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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李繼忠 | |
| dc.contributor.author | Yun-Ching Yang | en |
| dc.contributor.author | 楊韻靜 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:17:03Z | - |
| dc.date.available | 2017-08-20 | |
| dc.date.copyright | 2015-08-20 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-17 | |
| dc.identifier.citation | 1. Agarwala SS, Thompson JF, Smithers BM, Ross MI, Coventry BJ, Minor DR, Scoggins CR, Wachter EA. Chemoablation of metastatic melanoma with rose bengal (PV-10). J Clin Oncol (Meeting Abstracts) 28(15): 8534, 2010.
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Int J Physiol Pathophysiol Pharmacol 4(2): 99-107, 2012. 18. Luttrull DK, Valdes-Aguilera O, Linden SM, Paczkowski J, Neckers DC. Rose Bengal aggregation in rationally synthesized dimeric systems. J Photochem Photobiol 47(4): 551–557, 1988. 19. Masao O, Ryosuke T, Haruhiko Y, Shuichiro S. Treatment of Hepatocellular Carcinoma by Percutaneous Tumor Ablation Methods: Ethanol Injection Therapy and Radiofrequency Ablation. Gastroenterol 127: 159–166, 2004. 20. Mousavi H, Zhang X, Gillespie S, Wachter E, Hersey P. Rose Bengal induces dual modes of cell death in melanoma cells and has clinical activity against melanoma. Melanoma Res 16: 8, 2006. 21. Nagasawa, H, Little JB. Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52(22): 6394–6396, 1992. 22. Nonaka M, Yamamoto M, Yoshino S, Umemura S, Sasaki K, Fukushima T. Sonodynamic therapy consisting of focused ultrasound and a photosensitizer causes a selective antitumor effect in a rat intracranial glioma model. Anticancer Res 29: 943-950, 2009. 23. Panzarini E, Tenuzzo B, Dini L. Photodynamic therapy-induced apoptosis of HeLa cells. Ann N Y Acad Sci 1171: 617-626, 2009. 24. Panzarini E, Inguscio V, Dini L. Overview of cell death mechanisms induced by Rose Bengal acetate-photodynamic therapy. Int J Photoenergy 2011: 1-12, 2011. 25. Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T. Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers Med Sci 24: 259 – 268, 2009. 26. Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, Mu Z, Rasalan T, Adamow M, Ritter E, Sedrak C, Jungbluth AA, Chua R, Yang AS, Roman RA, Rosner S, Benson B, Allison JP, Lesokhin AM, Gnjatic S, Wolchok JD. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 366 (10): 925–31, 2012. 27. Ramos HC, Ruivo I, de Brito U. Use of intratumoral Cisplatinium in lung cancer. Exp Pathol Health Sci 2(2): 45-46, 2008. 28. Sastry KSR. Biological effects of Auger emitter iodine-125. A review. Med. Phys 19(6): 1361-1383, 1992. 29. Tavares AAS, Tavares JMRS. 99mTc Auger electrons for targeted tumour therapy: A review. Int J Radiat Biol 84(4): 261-270, 2010. 30. Thompson JF, Hersey P, Wachter E. Chemoablation of metastatic melanoma using intralesional Rose Bengal. Melanoma Res 18: 405–411, 2008. 31. Toomey P, Kodumudi K, Weber A, Kuhn L, Moore E. Intralesional injection of Rose Bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS ONE 8(7): e68561, 2013 32. Veterinary cooperative oncology group – common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1 VCOG, 2011. 33. Wang, CG and Helson, Lawrence, US Patent 7,981,928 B2; 2011 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52513 | - |
| dc.description.abstract | Rose Bengal腫瘤內注射為針對體表實質腫塊進行化學消融治療之方式．本研究對於治療組之腫瘤患犬，進行Rose Bengal腫瘤內注射合併正電壓放射線治療，藉由放射線激發Rose Bengal所含之碘原子於局部產生大量游離輻射能，稱Auger therapy，造成細胞內原子層級的變化與間接導致細胞死亡．本研究共納入八隻患有體表腫瘤之犬隻，其中三隻為對照組，分別接受單獨Rose Bengal腫瘤內注射或正電壓放射治療．另五隻為治療組，合併接受上述兩種治療．研究開始前，病患接受完整生理檢查，對腫瘤性疾病進行診斷與臨床分級．治療後的追蹤期內，紀錄個體客觀腫瘤體積變化、治療相關副作用、與腫瘤疾病之無病期或復發及轉移的發生時間．研究結果顯示，治療後治療組中的兩例口腔黑色素瘤病患出現完全的客觀腫瘤體積縮減，一良性乳腺腫瘤病患則呈現部分客觀腫瘤體積縮減．在其中一例口腔黑色素瘤病患，其診斷有腫瘤侵犯且腫大之同側顎下淋巴結，治療後並無體積縮減且仍由採樣證實腫瘤侵犯．依結果判斷，Rose Bengal腫瘤內注射治療合併正電壓放射治療，可作為犬隻體表腫瘤局部控制之方式．然而，腫瘤種類選擇、劑量調整，及轉移性疾病的治療效果，仍待進一步研究探討． | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:17:03Z (GMT). No. of bitstreams: 1 ntu-104-R02643004-1.pdf: 1156817 bytes, checksum: 722c454f9902823788b1f6a004318350 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 中文摘要…………………………………………………………………………….ii
