請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51115
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳示國(Shih-Kuo Chen) | |
dc.contributor.author | Yan-Fang Zou | en |
dc.contributor.author | 鄒硯芳 | zh_TW |
dc.date.accessioned | 2021-06-15T13:25:28Z | - |
dc.date.available | 2017-06-11 | |
dc.date.copyright | 2016-06-11 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-05-10 | |
dc.identifier.citation | References
Albers, H.E., Ferris, C.F., Leeman, S.E., and Goldman, B.D. (1984). Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region. Science 223, 833-835. Backhed, F., Ding, H., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A., Semenkovich, C.F., and Gordon, J.I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101, 15718-15723. Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M., and Weaver, D.R. (2001). Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30, 525-536. Barclay, J.L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S.M., Lehnert, H., and Oster, H. (2012). Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. PLoS One 7, e37150. Barlow, H.B., and Levick, W.R. (1969). Changes in the maintained discharge with adaptation level in the cat retina. The Journal of Physiology 202, 699-718. Bedrosian, T.A., Galan, A., Vaughn, C.A., Weil, Z.M., and Nelson, R.J. (2013). Light at night alters daily patterns of cortisol and clock proteins in female Siberian hamsters. J Neuroendocrinol 25, 590-596. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas, T.L., and Zoran, M.J. (2005). Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet 6, 544-556. Berson, D.M. (2003). Strange vision: ganglion cells as circadian photoreceptors. Trends in neurosciences 26, 314-320. Berson, D.M., Dunn, F.A., and Takao, M. (2002). Phototransduction by retinal ganglion cells that set the circadian clock. Science 295, 1070-1073. Borre, Y.E., O'Keeffe, G.W., Clarke, G., Stanton, C., Dinan, T.G., and Cryan, J.F. (2014). Microbiota and neurodevelopmental windows: implications for brain disorders. Trends in molecular medicine 20, 509-518. Brainard, G.C., Lewy, A.J., Menaker, M., Fredrickson, R.H., Miller, L.S., Weleber, R.G., Cassone, V., and Hudson, D. (1988). Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers. Brain Res 454, 212-218. Bray, M.S., Ratcliffe, W.F., Grenett, M.H., Brewer, R.A., Gamble, K.L., and Young, M.E. (2013). Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice. International journal of obesity (2005) 37, 843-852. Bray, M.S., Tsai, J.Y., Villegas-Montoya, C., Boland, B.B., Blasier, Z., Egbejimi, O., Kueht, M., and Young, M.E. (2010). Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice. International journal of obesity (2005) 34, 1589-1598. Bridges, C. (1959). Visual pigments of some common laboratory mammals. Nature 184, 1727-1728. Buijs, R.M., and Kalsbeek, A. (2001). Hypothalamic integration of central and peripheral clocks. Nature Reviews Neuroscience 2, 521-526. Bunger, M.K., Wilsbacher, L.D., Moran, S.M., Clendenin, C., Radcliffe, L.A., Hogenesch, J.B., Simon, M.C., Takahashi, J.S., and Bradfield, C.A. (2000). Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103, 1009-1017. Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P.D., and Bäckhed, F. (2015). Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling. Cell metabolism 22, 658-668. Castanon-Cervantes, O., Wu, M., Ehlen, J.C., Paul, K., Gamble, K.L., Johnson, R.L., Besing, R.C., Menaker, M., Gewirtz, A.T., and Davidson, A.J. (2010). Dysregulation of inflammatory responses by chronic circadian disruption. The Journal of Immunology 185, 5796-5805. Chandrashekhar, Y., Prahash, A.J., Sen, S., Gupta, S., Roy, S., and Anand, I.S. (2003). The role of arginine vasopressin and its receptors in the normal and failing rat heart. J Mol Cell Cardiol 35, 495-504. Chen, S.K., Badea, T.C., and Hattar, S. (2011). Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 476, 92-95. Cheng, M.Y., Bullock, C.M., Li, C., Lee, A.G., Bermak, J.C., Belluzzi, J., Weaver, D.R., Leslie, F.M., and Zhou, Q.-Y. (2002). Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417, 405-410. Cohen, R., Kronfeld-Schor, N., Ramanathan, C., Baumgras, A., and Smale, L. (2010). The substructure of the suprachiasmatic nucleus: Similarities between nocturnal and diurnal spiny mice. Brain Behav Evol 75, 9-22. Cotter, P.D., Stanton, C., Ross, R.P., and Hill, C. (2012). The impact of antibiotics on the gut microbiota as revealed by high throughput DNA sequencing. Discovery medicine 13, 193-199. Dauncey, M.J. (1986). Activity-induced thermogenesis in lean and genetically obese (ob/ob) mice. Experientia 42, 547-549. David, L.A., Materna, A.C., Friedman, J., Campos-Baptista, M.I., Blackburn, M.C., Perrotta, A., Erdman, S.E., and Alm, E.J. (2014). Host lifestyle affects human microbiota on daily timescales. Genome Biol 15, R89. De Mairan, J.J.d.O. (1729). Observation botanique. In Histoire de l'Academie Royale des Science., pp. 35-36. De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., and Mithieux, G. (2014). Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156, 84-96. Denou, E., Jackson, W., Lu, J., Blennerhassett, P., McCoy, K., Verdu, E.F., Collins, S.M., and Bercik, P. (2011). The Intestinal Microbiota Determines Mouse Behavior and Brain BDNF Levels. Gastroenterology 140, S-57. Duncan Jr, W.C., Johnson, K.A., Sutin, E., and Wehr, T.A. (1998). Disruption of the Activity–Rest Cycle by MAOI Treatment: Dependence on Light and a Secondary Visual Pathway to the Circadian Pacemaker. Brain Research Bulletin 45, 457-465. Ecker, J.L., Dumitrescu, O.N., Wong, K.Y., Alam, N.M., Chen, S.K., LeGates, T., Renna, J.M., Prusky, G.T., Berson, D.M., and Hattar, S. (2010). Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67, 49-60. Finegold, S.M. (2011). State of the art; microbiology in health and disease. Intestinal bacterial flora in autism. Anaerobe 17, 367-368. Fonken, L.K., Aubrecht, T.G., Melendez-Fernandez, O.H., Weil, Z.M., and Nelson, R.J. (2013). Dim light at night disrupts molecular circadian rhythms and increases body weight. J Biol Rhythms 28, 262-271. Fonken, L.K., Workman, J.L., Walton, J.C., Weil, Z.M., Morris, J.S., Haim, A., and Nelson, R.J. (2010). Light at night increases body mass by shifting the time of food intake. Proceedings of the National Academy of Sciences 107, 18664-18669. Frank, D.N., St. Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., and Pace, N.R. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences 104, 13780-13785. Freedman, M.S., Lucas, R.J., Soni, B., von Schantz, M., Munoz, M., David-Gray, Z., and Foster, R. (1999). Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 284, 502-504. Fuller, P.M., Lu, J., and Saper, C.B. (2008). Differential rescue of light- and food-entrainable circadian rhythms. Science 320, 1074-1077. Gonze, D., Bernard, S., Waltermann, C., Kramer, A., and Herzel, H. (2005). Spontaneous synchronization of coupled circadian oscillators. Biophys J 89, 120-129. Graeme, A., Reynolds, N., Smith, A.R., Kennedy, A., and Macfarlane, G.T. (2005). Effect of pH and antibiotics on microbial overgrowth in the stomachs and duodena of patients undergoing percutaneous endoscopic gastrostomy feeding. Journal of clinical microbiology 43, 3059-3065. Groos, G., and Hendriks, J. (1982). Circadian rhythms in electrical discharge of rat suprachiasmatic neurones recorded in vitro. Neurosci Lett 34, 283-288. Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E.A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J.A., et al. (2012). Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell metabolism 15, 848-860. Hattar, S., Liao, H.-W., Takao, M., Berson, D.M., and Yau, K.-W. (2002). Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295, 1065-1070. Honma, K., Honma, S., and Wada, T. (1987). Phase-dependent shift of free-running human circadian rhythms in response to a single bright light pulse. Experientia 43, 1205-1207. Hopkins, M.J., Sharp, R., and Macfarlane, G.T. (2002). Variation in human intestinal microbiota with age. Digestive and Liver Disease 34, Supplement 2, S12-S18. Hughes, M.E., Hogenesch, J.B., and Kornacker, K. (2010). JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. Journal of biological rhythms 25, 372-380. Iwamoto, A., Kawai, M., Furuse, M., and Yasuo, S. (2014). Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice. Chronobiol Int 31, 189-198. Iyer, R., Wang, T.A., and Gillette, M.U. (2014). Circadian gating of neuronal functionality: a basis for iterative metaplasticity. Front Syst Neurosci 8, 164. Jacobs, G.H., Fenwick, J.A., and Williams, G.A. (2001). Cone-based vision of rats for ultraviolet and visible lights. The Journal of experimental biology 204, 2439-2446. Jouvet, M. (1969). Biogenic amines and the states of sleep. Science 163, 32-41. Kalsbeek, A., Fliers, E., Romijn, J.A., La Fleur, S.E., Wortel, J., Bakker, O., Endert, E., and Buijs, R.M. (2001). The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 142, 2677-2685. Kalsbeek, A., Verhagen, L.A., Schalij, I., Foppen, E., Saboureau, M., Bothorel, B., Buijs, R.M., and Pevet, P. (2008). Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species. Eur J Neurosci 27, 818-827. Kiessling, S., Eichele, G., and Oster, H. (2010). Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag. The Journal of clinical investigation 120, 2600-2609. Kohsaka, A., Laposky, A.D., Ramsey, K.M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F.W., and Bass, J. (2007). High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell metabolism 6, 414-421. Kramer, A., Yang, F.-C., Snodgrass, P., Li, X., Scammell, T.E., Davis, F.C., and Weitz, C.J. (2001). Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294, 2511-2515. Kraves, S., and Weitz, C.J. (2006). A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nature neuroscience 9, 212-219. Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.M., Kennedy, S., et al. (2013). Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541-546. Leak, R.K., and Moore, R.Y. (2001). Topographic organization of suprachiasmatic nucleus projection neurons. Journal of Comparative Neurology 433, 312-334. Leone, V., Gibbons, S.M., Martinez, K., Hutchison, A.L., Huang, E.Y., Cham, C.M., Pierre, J.F., Heneghan, A.F., Nadimpalli, A., Hubert, N., et al. (2015). Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell host & microbe 17, 681-689. Ley, R.E., Backhed, F., Turnbaugh, P., Lozupone, C.A., Knight, R.D., and Gordon, J.I. (2005). Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102, 11070-11075. Lu, H.-P., Wang, Y.-b., Huang, S.-W., Lin, C.-Y., Wu, M., Hsieh, C.-h., and Yu, H.-T. (2012). Metagenomic analysis reveals a functional signature for biomass degradation by cecal microbiota in the leaf-eating flying squirrel (Petaurista alborufus lena). BMC genomics 13, 466. Lucas, R., Hattar, S., Takao, M., Berson, D., Foster, R., and Yau, K.-W. (2003). Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science 299, 245-247. Lucas, R.J., Douglas, R.H., and Foster, R.G. (2001). Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nat Neurosci 4, 621-626. Lucas, R.J., Freedman, M.S., Munoz, M., Garcia-Fernandez, J.M., and Foster, R.G. (1999). Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors. Science 284, 505-507. Lundkvist, G.B., Kwak, Y., Davis, E.K., Tei, H., and Block, G.D. (2005). A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons. J Neurosci 25, 7682-7686. Mäntele, S., Otway, D.T., Middleton, B., Bretschneider, S., Wright, J., Robertson, M.D., Skene, D.J., and Johnston, J.D. (2012). Daily Rhythms of Plasma Melatonin, but Not Plasma Leptin or Leptin mRNA, Vary between Lean, Obese and Type 2 Diabetic Men. PLoS ONE 7, e37123. Macfarlane, S., and Macfarlane, G.T. (2003). Regulation of short-chain fatty acid production. Proc Nutr Soc 62, 67-72. Macpherson, A.J., and Harris, N.L. (2004). Interactions between commensal intestinal bacteria and the immune system. Nature reviews. Immunology 4, 478-485. Macpherson, A.J., and Uhr, T. (2004). Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665. Maes, M., Kubera, M., and Leunis, J.C. (2008). The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro endocrinology letters 29, 117-124. Malek, Z.S., Pévet, P., and Raison, S. (2004). Circadian change in tryptophan hydroxylase protein levels within the rat intergeniculate leaflets and raphe nuclei. Neuroscience 125, 749-758. Marcelin, G., Jo, Y.-H., Li, X., Schwartz, G.J., Zhang, Y., Dun, N.J., Lyu, R.-M., Blouet, C., Chang, J.K., and Chua, S. (2014). Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Molecular metabolism 3, 19-28. Mazmanian, S.K., Liu, C.H., Tzianabos, A.O., and Kasper, D.L. (2005). An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107-118. Mittal, V.A., Ellman, L.M., and Cannon, T.D. (2008). Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications. Schizophrenia bulletin 34, 1083-1094. Moore, R.Y., Gustafson, E.L., and Card, J.P. (1984). Identical immunoreactivity of afferents to the rat suprachiasmatic nucleus with antisera against avian pancreatic polypeptide, molluscan cardioexcitatory peptide and neuropeptide Y. Cell Tissue Res 236, 41-46. Morin, L.P., and Allen, C.N. (2006). The circadian visual system, 2005. Brain research reviews 51, 1-60. Mukherji, A., Kobiita, A., Ye, T., and Chambon, P. (2013). Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 153, 812-827. Nagai, K., Nagai, N., Shimizu, K., Chun, S., Nakagawa, H., and Niijima, A. (1996). SCN output drives the autonomic nervous system: with special reference to the autonomic function related to the regulation of glucose metabolism. Progress in brain research 111, 253-272. Obayashi, K., Saeki, K., Iwamoto, J., Okamoto, N., Tomioka, K., Nezu, S., Ikada, Y., and Kurumatani, N. (2013). Exposure to light at night, nocturnal urinary melatonin excretion, and obesity/dyslipidemia in the elderly: a cross-sectional analysis of the HEIJO-KYO study. J Clin Endocrinol Metab 98, 337-344. Pakhotin, P., Harmar, A.J., Verkhratsky, A., and Piggins, H. (2006). VIP receptors control excitability of suprachiasmatic nuclei neurones. Pflugers Arch 452, 7-15. Patel, S.R., Malhotra, A., White, D.P., Gottlieb, D.J., and Hu, F.B. (2006). Association between reduced sleep and weight gain in women. American journal of epidemiology 164, 947-954. Peter, R., Alfredsson, L., Knutsson, A., Siegrist, J., and Westerholm, P. (1999). Does a stressful psychosocial work environment mediate the effects of shift work on cardiovascular risk factors? Scandinavian journal of work, environment & health, 376-381. Pinato, L., Ferreira, Z.S., Markus, R.P., and Nogueira, M.I. (2004). Bimodal Daily Variation in the Serotonin Content in the Raphe Nuclei of Rats. Biological Rhythm Research 35, 245-257. Pittendrigh, C.S. (1954). On Temperature Independence in the Clock System Controlling Emergence Time in Drosophila. Proc Natl Acad Sci U S A 40, 1018-1029. Pontes, A.L.B.d., Engelberth, R.C.G.J., Nascimento, J., Expedito da Silva, Cavalcante, J.C., Costa, M.S.M.d.O., Pinato, L., Toledo, C.A.B.d., and Cavalcante, J.d.S. (2010). Serotonin and circadian rhythms. Psychology & Neuroscience 3, 217-228. Preitner, N., Damiola, F., Lopez-Molina, L., Zakany, J., Duboule, D., Albrecht, U., and Schibler, U. (2002). The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260. Provencio, I., Jiang, G., De Grip, W.J., Hayes, W.P., and Rollag, M.D. (1998). Melanopsin: An opsin in melanophores, brain, and eye. Proceedings of the National Academy of Sciences of the United States of America 95, 340-345. Provencio, I., Rodriguez, I.R., Jiang, G., Hayes, W.P., Moreira, E.F., and Rollag, M.D. (2000). A novel human opsin in the inner retina. J Neurosci 20, 