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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林晃巖(Hoang-Yan Lin) | |
dc.contributor.author | Yi-Cheng Liu | en |
dc.contributor.author | 劉奕成 | zh_TW |
dc.date.accessioned | 2021-06-15T13:45:39Z | - |
dc.date.available | 2016-02-15 | |
dc.date.copyright | 2016-02-15 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-11-30 | |
dc.identifier.citation | [1] Lucia Panzella, Gennaro Gentile, Gerardino D’Errico, Nicola F Della Vecchia, Maria E Errico, Alessandra Napolitano, Cosimo Carfagna, and Marco d’Ischia. Atypical structural and -electron features of a melanin polymer that lead to superior free-radical-scavenging properties. Angewandte Chemie International Edition, 52(48):12684–12687, 2013.
[2] Ming-Chang Chou. Experimental study of optical-field-ionization collisionalexcitation soft X-ray lasers. PhD thesis, National Chung Cheng University, Chia-yi County 621, Taiwan, January 2007. [3] 朱旭新, 陳聿昕, 汪治平, 李超煌, and 陳賜原. 十兆瓦超短脈衝雷射系統. 科儀新知, 128:5–18, 2002. [4] Yi-Cheng Liu, Shih-Yu Tu, and Hoang-Yan Lin. Evaluation of the practicality of melanin as a photodynamic-inactivation photosensitizer by its nanonization. Journal of Photopolymer Science and Technology, 2016. accepted. [5] Yi-Cheng Liu, Sih-Min Chen, Jhong-Han Liu, Hsiang-Wei Hsu, Hoang-Yan Lin, and Szu-yuan Chen. Mechanical and photo-fragmentation processes for nanonization of melanin to improve its efficacy in protecting cells from reactive oxygen species stress. Journal of Applied Physics, 117(6):064701, 2015. [6] Efthimios Kaxiras, Argyrios Tsolakidis, George Zonios, and Sheng Meng. Structural model of eumelanin. Physical review letters, 97(21):218102, 2006. [7] Da Jeong Kim, Kuk-Youn Ju, and Jin-Kyu Lee. The synthetic melanin nanoparticles having an excellent binding capacity of heavy metal ions. Bull. Korean Chem. Soc., 33(11):3788–3792, 2012. [8] Rita R. Goncalves and Sandra Regina Pombeiro-Sponchiado. Antioxidant activity of the melanin pigment extracted from aspergillus nidulans. Biol. Pharm. Bull., 28(6):1129–1131, 2005. [9] Mika Tada, Masahiro Kohno, and Yoshimi Niwano. Scavenging or quenching effect of melanin on superoxide anion and singlet oxygen. J. Clin. Biochem. Nutr., 46(3): 224–228, 2010. [10] Craig G. Burkhart and Craig N. Burkhart. The mole theory: primary function of melanocytes and melanin may be antimicrobial defense and immunomodulation (not solar protection). Int. J. Dermatol., 44(4):340–342, 2005. [11] James A Mackintosh. The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J. Theor. Biol., 211(2):101–113, 2001. [12] Nahid Mohagheghpour, Nahid Waleh, Stephen J Garger, Linda Dousman, Laurence K Grill, and Daniel Tuse. Synthetic melanin suppresses production of proinflammatory cytokines. Cell. Immunol., 199(1):25–36, 2000. [13] Vincent Ball, Doriane Del Frari, Marc Michel, Markus J. Buehler, Valerie Toniazzo, Manoj K. Singh, Jose Gracio, and David Ruch. Deposition mechanism and properties of thin polydopamine films for high added value applications in surface science at the nanoscale. BioNanoSci., 2(1):16–34, 2012. [14] P. Meredith, C. J. Bettinger, M. Irimia-Vladu, A. B. Mostert, and P. E. Schwenn. Electronic and optoelectronic materials and devices inspired by nature. Rep. Prog. Phys., 76:034501, 2013. [15] Panchanathan Manivasagan, Jayachandran Venkatesan, Kannan Sivakumar, and Se-Kwon Kim. Actinobacterial melanins: current status and perspective for the future. World J. Microbiol. Biotechnol., 29:1737–1750, 2013. [16] Andrew D Schweitzer, Ekaterina Revskaya, Peter Chu, Valeria Pazo, Matthew Friedman, Joshua D Nosanchuk, Sean Cahill, Susana Frases, Arturo Casadevall, and Ekaterina Dadachova. Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer. Int. J. Radiat. Oncol. Biol. Phys., 78(5): 1494–1502, 2010. [17] Kuk-Youn Ju, Yuwon Lee, Sanghee Lee, Seung Bum Park, and Jin-Kyu Lee. Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property. Biomacromolecules, 12:625–632, 2011. [18] A. El-Obeid, S. Al-Harbi, N. Al-Jomah, and A. Hassib. Herbal melanin modulates tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine, 13:324–333, 2006. [19] Y.-C. Hung, V. M. Sava, M.