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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 范士岡(Shih-Kang Fan) | |
| dc.contributor.author | Hsin-Yi Lu | en |
| dc.contributor.author | 盧欣宜 | zh_TW |
| dc.date.accessioned | 2021-06-15T13:46:23Z | - |
| dc.date.available | 2019-02-15 | |
| dc.date.copyright | 2016-02-15 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-11-25 | |
| dc.identifier.citation | [1] M. G. Pollack, R. B. Fair and A. D. Shenderov, Appl Phys Lett, 2000, 77, 1725-1726.
[2] F. Mugele and J. C. Baret, J Phys-Condens Mat, 2005, 17, R705-R774. [3] K. Ichimura, S. K. Oh and M. Nakagawa, Science, 2000, 288, 1624-1626. [4] M. G. Lippmann, “Relations entre les phenomenes electrique etcapillaires et capillaries.” Diss. Gauthier-Villars, 1875. [5] B. Berge, C.R. Acad. Sci. Paris, Série 2, 1993, 317, 157-163. [6] S. K. Fan, C. Hashi, and C. J. Kim, IEEE International Conference on Micro Electro Mechanical Systems, 2003, 694-697. [7] S. K. Cho, S. K. Fan, H. Moon, and C. J. Kim, Micro Electro Mechanical Systems, 2002. The Fifteenth IEEE International Conference on. IEEE, 2002, 32-35. [8] S. K. Cho, H. Moon, and C. J. Kim, Microelectromechanical Systems, Journal of, 2003, 12, 70-80. [9] R. B. Fair, Microfluidics and Nanofluidics, 2007, 3, 245-281. [10] V. Srinivasan, V. K. Pamula, R. B. Fair, Lab on a chip, 2004, 4, 310-315. [11] A. Tourovskaia, X. Figueroa-Masot and A. Folch, Lab on a chip, 2005, 5, 14-19. [12] B. S. Cho, T. G. Schuster, X. Zhu, D. Chang, G. D. Smith and S. Takayama, Analytical chemistry, 2003, 75, 1671-1675. [13] A. D. Stroock, S. K. Dertinger, A. Ajdari, I. Mezić, H. A. Stone, and G. M. Whitesides, Science, 2002, 295, 647-651. [14] C. C. Hong, J. W. Choi, and C. H. Ahn, Lab on a Chip, 2004, 4, 109-113. [15] P. Renaud, H. Van Lintel, M. Heuschkel, and L. Guerin, In: Micro Total Analysis Systems’ 98. Springer Netherlands, 1998, 17-22. [16] B. H. Jo, L. M. Van Lerberghe, K. M. Motsegood and D. J. Beebe, J Microelectromech S, 2000, 9, 76-81. [17] A. del Campo and C. Greiner, J Micromech Microeng, 2007, 17, R81-R95. [18] H. Becker, K. Lowack and A. Manz, J Micromech Microeng, 1998, 8, 24-28. [19] H. Becker and U. Heim, Sensor Actuat a-Phys, 2000, 83, 130-135. [20] Y. Bellouard, A. Said, M. Dugan and P. Bado, Opt Express, 2004, 12, 2120-2129. [21] B. Zhao, J. S. Moore and D. J. Beebe, Science, 2001, 291, 1023-1026. [22] G. J. Shah and C. J. Kim, Lab on a chip, 2009, 9, 2402-2405. [23] S. K. Fan, W. J. Chen, T. H. Lin, T. T. Wang and Y. C. Lin, Lab on a chip, 2009, 9, 1590-1595. [24] M. Dhindsa, J. Heikenfeld, S. Kwon, J. Park, P. D. Rack and I. Papautsky, Lab on a Chip, 2010, 10, 832-836. [25] 王鳳英編繹，刈米孝夫原著，「界面活性劑的原理與應用」五版三刷，高立圖書有限公司，民國87年6月10日。 [26] C. Tanford, “The Hydrophobic Effect: Formation of Micelles and Biological Membranes” 2d Ed, J. Wiley., 1980. [27] B. S. Chang, B. S. Kendrick and J. F. Carpenter, Journal of pharmaceutical sciences, 1996, 85, 1325-1330. [28] A. D. Griffiths and D. S. Tawfik, Trends in biotechnology, 2006, 24, 395-402. [29] 林昭榮，「特殊的界面活性劑與異常的潤濕現象」，國立中央大學化學工程與材料工程學系碩士論文，民國97年。 [30] D. Myers, “Surfactant science and technology.” John Wiley & Sons, 2005. [31] G. Beni and S. Hackwood, Applied Physics Letters, 1981, 38, 207-209. [32] T. Young, Philosophical Transactions of the Royal Society of London, 1805, 65-87. [33] P. Y. Chiou, H. Moon, H. Toshiyoshi, C. J. Kim and M. C. Wu, Sensors and actuators A: physical, 2003, 104, 222-228. [34] S. Kuiper and B. H. W. Hendriks, Applied physics letters, 2004, 85, 1128-1130. [35] B. V. Kilikian, M. R. Bastazin, N. M. Minami, E. M. R. Goncalves and A. Pessoa, Braz J Chem Eng, 2000, 17, 29-38. [36] Y. Chevalier and T. Zemb, Rep Prog Phys, 1990, 53, 279-371. [37] C. O. Rangel-Yagui, A. Pessoa and D. Blankschtein, Braz J Chem Eng, 2004, 21, 531-544. [38] W. C. Preston, J Phys Colloid Chem, 1948, 52, 84-97. [39] 張有義、郭蘭生編譯，DUNCAN J. SHAW原著，「膠體及界面化學入門」初版二刷，高立圖書有限公司，民國88年1月10日。 [40] D. Attwood, A. T. Florence, “physical pharmacy.” Pharmaceutical Press, 2008. [41] P. Alexandridis, T. A. Hatton, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1995, 96, 1-46. [42] F. Sanger, A. R. Coulson, G. F. Hong, D. F. Hill, and G. D. Petersen, Journal of molecular biology, 1982, 162, 729-773. [43] C. Isenberg, “The science of soap films and soap bubbles.” Courier Corporation, 1978. [44] F. Ayorinde, S. V. Gelain, J. Johnson, and L. W. Wan, Rapid Communications in Mass Spectrometry, 2000, 14, 2116-2124. [45] D. Koley, and A. J. Bard, Proceedings of the National Academy of Sciences, 2010, 107, 16783-16787. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51723 | - |
| dc.description.abstract | 近年來，微觀尺度下建立微流道的技術已相當成熟，為了改善微流道由於物理邊界而導致操作上尺寸及設計靈活性的減少，本論文利用介電濕潤（Electrowetting-on-dielectric）作為驅動液體的機制，於數位微流體操控平台上，提出一種無固體邊界且具有重現性的虛擬微流道（Virtual microchannel）。在去離子水中加入臨界微胞濃度（Critical micelle concentration, CMC）之Pluronic F127、Pluronic F68、TWEEN 20以及Triton X-100等界面活性劑，液體及虛擬微流道皆在兩平行ITO玻璃基材結構間移動和形成，利用界面活性劑會降低液體表面張力的特性，在兩顆液滴之間可輕易地形成一可任意改變型態和寬度的虛擬微流道。藉由不同設計之電極，可建立不同型態、長度（1000 um至5000 um）、高度（20 um至180 um）的虛擬微流道陣列，並利用共軛焦顯微鏡觀察，在高度為100 um下，該虛擬微流道可達1.74 um的寬度，使其深寬比達60。再者，於虛擬微流道的兩端施予不同電壓值，使液體由於兩端的壓力差形成一幫浦，並加入1 um的粒子，其憑藉著液體的流動，於流道口一次一顆噴濺而出，目前得到液體流經虛擬微流道的流量約為0.0088 nL/s至0.0382 nL/s，進一步將該技術用於DNA拉伸。本論文提出一種簡單的無固體邊界之虛擬微流道建立方法，不僅具有可重複性，且可整合其他微流體應用於單一晶片，並利用液體幫浦移動溶液中的粒子或DNA。 | zh_TW |
| dc.description.abstract | In recent years, constructing flow channels on a micro scale has been intensively investigated. In order to improve the flexibility of the microchannels by removing their physical sidewalls, we demonstrate reprogrammable virtual microchannels on a digital microfluidic platform using electrowetting-on-dielectric (EWOD). We added different kinds of surfactants, Pluronic F127, Pluronic F68, TWEEN 20, and Triton X-100 to distilled deionized (DD) water at their critical micelle concentration (CMC). The virtual microchannels were established between two parallel Indium Tin Oxide (ITO) coated glass plates. A reprogrammable virtual microchannel without physical sidewalls between two droplets was achieved and stabilized simply due to the surfactant molecules. By using different patterns of the electrodes, we created virtual microchannels in various forms, lengths (from 1000 um to 5000 um), and heights (from 20 um to 180 um). We obtained high aspect ratios as 60 when the virtual microchannel was 100 um high and 1.74 um wide. We applied different voltages on the two sides of the microchannel to generate uneven pressure and to pump the liquid. Furthermore, we put 1 um particles into the liquid for visualizing the flow. Individual particles passing through the microchannel at a time were observed. The pumping rate was about 0.0088 nL/s to 0.0382 nL/s. Moreover, DNA molecules were stretched with the flow in the virtual microchannels. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T13:46:23Z (GMT). No. of bitstreams: 1 ntu-104-R02522111-1.pdf: 7975602 bytes, checksum: 1630684f8b7d9296b0611e740384b2fd (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 誌謝................................i
中文摘要.............................ii 英文摘要.............................iii 目錄.................................v 圖目錄...............................viii 表目錄...............................xiii 第一章 緒論.........................1 1-1 前言.............................1 1-2 微流體系統........................2 1-2.1 數位微流體晶片.................2 1-2.2 微流道........................5 1-2.3 虛擬微流道....................7 1-3 界面活性劑........................10 1-4 研究動機..........................12 1-5 論文組織架構.......................13 第二章 理論介紹......................14 2-1 介電濕潤..........................14 2-1.1 介電濕潤原理...................14 2-1.2 介電濕潤應用...................16 2-2 界面活性劑.........................17 2-2.1 臨界微胞濃度...................17 2-2.2 表面張力......................18 2-2.3 實驗用界面活性劑...............20 2-3 微流體幫浦.........................23 第三章 介電濕潤晶片實驗平台與實驗設計...25 3-1 晶片設計與製程參數..................25 3-1.1 介電濕潤晶片設計................25 3-1.2 介電濕潤晶片製程................28 3-2 實驗平台與儀器簡介..................33 3-2.1 實驗平台操作系統................33 3-2.2 電路設計.......................34 3-2.3 儀器簡介.......................36 3-2.4 微流體幫浦流速分析方法...........45 3-3 實驗操作流程........................47 3-3.1 實驗試劑配置....................47 3-3.2 實驗流程.......................47 第四章 結果與討論.....................48 4-1 表面張力量測.......................48 4-2 虛擬微流道的形成....................51 4-2.1 不同操作條件下之虛擬微流道.......53 4-2.2 不同型態的虛擬微流道.............57 4-2.3 虛擬微流道之三維結構.............60 4-3 虛擬微流道幫浦......................61 4-3.1 形成虛擬微流道幫浦 ..............61 4-3.2 虛擬微流道幫浦之流動速度.........64 4-4 虛擬微流道應用......................73 4-4.1 離子型粒子於微流體幫浦...........73 4-4.2 DNA拉伸........................74 第五章 結語與未來展望..................76 5-1 結語...............................76 5-2 未來展望...........................76 參考文獻...............................78 | |
| dc.language.iso | zh-TW | |
| dc.subject | DNA拉伸 | zh_TW |
| dc.subject | 虛擬微流道 | zh_TW |
| dc.subject | 介電濕潤 | zh_TW |
| dc.subject | 幫浦 | zh_TW |
| dc.subject | 界面活性劑 | zh_TW |
| dc.subject | DNA stretching | en |
| dc.subject | Virtual microchannel | en |
| dc.subject | surfactant | en |
| dc.subject | pumping | en |
| dc.subject | electrowetting | en |
| dc.title | 利用界面活性劑於介電濕潤驅動液滴間形成虛擬微流道 | zh_TW |
| dc.title | Surfactant-Stabilized Virtual Microchannels between Electrowetting-Driven Droplets | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 曹嘉文(Chia-Wen Tsao),趙玲(Ling Chao) | |
| dc.subject.keyword | 虛擬微流道,介電濕潤,幫浦,界面活性劑,DNA拉伸, | zh_TW |
| dc.subject.keyword | Virtual microchannel,electrowetting,pumping,surfactant,DNA stretching, | en |
| dc.relation.page | 80 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-11-26 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
| 顯示於系所單位： | 機械工程學系 | |
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