Abstract………………………………………………………………………………iii Abbreviation list .........................................................................................vii Chapter 1 Introduction……………………………………………………………....1 Chapter 2 Literature Review………………………………………….…………….6 2.1 Radiation therapy.....…………………………………………………….....6 2.2 Auger therapy ……………………………………………………………11 2.3 Rose Bengal..........………………………………………………………….13 2.3.1 Rose Bengal in photodynamic therapy………………………….15 2.3.2 Intralesional Rose Bengal injection……………………………….16 2.4 Bystander effect …………………………………………………………...19 Chapter 3 Aim…………………………………………………………………….22 Chapter 4 Material and Method…………………………………………………24 4.1 Rose Bengal……………………………………………………………25 4.2 Orthovoltage radiation therapy……………………………………...26 4.3 Patient enrollments and grouping…………………………………....27 4.3.1 Treatment group………………………………………………….27 4.3.2 Control group…………………………………………………..29 4.4 Pretreatment evaluation………………………………………………29 4.5 Treatment procedures…………………………………………………20 4.5.1 Generalized anesthesia…………………………………………30 4.5.2 Intralesional Rose Bengal injection…………………………...30 4.5.3 Orthovoltage radiation therapy……………………………….30 4.6 Post-treatment evaluation……………………………………………..31 Chapter 5 Result………………………………………………………………...33 5.1 Patient signalment………………………………………………………..34 5.1.1 Breed…………………………………………………………….34 5.1.2 Tumor location……………………………………………………34 5.1.3 Tumor type……………………………………………………..35 5.2 Objective tumor response…………………………………………….35 5.2.1 Treatment group………………………………………………36 5.2.2 Control group………………………………………………….36 5.2.3 Time of tumor regression and progression…………………..36 5.3 Treatment related adverse events………………………………………37 Chapter 6 Discussion…………………………………………………………...39 6.1 Tumor type and location………………………………………………….40 6.2 Treatment response……………………………………………………….40 6.2.1 Tumor type vs. Treatment response……………………………41 6.2.2 Tumor volume vs. Treatment response………………………41 6.2.3 Radiation fractionation vs. Treatment response…………….42 6.3 Bystander effect……………………………………………………….42 6.4 Treatment benefit of intralesional Rose Bengal injection…………….43 6.5 Treatment related adverse events……………………………………44 6.5.1 Intralesional injection………………………………………….44 6.5.2 Radiation therapy………………………………………………..45 6.6 Limitations……………………………………………………………..45 Chapter 7 Conclusion…………………………………………………………..47 Appendix………………………………………………………………………...49 Table 1. Patient signalment with clinical diagnosis and tumor grading...50 Table 2. Treatment response in the treatment group………......………….........51 Table 3. Treatment response in the control group………………………......…..52 Figure 1. The trends of tumor volume change (%) in the treatment group…...53 Figure 2. Tumor volume change (%) in each case in the treatment group……54 Figure 3. Tumor volume change (%) in the control group……….…………….55 Figure 4. Distribution of tumor locations in this study........................................56 Figure 5. Tumor types enrolled in this study.........................................................56 Figure 6. Objective tumor response in the treatment group................................57 Reference...........................................................................................58 | |
| dc.language.iso | en | |
| dc.subject | 標的性放射治療 | zh_TW |
| dc.subject | Auger電子 | zh_TW |
| dc.subject | 犬隻腫瘤 | zh_TW |
| dc.subject | 腫瘤內注射 | zh_TW |
| dc.subject | Rose Bengal | en |
| dc.subject | Canine tumor | en |
| dc.subject | Intralesional injection | en |
| dc.subject | Targeted radiation therapy | en |
| dc.subject | Auger electron | en |
| dc.title | 合併Rose Bengal腫瘤內注射與放射治療對於犬隻腫瘤之臨床應用與效果評估 | zh_TW |
| dc.title | Combination of Intralesional Rose Bengal Injection and Orthovoltage Radiation Therapy for Canine Cancer Treatment | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李雅珍,廖泰慶,林辰栖 | |
| dc.subject.keyword | 犬隻腫瘤,腫瘤內注射,標的性放射治療,Auger電子, | zh_TW |
| dc.subject.keyword | Canine tumor,Rose Bengal,Intralesional injection,Targeted radiation therapy,Auger electron, | en |
| dc.relation.page | 60 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-17 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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