請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5081完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳媺玫(Meei-Mei Chen) | |
| dc.contributor.author | Yu-Chiao Yang | en |
| dc.contributor.author | 楊雨樵 | zh_TW |
| dc.date.accessioned | 2021-05-15T17:51:40Z | - |
| dc.date.available | 2017-08-21 | |
| dc.date.available | 2021-05-15T17:51:40Z | - |
| dc.date.copyright | 2014-08-21 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-15 | |
| dc.identifier.citation | 涂堅（2003）。錦鯉疱疹病毒症之防治。行政院農業委員會家畜衛生試驗所。
楊勝勛（2011）。錦鯉疱疹病毒在持續感染錦鯉中排毒及潛伏位置之探討。國立台灣大學獸醫學研究所碩士論文。 Adamek, M., H. Syakuri, S. Harris, K. L. Rakus, G. Brogden, M. Matras, I. Irnazarow and D. Steinhagen (2013). 'Cyprinid herpesvirus 3 infection disrupts the skin barrier of common carp (Cyprinus carpio L.).' Vet Microbiol 162(2-4): 456-470. Aoki, T., I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier and R. P. Hedrick (2007). 'Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide.' J Virol 81(10): 5058-5065. Azad, I. S., K. M. Shankar, C. V. Mohan And and B. Kalita (1999). 'Biofilm vaccine of Aeromonas hydrophila– standardization of dose and duration for oral vaccination of carps.' Fish & Shellfish Immunology 9(7): 519 - 528. Azad, I. S., K. M. Shankar, C. V. Mohan and B. Kalita (2000). 'Uptake and processing of biofilm and free-cell vaccines of Aeromonas hydrophila in indian major carps and common carp following oral vaccination--antigen localization by a monoclonal antibody.' Dis Aquat Organ 43(2): 103-108. Bercovier, H., Y. Fishman, R. Nahary, S. Sinai, A. Zlotkin, M. Eyngor, O. Gilad, A. Eldar and R. P. Hedrick (2005). 'Cloning of the koi herpesvirus (KHV) gene encoding thymidine kinase and its use for a highly sensitive PCR based diagnosis.' BMC Microbiol 5: 13. Biering, E., S. Villoing, I. Sommerset and K. E. Christie (2005). 'Update on viral vaccines for fish.' Dev Biol (Basel) 121: 97-113. Boshra, H., J. Li and J. O. Sunyer (2006). 'Recent advances on the complement system of teleost fish.' Fish Shellfish Immunol 20(2): 239-262. Bowden, T. J., K. Adamson, P. MacLachlan, C. C. Pert and I. R. Bricknell (2003). 'Long-term study of antibody response and injection-site effects of oil adjuvants in Atlantic halibut (Hippoglossus hippoglossus L).' Fish Shellfish Immunol 14(4): 363-369. Bretzinger, A., T. Fischer-Scherl, M. Oumouna, R. Hoffmann and U. Truyen (1999). 'Mass mortalities in koi, Cyprinus carpio, associated with gill and skin disease. .' Bulletin of the European Association of Fish Pathologists 19(5): 4. Brudeseth, B. E., R. Wiulsrod, B. N. Fredriksen, K. Lindmo, K. E. Lokling, M. Bordevik, N. Steine, A. Klevan and K. Gravningen (2013). 'Status and future perspectives of vaccines for industrialised fin-fish farming.' Fish Shellfish Immunol. Caipang, C. M., I. Hirono and T. Aoki (2006). 'Immunogenicity, retention and protective effects of the protein derivatives of formalin-inactivated red seabream iridovirus (RSIV) vaccine in red seabream, Pagrus major.' Fish Shellfish Immunol 20(4): 597-609. Castro, R., D. Bernard, M. P. Lefranc, A. Six, A. Benmansour and P. Boudinot (2011). 'T cell diversity and TcR repertoires in teleost fish.' Fish Shellfish Immunol 31(5): 644-654. Corbeil, S., S. E. LaPatra, E. D. Anderson and G. Kurath (2000). 