請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50916完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈湯龍 | |
| dc.contributor.author | Yu-Ling Tai | en |
| dc.contributor.author | 戴佑玲 | zh_TW |
| dc.date.accessioned | 2021-06-15T13:06:21Z | - |
| dc.date.available | 2026-07-01 | |
| dc.date.copyright | 2016-10-17 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-07-02 | |
| dc.identifier.citation | CHAPTER 1:
1. Humphries, J. D., Byron, A., and Humphries, M. J. (2006) Integrin ligands at a glance. Journal of Cell Science 119, 3901-3903 2. Margadant, C., Monsuur, H. N., Norman, J. C., and Sonnenberg, A. (2011) Mechanisms of integrin activation and trafficking. Curr. Opin. Cell Biol. 23, 607-614 3. Shattil, S. J., Kim, C., and Ginsberg, M. H. (2010) The final steps of integrin activation: the end game. Nat. Rev. Mol. Cell Biol. 11, 288-300 4. Giancotti, F. G., and Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032 5. Barczyk, M., Carracedo, S., and Gullberg, D. (2010) Integrins. Cell Tissue Res. 339, 269-280 6. Hsu, Y. L., Wu, C. Y., Hung, J. Y., Lin, Y. S., Huang, M. S., and Kuo, P. L. (2013) Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin alpha6beta4 and Notch1/Jagged2 signaling pathway. Carcinogenesis 34, 1370-1381 7. Wang, H., Rana, S., Giese, N., Buchler, M. W., and Zoller, M. (2013) Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells. Int. J. Cancer 133, 416-426 8. Seguin, L., Kato, S., Franovic, A., Camargo, M. F., Lesperance, J., Elliott, K. C., Yebra, M., Mielgo, A., Lowy, A. M., Husain, H., Cascone, T., Diao, L., Wang, J., Wistuba, II, Heymach, J. V., Lippman, S. M., Desgrosellier, J. S., Anand, S., Weis, S. M., and Cheresh, D. A. (2014) An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 16, 457-468 9. Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G., and Giancotti, F. G. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126, 489-502 10. Trusolino, L., Bertotti, A., and Comoglio, P. M. (2001) A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 107, 643-654 11. Desgrosellier, J. S., and Cheresh, D. A. (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nature reviews. Cancer 10, 9-22 12. Seguin, L., Desgrosellier, J. S., Weis, S. M., and Cheresh, D. A. (2015) Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 25, 234-240 13. Borradori, L., and Sonnenberg, A. (1999) Structure and function of hemidesmosomes: more than simple adhesion complexes. J. Invest. Dermatol. 112, 411-418 14. Wilhelmsen, K., Litjens, S. H., and Sonnenberg, A. (2006) Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Molecular and Cellular Biology 26, 2877-2886 15. Litjens, S. H., de Pereda, J. M., and Sonnenberg, A. (2006) Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol. 16, 376-383 16. Rezniczek, G. A., de Pereda, J. M., Reipert, S., and Wiche, G. (1998) Linking integrin alpha6beta4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites. The Journal of Cell Biology 141, 209-225 17. Guo, L., Degenstein, L., Dowling, J., Yu, Q. C., Wollmann, R., Perman, B., and Fuchs, E. (1995) Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell 81, 233-243 18. Guo, W., and Giancotti, F. G. (2004) Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol. 5, 816-826 19. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 20. Jonkman, M. F., Pas, H. H., Nijenhuis, M., Kloosterhuis, G., and Steege, G. (2002) Deletion of a cytoplasmic domain of integrin beta4 causes epidermolysis bullosa simplex. J Invest Dermatol 119, 1275-1281 21. van der Neut, R., Krimpenfort, P., Calafat, J., Niessen, C. M., and Sonnenberg, A. (1996) Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat. Genet. 13, 366-369 22. Dowling, J., Yu, Q. C., and Fuchs, E. (1996) Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J. Cell Biol. 134, 559-572 23. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., and Le Meur, M. (1996) Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat. Genet. 