-Y. Hong, and G. S. Huang. Inhibitory effects on phospholipase A2 and antivenin activity of melanin extracted from thea sinensis linn. Life Sci., 74:2037–2047, 2004. [20] D. C. Montefiori and J. Zhou. Selective antiviral activity of synthetic soluble ltyrosine and l-dopa melanins against human immunodeficiency virus in vitro. Antiviral Res., 15:11–25, 1991. [21] Yao-Ching Hung, Vasyl M. Sava, Chi-Long Juang, Tzu-Chen Yeh, Wu-Chung Shen, and Guewha Steven Huang. Gastrointestinal enhancement of mri with melanin derived from tea leaves (thea sinensis linn.). J. Ethnopharmacology, 79:75–79, 2002. [22] Kuk-Youn Ju, Jae Won Lee, Geun Ho Im, Sanghee Lee, Jung Pyo, Seung Bum Park, Jung Hee Lee, and Jin-Kyu Lee. Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging. Biomacromolecules, 14:3491–3497, 2013. [23] Paul Meredith and Tadeusz Sarna. The physical and chemical properties of eumelanin. Pigment Cell Res., 19:572–594, 2006. [24] Andrew A. R. Watt, Jacques P. Bothma, and Paul Meredith. The supramolecular structure of melanin. Soft Matter, 5:3754–3760, 2009. [25] Klaus B Stark, James M Gallas, Gerry W Zajac, Joseph T Golab, Shirley Gidanian, Theresa McIntire, and Patrick J Farmer. Effect of stacking and redox state on optical absorption spectra of melanins-comparison of theoretical and experimental results. The Journal of Physical Chemistry B, 109(5):1970–1977, 2005. [26] Chun-Teh Chen, Vincent Ball, Jose Joaquim de Almeida Gracio, Manoj Kumarz Singh, Valerie Toniazzo, David Ruch, and Markus J. Buehler. Self-assembly of tetramers of 5,6-dihydroxyindole explains the primary physical properties of eumelanin: experiment, simulation, and design. ACS Nano, 7(2):1524–1532, 2013. [27] Jie Wang and Jing Yi. Cancer cell killing via ros: To increase or decrease, that is the question. Cancer Biol. Ther., 7(12):1875–1884, 2008. [28] J. B. Nofsinger, Y. Liu, and J. D. Simon. Aggregation of eumelanin mitigates photogeneration of reactive oxygen species. Free Rad. Bio. Med., 32(8):720–730, 2002. [29] Paul Meredith and Jennifer Riesz. Radiative relaxation quantum yields for synthetic eumelanin.. Photochemistry and photobiology, 79(2):211–216, 2004. [30] Jennifer Y Lin and David E Fisher. Melanocyte biology and skin pigmentation. Nature, 445(7130):843–850, 2007. [31] Brandon-Luke L. Seagle, Kourous A. Rezai, Yasuhiro Kobori, Elzbieta M. Gasyna, Kasra A. Rezaei, and James R. Norris, Jr. Melanin photoprotection in the human retinal pigment epithelium and its correlation with light-induced cell apoptosis. Proc. Nat. Acad. Sci., 102(25):8978–8983, 2005. [32] Alessandro Pezzella, Marco d’Ischia, Alessandra Napolitano, Anna Palumbo, and Giuseppe Prota. An integrated approach to the structure of sepia melanin. Evidence for a high proportion of degraded 5, 6-dihydroxyindole-2-carboxylic acid units in the pigment backbone. Tetrahedron, 53(24):8281–8286, 1997. [33] Shosuke Ito. Reexamination of the structure of eumelanin. Biochimica et Biophysica Acta (BBA)-General Subjects, 883(1):155–161, 1986. [34] JM Gallas, KC Littrell, S Seifert, GW Zajac, and P Thiyagarajan. Solution structure of copper ion-induced molecular aggregates of tyrosine melanin. Biophysical journal, 77(2):1135–1142, 1999. [35] MIN Da Silva, SN Deziderio, JC Gonzalez, CFO Graeff, and MA Cotta. Synthetic melanin thin films: Structural and electrical properties. Journal of applied physics, 96(10):5803–5807, 2004. [36] SN Deziderio, CA Brunello, MIN Da Silva, MA Cotta, and CFO Graeff. Thin films of synthetic melanin. Journal of non-crystalline solids, 338:634–638, 2004. [37] Teruki Sugiyama and Tsuyoshi Asahi. Fabrication of the smallest organic nanocolloids by a top-down method based on laser ablation. Chem. Rec., 11(1):54–58, 2011. [38] H.-H. Chu, S.-Y. Huang, L.-S. Yang, T.-Y. Chien, Y.-F. Xiao, J.-Y. Lin, C.-H. Lee, S.-Y. Chen, and J. Wang. A versatile 10-tw laser system with robust passive controls to achieve high stability and spatiotemporal quality. Appl. Phys. B, 79(2):193–201, 2004. [39] G. Mourou and D. Umstadter. Development and applications of compact highintensity lasers. Phys. Fluids B, 4:7, Jul 1992. [40] G. Mourou, C. P. J. Barty, and M. D. Perry. Ultrahigh-intensity lasers: physics of the extreme on a tabletop. Phys. Today, 51:22, Jan. 1998. [41] D. Umstadter. Review of physics and applications of relativistic plasmas driven by ultra-intense lasers. Phys. Plasmas, 8(5):1774, May 2004. [42] K. Yamanouchi. The next frontier. Science, 295:1659, Mar 2002. [43] K. W. D. Ledingham, P. Mckenna, and R. P. Singhal. Applications for nuclear phenomena generated by ultra-intense lasers. Science, 