'Nanogram quantities of a DNA vaccine protect rainbow trout fry against heterologous strains of infectious hematopoietic necrosis virus.' Vaccine 18(25): 2817-2824. Costes, B., G. Fournier, B. Michel, C. Delforge, V. S. Raj, B. Dewals, L. Gillet, P. Drion, A. Body, F. Schynts, F. Lieffrig and A. Vanderplasschen (2008). 'Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi.' J Virol 82(10): 4955-4964. Costes, B., V. S. Raj, B. Michel, G. Fournier, M. Thirion, L. Gillet, J. Mast, F. Lieffrig, M. Bremont and A. Vanderplasschen (2009). 'The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin.' J Virol 83(7): 2819-2830. Creriche, A. G. and A. J. Stahl (1994). 'Assay for scavenger receptors on human monocyte-derived macrophages.' J Immunol Methods 174(1-2): 103-107. Davison, A. J., R. Eberle, B. Ehlers, G. S. Hayward, D. J. McGeoch, A. C. Minson, P. E. Pellett, B. Roizman, M. J. Studdert and E. Thiry (2009). 'The order Herpesvirales.' Arch Virol 154(1): 171-177. Dishon, A., M. Davidovich, M. Ilouze and M. Kotler (2007). 'Persistence of cyprinid herpesvirus 3 in infected cultured carp cells.' J Virol 81(9): 4828-4836. Dishon, A., A. Perelberg, J. Bishara-Shieban, M. Ilouze, M. Davidovich, S. Werker and M. Kotler (2005). 'Detection of carp interstitial nephritis and gill necrosis virus in fish droppings.' Appl Environ Microbiol 71(11): 7285-7291. Dixon, P. (1997). 'Immunization with viral antigens: viral diseases of carp and catfish.' Dev Biol Stand 90: 221-232. Dixon, P. F., C. L. Joiner, K. Way, R. A. Reese, G. Jeney and Z. Jeney (2009). 'Comparison of the resistance of selected families of common carp, Cyprinus carpio L., to koi herpesvirus: preliminary study.' J Fish Dis 32(12): 1035-1039. Eggset, G. and H. Mikkelsen (1997). 'Immunocompetence and duration of immunity against Vibrio salmonicida and Aeromonas salmonicida after vaccination of Atlantic salmon (Salmo salar L.) at low and high temperatures.' Fish Shellfish Immunol 7: 14. Eide, K., T. Miller-Morgan, J. Heidel, R. Bildfell and L. Jin (2011). 'Results of total DNA measurement in koi tissue by Koi Herpes Virus real-time PCR.' J Virol Methods 172(1-2): 81-84. Eide, K. E., T. Miller-Morgan, J. R. Heidel, M. L. Kent, R. J. Bildfell, S. Lapatra, G. Watson and L. Jin (2011). 'Investigation of koi herpesvirus latency in koi.' J Virol 85(10): 4954-4962. Fischer, U., E. O. Koppang and T. Nakanishi (2013). 'Teleost T and NK cell immunity.' Fish Shellfish Immunol. Forlenza, M., I. R. Fink, G. Raes and G. F. Wiegertjes (2011). 'Heterogeneity of macrophage activation in fish.' Dev Comp Immunol 35(12): 1246-1255. Fournier, G., M. Boutier, V. Stalin Raj, J. Mast, E. Parmentier, P. Vanderwalle, D. Peeters, F. Lieffrig, F. Farnir, L. Gillet and A. Vanderplasschen (2012). 'Feeding Cyprinus carpio with infectious materials mediates cyprinid herpesvirus 3 entry through infection of pharyngeal periodontal mucosa.' Vet Res 43(1): 6. Fournier, G., M. Boutier, V. Stalin Raj, J. Mast, E. Parmentier, P. Vanderwalle, D. Peeters, F. Lieffrig, F. Farnir, L. Gillet, A. Vanderplasschen, B. Costes, V. S. Raj, B. Michel, G. Fournier, M. Thirion, L. Gillet, J. Mast, F. Lieffrig, M. Bremont and A. Vanderplasschen (2012). 