13, 370-373 24. Kennel, S. J., Foote, L. J., and Lankford, P. K. (1981) Analysis of surface proteins of mouse lung carcinomas using monoclonal antibodies. Cancer Research 41, 3465-3470 25. Falcioni, R., Kennel, S. J., Giacomini, P., Zupi, G., and Sacchi, A. (1986) Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice. Cancer Res. 46, 5772-5778 26. Margadant, C., Frijns, E., Wilhelmsen, K., and Sonnenberg, A. (2008) Regulation of hemidesmosome disassembly by growth factor receptors. Curr. Opin. Cell Biol. 20, 589-596 27. Nikolopoulos, S. N., Blaikie, P., Yoshioka, T., Guo, W., Puri, C., Tacchetti, C., and Giancotti, F. G. (2005) Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol. Cell. Biol. 25, 6090-6102 28. Chung, J., Bachelder, R. E., Lipscomb, E. A., Shaw, L. M., and Mercurio, A. M. (2002) Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J. Cell Biol. 158, 165-174 29. Bachelder, R. E., Ribick, M. J., Marchetti, A., Falcioni, R., Soddu, S., Davis, K. R., and Mercurio, A. M. (1999) p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. The Journal of Cell Biology 147, 1063-1072 30. Zahir, N., Lakins, J. N., Russell, A., Ming, W., Chatterjee, C., Rozenberg, G. I., Marinkovich, M. P., and Weaver, V. M. (2003) Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. The Journal of Cell Biology 163, 1397-1407 31. Bertotti, A., Comoglio, P. M., and Trusolino, L. (2005) Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis. Cancer Research 65, 10674-10679 32. Bertotti, A., Comoglio, P. M., and Trusolino, L. (2006) Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. The Journal of Cell Biology 175, 993-1003 33. Mainiero, F., Murgia, C., Wary, K. K., Curatola, A. M., Pepe, A., Blumemberg, M., Westwick, J. K., Der, C. J., and Giancotti, F. G. (1997) The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. The EMBO journal 16, 2365-2375 34. Mariotti, A., Kedeshian, P. A., Dans, M., Curatola, A. M., Gagnoux-Palacios, L., and Giancotti, F. G. (2001) EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. The Journal of Cell Biology 155, 447-458 35. Gagnoux-Palacios, L., Dans, M., van't Hof, W., Mariotti, A., Pepe, A., Meneguzzi, G., Resh, M. D., and Giancotti, F. G. (2003) Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. The Journal of Cell Biology 162, 1189-1196 36. Russell, A. J., Fincher, E. F., Millman, L., Smith, R., Vela, V., Waterman, E. A., Dey, C. N., Guide, S., Weaver, V. M., and Marinkovich, M. P. (2003) Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. Journal of Cell Science 116, 3543-3556 37. Raymond, K., Kreft, M., Janssen, H., Calafat, J., and Sonnenberg, A. (2005) Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. Journal of Cell Science 118, 1045-1060 38. Wilhelmsen, K., Litjens, S. H., Kuikman, I., Margadant, C., van Rheenen, J., and Sonnenberg, A. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Molecular Biology of the Cell 18, 3512-3522 39. Rabinovitz, I., and Mercurio, A. M. (1997) The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. The Journal of Cell Biology 139, 1873-1884 40. Shaw, L. M., Rabinovitz, I., Wang, H. H., Toker, A., and Mercurio, A. M. (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91, 949-960 41. Yilmaz, M., and Christofori, G. (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28, 15-33 42. O'Connor, K. L., Nguyen, B. K., and Mercurio, A. M. (2000) RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J. Cell Biol. 148, 253-258 43. Cruz-Monserrate, Z., and O'Connor, K. L. (2008) Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia 10, 408-417 44. O'Connor, K. L., Chen, M., and Towers, L. N. (2012) Integrin alpha6beta4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am. J. Physiol. Cell Physiol. 302, C605-614 45. Tani, T., Karttunen, T., Kiviluoto, T., Kivilaakso, E., Burgeson, R. E., Sipponen, P., and Virtanen, I. (1996) Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma. Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: implications for acquisition of the invading phenotype. Am. J. Pathol. 149, 781-793 46. Chao, C., Lotz, M. M., Clarke, A. C., and Mercurio, A. M. (1996) A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Research 56, 4811-4819 47. Kitajiri, S., Hosaka, N., Hiraumi, H., Hirose, T., and Ikehara, S. (2002) Increased expression of integrin beta-4 in papillary thyroid carcinoma with gross lymph node metastasis. Pathol. Int. 52, 438-441 48. Lipscomb, E. A., Dugan, A. S., Rabinovitz, I., and Mercurio, A. M. (2003) Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clinical and Experimental Metastasis 20, 569-576 49. Zhou, J., Zhou, L., and Jin, X. (2004) [Expression of the integrin alpha 6 beta 4 and effects of integrin alpha 6 beta 4 on adhesive and invasive behaviors of human laryngeal carcinoma cell lines]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 18, 164-166 50. Shaw, L. M. (2001) Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Molecular and Cellular Biology 21, 5082-5093 51. Rabinovitz, I., Gipson, I. K., and Mercurio, A. M. (2001) Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion. Molecular Biology of the Cell 12, 4030-4043 52. Tai, Y. L., Chu, P. Y., Lai, I. R., Wang, M. Y., Tseng, H. Y., Guan, J. L., Liou, J. Y., and Shen, T. L. (2015) An EGFR/Src-dependent beta4 integrin/FAK complex contributes to malignancy of breast cancer. Scientific reports 5, 16408 53. Yoon, S. O., Shin, S., and Lipscomb, E. A. (2006) A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. Cancer Res. 66, 2732-2739 54. Chen, M., Sinha, M., Luxon, B. A., Bresnick, A. R., and O'Connor, K. L. (2009) Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. The Journal of Biological Chemistry 284, 1484-1494 55. Garrett, S. C., Varney, K. M., Weber, D. J., and Bresnick, A. R. (2006) S100A4, a mediator of metastasis. J. Biol. Chem. 281, 677-680 56. Wan, X., Kim, S. Y., Guenther, L. M., Mendoza, A., Briggs, J., Yeung, C., Currier, D., Zhang, H., Mackall, C., Li, W. J., Tuan, R. S., Deyrup, A. T., Khanna, C., and Helman, L. (2009) Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. Oncogene 28, 3401-3411 57. Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., Pharmer, L., King, T., Bojmar, L., Davies, A. E., Ararso, Y., Zhang, T., Zhang, H., Hernandez, J., Weiss, J. M., Dumont-Cole, V. D., Kramer, K., Wexler, L. H., Narendran, A., Schwartz, G. K., Healey, J. H., Sandstrom, P., Jorgen Labori, K., Kure, E. H., Grandgenett, P. M., Hollingsworth, M. A., de Sousa, M., Kaur, S., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Brady, M. S., Fodstad, O., Muller, V., Pantel, K., Minn, A. J., Bissell, M. J., Garcia, B. A., Kang, Y., Rajasekhar, V. K., Ghajar, C. M., Matei, I., Peinado, H., Bromberg, J., and Lyden, D. (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527, 329-335 58. Borovski, T., De Sousa, E. M. F., Vermeulen, L., and Medema, J. P. (2011) Cancer stem cell niche: the place to be. Cancer Res. 71, 634-639 59. Chapman, H. A., Li, X., Alexander, J. P., Brumwell, A., Lorizio, W., Tan, K., Sonnenberg, A., Wei, Y., and Vu, T. H. (2011) Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J. Clin. Invest. 121, 2855-2862 60. McQualter, J. L., Yuen, K., Williams, B., and Bertoncello, I. (2010) Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung. Proceedings of the National Academy of Sciences of the United States of America 107, 1414-1419 61. Zheng, Y., de la Cruz, C. C., Sayles, L. C., Alleyne-Chin, C., Vaka, D., Knaak, T. D., Bigos, M., Xu, Y., Hoang, C. D., Shrager, J. B., Fehling, H. J., French, D., Forrest, W., Jiang, Z., Carano, R. A., Barck, K. H., Jackson, E. L., and Sweet-Cordero, E. A. (2013) A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. Cancer cell 24, 59-74 62. Yoshioka, T., Otero, J., Chen, Y., Kim, Y. M., Koutcher, J. A., Satagopan, J., Reuter, V., Carver, B., de Stanchina, E., Enomoto, K., Greenberg, N. M., Scardino, P. T., Scher, H. I., Sawyers, C. L., and