-mediated translation. Gene 502, 75-86. Kourtis, N., and Tavernarakis, N. (2009). Autophagy and cell death in model organisms. Cell Death Differ 16, 21-30. Kroemer, G., and Pouyssegur, J. (2008). Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13, 472-482. Kullmann, M., Gopfert, U., Siewe, B., and Hengst, L. (2002). ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev 16, 3087-3099. Kung, H.J. (2011). Targeting tyrosine kinases and autophagy in prostate cancer. Horm Cancer 2, 38-46. Lang, K.J., Kappel, A., and Goodall, G.J. (2002). Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 13, 1792-1801. Lee, M.F., Chan, C.Y., Hung, H.C., Chou, I.T., Yee, A.S., and Huang, C.Y. (2013). N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer. Oral Oncol 49, 129-135. Levine, B., and Klionsky, D.J. (2004). Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6, 463-477. Levine, B., and Yuan, J. (2005). Autophagy in cell death: an innocent convict? J Clin Invest 115, 2679-2688. Liang, J., and Mills, G.B. (2013). AMPK: a contextual oncogene or tumor suppressor? Cancer Res 73, 2929-2935. Liochev, S.I. (2013). Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 60, 1-4. Liu, L.Z., Hu, X.W., Xia, C., He, J., Zhou, Q., Shi, X., Fang, J., and Jiang, B.H. (2006). Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Free Radic Biol Med 41, 1521-1533. Liu, S.Y., Chen, C.L., Yang, T.T., Huang, W.C., Hsieh, C.Y., Shen, W.J., Tsai, T.T., Shieh, C.C., and Lin, C.F. (2012). Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation. Apoptosis 17, 1156-1169. Lum, J.J., DeBerardinis, R.J., and Thompson, C.B. (2005). Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 6, 439-448. Mahon, P.C., Hirota, K., and Semenza, G.L. (2001). FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15, 2675-2686. Majeski, A.E., and Dice, J.F. (2004). Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36, 2435-2444. Mathew, R., and White, E. (2011). Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev 21, 113-119. McFate, T., Mohyeldin, A., Lu, H., Thakar, J., Henriques, J., Halim, N.D., Wu, H., Schell, M.J., Tsang, T.M., Teahan, O., et al. (2008). Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem 283, 22700-22708. Meley, D., Bauvy, C., Houben-Weerts, J.H., Dubbelhuis, P.F., Helmond, M.T., Codogno, P., and Meijer, A.J. (2006). AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 281, 34870-34879. Meng, T.C., Buckley, D.A., Galic, S., Tiganis, T., and Tonks, N.K. (2004). Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem 279, 37716-37725. Meng, T.C., Fukada, T., and Tonks, N.K. (2002). Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9, 387-399. Mitchell, S.A., Brown, E.C., Coldwell, M.J., Jackson, R.J., and Willis, A.E. (2001). Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras. Mol Cell Biol 21, 3364-3374. Mitchell, S.A., Spriggs, K.A., Bushell, M., Evans, J.R., Stoneley, M., Le Quesne, J.P., Spriggs, R.V., and Willis, A.E. (2005). Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes Dev 19, 1556-1571. Mitchell, S.A., Spriggs, K.A., Coldwell, M.J., Jackson, R.J., and Willis, A.E. (2003). The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell 11, 757-771. Mizushima, N., Yoshimori, T., and Levine, B. (2010). Methods in mammalian autophagy research. Cell 140, 313-326. Montcourrier, P., Silver, I., Farnoud, R., Bird, I., and Rochefort, H. (1997). Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. Clin Exp Metastasis 15, 382-392. Mueller-Klieser, W., Walenta, S., Paschen, W., Kallinowski, F., and Vaupel, P. (1988). Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. J Natl Cancer Inst 80, 842-848. Mukhopadhyay, P., Rajesh, M., Hasko, G., Hawkins, B.J., Madesh, M., and Pacher, P. (2007). Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2, 2295-2301. Mukhtar, M.H., Payne, V.A., Arden, C., Harbottle, A., Khan, S., Lange, A.J., and Agius, L. (2008). Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Am J Physiol Regul Integr Comp Physiol 294, R766-774. Muller, O., Sattler, T., Flotenmeyer, M., Schwarz, H., Plattner, H., and Mayer, A. (2000). Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding. J Cell Biol 151, 519-528. Nishida, Y., Arakawa, S., Fujitani, K., Yamaguchi, H., Mizuta, T., Kanaseki, T., Komatsu, M., Otsu, K., Tsujimoto, Y., and Shimizu, S. (2009). Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461, 654-658. Nogueira, V., and Hay, N. (2013). Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res 19, 4309-4314. Ohsumi, Y., and Mizushima, N. (2004). Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol 15, 231-236. Olmos, G., Arenas, M.I., Bienes, R., Calzada, M.J., Aragones, J., Garcia-Bermejo, M.L., Landazuri, M.O., and Lucio-Cazana, J. (2009). 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. Cell Mol Life Sci 66, 2167-2180. Park, I.J., Hwang, J.T., Kim, Y.M., Ha, J., and Park, O.J. (2006). Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Ann N Y Acad Sci 1091, 102-109. Ponisovskiy, M.R. (2011). Warburg effect mechanism as the target for theoretical substantiation of a new potential cancer treatment. Crit Rev Eukaryot Gene Expr 21, 13-28. Porporato, P.E., Dhup, S., Dadhich, R.K., Copetti, T., and Sonveaux, P. (2011). Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2, 49. Pouyssegur, J., Dayan, F., and Mazure, N.M. (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443. Ray, P.D., Huang, B.W., and Tsuji, Y. (2012). Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 24, 981-990. Roche, T.E., and Hiromasa, Y. (2007). Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell Mol Life Sci 64, 830-849. Rozhin, J., Sameni, M., Ziegler, G., and Sloane, B.F. (1994). Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res 54, 6517-6525. Rutter, G.A., Da Silva Xavier, G., and Leclerc, I. (2003). Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J 375, 1-16. Rygiel, T.P., Mertens, A.E., Strumane, K., van der Kammen, R., and Collard, J.G. (2008). The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 121, 1183-1192. Sattler, T., and Mayer, A. (2000). Cell-free reconstitution of microautophagic vacuole invagination and vesicle formation. J Cell Biol 151, 529-538. Sattler, U.G., Meyer, S.S., Quennet, V., Hoerner, C., Knoerzer, H., Fabian, C., Yaromina, A., Zips, D., Walenta, S., Baumann, M., et al. (2010). Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol 94, 102-109. Sawicka, K., Bushell, M., Spriggs, K.A., and Willis, A.E. (2008). Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. Biochem Soc Trans 36, 641-647. Scarlatti, F., Maffei, R., Beau, I., Codogno, P., and Ghidoni, R. (2008a). Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ 15, 1318-1329. Scarlatti, F., Maffei, R., Beau, I., Ghidoni, R., and Codogno, P. (2008b). Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy 4, 1083-1085. Schepens, B., Tinton, S.A., Bruynooghe, Y., Beyaert, R., and Cornelis, S. (2005). The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia. Nucleic Acids Res 33, 6884-6894. Scherz-Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., and Elazar, Z. (2007). Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26, 1749-1760. Seglen, P.O., and Gordon, P.B. (1982). 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79, 1889-1892. Semenza, G.L. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732. Semenza, G.L. (2011). Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harb Symp Quant Biol 76, 347-353. Sena, L.A., and Chandel, N.S. (2012). Physiological roles of mitochondrial reactive oxygen species. Mol Cell 48, 158-167. Shaw, R.J., Bardeesy, N., Manning, B.D., Lopez, L., Kosmatka, M., DePinho, R.A., and Cantley, L.C. (2004). The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6, 91-99. Shi, Y., Frost, P., Hoang, B., Yang, Y., Fukunaga, R., Gera, J., and Lichtenstein, A. (2013). MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells. Oncogene 32, 190-197. Shi, Y., Sharma, A., Wu, H., Lichtenstein, A., and Gera, J. (2005). Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem 280, 10964-10973. Smith, D.M., Patel, S., Raffoul, F., Haller, E., Mills, G.B., and Nanjundan, M. (2010). Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 17, 1867-1881. Sugden, M.C., Kraus, A., Harris, R.A., and Holness, M.J. (2000). Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Biochem J 346 Pt 3, 651-657. Swietach, P., Vaughan-Jones, R.D., and Harris, A.L. (2007). Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 26, 299-310. Talloczy, Z., Jiang, W., Virgin, H.W.t., Leib, D.A., Scheuner, D., Kaufman, R.J., Eskelinen, E.L., and Levine, B. (2002). Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A 99, 190-195. Tanida, I., Sou, Y.S., Ezaki, J., Minematsu-Ikeguchi, N., Ueno, T., and Kominami, E. (2004). HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem 279, 36268-36276. Tian, S., Lin, J., Jun Zhou, J., Wang, X., Li, Y., Ren, X., Yu, W., Zhong, W., Xiao, J., Sheng, F., et al. (2010). Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 6, 1032-1041. Torii, S., Kurihara, A., Li, X.Y., Yasumoto, K., and Sogawa, K. (2011). Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression. J Biochem 149, 171-176. Vander Heiden, M.G., Cantley, L.C., and Thompson, C.B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033. Vaupel, P., Kallinowski, F., and Okunieff, P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49, 6449-6465. Wakisaka, N., Kondo, S., Yoshizaki, T., Murono, S., Furukawa, M., and Pagano, J.S. (2004). Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol 24, 5223-5234. Warburg, O. (1956). On the origin of cancer cells. Science 123, 309-314. Warburg, O., Wind, F., and Negelein, E. (1927). The Metabolism of Tumors in the Body. J Gen Physiol 8, 519-530. Wei, Y., Pattingre, S., Sinha, S., Bassik, M., and Levine, B. (2008). JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30, 678-688. Weljie, A.M., and Jirik, F.R. (2011). Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. Int J Biochem Cell Biol 43, 981-989. Whitehouse, S., Cooper, R.H., and Randle, P.J. (1974). Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 141, 761-774. Woods, A., Johnstone, S.R., Dickerson, K., Leiper, F.C., Fryer, L.G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., and Carling, D. (2003). LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13, 2004-2008. Wu, C.A., Chao, Y., Shiah, S.G., and Lin, W.W. (2013). Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase. Biochim Biophys Acta 1833, 1147-1156. Wu, P., Blair, P.V., Sato, J., Jaskiewicz, J., Popov, K.M., and Harris, R.A. (2000). Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch Biochem Biophys 381, 1-7. Wu, S.B., and Wei, Y.H. (2012). AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim Biophys Acta 1822, 233-247. Wu, Y.T., Tan, H.L., Shui, G., Bauvy, C., Huang, Q., Wenk, M.R., Ong, C.N., Codogno, P., and Shen, H.M. (2010). Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285, 10850-10861. Xing, Y., Musi, N., Fujii, N., Zou, L., Luptak, I., Hirshman, M.F., Goodyear, L.J., and Tian, R. (2003). Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem 278, 28372-28377. Yang, L., Zhao, D., Ren, J., and Yang, J. (2014). Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochim Biophys Acta. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001). XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891. Young, M.E., Radda, G.K., and Leighton, B. (1996). Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR--an activator of AMP-activated protein kinase. FEBS Lett 382, 43-47. Yu, J., Li, J., Zhang, S., Xu, X., Zheng, M., Jiang, G., and Li, F. (2012). IGF-1 induces hypoxia-inducible factor 1alpha-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells. Brain Res 1430, 18-24. Zahid, M., Saeed, M., Ali, M.F., Rogan, E.G., and Cavalieri, E.L. (2010). N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells. Free Radic Biol Med 49, 392-400. Zhou, C., Zhou, J., Sheng, F., Zhu, H., Deng, X., Xia, B., and Lin, J. (2012). The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway. Acta Biochim Biophys Sin (Shanghai) 44, 815-822. Zhou, J., Callapina, M., Goodall, G.J., and Brune, B. (2004). Functional integrity of nuclear factor kappaB, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha. Cancer Res 64, 9041-9048. Zhu, J.H., Horbinski, C., Guo, F., Watkins, S., Uchiyama, Y., and Chu, C.T. (2007). Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 170, 75-86. Zwingmann, C., and Bilodeau, M. (2006). Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver. Hepatology 43, 454-463. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5377 | - |
dc.description.abstract | 由於血流供給不足,缺氧與養分缺乏是固態腫瘤兩個很重要的特徵。與已經被廣泛研究的缺氧相反,養分不足,這另外一個固態腫瘤的特徵對癌細胞的影響則不清楚。在這篇論文中,我們嘗試去探索養分缺乏對癌細胞代謝與缺氧可誘發性因子甲型(Hypoxia-inducible factor-1α)的影響。
在第一部分,我們證明利用Hank's buffered salt solution (HBSS)造成養分缺乏會增加細胞外乳糖(lactate)的產生、細胞質內丙酮酸(pyruvate)的增加,並降低細胞氧氣的消耗,但是並不會影響乳糖脫氫酵素(lactate dehydrogenase)的活性或是葡萄糖的吸收。我們發現養分缺乏會快速的誘發丙酮酸脫氫酶酵素(pyruvate dehydrogenase kinase)之活化以及丙酮酸脫氫酶(pyruvate dehydrogenase)的磷酸化,而抑制ROS或AMPK會抑制這個現象。我們也證明ROS的產生會促進AMPK的活化。更進一步來說,抑制丙酮酸脫氫酶酵素、ROS與AMPK都可以顯著的減少養分缺乏所誘發的乳糖產生,同時促進養分缺乏所誘發的細胞凋亡。綜合來說,我們首次證明養分缺乏會經由ROS/AMPK依賴性的活化丙酮酸脫氫酶酵素這個新的機轉,來促使細胞經由糖解作用來產生ATP,也就產生瓦氏效應,而這個作用會延緩細胞因為養分缺乏而造成的死亡。 在第二個部分,我們的證據顯示,養分缺乏會經由cap非依賴性的內部核糖體進入位(internal ribosome entry site)的轉譯來增加可誘發性因子甲型的蛋白表現。特別的是,藉由si-ATG5、3-methyladenine或chloroquine來抑制自噬體(autophagy)可以顯著抑制養分缺乏所誘發的缺氧可誘發性因子甲型的表現,但是si-Beclin 1卻沒有這效果。此外,很有趣的是,缺氧時也會經由內部核糖體進入位來轉譯缺氧可誘發性因子甲型,但是與養分缺乏不同的是,si-Beclin 1而不是si-ATG5會抑制缺氧所誘發的缺氧可誘發性因子甲型內部核糖體進入位活性。綜合來說,我們首次證明養分缺乏與缺氧時替代性自噬體和缺氧可誘發性因子甲型的cap非依賴性轉譯的關聯性。我們證明Beclin 1非依賴性的自噬體可以正向調控養分缺乏所誘發的缺氧可誘發性因子甲型的內部核糖體進入位活性,而ATG5非依賴性的自噬體則參與缺氧所誘發的缺氧可誘發性因子甲型的內部核糖體進入位活性。 | zh_TW |
dc.description.abstract | Hypoxia and nutrient deprivation are two important phenomenon in solid cancer due to the poor blood supply. In contrast to well-studied effect of hypoxia on tumor growth, the effect of nutrient deficiencies on cancer is not well defined. In this thesis, we try to explore the effect of nutrient deprivation on tumor cell metabolism and HIF-1α expression.