'Feeding Cyprinus carpio with infectious materials mediates cyprinid herpesvirus 3 entry through infection of pharyngeal periodontal mucosa: The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin.' Vet Res 43(7): 6. Gilad, O., S. Yun, F. J. Zagmutt-Vergara, C. M. Leutenegger, H. Bercovier and R. P. Hedrick (2004). 'Concentrations of a Koi herpesvirus (KHV) in tissues of experimentally infected Cyprinus carpio koi as assessed by real-time TaqMan PCR.' Dis Aquat Organ 60(3): 179-187. Goldstein, J. L., Y. K. Ho, S. K. Basu and M. S. Brown (1979). 'Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.' Proc Natl Acad Sci U S A 76(1): 333-337. Gomez-Casado, E., A. Estepa and J. M. Coll (2011). 'A comparative review on European-farmed finfish RNA viruses and their vaccines.' Vaccine 29(15): 2657-2671. Hartman, K., R. Yanong, D. Pouder, D. Petty, R. Francis-Floyd, A. Riggs and T. Waltzek (2008). 'Koi Herpesvirus Disease (KHVD).' Fact Sheet VM-149. Hedrick, R. P., O. Gilad, S. C. Yun, T. S. McDowell, T. B. Waltzek, G. O. Kelley and M. A. Adkison (2005). 'Initial isolation and characterization of a herpes-like virus (KHV) from koi and common carp.' Bulletin of Fisheries Research Agency 2: 7. Hopkins, B. A. and L. D. Olson (1997). 'Comparison of live avirulent PM-1 and CU fowl cholera vaccines in turkeys.' Avian Dis 41(2): 317-325. Horiuchi, S., M. Murakami, K. Takata and Y. Morino (1986). 'Scavenger receptor for aldehyde-modified proteins.' J Biol Chem 261(11): 4962-4966. Huising, M. O., T. Guichelaar, C. Hoek, B. M. Verburg-van Kemenade, G. Flik, H. F. Savelkoul and J. H. Rombout (2003). 'Increased efficacy of immersion vaccination in fish with hyperosmotic pretreatment.' Vaccine 21(27-30): 4178-4193. Ilouze, M., A. Dishon and M. Kotler (2006). 'Characterization of a novel virus causing a lethal disease in carp and koi.' Microbiol Mol Biol Rev 70(1): 147-156. Ilouze M., D. M., Diamant A., Kotler M. & Dishon A. (2010). 'The outbreak of carp disease caused by CyHV-3 as a model for new emerging viral diseases in aquaculture: a review.' Ecological Research 26(5): 8. Kai, Y. H. and S. C. Chi (2008). 'Efficacies of inactivated vaccines against betanodavirus in grouper larvae (Epinephelus coioides) by bath immunization.' Vaccine 26(11): 1450-1457. Karlsen, M., T. Tingbo, I. T. Solbakk, O. Evensen, A. Furevik and A. Aas-Eng (2012). 'Efficacy and safety of an inactivated vaccine against Salmonid alphavirus (family Togaviridae).' Vaccine 30(38): 5688-5694. Kaur, H., L. Jaso-Friedmann and D. L. Evans (2003). 'Identification of a scavenger receptor homologue on nonspecific cytotoxic cells and evidence for binding to oligodeoxyguanosine.' Fish Shellfish Immunol 15(3): 169-181. Kim, M. S., D. S. Kim and K. H. Kim (2011). 'Oral immunization of olive flounder (Paralichthys olivaceus) with recombinant live viral hemorrhagic septicemia virus (VHSV) induces protection against VHSV infection.' Fish Shellfish Immunol 31(2): 212-216. Knopf, K., R. Lucius, A. K. Oye and E. Rimstad (2008). 'Vaccination of eels (Anguilla japonica and Anguilla anguilla) against Anguillicola crassus with irradiated L3: Inactivation of infectious salmon anaemia virus, viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus in water using UVC irradiation.' Parasitology 135(5): 633-640. Koppang, E. O., E. Haugarvoll, I. Hordvik, L. Aune and T. T. Poppe (2005). 