Giancotti, F. G. (2013) beta4 Integrin signaling induces expansion of prostate tumor progenitors. Journal of Clinical Investigation 123, 682-699 63. Vieira, A. F., Ribeiro, A. S., Dionisio, M. R., Sousa, B., Nobre, A. R., Albergaria, A., Santiago-Gomez, A., Mendes, N., Gerhard, R., Schmitt, F., Clarke, R. B., and Paredes, J. (2014) P-cadherin signals through the laminin receptor alpha6beta4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells. Oncotarget 5, 679-692 64. Mainiero, F., Pepe, A., Yeon, M., Ren, Y., and Giancotti, F. G. (1996) The intracellular functions of alpha6beta4 integrin are regulated by EGF. The Journal of Cell Biology 134, 241-253 65. Pullar, C. E., Baier, B. S., Kariya, Y., Russell, A. J., Horst, B. A., Marinkovich, M. P., and Isseroff, R. R. (2006) beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Molecular Biology of the Cell 17, 4925-4935 66. Folgiero, V., Avetrani, P., Bon, G., Di Carlo, S. E., Fabi, A., Nistico, C., Vici, P., Melucci, E., Buglioni, S., Perracchio, L., Sperduti, I., Rosano, L., Sacchi, A., Mottolese, M., and Falcioni, R. (2008) Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas. PloS one 3, e1592 67. Kawano, S., Mizutani, K., Miyata, M., Ikeda, W., and Takai, Y. (2010) Interaction of integrin alpha(6)beta(4) with ErbB3 and implication in heregulin-induced ErbB3/ErbB2-mediated DNA synthesis. Genes to cells : devoted to molecular & cellular mechanisms 15, 995-1001 68. Carpenter, B. L., Chen, M., Knifley, T., Davis, K. A., Harrison, S. M., Stewart, R. L., and O'Connor, K. L. (2015) Integrin alpha6beta4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF). The Journal of Biological Chemistry 290, 27228-27238 69. Lipscomb, E. A., Simpson, K. J., Lyle, S. R., Ring, J. E., Dugan, A. S., and Mercurio, A. M. (2005) The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Research 65, 10970-10976 70. Bassani, S., and Cingolani, L. A. (2012) Tetraspanins: Interactions and interplay with integrins. Int J Biochem Cell Biol 44, 703-708 71. Stipp, C. S. (2010) Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets. Expert reviews in molecular medicine 12, e3 72. Sterk, L. M., Geuijen, C. A., Oomen, L. C., Calafat, J., Janssen, H., and Sonnenberg, A. (2000) The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. The Journal of Cell Biology 149, 969-982 73. Baudoux, B., Castanares-Zapatero, D., Leclercq-Smekens, M., Berna, N., and Poumay, Y. (2000) The tetraspanin CD9 associates with the integrin alpha6beta4 in cultured human epidermal keratinocytes and is involved in cell motility. European journal of cell biology 79, 41-51 74. Herlevsen, M., Schmidt, D. S., Miyazaki, K., and Zoller, M. (2003) The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation. Journal of Cell Science 116, 4373-4390 75. Gesierich, S., Paret, C., Hildebrand, D., Weitz, J., Zgraggen, K., Schmitz-Winnenthal, F. H., Horejsi, V., Yoshie, O., Herlyn, D., Ashman, L. K., and Zoller, M. (2005) Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clinical Cancer Research 11, 2840-2852 76. Hasegawa, M., Furuya, M., Kasuya, Y., Nishiyama, M., Sugiura, T., Nikaido, T., Momota, Y., Ichinose, M., and Kimura, S. (2007) CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity. Laboratory investigation; a journal of technical methods and pathology 87, 882-892 77. Lu, S., Simin, K., Khan, A., and Mercurio, A. M. (2008) Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin. Cancer Res. 14, 1050-1058 78. Falcioni, R., Turchi, V., Vitullo, P., Navarra, G., Ficari, F., Cavaliere, F., Sacchi, A., and Marianicostantini, R. (1994) Integrin Beta-4 expression in colorectal-cancer. International journal of oncology 5, 573-578 79. Logsdon, C. D., Simeone, D. M., Binkley, C., Arumugam, T., Greenson, J. K., Giordano, T. J., Misek, D. E., Kuick, R., and Hanash, S. (2003) Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Research 63, 2649-2657 