600-605. Provencio, I., Rollag, M.D., and Castrucci, A.M. (2002). Photoreceptive net in the mammalian retina. This mesh of cells may explain how some blind mice can still tell day from night. Nature 415, 493. Rakoff-Nahoum, S., and Medzhitov, R. (2008). Innate immune recognition of the indigenous microbial flora. Mucosal immunology 1 Suppl 1, S10-14. Ralph, M.R., Foster, R.G., Davis, F.C., and Menaker, M. (1990). Transplanted suprachiasmatic nucleus determines circadian period. Science 247, 975-978. Rao, M.N., Blackwell, T., Redline, S., Stefanick, M.L., Ancoli-Israel, S., Stone, K.L., and Group, O.F.i.M.S. (2009). Association between sleep architecture and measures of body composition. Sleep 32, 483-490. Rawls, J.F., Mahowald, M.A., Ley, R.E., and Gordon, J.I. (2006). Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell 127, 423-433. Ridaura, V.K., Faith, J.J., Rey, F.E., Cheng, J., Duncan, A.E., Kau, A.L., Griffin, N.W., Lombard, V., Henrissat, B., Bain, J.R., et al. (2013). Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice. Science (New York, N.Y.) 341, 10.1126/science.1241214. Ruby, N.F., Brennan, T.J., Xie, X., Cao, V., Franken, P., Heller, H.C., and O'Hara, B.F. (2002). Role of melanopsin in circadian responses to light. Science 298, 2211-2213. Ruiter, M., La Fleur, S.E., van Heijningen, C., van der Vliet, J., Kalsbeek, A., and Buijs, R.M. (2003). The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior. Diabetes 52, 1709-1715. Sadacca, L.A., Lamia, K.A., deLemos, A.S., Blum, B., and Weitz, C.J. (2011). An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia 54, 120-124. Sage, D., Ganem, J., Guillaumond, F., Laforge-Anglade, G., François-Bellan, A.-M., Bosler, O., and Becquet, D. (2004). Influence of the corticosterone rhythm on photic entrainment of locomotor activity in rats. Journal of biological rhythms 19, 144-156. Scheer, F.A., Hilton, M.F., Mantzoros, C.S., and Shea, S.A. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A 106, 4453-4458. Schwartz, W.J., Tavakoli-Nezhad, M., Lambert, C.M., Weaver, D.R., and de la Iglesia, H.O. (2011). Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci U S A 108, 17219-17224. Shi, S.Q., Ansari, T.S., McGuinness, O.P., Wasserman, D.H., and Johnson, C.H. (2013). Circadian disruption leads to insulin resistance and obesity. Current biology : CB 23, 372-381. Simões, C. (2013). Dietary effects on human fecal microbiota. VTT Science. Smale, L., Lee, T., and Nunez, A.A. (2003). Mammalian diurnality: some facts and gaps. J Biol Rhythms 18, 356-366. Srinivasan, V., De Berardis, D., Shillcutt, S.D., and Brzezinski, A. (2012). Role of melatonin in mood disorders and the antidepressant effects of agomelatine. Expert opinion on investigational drugs 21, 1503-1522. Stephan, F.K., and Nunez, A.A. (1977). Elimination of circadian rhythms in drinking, activity, sleep, and temperature by isolation of the suprachiasmatic nuclei. Behav Biol 20, 1-61. Stokkan, K.A., Yamazaki, S., Tei, H., Sakaki, Y., and Menaker, M. (2001). Entrainment of the circadian clock in the liver by feeding. Science 291, 490-493. Stucchi, P., Gil-Ortega, M., Merino, B., Guzman-Ruiz, R., Cano, V., Valladolid-Acebes, I., Somoza, B., Le Gonidec, S., Argente, J., Valet, P., et al. (2012). Circadian feeding drive of metabolic activity in adipose tissue and not hyperphagia triggers overweight in mice: is there a role of the pentose-phosphate pathway? Endocrinology 153, 690-699. Taheri, S., Lin, L., Austin, D., Young, T., and Mignot, E. (2004). Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 1, e62. Takahashi, J.S. (2004). Finding new clock components: past and future. J Biol Rhythms 19, 339-347. Thaiss, C.A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A.C., Abramson, L., Katz, M.N., Korem, T., and Zmora, N. (2014). Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159, 514-529. Travnickova-Bendova, Z., Cermakian, N., Reppert, S.M., and Sassone-Corsi, P. (2002). Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A 99, 7728-7733. Turnbaugh, P.J., Backhed, F., Fulton, L., and Gordon, J.I. (2008). Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell host & microbe 3, 213-223. Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., and Gordon, J.I. (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1131. Vijay-Kumar, M., Aitken, J.D., Carvalho, F.A., Cullender, T.C., Mwangi, S., Srinivasan, S., Sitaraman, S.V., Knight, R., Ley, R.E., and Gewirtz, A.T. (2010). Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228-231. Vrieze, A., Van Nood, E., Holleman, F., Salojarvi, J., Kootte, R.S., Bartelsman, J.F., Dallinga-Thie, G.M., Ackermans, M.T., Serlie, M.J., Oozeer, R., et al. (2012). Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143, 913-916.e917. Walker, A.W., and Parkhill, J. (2013). Microbiology. Fighting obesity with bacteria. Science 341, 1069-1070. Welsh, D.K., Takahashi, J.S., and Kay, S.A. (2010). Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol 72, 551-577. Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R., Ueda, M., Block, G.D., Sakaki, Y., Menaker, M., and Tei, H. (2000). Resetting central and peripheral circadian oscillators in transgenic rats. Science 288, 682-685. Yoshimura, T., and Ebihara, S. (1996). Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 178, 797-802. Zarrinpar, A., Chaix, A., Yooseph, S., and Panda, S. (2014). Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell metabolism 20, 1006-1017. Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., Ben-Yacov, O., Lador, D., Avnit-Sagi, T., and Lotan-Pompan, M. (2015). Personalized nutrition by prediction of glycemic responses. Cell 163, 1079-1094. Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z.S., Eichele, G., Bradley, A., et al. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-694. Zheng, B., Larkin, D.W., Albrecht, U., Sun, Z.S., Sage, M., Eichele, G., Lee, C.C., and Bradley, A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-173. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51115 | - |
dc.description.abstract | 打亂正常生理時鐘常會提高罹患代謝相關疾病的風險,例如胰島素不耐症、肥胖、高血脂等等的代謝問題可能導致嚴重的第二型糖尿病。研究顯示光線到達視網膜訊息除了與視覺的形成有關,也會透過自主感光視神經節細胞參與非視覺形成的生理時鐘的功能。雖然現階段研究認為生理時鐘在調控能量代謝中扮演重要的角色,但光線究竟如何影響生理代謝的功能仍不清楚。由於近年許多證據顯示腸道菌相對身體的代謝狀態有直接的影響,故本研究欲探討來自視網膜的光線訊息是否會透過改變腸道菌相來調控能量代謝的功能。我們建立了野生基因型及黑視素(melanopsin)剔除小鼠總體基因體學的腸道菌樣本,利用次世代定序技術得到在夜晚接受光照的小鼠腸道菌相。本研究發現不同腸道部位有不同的菌相分布,支持前人研究結果。我們也發現夜晚光照改變了腸道菌的組成及節律,黑視素剔除也會造成腸道菌相的改變,而夜晚光照引起的肥胖則與特定菌相總量的增減有關,代表腸道菌相確實在光照影響代謝的途徑上扮演重要角色。總結上述,本研究顯示腸道菌相在光照影響能量代謝途徑的重要調控功能,並提供一解釋生理時鐘與能量代謝交互作用的機制,並為日後研究光照引起之代謝疾病的解決方案奠定基礎。 | zh_TW |
dc.description.abstract | It has long been revealed that the environmental light signals influence non-image forming physiological functions, such as pupillary light reflex and phototaxis. It has been shown that these physiological functions were mediated through the melanopsin –expressing intrinsically photosensitive retina ganglion cells (ipRGCs). The ipRGCs also synchronize numerous physiological homeostasis and behaviors, including circadian rhythm, activity cycle, hormone release, and body temperature, to the external light dark cycle. Recent studies suggests that the circadian rhythm is involved in modulation of physiological regeneration and storage of energy. The disrupted circadian rhythm in mammals is also found to be related to higher risks of acquiring metabolic disorders, such as insulin resistance, obesity and hyperlipidemia, which could further develop into severe diseases including type II diabetes. However, the mechanism responsible for the manipulation of metabolism by light signals remains unknown. There are evidences showing that the gut microbiota has a direct impact on the metabolic status of mammals. Thus, we want to determine whether the ipRGC -mediated light signal transduction from the retina would affect body metabolism through the alterations of gut microbiota.