'Vaccine-associated granulomatous inflammation and melanin accumulation in Atlantic salmon, Salmo salar L., white muscle.' J Fish Dis 28(1): 13-22. Lee JG, Liu SC and C. MM. (2014). 'Developments of an Isolation System and a Nested PCR Diagnosis Method with Superior Sensitivity for Koi Herpesvirus.' Taiwan Vet J 40B(S1): 15-25. Lee, S. W., P. F. Markham, M. J. Coppo, A. R. Legione, J. F. Markham, A. H. Noormohammadi, G. F. Browning, N. Ficorilli, C. A. Hartley and J. M. Devlin (2012). 'Attenuated vaccines can recombine to form virulent field viruses.' Science 337(6091): 188. Lopez-Doriga, M. V., D. A. Smail, R. J. Smith, A. Domenech, J. Castric, P. D. Smith and A. E. Ellis (2001). 'Isolation of salmon pancreas disease virus (SPDV) in cell culture and its ability to protect against infection by the 'wild-type' agent.' Fish Shellfish Immunol 11(6): 505-522. Lorenzen, N. and S. E. Lapatra (1999). 'Immunity to rhabdoviruses in rainbow trout: the antibody response.' Fish Shellfish Immunol 9: 16. Maeshima, Y., K. Fukatsu, T. Moriya, F. Ikezawa, C. Ueno, D. Saitoh and H. Mochizuki (2007). 'Influence of adding fish oil to parenteral nutrition on gut-associated lymphoid tissue.' JPEN J Parenter Enteral Nutr 31(5): 416-422. Matsui, K., M. I. E. Honjo, Y. Kohmatsu, K. Uchii, R. Yonekura and Z. I. Kawabata (2008). 'Detection and significance of koi herpesvirus (KHV) in freshwater environments.' freshwater biol 53(6): 1262-1272. Matsuo, A., H. Oshiumi, T. Tsujita, H. Mitani, H. Kasai, M. Yoshimizu, M. Matsumoto and T. Seya (2008). 'Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.' J Immunol 181(5): 3474-3485. Meng, Z., X. Y. Zhang, J. Guo, L. X. Xiang and J. Z. Shao (2012). 'Scavenger receptor in fish is a lipopolysaccharide recognition molecule involved in negative regulation of NF-kappaB activation by competing with TNF receptor-associated factor 2 recruitment into the TNF-alpha signaling pathway.' J Immunol 189(8): 4024-4039. Michel, B., G. Fournier, F. Lieffrig, B. Costes and A. Vanderplasschen (2010). 'Cyprinid herpesvirus 3.' Emerg Infect Dis 16(12): 1835-1843. Midtlyng, P. J., L. J. Reitan, A. Lillehaug and A. Ramstad (1996). 'Protection, immune responses and side effects in Atlantic salmon (Salmo salar L.) vaccinated against furunculosis by different procedures.' Fish & Shellfish Immunology 6(8): 15. Minamoto, T., M. N. Honjo and Z. Kawabata (2009). 'Seasonal distribution of cyprinid herpesvirus 3 in Lake Biwa, Japan.' Appl Environ Microbiol 75(21): 6900-6904. Minamoto, T., M. N. Honjo, H. Yamanaka, N. Tanaka, T. Itayama and Z. Kawabata (2011). 'Detection of cyprinid herpesvirus-3 DNA in lake plankton.' Res Vet Sci 90(3): 530-532. Mitchell, H. (1995). 'Choosing a furunculosis vaccine: points to consider.' Bull. Aquacult. Assoc. Can. 95: 8. Munang'andu, H. M., B. N. Fredriksen, S. Mutoloki, B. Brudeseth, T. Y. Kuo, I. S. Marjara, R. A. Dalmo and O. Evensen (2012). 'Comparison of vaccine efficacy for different antigen delivery systems for infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L.) in a cohabitation challenge model.' Vaccine 30(27): 4007-4016. Mutoloki, S., S. Alexandersen and O. Evensen (2004). 