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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 繆希椿 | |
dc.contributor.author | Chih-Chun Liu | en |
dc.contributor.author | 劉芷君 | zh_TW |
dc.date.accessioned | 2021-06-15T16:17:09Z | - |
dc.date.available | 2020-09-24 | |
dc.date.copyright | 2015-09-24 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-08-17 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52516 | - |
dc.description.abstract | c-Maf是具有basic leucine zipper的轉錄因子,在第二型輔助T細胞中是介白素四重要及專一的調控因子。在第二型輔助T細胞中發現,c-Maf中第21/92/131酪胺酸的磷酸化增加c-Maf聚集於DNA,使得c-Maf轉錄介白素四基因能力增強。另一方面c-Maf中第33的離胺酸可被Ubc9及PIAS1等Sumo相關之酵素進行Sumo化修飾, Sumo化修飾降低c-Maf聚集於DNA上,導致c-Maf 轉錄介白素四的能力降低。然而,c-Maf在其他的輔助型T細胞是否也會進行酪胺酸磷酸化及Sumo化,以及這兩種後轉譯修飾是否影響c-Maf的轉錄活性仍有待闡明。在我的研究中證實,c-Maf 的酪胺酸磷酸化可發生於第十七型輔助T細胞中,並正向增強介白素十及介白素二十一基因之表達。此外Tec kinase在此被證明是c-Maf的酪胺酸激酶,可對c-Maf直接進行酪胺酸磷酸化。Tec kinase和 Ptpn22交互調節c-Maf的酪胺酸磷酸化,而Ptpn22則抵消Tec kinase所增強之c-Maf的轉錄能力。另一方面,第十七型輔助T細胞中, Sumo化修飾扮演負向調控c-Maf於介白素十及介白素二十一基因的轉錄能力。 | zh_TW |
dc.description.abstract | c-Maf, containing basic leucine zipper, is an important and specific transcription factor of Interleukin-4 (IL-4) in T helper 2 (TH2) cells. The phosphorylation at the tyrosine residues 21/92/131 of c-Maf enhances IL-4 gene expression via increasing recruitment of c-Maf on IL-4 promoter. On the other hand, the lysine residue 33 of c-Maf is the substrate of Ubc9 and PIAS1 that are the enzymes of sumoylation. Sumoylation represses the transactivity of c-Maf on IL-4 gene expression through reducing recruitment of c-Maf on IL-4 promoter. However, whether tyrosine phosphorylation and sumoylation of c-Maf undergo in other helper T cell subsets remains unknown. In this thesis, I demonstrated that the phosphorylation at tyrosine residues 21/92/131 of c-Maf enhances the IL-10 and IL-21 production in TH17 cells. Furthermore, that the Tec kinase (Tec) and protein tyrosine phosphatase non-receptor type 22 (Ptpn22) modulate c-Maf was characterized. Tec kinase and Ptpn22 act reciprocally in regulating the tyrosine phosphorylation and transactivity of c-Maf. Conversely, sumoylation represses the c-Maf dependent IL-10 and IL-21 production in TH17 cells. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T16:17:09Z (GMT). No. of bitstreams: 1 ntu-104-F93449007-1.pdf: 3167300 bytes, checksum: f50e3d46fbaa57013c9ba0cbd8cbf963 (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | 中文摘要 v Abstract vi 第一章 緒論 1 CD4 輔助型T細胞: 1 二. c-Maf 3 2.1. c-Maf概述 3 2.2. c-Maf在CD4 T細胞中的表現及功能 5 2.3 c-Maf 轉錄活性的調控: 8 三、酪胺酸磷酸化: 8 3.1酪胺酸激酶 9 3.2酪胺酸磷酸酶: 10 四、c-Maf 磷酸化: 10 五、Sumo化修飾: 12 六、c-Maf之Sumo化修飾: 13 七、研究動機及方向: 13 第二章 材料與方法 15 ㄧ、實驗材料 15 2.1.1抗體Antibodies 15 2.1.2緩衝液配方Buffers 16 2.1.3 SDS-PAGE Gel 19 2.1.4細胞株Cell line 20 2.1.5細胞激素Cytokines 20 2.1.6化學藥品及試劑Chemicals and reagents 20 2.1.7實驗材料 22 2.1.8實驗小鼠Mice 22 2.1.9試劑組Kits 23 2.1.10培養液Mediums 23 2.1.11質體Plasmids 24 2.2.1細胞培養 (cell culture) 24 2.2.2輔助型T細胞分化 (In vitro CD4 T cell differentiation) 25 2.2.3反轉錄病毒製備及濃縮 (Retrovirus preparation and concentration) 25 2.2.4反轉錄病毒感染法 (Retroviral transduction) 26 2.2.5酵素聯結免疫吸附法 (enzyme-linked immunosorbent assay ; ELISA) 26 2.2.6冷光酵素分析法 (Luciferase assay) 27 2.2.7西方墨點法 (Western blotting) 28 2.2.8免疫沉澱法 (Immunoprecipitation) 28 2.2.9統計分析 (Statistical analysis) 29 第三章 結果 30 3.1 c-Maf 在第十七型輔助T細胞進行酪胺酸磷酸化 30 3.2第十七型輔助T細胞中酪胺酸21/92/131是c-Maf進行酪胺酸磷酸化的主要酪胺酸位置 30 3.3第十七型輔助T細胞中c-Maf的21/92/131酪胺酸磷酸化增強介白素十及介白素二十一產生 32 3.4 Tec是c-Maf的酪胺酸磷酸酶 33 3.5 Ptpn22抑制c-Maf對介白素十及介白素二十一啟動子的轉錄能力 35 3.6 Tec與Ptpn22交互調節c-Maf的轉錄活性 36 3.7 c-Maf sumo化抑制第十七型輔助T細胞之c-Maf所媒介之介白素十及介白素二十一產生 37 3.8 c-Maf K33R基因轉殖NOD小鼠的第十七型輔助T細胞產生較高的介白素二十一 38 第四章 討論 40 4.1 c-Maf 酪胺酸磷酸化 40 4.2 c-Maf之 Sumo化: 42 圖表 45 參考文獻 72 附錄 99 | |
dc.language.iso | zh-TW | |
dc.title | 探討c-Maf酪胺酸磷酸化與Sumo化於第十七型輔助T細胞產生介白素十與介白素二十一之調控 | zh_TW |
dc.title | Tyrosine phosphorylation and sumoylation modulate c-Maf transactivity on IL-10 and IL-21 gene expression in TH17 cells | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 孔祥智,伍安怡,司徒惠康,廖南詩 | |
dc.subject.keyword | c-Maf,酪胺酸磷酸化,Sumo化,第十七型輔助T細胞,介白素十,介白素二十一, | zh_TW |
dc.subject.keyword | c-Maf,Tyrosine phosphorylation,Sumoylation,IL-10,IL-21,TH17 cells, | en |
dc.relation.page | 118 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-08-17 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 免疫學研究所 | zh_TW |
顯示於系所單位: | 免疫學研究所 |
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