80. Tagliabue, E., Ghirelli, C., Squicciarini, P., Aiello, P., Colnaghi, M. I., and Menard, S. (1998) Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clinical Cancer Research 4, 407-410 81. Diaz, L. K., Cristofanilli, M., Zhou, X., Welch, K. L., Smith, T. L., Yang, Y., Sneige, N., Sahin, A. A., and Gilcrease, M. Z. (2005) Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Mod Pathol 18, 1165-1175 82. Stewart, R. L., and O'Connor, K. L. (2015) Clinical significance of the integrin alpha6beta4 in human malignancies. Laboratory investigation; a journal of technical methods and pathology 95, 976-986 83. Crnogorac-Jurcevic, T., Missiaglia, E., Blaveri, E., Gangeswaran, R., Jones, M., Terris, B., Costello, E., Neoptolemos, J. P., and Lemoine, N. R. (2003) Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. The Journal of Pathology 201, 63-74 84. Cruz-Monserrate, Z., Qiu, S., Evers, B. M., and O'Connor, K. L. (2007) Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression. Mod Pathol 20, 656-667 85. Masugi, Y., Yamazaki, K., Emoto, K., Effendi, K., Tsujikawa, H., Kitago, M., Itano, O., Kitagawa, Y., and Sakamoto, M. (2015) Upregulation of integrin beta4 promotes epithelial-mesenchymal transition and is a novel prognostic marker in pancreatic ductal adenocarcinoma. Laboratory investigation; a journal of technical methods and pathology 95, 308-319 86. Stallmach, A., von Lampe, B., Matthes, H., Bornhoft, G., and Riecken, E. O. (1992) Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation. Gut 33, 342-346 87. Sordat, I., Bosman, F. T., Dorta, G., Rousselle, P., Aberdam, D., Blum, A. L., and Sordat, B. (1998) Differential expression of laminin-5 subunits and integrin receptors in human colorectal neoplasia. The Journal of Pathology 185, 44-52 88. Ni, H., Dydensborg, A. B., Herring, F. E., Basora, N., Gagne, D., Vachon, P. H., and Beaulieu, J. F. (2005) Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expression. Oncogene 24, 6820-6829 89. Nishida, K., Kitazawa, R., Mizuno, K., Maeda, S., and Kitazawa, S. (1997) Identification of regulatory elements of human alpha 6 integrin subunit gene. Biochem Biophys Res Commun 241, 258-263 90. Navab, R., Strumpf, D., Bandarchi, B., Zhu, C. Q., Pintilie, M., Ramnarine, V. R., Ibrahimov, E., Radulovich, N., Leung, L., Barczyk, M., Panchal, D., To, C., Yun, J. J., Der, S., Shepherd, F. A., Jurisica, I., and Tsao, M. S. (2011) Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America 108, 7160-7165 91. Cress, A. E., Rabinovitz, I., Zhu, W., and Nagle, R. B. (1995) The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer metastasis reviews 14, 219-228 92. Allen, M. V., Smith, G. J., Juliano, R., Maygarden, S. J., and Mohler, J. L. (1998) Downregulation of the beta4 integrin subunit in prostatic carcinoma and prostatic intraepithelial neoplasia. Human pathology 29, 311-318 93. Davis, T. L., Cress, A. E., Dalkin, B. L., and Nagle, R. B. (2001) Unique expression pattern of the alpha6beta4 integrin and laminin-5 in human prostate carcinoma. The Prostate 46, 240-248 94. Bonaccorsi, L., Carloni, V., Muratori, M., Salvadori, A., Giannini, A., Carini, M., Serio, M., Forti, G., and Baldi, E. (2000) Androgen receptor expression in prostate carcinoma cells suppresses alpha6beta4 integrin-mediated invasive phenotype. Endocrinology 141, 3172-3182 95. Goodman, S. L., and Picard, M. (2012) Integrins as therapeutic targets. Trends in pharmacological sciences 33, 405-412 96. Noh, T. W., Soung, Y. H., Kim, H. I., Gil, H. J., Kim, J. M., Lee, E. J., and Chung, J. (2010) Effect of {beta}4 integrin knockdown by RNA interference in anaplastic thyroid carcinoma. Anticancer research 30, 4485-4492 97. Leveille, C., Bouillon, M., Guo, W., Bolduc, J., Sharif-Askari, E., El-Fakhry, Y., Reyes-Moreno, C., Lapointe, R., Merhi, Y., Wilkins, J. A., and Mourad, W. (2007) CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling. J. Biol. Chem. 282, 5143-5151 