By constructing a metagenomics library of gut microbiota from wild-type and melanopsin knock-out (MKO) mice and performing next generation sequencing(NGS), our findings shows distinct microbial categories in different compartments of digestive track in mice. This finding indicates the importance of investigating gut microtiota along the total digestive track instead of examining stool. Also, we discover distinct gut microbiota in wild-type and MKO mice that are exposed to dim light during the night time, comparing to the mice living in normal light-dark cycle. This finding indicates that the gut microbiota being a critical modulator of the bidirectional relationships between metabolism and light signal transduction. In addition, we find diverse composition of gut microbiota in the MKO mice when compared to wildtype mice even in the normal light-dark cycle. It also provides evidence for a new phenotype of MKO mice. Furthermore, we investigate the correlation between dim-light-exposure-at-night (dLAN) induced obesity and the altered gut microbiota. We show the diversified amount of some specific gut microbes may contribute to dLAN induced obesity. To sum up, our results suggest that the gut microbiota is a critical modulator of the dLAN induced metabolic disorder, and we provide possible mechanisms of the circadian-metabolic converges. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T13:25:28Z (GMT). No. of bitstreams: 1 ntu-105-R02b21002-1.pdf: 120053816 bytes, checksum: 56b12929d9867b7ac9525a93016231d0 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | Contents
口試委員審定書 i 謝誌 ii 摘要 iv Abstract v Abbreviations vii Contents viii Chapter I 1 Introduction 1 1.1 Circadian rhythm 1 1.2 The suprachiasmatic nucleus 2 1.3 The molecular mechanism of circadian 4 1.4 Inputs of circadian 5 1.5 Circadian synchronization 7 1.6 Outputs of circadian 7 1.7 Peripheral clocks 8 1.8 The circadian clock and metabolism crosstalk 8 1.9 Obesity and circadian clock complementary 10 1.10 Light effects on circadian and metabolism 11 1.11 The intrinsically photosensitive retinal ganglion cells (ipRGCs) 12 1.12 Gut microbiota 14 1.12.1 The gut microbiome 14 1.12.2 Gut microbiota in health and disease 16 1.12.3 Gut microbiota and metabolism 18 Statement of purpose 20 Chapter II 21 Materials and Methods 21 2.1 Mice 21 2.2 Experimental design 21 2.3 Genotyping 22 2.4 Metabolic phynotype measurement 22 2.5 RNA extraction and reverse transcript PCR 24 2.6 RealTime-Quantification PCR 25 2.7 Metagenomic 16s rRNA sequencing 26 2.7.1 The 16s ribosomal DNA extraction 26 2.7.2 Metagenomic library preparation 27 2.7.3 PCR clean-up 28 2.7.4 Qubit assay 29 2.7.5 BioAnalyze 30 2.7.6 Fragment Analyze 30 2.7.7 Next generation sequencing (NGS) 31 2.8 Statistical analysis for NGS 31 2.8.1 Principle component analysis(PCA) 31 2.8.2 Bar graph for relatve percentage of gut microbiota 32 2.8.3 Heat map for different dominance of gut microbiota in mice 32 2.8.4 Heat map for rhythmicity of gut microbiota 32 2.8.5 Relative abundance of gut microbiota 33 Chapter III 34 Results 34 3.1 Metabolic phenotypes differ between wildtype, MKO, 3bDTA and antibiotics treated mice. 34 3.2 Distinctive microbiota composition in different segments of mice digestive track 36 3.3 Microbiota aleration in MKO mice 38 3.4 Microbiota alter rhythmicity when expose dim light at night 39 3.5 Changed abundance of critical gut microbes correlated to the dLAN-induced obesity. 40 3.6 Clock genes expression persist oscillations in central and peripheral clocks. 40 Chapter IV 42 Discussion 42 4.1 Night light exposure induced metabolic effects are directly modulate by melanopsin and ipRGCs . 42 4.2 Different compartment of gut exhibit their distinct microbiomes . 43 4.3 Important functions of melanopsin other than circadian photo-entrainment. 44 4.5 The daily oscillations of the gut microbiota can be diminished by dim light exposure at night. 