請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53083
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 錢宗良 | |
dc.contributor.author | Chuan-Chuan Chao | en |
dc.contributor.author | 趙娟娟 | zh_TW |
dc.date.accessioned | 2021-06-15T16:43:21Z | - |
dc.date.available | 2020-09-25 | |
dc.date.copyright | 2015-09-25 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-08-10 | |
dc.identifier.citation | Abramovitch, R., Meir, G., and Neeman, M. (1995). Neovascularization inducedgrowth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging. Cancer Res 55, 1956-1962.
Agostini, M., Tucci, P., Steinert, J.R., Shalom-Feuerstein, R., Rouleau, M., Aberdam, D., Forsythe, I.D., Young, K.W., Ventura, A., Concepcion, C.P., et al. (2011). microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A 108, 21099-21104. Alvarez-Garcia, I., and Miska, E.A. (2005). MicroRNA functions in animal development and human disease. Development 132, 4653-4662. Auer, R.N., Del Maestro, R.F., and Anderson, R. (1981). A simple and reproducible experimental in vivo glioma model. Can J Neurol Sci 8, 325-331. Baker, B.J., Qin, H., and Benveniste, E.N. (2008). Molecular basis of oncostatin Minduced SOCS-3 expression in astrocytes. Glia 56, 1250-1262. Benda, P., Lightbody, J., Sato, G., Levine, L., and Sweet, W. (1968). Differentiated rat glial cell strain in tissue culture. Science 161, 370-371. Bernstein, J.J., Goldberg, W.J., Laws, E.R., Jr., Conger, D., Morreale, V., and Wood, L.R. (1990). C6 glioma cell invasion and migration of rat brain after neural homografting: ultrastructure. Neurosurgery 26, 622-628. Bernstein, J.J., Laws, E.R., Jr., Levine, K.V., Wood, L.R., Tadvalkar, G., andGoldberg, W.J. (1991). C6 glioma-astrocytoma cell and fetal astrocyte migration intoartificial basement membrane: a permissive substrate for neural tumors but not fetal astrocytes. Neurosurgery 28, 652-658. Bianchi, M.G., Gazzola, G.C., Tognazzi, L., and Bussolati, O. (2008). C6 glioma cellsdifferentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1). Neuroscience 151, 1042-1052. Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D.A., Rozovsky, I., Stahl, N., Yancopoulos, G.D., and Greenberg, M.E. (1997). Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278, 477-483. Bridge, G., Monteiro, R., Henderson, S., Emuss, V., Lagos, D., Georgopoulou, D., Patient, R., and Boshoff, C. (2012). The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood 120, 5063-5072. Bushati, N., and Cohen, S.M. (2007). microRNA functions. Annu Rev Cell Dev Biol 23, 175-205. Caccamo, D., Katsetos, C.D., Herman, M.M., Frankfurter, A., Collins, V.P., and Rubinstein, L.J. (1989). Immunohistochemistry of a spontaneous murine ovarian teratoma with neuroepithelial differentiation. Neuron-associated beta-tubulin as a marker for primitive neuroepithelium. Laboratory investigation; a journal of technical methods and pathology 60, 390-398. Calin, G.A., and Croce, C.M. (2006a). MicroRNA signatures in human cancers. Nat Rev Cancer 6, 857-866. Calin, G.A., and Croce, C.M. (2006b). MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 66, 7390-7394. Cao, F., Hata, R., Zhu, P., Ma, Y.J., Tanaka, J., Hanakawa, Y., Hashimoto, K., Niinobe, M., Yoshikawa, K., and Sakanaka, M. (2006). Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells. Journal of neurochemistry 98, 459-470. Chao, C.C., Kan, D., Lu, K.S., and Chien, C.L. (2015). The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells. Stem Cell Res 14, 211-223. Chen, G., Umelo, I.A., Lv, S., Teugels, E., Fostier, K., Kronenberger, P., Dewaele, A., Sadones, J., Geers, C., and De Greve, J. (2013). miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells. PLoS One 8, e60317. Chicoine, M.R., and Silbergeld, D.L. (1995). Invading C6 glioma cells maintaining tumorigenicity. J Neurosurg 83, 665-671. Ciafre, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., and Farace, M.G. (2005). Extensive modulation of a set of microRNAs in primary glioblastoma. Biochemical and biophysical researchcommunications 334, 1351-1358. Clarke, M.F., Dick, J.E., Dirks, P.B., Eaves, C.J., Jamieson, C.H., Jones, D.L., Visvader, J., Weissman, I.L., and Wahl, G.M. (2006). Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66, 9339-9344. Das, G.C., Holiday, D., Gallardo, R., and Haas, C. (2001). Taxol-induced cell cycle arrest and apoptosis: dose-response relationship in lung cancer cells of different wildtype p53 status and under isogenic condition. Cancer letters 165, 147-153. Delaloy, C., Liu, L., Lee, J.A., Su, H., Shen, F., Yang, G.Y., Young, W.L., Ivey, K.N., and Gao, F.B. (2010). MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell 6, 323-335. DeSano, J.T., and Xu, L. (2009). MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J 11, 682-692. Diao, H.J., Low, W.C., Milbreta, U., Lu, Q.R., and Chew, S.Y. (2015). Nanofibermediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. J Control Release 208, 85-92. Dugas, J.C., Cuellar, T.L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J.L., Foo, L.C., McManus, M.T., and Barres, B.A. (2010). Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron 65, 597-611. Engelhard, H.H., Duncan, H.A., Kim, S., Criswell, P.S., and Van Eldik, L. (2001). Therapeutic effects of sodium butyrate on glioma cells in vitro and in the rat C6 glioma model. Neurosurgery 48, 616-624; discussion 624-615. Fineberg, S.K., Kosik, K.S., and Davidson, B.L. (2009). MicroRNAs potentiate neural development. Neuron 64, 303-309. Gao, J., Yang, T., Han, J., Yan, K., Qiu, X., Zhou, Y., Fan, Q., and Ma, B. (2011). MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow. J Cell Biochem 112, 1844-1856. Gil, Y.G., and Kang, M.K. (2008). Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells. Life Sci 82, 997-1003. Godlewski, J., Newton, H.B., Chiocca, E.A., and Lawler, S.E. (2010). MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ 17, 221-228. Goetschy, J.F., Ulrich, G., Aunis, D., and Ciesielski-Treska, J. (1986). The organization and solubility properties of intermediate filaments and microtubules of cortical astrocytes in culture. J Neurocytol 15, 375-387. Griffiths-Jones, S., Saini, H.K., van Dongen, S., and Enright, A.J. (2008). miRBase: tools for microRNA genomics. Nucleic Acids Res 36, D154-158. Grobben, B., De Deyn, P.P., and Slegers, H. (2002). Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion. Cell Tissue Res 310, 257-270. Han, F., Huo, Y., Huang, C.J., Chen, C.L., and Ye, J. (2015). MicroRNA-30b promotes axon outgrowth of retinal ganglion cells by inhibiting Semaphorin3A expression. Brain Res 1611, 65-73. Han, J., Wang, B., Xiao, Z., Gao, Y., Zhao, Y., Zhang, J., Chen, B., Wang, X., and Dai, J. (2008). Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin. Molecular and cellular neurosciences 39, 118-124. Hand, N.J., Master, Z.R., Eauclaire, S.F., Weinblatt, D.E., Matthews, R.P., and Friedman, J.R. (2009). The microRNA-30 family is required for vertebratehepatobiliary development. Gastroenterology 136, 1081-1090. Hari, M., Yang, H., Zeng, C., Canizales, M., and Cabral, F. (2003). Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel. Cell Motil Cytoskeleton 56, 45-56. Hatfield, S., and Ruohola-Baker, H. (2008). microRNA and stem cell function. Cell Tissue Res 331, 57-66. Holland, E.C. (2000). Glioblastoma multiforme: the terminator. Proc Natl Acad Sci U S A 97, 6242-6244. Hong, X., Chedid, K., and Kalkanis, S.N. (2012). Glioblastoma cell line-derived spheres in serumcontaining medium versus serum-free medium: a comparison of cancer stem cell properties. Int J Oncol 41, 1693-1700. Horwitz, S.B. (1994). Taxol (paclitaxel): mechanisms of action. Ann Oncol 5 Suppl 6, S3-6. Hu, W., Onuma, T., Birukawa, N., Abe, M., Ito, E., Chen, Z., and Urano, A. (2008). Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells. Cell Mol Neurobiol 28, 519-528. Huang, J., Zhao, L., Xing, L., and Chen, D. (2010). MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28, 357-364. Jia, L., Li, Y.F., Wu, G.F., Song, Z.Y., Lu, H.Z., Song, C.C., Zhang, Q.L., Zhu, J.Y., Yang, G.S., and Shi, X.E. (2014). MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway. International journal of molecular sciences 15, 296-308. Jia, L., Zhang, S., Ye, Y., Li, X., Mercado-Uribe, I., Bast, R.C., Jr., and Liu, J. (2012). Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett 326, 176-182. Karbiener, M., Neuhold, C., Opriessnig, P., Prokesch, A., Bogner-Strauss, J.G., and Scheideler, M. (2011). MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2. RNA Biol 8, 850-860. Karmakar, S., Banik, N.L., and Ray, S.K. (2008). Combination of all-trans retinoicacid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer 112, 596-607. Katsetos, C.D., Draberova, E., Smejkalova, B., Reddy, G., Bertrand, L., de Chadarevian, J.P., Legido, A., Nissanov, J., Baas, P.W., and Draber, P. (2007). Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. Neurochemical research 32, 1387-1398. Katsetos, C.D., Legido, A., Perentes, E., and Mork, S.J. (2003). Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology. J Child Neurol 18, 851-866; discussion 867. Kavallaris, M. (2010). Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 10, 194-204. Kavallaris, M., Burkhart, C.A., and Horwitz, S.B. (1999). Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol. Br J Cancer 80, 1020-1025. Kavallaris, M., Kuo, D.Y., Burkhart, C.A., Regl, D.L., Norris, M.D., Haber, M., and Horwitz, S.B. (1997). Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest 100, 1282-1293. Kondo, T., Setoguchi, T., and Taga, T. (2004). Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 101, 781-786. Kosik, K.S. (2006). The neuronal microRNA system. Nat Rev Neurosci 7, 911-920. Lange, A., Gustke, H., Glassmeier, G., Heine, M., Zangemeister-Wittke, U., Schwarz, J.R., Schumacher, U., and Lange, T. (2011). Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer 74, 178-187. Lariviere, R.C., and Julien, J.P. (2004). Functions of intermediate filaments in neuronal development and disease. J Neurobiol 58, 131-148. Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N.M., Pastorino, S., Purow, B.W., Christopher, N., Zhang, W., et al. (2006). Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403. Lee, K.M., Cao, D., Itami, A., Pour, P.M., Hruban, R.H., Maitra, A., and Ouellette, M.M. (2007). Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. Histopathology 51, 539-546. Letzen, B.S., Liu, C., Thakor, N.V., Gearhart, J.D., All, A.H., and Kerr, C.L. (2010). MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS One 5, e10480. Li, W.B., Ma, M.W., Dong, L.J., Wang, F., Chen, L.X., and Li, X.R. (2011). MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. Cancer Biol Ther 12, 477-483. Lim, J.S., Yoo, M., Kwon, H.J., Kim, H., and Kwon, Y.K. (2010). Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochemical and biophysical research communications 402, 42-47. Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Burger, P.C., Jouvet, A.,Scheithauer, B.W., and Kleihues, P. (2007). The 2007 WHO classification of tumoursof the central nervous system. Acta neuropathologica 114, 97-109. Mao, J., Zhang, M., Zhong, M., Zhang, Y., and Lv, K. (2014). MicroRNA-204, a direct negative regulator of ezrin gene expression, inhibits glioma cell migration and invasion. Mol Cell Biochem 396, 117-128. McMorris, F.A. (1977). Norepinephrine induces glial-specific enzyme activity in cultured plasma glioma cells. Proceedings of the National Academy of Sciences of the United States of America 74, 4501-4504. Kavallaris, M., Kuo, D.Y., Burkhart, C.A., Regl, D.L., Norris, M.D., Haber, M., and Horwitz, S.B. (1997). Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest 100, 1282-1293. Kondo, T., Setoguchi, T., and Taga, T. (2004). Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 101, 781-786. Kosik, K.S. (2006). The neuronal microRNA system. Nat Rev Neurosci 7, 911-920. Lange, A., Gustke, H., Glassmeier, G., Heine, M., Zangemeister-Wittke, U., Schwarz, J.R., Schumacher, U., and Lange, T. (2011). Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer 74, 178-187. Lariviere, R.C., and Julien, J.P. (2004). Functions of intermediate filaments in neuronal development and disease. J Neurobiol 58, 131-148. Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N.M., Pastorino, S., Purow, B.W., Christopher, N., Zhang, W., et al. (2006). Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 91-403. Lee, K.M., Cao, D., Itami, A., Pour, P.M., Hruban, R.H., Maitra, A., and Ouellette, M.M. (2007). Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. Histopathology 51, 539-546. Letzen, B.S., Liu, C., Thakor, N.V., Gearhart, J.D., All, A.H., and Kerr, C.L. (2010). MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS One 5, e10480. Li, W.B., Ma, M.W., Dong, L.J., Wang, F., Chen, L.X., and Li, X.R. (2011). MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. Cancer Biol Ther 12, 477-483. Lim, J.S., Yoo, M., Kwon, H.J., Kim, H., and Kwon, Y.K. (2010). Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochemical and biophysical research communications 402, 42-47. Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Burger, P.C., Jouvet, A., Scheithauer, B.W., and Kleihues, P. (2007). The 2007 WHO classification of tumours of the central nervous system. Acta neuropathologica 114, 97-109. Mao, J., Zhang, M., Zhong, M., Zhang, Y., and Lv, K. (2014). MicroRNA-204, a direct negative regulator of ezrin gene expression, inhibits glioma cell migration and invasion. Mol Cell Biochem 396, 117-128. McMorris, F.A. (1977). Norepinephrine induces glial-specific enzyme activity in cultured plasma glioma cells. Proceedings of the National Academy of Sciences of the United States of America 74, 4501-4504. McMorris, F.A. (1983). Cyclic AMP induction of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase in rat oligodendrocytes. Journal of neurochemistry 41, 506-515. Mei, J., Bachoo, R., and Zhang, C.L. (2011). MicroRNA-146a inhibits glioma development by targeting Notch1. Molecular and cellular biology 31, 3584-3592. Messens, J., and Slegers, H. (1992). Synthesis of glial fibrillary acidic protein in rat C6 glioma in chemically defined medium: cyclic AMP-dependent transcriptional and translational regulation. Journal of neurochemistry 58, 2071-2080. Michels, T., Shurin, G.V., Naiditch, H., Sevko, A., Umansky, V., and Shurin, M.R. (2012). Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner. Journal of immunotoxicology 9, 292-300. Moorthi, A., Vimalraj, S., Avani, C., He, Z., Partridge, N.C., and Selvamurugan, N. (2013). Expression of microRNA-30c and its target genes in human osteoblastic cells by nano-bioglass ceramic-treatment. Int J Biol Macromol 56, 181-185. Murakami, Y., Yasuda, T., Saigo, K., Urashima, T., Toyoda, H., Okanoue, T., and Shimotohno, K. (2006). Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 25, 2537-2545. Nagano, N., Sasaki, H., Aoyagi, M., and Hirakawa, K. (1993). Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells. Acta neuropathologica 86, 117-125. Parker, N.R., Khong, P., Parkinson, J.F., Howell, V.M., and Wheeler, H.R. (2015). Molecular heterogeneity in glioblastoma: potential clinical implications. Frontiers in oncology 5, 55. Pellegatta, S., Poliani, P.L., Corno, D., Menghi, F., Ghielmetti, F., Suarez-Merino, B., Caldera, V., Nava, S., Ravanini, M., Facchetti, F., et al. (2006). Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cellmediated immune response against malignant gliomas. Cancer Res 66, 10247-10252. Pushkarev, V.M., Starenki, D.V., Saenko, V.A., Namba, H., Kurebayashi, J., Tronko, M.D., and Yamashita, S. (2004). Molecular mechanisms of the effects of low concentrations of taxol in anaplastic thyroid cancer cells. Endocrinology 145, 3143-3152. Qian, X., Zhao, P., Li, W., Shi, Z.M., Wang, L., Xu, Q., Wang, M., Liu, N., Liu, L.Z., and Jiang, B.H. (2013). MicroRNA-26a Promotes Tumor Growth and Angiogenesis in Glioma by Directly Targeting Prohibitin. CNS Neurosci Ther. Qin, H., Niyongere, S.A., Lee, S.J., Baker, B.J., and Benveniste, E.N. (2008). Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes. J Immunol 181, 3167-3176. Ranganathan, S., Dexter, D.W., Benetatos, C.A., Chapman, A.E., Tew, K.D., and Hudes, G.R. (1996). Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance. Cancer res 56, 2584-2589. Ranganathan, S., Dexter, D.W., Benetatos, C.A., and Hudes, G.R. (1998). Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents. Biochim Biophys Acta 1395, 237-245. Rani, S.B., Rathod, S.S., Karthik, S., Kaur, N., Muzumdar, D., and Shiras, A.S.(2013). MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro Oncol 15, 1302-1316. San-Galli, F., Vrignaud, P., Robert, J., Coindre, J.M., and Cohadon, F. (1989). Assessment of the experimental model of transplanted C6 glioblastoma in Wistar rats. J Neurooncol 7, 299-304. Sasaki, Y., Gross, C., Xing, L., Goshima, Y., and Bassell, G.J. (2014). Identification of axon-enriched microRNAs localized to growth cones of cortical neurons. Dev Neurobiol 74, 397-406. Schmidek, H.H., Nielsen, S.L., Schiller, A.L., and Messer, J. (1971). Morphological studies of rat brain tumors induced by N-nitrosomethylurea. J Neurosurg 34, 35-340. Scott, P.H., Brunn, G.J., Kohn, A.D., Roth, R.A., and Lawrence, J.C., Jr. (1998). Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci U S A 95, 7772-7777. Sekulic, A., Hudson, C.C., Homme, J.L., Yin, P., Otterness, D.M., Karnitz, L.M., and Abraham, R.T. (2000). A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60, 3504-3513. Seternes, O.M., Sorensen, R., Johansen, B., and Moens, U. (1999). Activation of protein kinase A by dibutyryl cAMP treatment of NIH 3T3 cells inhibits proliferation but fails to induce Ser-133 phosphorylation and transcriptional activation of CREB. Cell Signal 11, 211-219. Shen, G., Shen, F., Shi, Z., Liu, W., Hu, W., Zheng, X., Wen, L., and Yang, X. (2008). Identification of cancer stem-like cells in the C6 glioma cell line and the limitation of current identification methods. In Vitro Cell Dev Biol Anim 44, 280-289. Shen, L., Sun, C., Li, Y., Li, X., Sun, T., Liu, C., Zhou, Y., and Du, Z. (2015). MicroRNA-199a-3p suppresses glioma cell proliferation by regulating the AKT/mTOR signaling pathway. Tumour Biol. Shi, M.G., Huang, Q., Dong, J., Sun, Z.F., and Lan, Q. (2002). [Experimental study of combination therapy against human glioma xenograft by differentiation-inducing agent and cytotoxic chemotherapeutic drug]. Ai zheng = Aizheng = Chinese journal of cancer 21, 1090-1094. Silbergeld, D.L., Chicoine, M.R., and Madsen, C.L. (1995). In vitro assessment of Taxol for human glioblastoma: chemosensitivity and cellular locomotion. Anticancer Drugs 6, 270-276. Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J., and Dirks, P.B. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Res 63, 5821-5828. Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R.M., Cusimano, M.D., and Dirks, P.B. (2004). Identification of human brain tumour initiating cells. Nature 432, 396-401. Stevanato, L., and Sinden, J.D. (2014). The effects of microRNAs on human neural stem cell differentiation in two- and three-dimensional cultures. Stem cell research & therapy 5, 49-59. Svendsen, C.N., Bhattacharyya, A., and Tai, Y.T. (2001). Neurons from stem cells: preventing an identity crisis. Nature reviews Neuroscience 2, 831-834. Takanaga, H., Yoshitake, T., Hara, S., Yamasaki, C., and Kunimoto, M. (2004). cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. The Journal of biological chemistry 279, 15441-15447. Tan, X., Wang, S., Yang, B., Zhu, L., Yin, B., Chao, T., Zhao, J., Yuan, J., Qiang, B., and Peng, X. (2012). The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. PLoS One 7, e49570. Umezu, T., Shibata, K., Kajiyama, H., Terauchi, M., Ino, K., Nawa, A., and Kikkawa, F. (2008). Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III beta-tubulin. Int J Gynecol Pathol 27, 207-212. Vimalraj, S., and Selvamurugan, N. (2014). MicroRNAs expression and their regulatory networks during mesenchymal stem cells differentiation toward osteoblasts. Int J Biol Macromol 66, 194-202. Vorwerk, S., Ganter, K., Cheng, Y., Hoheisel, J., Stahler, P.F., and Beier, M. (2008). Microfluidic-based enzymatic on-chip labeling of miRNAs. N Biotechnol 25, 142-149. Whittle, I.R., Macarthur, D.C., Malcolm, G.P., Li, M., Washington, K., and Ironside, J.W. (1998). Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. J Neurooncol 36, 231-242. Wu, Y., Shen, D., Chen, Z., Clayton, S., and Vadgama, J.V. (2007). Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis : an international journal on programmed cell death 12, 593-612. Xiao, H., Verdier-Pinard, P., Fernandez-Fuentes, N., Burd, B., Angeletti, R., Fiser, A., Horwitz, S.B., and Orr, G.A. (2006). Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A 103, 10166-10173. Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J.A., and Kosik, K.S. (2009a). MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137, 647-658. Xu, Q., Yuan, X., Tunici, P., Liu, G., Fan, X., Xu, M., Hu, J., Hwang, J.Y., Farkas, D.L., Black, K.L., et al. (2009b). Isolation of tumour stem-like cells from benign tumours. Br J Cancer 101, 303-311. Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., Stephens, R.M., Okamoto, A., Yokota, J., Tanaka, T., et al. (2006). Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9, 189-198. Yang, B., Guo, H., Zhang, Y., Chen, L., Ying, D., and Dong, S. (2011). MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9. PLoS One 6, e21679. Yin, R., Zhang, S., Wu, Y., Fan, X., Jiang, F., Zhang, Z., Feng, D., Guo, X., and Xu, L. (2011). microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4. Oncology reports 25, 1747-1754. Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., Li, W., Hu, B., Cheng, S.Y., and Li, M. (2013). Loss of miR-204 expression enhances glioma migration and stem celllike phenotype. Cancer research 73, 990-999. Yoshimura, S., Sakai, H., Nakashima, S., Nozawa, Y., Shinoda, J., Sakai, N., and Yamada, H. (1997). Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Brain Res Mol Brain Res 45, 90-98. Yu, S.C., Ping, Y.F., Yi, L., Zhou, Z.H., Chen, J.H., Yao, X.H., Gao, L., Wang, J.M., and Bian, X.W. (2008). Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett 265, 124-134. Yuan, X., Curtin, J., Xiong, Y., Liu, G., Waschsmann-Hogiu, S., Farkas, D.L., Black, K.L., and Yu, J.S. (2004). Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23, 9392-9400. Zaman, M.S., Chen, Y., Deng, G., Shahryari, V., Suh, S.O., Saini, S., Majid, S., Liu, J., Khatri, G., Tanaka, Y., et al. (2010). The functional significance of microRNA-145 in prostate cancer. British journal of cancer 103, 256-264. Zhang, Y., Xie, R.L., Gordon, J., LeBlanc, K., Stein, J.L., Lian, J.B., van Wijnen, A.J., and Stein, G.S. (2012). Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. The Journal of biological chemistry 287, 21926-21935. Zhao, C., Sun, G., Li, S., and Shi, Y. (2009). A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nature structural & molecular biology 16, 365-371. Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.S., Xin, M., et al. (2010). MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65, 612-626. Zheng, X., Shen, G., Yang, X., and Liu, W. (2007). Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res 67, 3691-3697. Zhuang, W., Li, B., Long, L., Chen, L., Huang, Q., and Liang, Z. (2011). Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. International journal of cancer Journal international du cancer 129, 2720-2731. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53083 | - |
dc.description.abstract | 惡性神經膠質瘤(malignant gliomas)是成人中最常見的原發性腦腫瘤。科學家嘗試著利用包括紫杉醇(taxol)在內的各種抗癌藥物治療膠質母細胞瘤,發現這些藥物不僅造成細胞死亡,同時也可以觀察到細胞的形態變化。然而治療效果卻不盡理想,或許是受到腫瘤幹細胞(cancer stem cells, CSC)的存在所致。
腫瘤幹細胞是腫瘤細胞中一群具有自我更新能力及並可以不斷形成腫瘤的細胞。將腫瘤幹細胞培養在含有bFGF及EGF的無血清培養基中,細胞則會形成具有神經幹細胞的球體(spheres)並具有表現神經幹細胞的標記—Nestin 蛋白。將細胞加以誘導分化則會形成表達bIII-tubulin, GFAP及CNPase等神經或是膠質標定蛋白的細胞。 MiRNA是真核生物中廣泛存在的一種RNA分子,其可藉由與其目標基因mRNA之3’-UTR互補結合,抑制轉錄後基因的表達,進而達到其基因調控的目的。除了在腫瘤幹細胞中扮演調控的角色外,這些miRNAs也與神經發育及腫瘤形成有關。 在本篇研究中,我們首先利用紫杉醇的刺激來觀察rat C6 glioma cells形態上的變化,同時並檢測經由紫杉醇刺激後glioma cells中其bIII-tubulin, GFAP及CNPase等神經標定蛋白的變化。結果發現C6 glioma cells受到紫杉醇的誘導引發神經分化。在神經膠質瘤的治療上,紫杉醇的給予提升了神經細胞的分化能力。此一“分化治療”或許可作為抗癌藥物在癌症治療上提供一潛在的治療方式。 其次,由於C6 glioma cells具有腫瘤幹細胞的三大特性—自我更新、多能分化及致癌能力,因此將C6 cells培養成球體細胞並進一步證明這些球體細胞具有腫瘤幹細胞的特性,結果發現C6 cells形成球體提升了多能分化的潛力並且受到IBMX的刺激後則會誘發神經分化。同時利用miRNA 微陣列進行球體細胞中miRNA的分析後發現miRNA-30c在球體細胞中高度表達。此外,在IBMX誘導神經分化的過程中,miRNA-30c藉由影響JAK-STAT3 訊息傳導路徑而抑制GFAP的表現。因此,miRNA-30c在腫瘤幹細胞其自我更新及神經分化的能力中扮演“調節者”的角色。 | zh_TW |
dc.description.abstract | Malignant gliomas are the most common intrinsic primary brain tumors in adults. Treating the cells from glioblastoma multiforme (GBM) with various anti-cancer drugs, not only cell death but also morphological changes have been observed. Scientists try to use anti-cancer drugs to treat tumors including taxol.