300:1107, May 2003. [44] B. A. Remington, D. Arnett, R. P. Drake, and H. Takabe. Modeling astrophysical phenomena in the laboratory with intense lasers. Science, 284:1488, May 1999. [45] D. Strickland and G. Mourou. Compression of amplified chirped optical pulses. Opt. Commun., 56(3):219–221, December 1985. [46] P. Maine, D. Strickland, P. Bado, M. Pessot, and G. Mourou. Generation of ultrahigh peak power pulses by chirped pulse amplification. IEEE J. Quantum Electron., 24(2):398–403, February 1988. [47] K. Yamakawa, P. H. Chiu, A. Magana, and J. D. Kmetec. Generation of high peak and average power femtosecond pulses at a 10 Hz repetition rate in a titanium-doped sapphire laser. IEEE J. Quantum Electron., 30(11):2698–2706, 1994. [48] Detao Du, Jeff Squier, Steve Kane, Georg Korn, Gerard Mourou, Charles Bogusch, and Christopher T. Cotton. Terawatt Ti:sapphire laser with a spherical reflectiveoptic pulse expander. Opt. Lett., 20(20):2114–2116, 1995. [49] G. Albrecht, A. Antonetti, and G. Mourou. Temporal shape analysis of Nd3+:YAG active passive mode-locked pulses. Opt. Commun., 40(1):59–62, Dec 1981. [50] Christine MR Clancy and John D Simon. Ultrastructural organization of eumelanin from sepia officinalis measured by atomic force microscopy. Biochemistry, 40(44): 13353–13360, 2001. [51] Przemyslaw M Plonka. Electron paramagnetic resonance as a unique tool for skin and hair research. Experimental dermatology, 18(5):472–484, 2009. [52] Tadeusz Sarna, Janice M Burke, Witold Korytowski, Ma.gorzata Ro.anowska, Christine MB Skumatz, Agnieszka Zar.ba, and Mariusz Zar.ba. Loss of melanin from human rpe with aging: possible role of melanin photooxidation. Experimental eye research, 76(1):89–98, 2003. [53] Lidia Najder-Kozdrowska, Barbara Pilawa, Ewa Buszman, Dorota Wrzesniok, et al. Electron paramagnetic resonance (epr) study of dopa–melanin complexes with kanamycin and copper (ii) ions. Journal of Spectroscopy, 25(3-4):197–205, 2011. [54] John A Weil and James R Bolton. Electron paramagnetic resonance: elementary theory and practical applications. John Wiley & Sons, 2007. [55] Hiroshi Hirata, Tadeusz Walczak, and Harold M Swartz. Electronically tunable surface-coil-type resonator for l-band epr spectroscopy. Journal of Magnetic Resonance, 142(1):159–167, 2000. [56] Rowan Gilmore and Les Besser. Practical RF circuit design for modern wireless systems, volume 2. Artech House, 2003. [57] K Mobius, R Biehl, MM Dorio, and JH Freed. Multiple electron resonance spectroscopy. by MM Dorio and JH Freed, Plenum Press, New York, 1979. [58] Ulrich Schraermeyer, Swaantje Peters, Gabriele Thumann, Norbert Kociok, and Klaus Heimann. Melanin granules of retinal pigment epithelium are connected with the lysosomal degradation pathway. Exp. Eye Res., 68(2):237–245, 1999. [59] IC Le Poole, RMJGJ Van den Wijngaard, W Westerhof, RP Verkruisen, RP Dutrieux, KP Dingemans, and PK Das. Phagocytosis by normal human melanocytes in Vitro. Exp. Cell. Res., 205(2):388–395, 1993. [60] Stephanie Diment, Michael Eidelman, G Marcela Rodriguez, and Seth J Orlow. Lysosomal hydrolases are present in melanosomes and are elevated in melanizing cells. J. Biol. Chem., 270(9):4213–4215, 1995. [61] Adnan MT Al Badri, Alan K Foulis, Pamela M Todd, Jennifer J Garioch, Janet E Gudgeon, D Graeme Stewart, J Alastair Gracie, and Robert B Goudie. Abnormal expression of mhc class ii and icam-1 by melanocytes in vitiligo. J. Pathol., 169(2): 203–206, 1993. [62] PA Riley. Melanin. Int. J. Biochem. Cell Biol., 29(11):1235–1239, 1997. [63] Manpreet Bhatti, Alexander MacRobert, Sajeda Meghji, Brian Henderson, and Michael Wilson. A study of the uptake of toluidine blue o by porphyromonas gingivalis and the mechanism of lethal photosensitization. Photochem. Photobiol., 68(3):370–376, 1998. [64] Junkoh Yamamoto, Seiji Yamamoto, Toru Hirano, Shaoyi Li, Masayo Koide, Eiji Kohno, Mitsuo Okada, Chikanori Inenaga, Tsutomu Tokuyama, Naoki Yokota, et al. Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Clin. Cancer Res., 12(23):7132–7139, 2006. [65] Kirika Ishiyama, Keisuke Nakamura, Hiroyo Ikai, Taro Kanno, Masahiro Kohno, Keiichi Sasaki, and Yoshimi Niwano. Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents. PLOS ONE, 7(5):e37871, 2012. [66] Mindong Bai, Zhitao Zhang, Xiaohong Xue, Xianli Yang, Liusan Hua, and Dan Fan. Killing effects of hydroxyl radical on algae and bacteria in ship’s ballast water and on their cell morphology. Plasma Chem. Plasma Process., 30(6):831–840, 2010. [67] Tadeusz Sarna. New trends in photobiology: properties and function of the ocular melanin—a photobiophysical view. J. Photochem. Photobiol. B, 12(3):215–258, 1992. [68] C. C. Felix, J. S. Hyde, and R. C. Sealy. Photoreactions of melanin: a new transient species and evidence for triplet state involvement. Biochem. Biophys. Res. Commun., 88(2):456–461, 1979. [69] Roger C Sealy, James S Hyde, Christopher C Felix, IA Menon, and Guiseppe Prota. Eumelanins and pheomelanins: characterization by electron spin resonance spectroscopy. Science, 217(4559):545–547, 1982. [70] Brandon-Luke L. Seagle, Elzbieta M. Gasyna, William F. Mieler, and James R. Norris, Jr. Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis. Proc. Nat. Acad. Sci., 103(45):16644–16648, 2006. [71] T. Sarna and Roger C Sealy. Photoinduced oxygen consumption in melanin systems. action spectra and quantum yields for eumelanin and synthectic melanin. Photochem. Photobiol., 39(1):69–74, 1984. [72] E. S. Krol and D. C. Liebler. Photoprotective actions of natural and synthetic melanins. Chem. Res. Toxicol., 11(12):1434–1440, 1998. [73] Barbara W. Henderson and Thomas John Dougherty, editors. Photodynamic therapy: basic principles and clinical applications. Marcel Dekker, New York, 1992. [74] Giuliana Valduga, Barbara Breda, Giorgio M Giacometti, Giulio Jori, and Elena Reddi. Photosensitization of wild and mutant strains ofescherichia colibymeso-tetra (n-methyl-4-pyridyl) porphine. Biochemical and biophysical research communications, 256(1):84–88, 1999. [75] Mali Salmon-Divon, Yeshayahu Nitzan, and Zvi Malik. Mechanistic aspects of Escherichia coli photodynamic inactivation by cationic tetra-meso (n-methylpyridyl) porphine. Photochem. Photobiol. Sci., 3(5):423–429, 2004. [76] Giulio Bertolini, Francesca Rossi, Giuliana Valduga, Giulio Jori, and Johan van Lier. Photosensitizing activity of water-and lipid-soluble phthalocyanines on Escherichia coli. FEMS Microbiol. Lett., 71(1):149–155, 1990. [77] Yeshayahu Nitzan, Mina Gutterman, Zvi Malik, and Benjamin Ehrenberg. Inactivation of Gram-negative bacteria by photosensitized porphyrins. Photochem. Photobiol., 55(1):89–96, 1992. [78] Andrew Minnock, David I. Vernon, Jack Schofield, John Griffiths, Parish J. Howard, and Stanley B. Brown. Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both Gram-negative and Gram-positive bacteria. J. Photochem. Photobiol. B, 32(3):159–164, 1996. [79] JC Scaiano, RW Redmond, B Mehta, and JT Arnason. Efficiency of the photoprocesses leading to singlet oxygen (1 g) generation by -terthienyl: Optical absorption, optoacoustic calorimetry and infrared luminescence studies*. Photochemistry and photobiology, 52(4):655–659, 1990. [80] Sean Mathai, Trevor A Smith, and Kenneth P Ghiggino. Singlet oxygen quantum yields of potential porphyrin-based photosensitisers for photodynamic therapy. Photochemical & Photobiological Sciences, 6(9):995–1002, 2007. [81] R Sander. Compilation of henry’s law constants (version 4.0) for water as solvent. Atmospheric Chemistry and Physics, 15(8):4399–4981, 2015. [82] Ling Zhang and J Ilja Siepmann. Direct calculation of henry’s law constants from gibbs ensemble monte carlo simulations: nitrogen, oxygen, carbon dioxide and methane in ethanol. Theoretical Chemistry Accounts, 115(5):391–397, 2006. [83] Reza Fekrazad, Hadi Zare, Sara Mohammadi Sepahvand, and Parisa Morsali. The effect of antimicrobial photodynamic therapy with radachlorin® on staphylococcus aureus and escherichia coli: An in vitro study. Journal of lasers in medical sciences, 5(2):82, 2014. [84] Reza Fekrazad, Majid Bargrizan, Sepideh Sajadi, and Soodabeh Sajadi. Evaluation of the effect of photoactivated disinfection with radachlorin® against streptococcus mutans (an in vitro study). Photodiagnosis and photodynamic therapy, 8(3):249–253, 2011. [85] Faten Gad, Touqir Zahra, Tayyaba Hasan, and Michael R Hamblin. Effects of growth phase and extracellular slime on photodynamic inactivation of Grampositive pathogenic bacteria. Antimicrobial agents and chemotherapy, 48(6):2173–2178, 2004. [86] T. Sarna and Roger C Sealy. Free radicals from eumelanins: quantum yields and wavelength depedence. Arch. Biochem. and Biophys., 232(2):574–578, 1984. [87] T Sarna, IA Menon, and Roger C Sealy. Photosensitization of melanins: a comparative study. Photochem. Photobiol., 42(5):529–532, 1985. [88] James R Stone and Suping Yang. Hydrogen peroxide: a signaling messenger. Antioxidants & redox signaling, 8(3-4):243–270, 2006. [89] Simone Reuter, Subash C Gupta, Madan M Chaturvedi, and Bharat B Aggarwal. Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biology and Medicine, 49(11):1603–1616, 2010. [90] Yao Wu, Linjun Shan, Shuangxi Yang, and Aimin Ma. Identification and antioxidant activity of melanin isolated from hypoxylon archeri, a companion fungus of tremella fuciformis. Journal of basic microbiology, 48(3):217–221, 2008. [91] Eric S Jacobson, Erica Hove, and Herschell S Emery. Antioxidant function of melanin in black fungi. Infection and immunity, 63(12):4944–4945, 1995. [92] Brandon-Luke L Seagle, Kourous A Rezai, Elzbieta M Gasyna, Yasuhiro Kobori, Kasra A Rezaei, and James R Norris. Time-resolved detection of melanin free radicals quenching reactive oxygen species. Journal of the American Chemical Society, 127(32):11220–11221, 2005. [93] SJS Flora, G Flora, and G Saxena. Environmental occurrence, health effects and management of lead poisoning. Lead chemistry, analytical aspects, environmental impacts and health effects. Netherlands: Elsevier Publication, pages 158–228, 2006. [94] Kiran Kalia and Swaran JS Flora. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. Journal of occupational health, 47(1): 1–21, 2005. [95] Lyn Patrick. Lead toxicity part ii: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Alternative Medicine Review, 11(2):114, 2006. [96] Monika Damek-Poprawa and Katarzyna Sawicka-Kapusta. Histopathological changes in the liver, kidneys, and testes of bank voles environmentally exposed to heavy metal emissions from the steelworks and zinc smelter in poland. Environmental Research, 96(1):72–78, 2004. [97] CN Martyn, C Osmond, JA Edwardson, DJP Barker, EC Harris, and RF Lacey. Geographical relation between alzheimer’s disease and aluminium in drinking water. The Lancet, 333(8629):61–62, 1989. [98] Tomás R Guilarte. Manganese and parkinson’s disease: a critical review and new findings. Environmental health perspectives, pages 1071–1080, 2010. [99] Christopher D Toscano and Tomás R Guilarte. Lead neurotoxicity: from exposure to molecular effects. Brain Research Reviews, 49(3):529–554, 2005. [100] Yasuyuki Fujiwara and Toshiyuki Kaji. Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis. Toxicology, 133(2):147–157, 1999. [101] Nosratola D Vaziri and Yaoxian Ding. Effect of lead on nitric oxide synthase expression in coronary endothelial cells role of superoxide. Hypertension, 37(2):223–226, 2001. [102] Joseph P Bressler and Gary W Goldstein. Mechanisms of lead neurotoxicity. Biochemical pharmacology, 41(4):479–484, 1991. [103] Theodore I Lidsky and Jay S Schneider. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain, 126(1):5–19, 2003. [104] Douglas G Hodgkins, Thomas G Robins, David L Hinkamp, Anthony M Schork, Steven P Levine, and William H Krebs. The effect of airborne lead particle size on worker blood-lead levels: An empirical study of battery workers. Journal of Occupational and Environmental Medicine, 33(12):1265–1273, 1991. [105] AC Wells, JB Venn, and MJ Heard. Deposition in the lung and uptake to blood of motor exhaust labelled with 203pb. Inhaled particles, 4:175–189, 1975. [106] US Department of Health, Human Services, et al. Agency for toxic substances and disease registry. 2010. Case Studies in Envionmental medicin-Lead toxicity. ATSDR Publication ATSDR-HE-CS-2001-0001, 2007. [107] AJA Al-Modhefer, MWB Bradbury, and TJB Simons. Observations on the chemical nature of lead in human blood serum. Clin Sci, 81:823–829, 1991. [108] MW Bradbury and R Deane. Permeability of the blood-brain barrier to lead. Neurotoxicology, 14(2-3):131–136, 1992. [109] Robert A Yokel. Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. Journal of Alzheimer’s Disease, 10(2):223–254, 2006. [110] Desmond I Bannon, Roger Abounader, Peter SJ Lees, and Joseph P Bressler. Effect of dmt1 knockdown on iron, cadmium, and lead uptake in caco-2 cells. American Journal of Physiology-Cell Physiology, 284(1):C44–C50, 2003. [111] K Williams, MA Wilson, and J Bressler. Regulation and developmental expression of the divalent metal-ion transporter in the rat brain. Cellular and molecular biology (Noisy-le-Grand, France), 46(3):563–571, 2000. [112] R Tomás et al. Mechanisms of heavy metal neurotoxicity: Lead and manganese. Journal of Drug Metabolism & Toxicology, 2012. [113] Qiang Wang, Wenjing Luo, Wenbin Zhang, Mingchao Liu, Haifeng Song, and Jingyuan Chen. Involvement of DMT1 +IRE in the transport of lead in an in vitro BBB model. Toxicology in Vitro, 25(4):991–998, 2011. [114] Carla Marchetti. Molecular targets of lead in brain neurotoxicity. Neurotoxicity research, 5(3):221–235, 2003. [115] EJ Fjerdingstad, Gorm Danscher, and Erik Fjerdingstad. Hippocampus: selective concentration of lead in the normal rat brain. Brain Research, 80(2):350–354, 1974. [116] Paola Gavazzo, Andrea Gazzoli, Monica Mazzolini, and Carla Marchetti. Lead inhibition of nmda channels in native and recombinant receptors. Neuroreport, 12(14):3121–3125, 2001. [117] SM Lasley and ME Gilbert. Lead inhibits the rat n-methyl-d-aspartate receptor channel by binding to a site distinct from the zinc allosteric site. Toxicology and applied pharmacology, 159(3):224–233, 1999. [118] DV Widzowski and DA Cory-Slechta. Homogeneity of regional brain lead concentrations. Neurotoxicology, 15(2):295–307, 1993. [119] Joel G Pounds, Gregory J Long, and John F Rosen. Cellular and molecular toxicity of lead in bone. Environmental health perspectives, 91:17, 1991. [120] Swaran JS Flora and Vidhu Pachauri. Chelation in metal intoxication. International journal of environmental research and public health, 7(7):2745–2788, 2010. [121] Ole Andersen. Principles and recent developments in chelation treatment of metal intoxication. Chemical reviews, 99(9):2683–2710, 1999. [122] Curtis D Klaassen. Heavy metals and heavy-metal antagonists. The pharmacological basis of therapeutics, 12:1851–75, 1996. [123] Sally Bradberry and Allister Vale. A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (dmsa) in the treatment of inorganic lead poisoning. Clinical toxicology, 47(9):841–858, 2009. [124] Ole Andersen. Chemical and biological considerations in the treatment of metal intoxications by chelating agents. Mini Reviews in medicinal chemistry, 4(1):11–21, 2004. [125] Nina Mikirova, Jiseph Casciari, Ronald Hunninghake, and Neil Riordan. Edta chelation therapy in the treatment of toxic metals exposure. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery, 1(2):81–89, 2011. [126] JM Bowness, RA Morton, MH Shakir, and AL Stubbs. Distribution of copper and zinc in mammalian eyes. Occurrence of metals in melanin fractions from eye tissues. Biochemical Journal, 51(4):521, 1952. [127] Albert M Potts and Pin Chit Au. The affinity of melanin for inorganic ions. Experimental eye research, 22(5):487–491, 1976. [128] CC Felix, JS Hyde, T Sarna, and RC Sealy. Interactions of melanin with metal ions. electron spin resonance evidence for chelate complexes of metal ions with free radicals. Journal of the American Chemical Society, 100(12):3922–3926, 1978. [129] Corrado Sarzanini, Edoardo Mentasti, Ornella Abollino, Mauro Fasano, and Silvio Aime. Metal ion content in Sepia officinalis melanin. Marine chemistry, 39(4): 243–250, 1992. [130] Lian Hong, Yan Liu, and John D Simon. Binding of metal ions to melanin and their effects on the aerobic reactivity¶. Photochemistry and photobiology, 80(3):477–481, 2004. [131] Alexander Samokhvalov, Yan Liu, and John D Simon. Characterization of the Fe (III)-binding site in Sepia eumelanin by resonance raman confocal microspectroscopy¶. Photochemistry and photobiology, 80(1):84–88, 2004. [132] Yan Liu, Lian Hong, Valerie R Kempf, Kazumasa Wakamatsu, Shosuke Ito, and John D Simon. Ion-exchange and adsorption of Fe (III) by Sepia melanin. Pigment Cell Research, 17(3):262–269, 2004. [133] Li-Ming Zhang and Dan-Qing Chen. An investigation of adsorption of lead (II) and copper (II) ions by water-insoluble starch graft copolymers. Colloids and surfaces A: physicochemical and engineering aspects, 205(3):231–236, 2002. [134] Bingjun Pan, Hui Qiu, Bingcai Pan, Guangze Nie, Lili Xiao, Lu Lv, Weiming Zhang, Quanxing Zhang, and Shourong Zheng. Highly efficient removal of heavy metals by polymer-supported nanosized hydrated Fe (III) oxides: behavior and XPS study. Water research, 44(3):815–824, 2010. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51708 | - |