98. Guan, J. L., Trevithick, J. E., and Hynes, R. O. (1991) Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell regulation 2, 951-964 99. Schaller, M. D., Borgman, C. A., Cobb, B. S., Vines, R. R., Reynolds, A. B., and Parsons, J. T. (1992) pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proceedings of the National Academy of Sciences of the United States of America 89, 5192-5196 100. Hanks, S. K., Calalb, M. B., Harper, M. C., and Patel, S. K. (1992) Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proceedings of the National Academy of Sciences of the United States of America 89, 8487-8491 101. Zhao, J., and Guan, J. L. (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 28, 35-49 102. Cooper, L. A., Shen, T. L., and Guan, J. L. (2003) Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol. Cell. Biol. 23, 8030-8041 103. Dunty, J. M., Gabarra-Niecko, V., King, M. L., Ceccarelli, D. F., Eck, M. J., and Schaller, M. D. (2004) FERM domain interaction promotes FAK signaling. Molecular and Cellular Biology 24, 5353-5368 104. Lietha, D., Cai, X., Ceccarelli, D. F., Li, Y., Schaller, M. D., and Eck, M. J. (2007) Structural basis for the autoinhibition of focal adhesion kinase. Cell 129, 1177-1187 105. Han, D. C., and Guan, J. L. (1999) Association of focal adhesion kinase with Grb7 and its role in cell migration. The Journal of Biological Chemistry 274, 24425-24430 106. Han, D. C., Shen, T. L., and Guan, J. L. (2000) Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J. Biol. Chem. 275, 28911-28917 107. Reiske, H. R., Kao, S. C., Cary, L. A., Guan, J. L., Lai, J. F., and Chen, H. C. (1999) Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. The Journal of Biological Chemistry 274, 12361-12366 108. Schaller, M. D., Hildebrand, J. D., Shannon, J. D., Fox, J. W., Vines, R. R., and Parsons, J. T. (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Molecular and Cellular Biology 14, 1680-1688 109. Calalb, M. B., Polte, T. R., and Hanks, S. K. (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Molecular and Cellular Biology 15, 954-963 110. Schlaepfer, D. D., and Hunter, T. (1996) Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Molecular and Cellular Biology 16, 5623-5633 111. Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791 112. Shen, T. L., and Guan, J. L. (2001) Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett. 499, 176-181 113. McLean, G. W., Carragher, N. O., Avizienyte, E., Evans, J., Brunton, V. G., and Frame, M. C. (2005) The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nature Reviews Cancer 5, 505-515 114. Cretu, A., and Brooks, P. C. (2007) Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities. J. Cell. Physiol. 213, 391-402 115. Whiteside, T. L. (2008) The tumor microenvironment and its role in promoting tumor growth. Oncogene 27, 5904-5912 116. Ungefroren, H., Sebens, S., Seidl, D., Lehnert, H., and Hass, R. (2011) Interaction of tumor cells with the microenvironment. Cell communication and signaling : CCS 9, 18 117. Kim, Y. N., Koo, K. H., Sung, J. Y., Yun, U. J., and Kim, H. (2012) Anoikis resistance: an essential prerequisite for tumor metastasis. International journal of cell biology 2012, 306879 118. Reddig, P. J., and Juliano, R. L. (2005) Clinging to life: cell to matrix adhesion and cell survival. Cancer metastasis reviews 24, 425-439 119. Bouchard, V., Demers, M. J., Thibodeau, S., Laquerre, V., Fujita, N., Tsuruo, T., Beaulieu, J. F., Gauthier, R., Vezina, A., Villeneuve, L., and Vachon, P. H. (2007) Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. Journal of Cellular Physiology 212, 717-728 120. Horowitz, J. C., Rogers, D. S., Sharma, V., Vittal, R., White, E. S., Cui, Z., and Thannickal, V. J. (2007) Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cellular signalling 19, 761-771 121. Zhang, Y., Lu, H., Dazin, P., and Kapila, Y. (2004) Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. The Journal of