'Sequential study of antigen persistence and concomitant inflammatory reactions relative to side-effects and growth of Atlantic salmon (Salmo salar L.) following intraperitoneal injection with oil-adjuvanted vaccines.' Fish Shellfish Immunol 16(5): 633-644. Nakanishi, T. and Ototake, M. (1997). 'Antigen uptake and immune responses after immersion vaccination.' Dev Biol Stand 90: 59-68. Noraini, O., M. Y. Sabri and A. Siti-Zahrah (2013). 'Efficacy of spray administration of formalin-killed Streptococcus agalactiae in hybrid Red Tilapia.' J Aquat Anim Health 25(2): 142-148. Olesen, N., N. Lorenzen and P. Jorgensen (1991). 'Detection of rainbow trout antibody to Egted virus by enzyme-linked immunosorbent assay (ELISA).' Diseases of aquatic organisms 10: 9. Ototake, M., J. Moore and N. T. (1999). 'Prolonged immersion improves the effectiveness of dilute vibrio vaccine for rainbow trout.' Fish Pathol., 34: 5. Oye, A. K. and E. Rimstad (2001). 'Inactivation of infectious salmon anaemia virus, viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus in water using UVC irradiation.' Dis Aquat Organ 48(1): 1-5. Pakingking, R., Jr., N. B. Bautista, E. G. de Jesus-Ayson and O. Reyes (2010). 'Protective immunity against viral nervous necrosis (VNN) in brown-marbled grouper (Epinephelus fuscogutattus) following vaccination with inactivated betanodavirus.' Fish Shellfish Immunol 28(4): 525-533. Paolini, A., V. Ridolfi, D. Zezza, M. Cocchietto, M. Musa, A. Pavone, A. Conte and G. Giorgetti (2005). 'Vaccination trials of sea bass (Dicentrarchus labrax) against pasteurellosis using oral, intraperitoneal and immersion methods.' Vet Ital 41(2): 137-144. Paust, S. and U. H. von Andrian (2011). 'Natural killer cell memory.' Nat Immunol 12(6): 500-508. Perelberg, A., M. Ilouze, M. Kotler and M. Steinitz (2008). 'Antibody response and resistance of Cyprinus carpio immunized with cyprinid herpes virus 3 (CyHV-3).' Vaccine 26(29-30): 3750-3756. Pikarsky, E., A. Ronen, J. Abramowitz, B. Levavi-Sivan, M. Hutoran, Y. Shapira, M. Steinitz, A. Perelberg, D. Soffer and M. Kotler (2004). 'Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus.' J Virol 78(17): 9544-9551. Plant, K. P. and S. E. Lapatra (2011). 'Advances in fish vaccine delivery.' Dev Comp Immunol 35(12): 1256-1262. Quentel, C. and M. Vigneulle (1997). 'Antigen uptake and immune responses after oral vaccination.' Dev Biol Stand 90: 69-78. Rauta, P. R., B. Nayak and S. Das (2012). 'Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms.' Immunol Lett 148(1): 23-33. Ridpath, J. F. (2013). 'Immunology of BVDV vaccines.' Biologicals 41(1): 14-19. Rivas-Aravena, A., M. Cortez-San Martin, J. Galaz, M. Imarai, D. Miranda, E. Spencer and A. M. Sandino (2012). 'Evaluation of the immune response against immature viral particles of infectious pancreatic necrosis virus (IPNV): a new model to develop an attenuated vaccine.' Vaccine 30(34): 5110-5117. Romoren, K., X. T. Fjeld, A. B. Poleo, G. Smistad, B. J. Thu and O. Evensen (2005). 'Transfection efficiency and cytotoxicity of cationic liposomes in primary cultures of rainbow trout (Oncorhynchus mykiss) gill cells.' Biochim Biophys Acta 1717(1): 50-57. Ronen, A., A. Perelberg, J. Abramowitz, M. Hutoran, S. Tinman, I. Bejerano, M. Steinitz and M. Kotler (2003). 