dc.description.abstract | 黑色素是人體組織中最普遍的異質生物聚合物之一,但其分子結構至今還無法完全被解析出來。黑色素具有很寬的吸收光譜,並且可生產永久自由基和光致自由基,皮膚表層的黑色素細胞中有許多與免疫系統相關聯的酶,有助於幫助人體對抗微生物,其中的黑色素可能就扮演重要的角色。此外研究指出黑色素細胞能保護皮膚不受紫外線的傷害,靠的不僅是經由吸收作用衰減紫外線強度,還有清除自由基和活性氧的功能,更多的研究指出黑色素具有抗輻射、抗氧化、抗癌、抗蛇毒、抗病毒和清除重金屬離子等功能。在這些潛在應用中,不論是天然黑色素或人工合成黑色素都無法在適合生物生存的溶劑中被溶解,大量的沉澱聚集形成更大的顆粒,造成其效用大大降低。於是我們著手開發利用飛秒脈衝雷射與機械粉碎的技術將黑色素奈米化,製造黑色素奈米顆粒使之可以分散於水溶液中,以便更可靠地研究黑色素的生物功能,並增強其作為藥物的療效。結果顯示被奈米化的烏賊和合成黑色素呈片狀,顆粒大小約為直徑42.5奈米與高度0.95奈米,可以均勻分散在水溶液中超過一週不會沉澱,理論上,此技術適用於任何種類的黑色素,而且用飛秒脈衝雷射進行奈米化的製程還可用來解析黑色素的結構,我們推斷烏賊黑色素是由許多奈米薄片聚集而成,其間是靠凡得瓦力和疏水作用力來維繫的,而合成黑色素是由許多奈米薄片堆疊而成的微米薄片,其間靠的是π–π相互作用力來維繫的,此作用力比前者大。在生物醫學應用方面,雖然過去研究指出黑色素在皮膚中具有抗微生物能力,但我們的實驗證明並非黑色素奈米顆粒直接殺死微生物,同時也證明黑色素奈米顆粒在有無照光的情況下都不具有細胞毒性,更加確認它做為藥物的可行性。此外,我們證明了奈米化後大大提高黑色素對抗急性氧化壓力和清除重金屬離子的效用,甚至不需要外加照光來增強其效果,對於日後做為注射劑應用到人體會更加方便。 | zh_TW |
dc.description.abstract | Melanin is one of the most ubiquitous heterogeneous biological polymer widespread in our body tissue. However, its complete molecular hierarchical structure is still unknown. Melanin has a broadband absorption spectrum and it can generate permanent and light-induced free radicals. In the human epidermis, melanocytes have numerous enzymes with capabilities in antimicrobial defense and functional links to the immune system, in which melanin may play an activating role. Furthermore, it is believed that melanocytes in the human epidermis play a key role in protecting our skin from the damaging effects of UV radiation by scavenging free radicals and reactive oxygen species, besides simply attenuating the radiation. It is well established that melanin has multiple functions such as anti-radiation, antioxidant, antitumor, antivenin, anti-virus, and removing heavy metal ions. In all these potential applications, insolubility of both natural melanin and synthetic melanin in bio-compatible solvent leads to quick precipitation and formation of large aggregates, drastically reducing the efficacy in in vivo and in vitro experiments. We deliberately set out to develop techniques based on photo-fragmentation with femtosecond laser pulses and mechanical smashing respectively for nanonization and dispersibilization of melanin, in order to more reliably study the biological functions of melanin and to promote the efficacy of melanin as medicine. It was found that both Sepia melanin and synthetic melanin particles processed with either method represent flaky shape with the diameter of ~42.5 nm and height of ~0.95 nm. Therefore, they can disperse in water and avoid precipitation for more than a week. In principle, the techniques can be applied to any kind of melanin. Amount them, the nanonization process by femtosecond laser pulses also serves as a top-down approach for resolving melanin structure. We inferred that in Sepia melanin the aggregation of nano-flakes is mediated by van der Waals interaction and hydrophobic interaction, whereas in synthetic melanin the formation of micro-flakes from nano-flakes is mediated by π–π interaction, which is substantially stronger than the former. As for the biomedical applications, experiments on the antimicrobial efficacy concluded that even if melanin plays a role in antimicrobial capability of skin, as proposed previously by others, it does not result from direct killing of microbe by melanin nanoparticle. In addition, this shows that melanin nanoparticle whether illuminated or not is not cytotoxic, therefore promises its use as medicine. Moreover, we demonstrated that nanonization dramatically improves the efficacy of melanin against acute oxidative stress and heavy metal ions. The effect was even more prominent without simultaneous light irradiation, promising for effective in vivo intravenous application to the whole body. | en |
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dc.description.tableofcontents | 口試委員會審定書 i
致謝 ii 中文摘要 iii Abstract iv Contents vi List of Figures x List of Tables xviii 1 Overview 1 2 Nanonization Process by Femtosecond Lasers as a Top-Down Approach for Resolving Melanin Structure 4 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2.1 Melanin preparation . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2.2 High power laser system . . . . . . . . . . . . . . . . . . . . . . 7 2.2.3 Laser-induced fragmentation for nanonization of melanin . . . . . 14 2.2.4 Atomic force microscopy . . . . . . . . . . . . . . . . . . . . . . 15 2.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 2.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 3 Nanonization Process by Mechanical Stir for Mass Production 25 3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2.1 Melanin preparation . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2.2 Mechanical stir for nanonization of melanin . . . . . . . . . . . . 26 3.2.3 Electron paramagnetic resonance . . . . . . . . . . . . . . . . . 26 3.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 4 Electron Paramagnetic Resonance (EPR) Study for Characterizing Melanin Radical Property 39 4.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 4.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 4.2.1 Development of the home-made EPR . . . . . . . . . . . . . . . 41 4.2.2 Utilization of the commercial EPR . . . . . . . . . . . . . . . . . 44 4.2.3 Irradiation light sources . . . . . . . . . . . . . . . . . . . . . . 45 4.2.4 Samples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 4.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 4.3.1 Status dependence . . . . . . . . . . . . . . . . . . . . . . . . . 47 4.3.2 Concentration and irradiation dependence . . . . . . . . . . . . . 47 4.3.3 Irradiation time dependence . . . . . . . . . . . . . . . . . . . . 51 4.3.4 Solvent dependence . . . . . . . . . . . . . . . . . . . . . . . . 52 4.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 5 Evaluation of the Practicality of Melanin as a Photodynamic-Inactivation Photosensitizer by Its Nanonization 56 5.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 5.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 5.2.1 Reagents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 5.2.2 Photosensitization setup and procedure . . . . . . . . . . . . . . 59 5.2.3 Bacterial strain . . . . . . . . . . . . . . . . . . . . . . . . . . . 60 5.2.4 Bacterial survival rate measurement . . . . . . . . . . . . . . . . 61 5.2.5 Evaluation of singlet oxygen quantum yield . . . . . . . . . . . . 61 5.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 5.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 6 Application of Nanonized Melanin to Protecting Cells from Acute Oxidative Stress 70 6.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 6.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 6.2.1 Reagents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 6.2.2 Culture of human RPE cells . . . . . . . . . . . . . . . . . . . . 71 6.2.3 Cell viability measurement by flow cytometer . . . . . . . . . . . 72 6.2.4 Induction of cell apoptosis by externally added H2O2 . . . . . . . 72 6.2.5 Assays on the protective power of melanin against H2O2-induced cell apoptosis and necrosis . . . . . . . . . . . . . . . . . . . . . 72 6.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 6.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 7 Application of Nanonized Melanin to Cleaning Heavy Metal Ions 80 7.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 7.2 Materials and methods . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 7.2.1 Preparation of water-dispersible melanin solution . . . . . . . . . 82 7.2.2 Binding of heavy metal ions . . . . . . . . . . . . . . . . . . . . 83 7.3 Results and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 7.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 8 Conclusions and Perspective 87 8.1 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 8.2 Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 8.3 Funding information . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 A Design Diagram 90 B Additional Homemade Instruments 94 Bibliography 97 | |
dc.language.iso | en | |
dc.title | 黑色素的奈米化與其在生物醫學上之應用 | zh_TW |
dc.title | NANONIZATION OF MELANIN AND ITS APPLICATIONS TO BIOMEDICINE | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-1 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 陳賜原(Szu-yuan Chen) | |
dc.contributor.oralexamcommittee | 陳師慶(Ssu-Ching Chen),朱唯勤(Woei-Chyn Chu),李俊賢(Jyuhn-Hsiarn Lee),廖仲麒(Jung-Chi Liao) | |
dc.subject.keyword | 黑色素,飛秒雷射,電子順磁共振,奈米藥物,奈米顆粒,水分散,活性氧,抗氧化,抗微生物,金屬離子,螯合, | zh_TW |
dc.subject.keyword | melanin,femtosecond laser,electron paramagnetic resonance (EPR),nano-medicine,nanoparticle,water-dispersible,reactive oxygen species,antioxidant,antimicrobial,metal ion,chelation, | en |
dc.relation.page | 112 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-11-30 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
顯示於系所單位: | 光電工程學研究所 |
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