For the part I, we demonstrate that Hank's buffered salt solution (HBSS) starvation increased lactate production, cytoplasmic pyruvate content and decreased oxygen consumption, but failed to change the lactate dehydrogenase (LDH) activity or the glucose uptake. We found that HBSS starvation rapidly induced pyruvate dehydrogenase kinase (PDK) activation and pyruvate dehydrogenase (PDH) phosphorylation, both of which were reversed by inhibition of ROS and AMPK. Our data further revealed the involvement of ROS production in AMPK activation. Moreover, inhibition of PDK, ROS, and AMPK all significantly decreased HBSS starvation-induced lactate production accompanied by enhancement of HBSS starvation-induced cell apoptosis. Taken together, we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP (the Warburg effect) through a novel mechanism involving ROS/AMPK-dependent activation of PDK. Such an event contributes to protecting cells from apoptosis upon nutrient deprivation. For the part II, Our data showed that nutrient deprivation induces a significant HIF-1α protein expression through the internal ribosome entry site (IRES)-dependent translation. Notably inhibition of autophagy by si-ATG5, 3-methyladenine and chloroquine, but not si-Beclin-1, significantly reverses nutrient deprivation-induced HIF-1α responses. Furthermore, it is interesting to note that different from nutrient starvation, si-Beclin 1 but not si-ATG5 can inhibit hypoxia-induced HIF-1α IRES activation. Taken together, we for the first time highlight a link from alternative autophagy to IRES-dependent protein translation of HIF-1α under two unique stress conditions. We demonstrate Beclin 1-independent autophagy is involved to positively regulate nutrient deprivation induced-HIF-1α IRES activity, while ATG5-independent autophagy is involved in the HIF-1α IRES activation caused by hypoxia. | en |
dc.description.provenance | Made available in DSpace on 2021-05-15T17:57:16Z (GMT). No. of bitstreams: 1 ntu-103-D96443001-1.pdf: 3666161 bytes, checksum: 75f2337f6e82ddf106b0bdfa5af6d5f0 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | Abbreviations----------------------------------------------1
English Abstract-------------------------------------------3 Chinese Abstract-------------------------------------------5 Introduction-----------------------------------------------7 Specific Aims---------------------------------------------25 Materials and Methods-------------------------------------26 Part I: Nutrient deprivation induces the Warburg effect through ROS/ AMPK-dependent activation of pyruvate dehydrogenase kinase Results---------------------------------------------------37 Discussion------------------------------------------------46 Figures---------------------------------------------------54 Part II: Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation Results-----------------------------------------------------------------------------69 Discussion------------------------------------------------------------------------80 Figures-----------------------------------------------------------------------------87 Conclusion---------------------------------------------------------------------103 Appendix------------------------------------------------------------------------104 References-----------------------------------------------------------------------112 Publications---------------------------------------------------------------------137 | |
dc.language.iso | en | |
dc.title | 探討養分缺乏影響癌細胞代謝及HIF-1alpha表現的分子機制 | zh_TW |
dc.title | The molecular mechanisms for nutrient deprivation-induced energy homeostasis and HIF-1α induction in cancer cells | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-1 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 黃彥華,陳昆鋒,陳彥州,符文美 | |
dc.subject.keyword | 瓦氏效應,丙酮酸脫氫?酵素,缺氧可誘發性因子甲型,自噬體,內部核糖體進入位, | zh_TW |
dc.subject.keyword | Warburg effect,PDK,HIF-1α,Autophagy,IRES, | en |
dc.relation.page | 137 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2014-10-22 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥理學研究所 | zh_TW |
顯示於系所單位: | 藥理學科所 |
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