'Efficient vaccine against the virus causing a lethal disease in cultured Cyprinus carpio.' Vaccine 21(32): 4677-4684. Salinas, I., Y. A. Zhang and J. O. Sunyer (2011). 'Mucosal immunoglobulins and B cells of teleost fish.' Dev Comp Immunol 35(12): 1346-1365. Samuelsen, O. B., A. H. Nerland, T. Jorgensen, M. B. Schroder, T. Svasand and O. Bergh (2006). 'Viral and bacterial diseases of Atlantic cod Gadus morhua, their prophylaxis and treatment: a review.' Dis Aquat Organ 71(3): 239-254. Shapira, Y., Y. Magen, T. Zak, M. Kotler, G. Hulata and B. Levavi-Sivan (2005). 'Differential resistance to koi herpesvirus (KHV)/carp interstitial nephritis and gill necrosis virus (CNGV) among common carp (Cyprinus carpio L.).' Aquaculture 245(1-4): 1-11. Shimizu, T., N. Yoshida, H. Kasai and M. Yoshimizu (2006). 'Survival of koi herpesvirus (KHV) in environmental water.' Fish Pathology 41(4): 5. Sinyakov, M. S., M. Dror, T. Lublin-Tennenbaum, S. Salzberg, S. Margel and R. R. Avtalion (2006). 'Nano- and microparticles as adjuvants in vaccine design: success and failure is related to host natural antibodies.' Vaccine 24(42-43): 6534-6541. Siripornadulsil, S., K. Dabrowski and R. Sayre (2007). 'Microalgal vaccines.' Adv Exp Med Biol 616: 122-128. Sitja-Bobadilla, A., O. Palenzuela and P. Alvarez-Pellitero (2008). 'Immune response of turbot, Psetta maxima (L.) (Pisces: Teleostei), to formalin-killed scuticociliates (Ciliophora) and adjuvanted formulations.' Fish Shellfish Immunol 24(1): 1-10. Somamoto, T., M. Kondo, T. Nakanishi and M. Nakao (2014). 'Helper function of CD4(+) lymphocytes in antiviral immunity in ginbuna crucian carp, Carassius auratus langsdorfii.' Dev Comp Immunol 44(1): 111-115. Sommerset, I., B. Krossoy, E. Biering and P. Frost (2005). 'Vaccines for fish in aquaculture.' Expert Rev Vaccines 4(1): 89-101. St-Hilaire, S., N. Beevers, C. Joiner, R. P. Hedrick and K. Way (2009). 'Antibody response of two populations of common carp, Cyprinus carpio L., exposed to koi herpesvirus.' J Fish Dis 32(4): 311-320. St-Hilaire, S., N. Beevers, K. Way, R. M. Le Deuff, P. Martin and C. Joiner (2005). 'Reactivation of koi herpesvirus infections in common carp Cyprinus carpio.' Dis Aquat Organ 67(1-2): 15-23. Tafalla, C., J. Bogwald and R. A. Dalmo (2013). 'Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives.' Fish Shellfish Immunol. Toda, H., K. Araki, T. Moritomo and T. Nakanishi (2011). 'Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in ginbuna crucian carp, Carassius auratus langsdorfii.' Dev Comp Immunol 35(1): 88-93. Toda, H., T. Yabu, H. Shiba, T. Moritomo and T. Nakanishi (2011). 'Evaluating antigen-specific cytotoxicity of CD8+ T cells in fish by granzyme B-like activity.' Vet Immunol Immunopathol 141(1-2): 168-172. Tort, L., J. Balasch and S. Mackenzie (2003). 'Fish immune system. A crossroads between innate and adaptive responses.' Inmunologia 22(3): 10. Tsao, J. I., J. T. Wootton, J. Bunikis, M. G. Luna, D. Fish and A. G. Barbour (2004). 'An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle.' Proc Natl Acad Sci U S A 101(52): 18159-18164. Tsunetsugu-Yokota, Y., M. Ato, Y. Takahashi, S. Hashimoto, T. Kaji, M. Kuraoka, K. Yamamoto, Y. Y. Mitsuki, T. Yamamoto, M. Oshima, K. Ohnishi and T. Takemori (2007). 