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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5349完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉如熹 | |
| dc.contributor.author | Po-Han Lee | en |
| dc.contributor.author | 李柏漢 | zh_TW |
| dc.date.accessioned | 2021-05-15T17:56:33Z | - |
| dc.date.available | 2016-07-08 | |
| dc.date.available | 2021-05-15T17:56:33Z | - |
| dc.date.copyright | 2014-07-08 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-06-26 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5349 | - |
| dc.description.abstract | 上轉換奈米粒子(UCNPs)為一可吸收多顆近紅外光激發光子並轉換為可見光波段光子之發光材料，此特性使其於生醫領域具高度應用潛力。目前上轉換奈米粒子相關之研究可分為直接利用其放光特性應用於生物標記，或者間接轉換釋放之光能於分子檢測及癌症治療之領域，於癌症治療領域主要為結合光敏劑進行光動力療法，利用活性氧物質以致使腫瘤癌細胞死亡。除光動力療法外，上轉換奈米粒子於光熱治療部分之研究仍具許多應用潛力。本研究所合成之多功能奈米複合材料為結合上轉換奈米粒子與不同形貌之金奈米粒子，利用金奈米粒子於特定入射光波長之具表面電漿共振之性質，並透過表面電漿共振所吸收之光能轉換為熱能，搭配具多重放光特性之上轉換奈米粒子提供光能來源以產生熱能致使細胞死亡。本研究利用厚度3 ± 0.5 nm之二氧化矽殼層包覆於大小為19 ± 1.1 nm之上轉換奈米粒子表面，並修飾胺基於以連接大小為3.6 ± 1.11 nm之球狀金奈米粒子(UCNP@SiO2-AuNPs)或徑長比為2.5之棒狀金奈米粒子(UCNP@SiO2-AuNRs)，探討不同形貌之金奈米粒子於此複合材料之光熱轉換效率差異。於細胞毒性測試中，本研究所合成之奈米複合材料即便於250 μg/mL高濃度下，對於口腔癌細胞依然具相當低之毒性，可驗證其為低毒性之奈米材料。於光熱治療實驗中，UCNP@SiO2-AuNRs組別相較於UCNP@SiO2-AuNPs及其餘對照組，細胞死亡之數目與範圍皆明顯提升，顯示棒狀金奈米粒子具較強之光熱治療效果。本研究所製備之奈米複合材料，克服傳統金奈米粒子於生物標記之限制，並結合上轉換奈米粒子之螢光成像與金奈米粒子之光熱轉換特性，成功製備具多功能之奈米複合材料。 | zh_TW |
| dc.description.abstract | Upconversion nanoparticles (UCNPs) refer to a highly potent nanomaterial for bioassay and bioimage because it can convert two or more low energy photons to a high energy photon. We demonstrate a nanocomposite consisting of UCNPs and gold nanoparticles as a multifunctional nanomaterial to apply in biomedical application. Noble metallic nanoparticles such as gold nanoparticle have a unique optical property because of the surface plasmon resonance (SPR). Furthermore NaYF4:Yb/Er upconversion nanoparticles emit the photoluminescence from green-to-red which can provide gold nanoparticles inducing photothermal effect. We further used silica coated UCNPs to functionalize amino groups on silica shell to combine 3.5 nm gold nanoparticles (UCNP@SiO2-AuNPs) or gold nanorods (UCNP@SiO2-AuNRs). The size of UCNPs and UCNP@SiO2 are define as 19 ± 1.1 nm and 26 ± 0.5 nm by HRTEM, respectively, and the silica shell is 3 ± 0.5 nm. According to the result of photoluminescence spectra, the intensity of UCNP@SiO2-AuNRs is lower than UCNP@SiO2-AuNPs and this confirm highly energy transfer from UCNP to gold nanorods. In vitro cytotoxicity study, this nanocomposites is nontoxicty to oral cancer cell through the MTT assay even the concentration of nanocomposites approaching 250 μg/mL. The photothermal effect of UCNP@SiO2-AuNRs is demonstrated by irradiating a 980 nm laser and staining with trypan blue, there is huge cell death compare to UCNP@SiO2-AuNPs. In summary, we successfully develop nanocomposites based on UCNPs which reveal obviously photothermal effect and cell imaging to overcome non-fluorescent material like gold nanorods as nanocarriers in biological application. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-15T17:56:33Z (GMT). No. of bitstreams: 1 ntu-103-R01223161-1.pdf: 5712933 bytes, checksum: d8c0ffbe7be08ec8e4ed288cff08ef24 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