45 4.6 The relative abundance of gut microbiota may play important functions in the effect of dim light exposure at night. 45 4.7 The dim light exposure at night which affects the metabolism through melanopsin signal conduction is independent of core clock functions. 46 4.8 Limitations and future direction for addressing mechanisms between the circadian-metabolism crosstalk. 46 Chapter V 51 Significance of work 51 Chapter VI 53 References 53 Figures 63 Figure 1. Experimental design 63 Figure 2. Body weight of chow-diet fed mice and high-fat-diet fed miceFigure 3. Weight gain of chow-diet fed mice and high-fat-diet fed mice 64 Figure 4. Caloric intake of high-fat-diet fed mice 66 Figure 5. Glucose tolerance test of chow-diet fed mice and high-fat-diet fed mice 67 Figure 6. Insulin tolerance test of high-fat-diet fed mice 68 Figure 7. Total weight gain of antibiotics treated, high-fat-diet fed mice 69 Figure 8. Glucose tolerance test of antibiotics treated, high-fat-diet fed mice 70 Figure 9. Distinctive microbiota composition in different segments of digestive track of mice 71 Figure 10. Relative proportion of the gut microbiota 72 Figure 11. Diurnal expressions of relative proportions of gut microbiota 73 Figure 12. Hierarchical clustering of intestinal microbiota of WT and MKO mice 74 Figure 13. Hierarchical clustering of microbiota from caecum of WT and MKO mice 75 Figure 14. Hierarchical clustering of microbiota from colon of WT and MKO mice 76 Figure 15. The gut microbial species composition of WT and MKO mice 77 Figure 16. Rhythmic gut microbiota from intestine loss in dim-light exposed mice 78 Figure 17. Rhythmic gut microbiota from caecum loss in dim-light exposed mice 79 Figure 18. Rhythmic gut microbiota from colon loss in dim-light exposed mice 80 Figure 19. Altered abundance of gut microbial species correlated to dim-light induced obesity 81 Figure 20. Clock gene expression in the central clock-SCN 82 Figure 21. Clock genes expression in the peripheral clock-liver 83 Figure 22. Hypoyhesis of the interrelationships between the light-at-night effect on metabolism and gut microbiota 84 Figure 23. Schematic representation of the mouse genetic lines 85 Tables 86 Table 1. Primer list for NGS 86 Table 2.Primer list for genotyping 87 Table 3. Primer list for QPCR 88 Table 4. Different microbial species in the intestine between LD and MLD mice. 89 Table 5. Different microbial species in the caecum between LD and MLD mice. 92 Table 6. Different microbial species in the colon between LD and MLD mice. 95 Table 7. Rhythmic microbial species in the intestine of LD mice. 97 Table 8. Rhythmic microbial species in the caecum of LD mice. 99 Table 9. Rhythmic microbial species in the caecum of LD mice. 101 Table 10. Rhythmic microbial species in the colon of LD mice. 103 Table 11. Rhythmic microbial species in the intestine of MLD mice. 104 Table 12. Rhythmic microbial species in the caecum of MLD mice. 105 Table 13. Rhythmic microbial species in the colon of MLD mice. 107 Appendix 108 Appendix I Abstrack and Poster 108 | |
dc.language.iso | en | |
dc.title | 夜晚光線之照射以及自主感光視神經細胞參予小鼠腸道菌相的調控 | zh_TW |
dc.title | Light Exposure at Night and Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Modulate the Gut Microbiota in Mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 于宏燦(Hon-Tsen Yu),謝志豪(Chih-Hao Hsieh),周信宏(Hsin-Hung Chou) | |
dc.subject.keyword | 腸道菌,黑視素,夜晚光照,生理時鐘,次世代定序,總體基因體學, | zh_TW |
dc.subject.keyword | gut microbiota,melanopsin,dim-light-at-night,circadian rhythm,next generation sequencing,metagenomics, | en |
dc.relation.page | 111 | |
dc.identifier.doi | 10.6342/NTU201600241 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-05-10 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生命科學系 | zh_TW |
顯示於系所單位: | 生命科學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-105-1.pdf 目前未授權公開取用 | 117.24 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。