Cancer stem cells (CSCs) are a subpopulation of cells in the tumor that have self-renewal capacity and can give rise to heterogeneous cancer cells that constitute the tumor. CSCs were cultured in vitro as spheres using serum-free medium containing basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) and also showed remarkable similarities to normal neural stem cells (NSCs), expressing neural stem/progenitor markers such as Nestin, and, upon induction, could be differentiated to cells expressing neuronal or glial markers, including bIII-tubulin, glial fibrillary acidic protein (GFAP) and 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase). MicroRNAs (miRNAs) are noncoding sequences that act as “post-transcriptional” regulators that bind to complementary sequences in the 3′-untranslated regions of target mRNA transcripts by imperfect base-pairing, usually resulting in gene silencing. MiRNAs play a regulatory role in cancer stem-like cells including GBM. MiRNAs are also involved in neural development and tumor formation. In this study, we first present the effects of taxol challenge on rat C6 glioma cells in the aspects of cellular morphological changes and differentiation. Characterizations of neural molecular markers including bIII-tubulin (for neurons), GFAP (for astrocytes) and CNPase (for oligodendrocytes) in the taxol-treated cells revealed that taxol might induce neural differentiation. In glioma cells, base on the fact that neural differentiation could be promoted by taxol administration, a potential therapeutic application of anti-cancer drugs on the differentiation of tumor cells was suggested. Secondary, it also has been proved that C6 cells have the attributes of self-renewal, multipotency, and tumorigenicity, which are the characteristics of cancer stem-like cells. In these studies, the ability of self-renewal was characterized by using “sphere formation” under culture conditions including bFGF, EGF, and B27 supplementation. These sphere cells were further confirmed as “cancer stem-like cells” based on their characteristics of multipotency and tumorigenicity. In our studies, we demonstrated that a miRNA microarray served as a good platform for investigating which miRNA contributes in the processes of sphere formation and neural differentiation in this glioma cell model. Spheres were formed at first to enhance the potential for multipotency, and then neural differentiation was induced by 3-isobutyl-1-methylxanthine (IBMX) stimulation. Several miRNAs involved in sphere formation were identified by the miRNA microarray, and miRNA-30c was confirmed to play an important role in sphere formation. Furthermore, miRNA-30c suppressed the expression of GFAP by affecting the JAK-STAT3 pathway. These results suggest that miRNA-30c has a regulatory role in self-renewal and neural differentiation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T16:43:21Z (GMT). No. of bitstreams: 1 ntu-104-D94446002-1.pdf: 12227687 bytes, checksum: f226038fda61e98fd15b9c6e9e643b3a (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | Signature of Committees ------------------------------------------- i
Acknowledgement --------------------------------------------------- ii Abbreviation ---------------------------------------------------------- iv Summary of Dissertation in Chinese ---------------------------- 1 Summary of Dissertation in English ----------------------------- 3 Chapter I. General Introduction --------------------------------- 5 Brain tumors and glioblastoma multiforme (GBM) ---------- 6 Cancer stem cells -------------------------------------------------- 7 Anti-cancer drugs, taxol and differentiation therapy --------- 7 MicroRNAs (miRNAs) ------------------------------------------- 9 Rat C6 glioma cell line ------------------------------------------- 9 Aims ----------------------------------------------------------------- 10 Chapter II. Induction of neural differentiation in rat C6 glioma cells with taxol --------------------------------------------- 12 Abstract ------------------------------------------------------------- 13 Introduction -------------------------------------------------------- 14 Material and Methods -------------------------------------------- 16 Results -------------------------------------------------------------- 20 Discussions --------------------------------------------------------- 23 Figure legends, Figures and Tables ----------------------------- 27 Chapter III. The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells---------------------------- 40 Abstract -------------------------------------------------------------- 41 Introduction --------------------------------------------------------- 42 Material and Methods --------------------------------------------- 44 Results --------------------------------------------------------------- 51 Discussions --------------------------------------------------------- 57 Figure legends, Figures and Tables ------------------------------ 61 Chapter IV. Conclusions and Future Perspective ------------ 82 References ------------------------------------------------------------- 95 Appendix------------------------------------------------------------- 105 | |
dc.language.iso | en | |
dc.title | 探討神經膠質瘤C6 glioma cell自我更新及神經細胞分化 | zh_TW |
dc.title | Studies of the self-renewal and the neural diferentiation of C6 glioma cells | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 盧國賢,陳玉怜,陳惠文,何中良 | |
dc.subject.keyword | 腫瘤幹細胞,自我更新,神經分化,微小核醣核?酸, | zh_TW |
dc.subject.keyword | cancer stem cell,self-renewal,neural differentiation,microRNA, | en |
dc.relation.page | 105 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-08-11 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學暨細胞生物學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-104-1.pdf 目前未授權公開取用 | 11.94 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。