誌謝 II 摘要 III Abstract IV 第一章 緒論 1 1.1 奈米材料之定義與特性 1 1.1.1 表面效應 3 1.1.2 小尺寸效應 3 1.1.2.1 磁力性質 3 1.1.2.2 光學性質 4 1.1.2.3 熱力學性質 4 1.1.3 量子尺寸效應 4 1.2 金奈米粒子之簡介 5 1.2.1 表面電漿共振之簡介 5 1.2.1.1 表面電漿傳遞(Surface plasmon propagation) 6 1.2.1.2 侷域性表面電漿共振(Localized surface plasmon resonance) 6 1.2.2 光熱治療(Photothermal therapy; PTT) 8 1.3 上轉換奈米粒子之簡介 10 1.3.1 上轉換奈米粒子之組成 12 1.3.1.1 主體材料(Host) 13 1.3.1.2 活化劑(Activator) 14 1.3.1.3 敏化劑(Sensitizer) 14 1.3.2 上轉換奈米粒子發光之機制 15 1.3.2.1 激發態吸收(Excited state absorption; ESA) 15 1.3.2.2 能量轉移上轉換(Energy transfer upconversion; ETU) 16 1.3.2.3 光子雪崩(Photon avalanche; PA) 16 1.4 文獻回顧 17 1.5 研究動機與目的 19 第二章 實驗方法與儀器原理 22 2.1 化學藥品 22 2.2 實驗步驟 23 2.2.1 上轉換奈米粒子之製備 23 2.2.2 球狀奈米金粒子之製備 24 2.2.3 棒狀金奈米粒子之製備 24 2.2.4 製備以甲殼素修飾之奈米複合材料 25 2.2.5 製備以二氧化矽修飾之奈米複合材料 26 2.2.6 細胞毒性之測試 26 2.2.7 光熱治療之測試 26 2.3 儀器原理 27 2.3.1 穿透式電子顯微鏡(Transmission electron microscope; TEM) 27 2.3.2 X光能量散布光譜(Energy Dispersive X-ray Spectrum; EDS) 29 2.3.3 X光粉末繞射(X-ray powder diffraction; XRD) 31 2.3.4 紫外光/可見光吸收光譜(UV/Vis absorption spectrum) 33 2.3.4.1 σ、π或n電子之吸收 34 2.3.4.2 d、f軌域電子之吸收 35 2.3.4.3 分子電荷轉移之吸收 35 2.3.5 光激發放光光譜(photoluminescence spectrum; PL) 36 2.3.5.1 振動鬆弛(Vibration relaxation) 37 2.3.5.2 內部轉移(Internal conversion) 37 2.3.5.3 螢光(Fluorescence) 37 2.3.5.4 系統跨躍(Intersystem crossing) 38 2.3.5.5 磷光(Phosphorescence) 38 2.3.5.6 外部轉移(External conversion) 38 2.3.6 紅外光振動光譜(Infrared spectrum; IR) 39 2.3.7 雷射掃描共軛聚焦顯微鏡(Laser scanning confocal microscopy) 40 第三章 結果與討論 43 3.1 上轉換奈米粒子之合成與鑑定 43 3.1.1 上轉換奈米粒子之XRD圖譜 44 3.1.2 上轉換奈米粒子之TEM影像 45 3.1.3 上轉換奈米粒子之PL光譜 46 3.2 金奈米粒子之合成與鑑定 47 3.2.1 球狀金奈米粒子之UV/Vis吸收光譜 47 3.2.2 棒狀金奈米粒子之成長機制 48 3.2.3 棒狀金奈米粒子之UV/Vis吸收光譜 49 3.2.4 棒狀金奈米粒子之TEM影像 51 3.3 奈米複合材料之合成與鑑定 51 3.3.1 以甲殼素修飾奈米複合材料之合成與鑑定 52 3.3.1.1 以甲殼素修飾奈米複合材料之TEM影像 54 3.3.1.2 以甲殼素修飾奈米複合材料之特性放光圖譜 55 3.3.2 以二氧化矽修飾奈米複合材料之合成與鑑定 57 3.3.2.1 以二氧化矽修飾奈米複合材料之TEM影像 58 3.3.2.2 以二氧化矽修飾奈米複合材料之PL光譜 61 3.4 奈米複合材料於生物應用之結果與討論 63 3.4.1 細胞毒性之測試 64 3.4.2 共軛聚焦顯微鏡之螢光成像 65 3.4.3 光熱治療於Cal 27細胞之測試 66 第四章 結論 69 參考文獻 70 | |
| dc.language.iso | zh-TW | |
| dc.subject | 二氧化矽殼層 | zh_TW |
| dc.subject | 上轉換奈米粒子 | zh_TW |
| dc.subject | 光熱治療 | zh_TW |
| dc.subject | 金奈米粒子 | zh_TW |
| dc.subject | photothermal therapy | en |
| dc.subject | gold nanoparticles | en |
| dc.subject | upconversion nanoparticles | en |
| dc.subject | silica shell | en |
| dc.title | 具多功能之形貌控制金奈米粒子與上轉換奈米粒子複合材料 | zh_TW |
| dc.title | Multifunctional Nanocomposite of Upconversion Nanoparticle with Different Morphology of Gold Nanoparticles | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳仲瑄,蔡定平,蕭宏昇,蔣孝澈 | |
| dc.subject.keyword | 上轉換奈米粒子,金奈米粒子,二氧化矽殼層,光熱治療, | zh_TW |
| dc.subject.keyword | upconversion nanoparticles,gold nanoparticles,silica shell,photothermal therapy, | en |
| dc.relation.page | 77 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2014-06-26 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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