Biological Chemistry 279, 48342-48349 122. Kamarajan, P., and Kapila, Y. L. (2007) An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis : an international journal on programmed cell death 12, 2221-2231 123. Duxbury, M. S., Ito, H., Zinner, M. J., Ashley, S. W., and Whang, E. E. (2004) Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 135, 555-562 124. Sonoda, Y., Matsumoto, Y., Funakoshi, M., Yamamoto, D., Hanks, S. K., and Kasahara, T. (2000) Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J. Biol. Chem. 275, 16309-16315 125. Huang, D., Khoe, M., Befekadu, M., Chung, S., Takata, Y., Ilic, D., and Bryer-Ash, M. (2007) Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. American Journal Of Physiology-Cell Physiology 292, C1339-1352 126. Cicchini, C., Laudadio, I., Citarella, F., Corazzari, M., Steindler, C., Conigliaro, A., Fantoni, A., Amicone, L., and Tripodi, M. (2008) TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling. Experimental Cell Research 314, 143-152 127. Kurenova, E., Xu, L. H., Yang, X., Baldwin, A. S., Jr., Craven, R. J., Hanks, S. K., Liu, Z. G., and Cance, W. G. (2004) Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Molecular and Cellular Biology 24, 4361-4371 128. Dunn, K. B., Heffler, M., and Golubovskaya, V. M. (2010) Evolving therapies and FAK inhibitors for the treatment of cancer. Anti-cancer agents in medicinal chemistry 10, 722-734 129. Zhao, J. H., Reiske, H., and Guan, J. L. (1998) Regulation of the cell cycle by focal adhesion kinase. The Journal of Cell Biology 143, 1997-2008 130. Zhao, J., Pestell, R., and Guan, J. L. (2001) Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Molecular Biology of the Cell 12, 4066-4077 131. Ding, Q., Grammer, J. R., Nelson, M. A., Guan, J. L., Stewart, J. E., Jr., and Gladson, C. L. (2005) p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J. Biol. Chem. 280, 6802-6815 132. Zilfou, J. T., and Lowe, S. W. (2009) Tumor suppressive functions of p53. Cold Spring Harbor perspectives in biology 1, a001883 133. Golubovskaya, V. M., Finch, R., and Cance, W. G. (2005) Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. The Journal of Biological Chemistry 280, 25008-25021 134. Lim, S. T., Chen, X. L., Lim, Y., Hanson, D. A., Vo, | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50916 | - |
| dc.description.abstract | β4 integrin和focal adhesion kinase (FAK)分別皆顯示與癌惡化有相關性，近期研究推測此二種蛋白質可共同調控癌惡化的訊息傳遞。在此，我們的研究首次發現，β4 integrin和FAK蛋白質的共同大量表現與具有三陰性型乳癌或晚期結腸癌的病人之間，呈現顯著的正相關性。此外，在in vivo和in vitro情況下，β4 integrin和FAK蛋白質之間，具有物理性和功能性的直接交互作用，進而參與調控三陰性型乳癌和晚期結腸癌的惡化。其中，FAK蛋白質的氨基端與激酶之間的連結片段和β4 integrin的cytodomain有直接交互作用。我們亦發現EGFR/Src的訊息傳遞或層黏蛋白質(laminin)的刺激會促進β4 integrin的酪胺酸之磷酸化，進一步吸引FAK與其結合，且促使FAK活化。再者，若阻斷β4 integrin/FAK複合體的形成或FAK的活性，會抑制致癌性與癌轉移。綜合言之，我們的研究發現EGFR/Src或層黏蛋白質調控β4 integrin/FAK複合體的形成會影響癌惡化，進而提供癌症治療的新策略。 | zh_TW |
| dc.description.abstract | Although β4 integrin and focal adhesion kinase (FAK) are associated with cancer malignancies, only recently has the signaling event of these two molecules been implicated in cancer malignancy. Here, we demonstrate, for the first time, that the concomitant overexpression of β4 integrin and FAK significantly correlates in patients with malignant triple-negative breast cancer or advanced stages of colon cancer. Consistently, in vitro and in vivo physical and functional interactions between β4 integrin and FAK regulate triple-negative breast cancer and colon cancer malignancy. An amino-terminal linker within FAK is essential for its binding to the cytodomain of β4 integrin. Moreover, the EGFR/Src-signaling or laminin triggers the tyrosine phosphorylation of β4 integrin, leading to recruitment of FAK to β4 integrin as well as FAK activation. Furthermore, disruption of the β4 integrin/FAK complex and/or FAK activation markedly reduces tumorigenicity and cancer metastasis. Our studies show an EGFR/Src and/or laminin-dependent β4 integrin/FAK complex that governs cancer malignancy and sheds a novel strategy for cancer therapies. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T13:06:21Z (GMT). No. of bitstreams: 1 ntu-105-D98633002-1.pdf: 21095270 bytes, checksum: 40c505b7bb9a47422a39f2862a616d1f (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | TABLE OF CONTENTS
口試委員會審定書……………………………………………………………………i 中文摘要……………………………………………………………………………….ii ABSTRACT………………………………………..…………………………………...iii TABLE OF CONTENTS…………………………….…………………………………..iv LIST OF FIGURES……………………………………...……………………………....vi CHAPTER 1: INTRODUCTION…………………………………………..……….1 A. β4 Integrin…………………………………………..…………………….……….2 B. Focal adhesion kinase…………………………………..…………………….…..27 C. References…………………………..…………………….………………….......57 CHAPTER 2: AN EGFR/SRC-DEPENDENT β4 INTEGRIN/FAK COMPLEX CONTRIBUTES TO MALIGNANCY OF BREAST CANCER.…………........104 A. Abstract………………………………………..………………………..………105 B. Introduction…………………………………..………………………..…….….105 C. Materials and methods……………………..………………………..…….……108 D. Results…………………..…………………………………….……..…….……119 E. Discussion……………..…………………………………….……..……...……129 F. Figures……..………………………………………..……….……..……...……134 G. References……………………………………..…………….……..……...……157 CHAPTER 3: ACTIVATION OF FOCAL ADHESION KINASE THROUGH AN INTERACTION WITH β4 INTEGRIN CONTRIBUTES TO TUMORIGENICITY OF COLON CANCER……………………...……...….…165 A. Abstract……………………………………..…………….……..………...……166 B. Introduction………………………………..…………..….……..………...……166 C. Materials and methods…………………..…………..….……..………......…169 D. Results………………………………..…………..….……..………...........……174 E. Discussion……………………………..…………..….……..…….............……181 F. Figures……………………………..…………..……..……..…….............……185 G. References…………………………..…………..…….……..…….............……201 CHAPTER 4: GRB7 PROTEIN STABILITY MODULATED BY PIN1 IN ASSOCIATION WITH CELL CYCLE PROGRESSION...........................……210 A. Abstract……………………………………..…………….……..………...……211 B. Introduction………………………………..…………..….……..………...……211 C. Materials and methods…………………..…………..….……..………......…214 D. Results………………………………..…………..….……..………...........……224 E. Discussion……………………………..…………..….……..…….............……231 F. Figures……………………………..…………..……..……..…….............……237 G. References…………………………..…………..…….……..…….............……251 CHAPTER 5: PROSPECTS……..…….……..……......................................……259 | |
| dc.language.iso | en | |
| dc.subject | 結腸癌 | zh_TW |
| dc.subject | β4 integrin | zh_TW |
| dc.subject | FAK | zh_TW |
| dc.subject | 三陰性型乳癌 | zh_TW |
| dc.subject | 致癌性 | zh_TW |
| dc.subject | 癌轉移 | zh_TW |
| dc.subject | β4 integrin | zh_TW |
| dc.subject | FAK | zh_TW |
| dc.subject | 三陰性型乳癌 | zh_TW |
| dc.subject | 結腸癌 | zh_TW |
| dc.subject | 致癌性 | zh_TW |
| dc.subject | 癌轉移 | zh_TW |
| dc.subject | cancer metastasis | en |
| dc.subject | FAK | en |
| dc.subject | β4 integrin | en |
| dc.subject | cancer metastasis | en |
| dc.subject | tumorigenicity | en |
| dc.subject | colon cancer | en |
| dc.subject | triple-negative breast cancer | en |
| dc.subject | β4 integrin | en |
| dc.subject | FAK | en |
| dc.subject | triple-negative breast cancer | en |
| dc.subject | colon cancer | en |
| dc.subject | tumorigenicity | en |
| dc.title | β4 integrin/FAK複合體對癌進程之調控機制 | zh_TW |
| dc.title | Regulatory Mechanisms of β4 Integrin/FAK Complex in Cancer Progression | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 陳瑞華,湯銘哲,劉俊揚,黃敏銓,廖憶純 | |
| dc.subject.keyword | β4 integrin,FAK,三陰性型乳癌,結腸癌,致癌性,癌轉移, | zh_TW |
| dc.subject.keyword | β4 integrin,FAK,triple-negative breast cancer,colon cancer,tumorigenicity,cancer metastasis, | en |
| dc.relation.page | 266 | |
| dc.identifier.doi | 10.6342/NTU201600626 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-07-04 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 植物病理與微生物學研究所 | zh_TW |
| 顯示於系所單位： | 植物病理與微生物學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-105-1.pdf 未授權公開取用 | 20.6 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。