'Formalin-treated UV-inactivated SARS coronavirus vaccine retains its immunogenicity and promotes Th2-type immune responses.' Jpn J Infect Dis 60(2-3): 106-112. Tu, C., M. Weng, J. Shiau and S. Lin (2004). 'Detection of koi herpesvirus in koi, Cyprinus carpio, in Taiwan.' Fish Pathology 39: 2. Vasta, G. R., M. Nita-Lazar, B. Giomarelli, H. Ahmed, S. Du, M. Cammarata, N. Parrinello, M. A. Bianchet and L. M. Amzel (2011). 'Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.' Dev Comp Immunol 35(12): 1388-1399. Villumsen, K. R. and M. K. Raida (2013). 'Long-lasting protection induced by bath vaccination against Aeromonas salmonicida subsp. salmonicida in rainbow trout.' Fish Shellfish Immunol 35(5): 1649-1653. Waltzek, T. B., G. O. Kelley, M. E. Alfaro, T. Kurobe, A. J. Davison and R. P. Hedrick (2009). 'Phylogenetic relationships in the family Alloherpesviridae.' Dis Aquat Organ 84(3): 179-194. Waltzek, T. B., G. O. Kelley, D. M. Stone, K. Way, L. Hanson, H. Fukuda, I. Hirono, T. Aoki, A. J. Davison and R. P. Hedrick (2005). 'Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae.' J Gen Virol 86(Pt 6): 1659-1667. Weiner, D. B. and R. C. Kennedy (1999). 'Genetic vaccines.' Sci Am 281(1): 50-57. Willis, M. S., L. W. Klassen, D. J. Tuma, M. F. Sorrell and G. M. Thiele (2002). 'Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation.' Alcohol Clin Exp Res 26(1): 94-106. Workenhe, S. T., M. L. Rise, M. J. Kibenge and F. S. Kibenge (2010). 'The fight between the teleost fish immune response and aquatic viruses.' Mol Immunol 47(16): 2525-2536. Xu, C., S. Mutoloki and O. Evensen (2012). 'Superior protection conferred by inactivated whole virus vaccine over subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon (Salmo salar L.).' Vaccine 30(26): 3918-3928. Yamashita, H., Y. Fujita and H. Kawakami (2005). 'The Efficacy of inactivated Virus Vaccine against Viral Nervous Necrosis (VNN).' Fish Pathol., 40(1): 7. Yasumoto, S., Y. Kuzuya, M. Y., T. Yoshimura and T. Miyazaki (2008). 'Oral Immunization of Common Carp with a Liposome Vaccine Fusing Koi Herpesvirus Antigen.' Fish Pathology 41(4): 5. Zarkadis, I. K., D. Mastellos and J. D. Lambris (2001). 'Phylogenetic aspects of the complement system.' Dev Comp Immunol 25(8-9): 745-762. Zeman, D., R. Neiger, J. Nietfield, D. Miskimins, M. Libal, D. Johnson, B. Janke, C. Gates and K. Forbes (1993). 'Systemic Pasteurella haemolytica infection as a rare sequel to avirulent live Pasteurella haemolytica vaccination in cattle.' J Vet Diagn Invest 5(4): 555-559. Zhang, Y. B. and J. F. Gui (2012). 'Molecular regulation of interferon antiviral response in fish.' Dev Comp Immunol 38(2): 193-202. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5081 | - |
| dc.description.abstract | 錦鯉疱疹病毒 (Koi herpesvirus，KHV)，亦稱為鯉魚疱疹病毒第三型 (Cyprinid herpes virus-3， CyHV-3)，或鯉魚間質性腎炎及鰓壞死病毒 (carp interstitial nephritis and gill necrosis virus，CNGV)，為一具封套的二十面體病毒，歸屬於 Alloherpesviridae科。KHV自1998年於以色列爆發以來，2000年便已在世界各地接連傳出災情，且由世界動物衛生組織（World Organization for Animal Health，OIE）列為水生動物輸出入檢疫疾病。我國亦於2002年12月出現首項確診病例。目前台灣的錦鯉養殖場在季節交替之際，時常傳出KHV感染症的病情報告，但截至目前為止，除了隔離病魚、撲殺與清池外，尚無有效防治手段。因此KHV之疫苗開發刻不容緩。
2003年Ronen等人藉由KHV的連續繼代方式製造減毒疫苗，但由於臨床上無法免除病毒毒力回復之風險，因此限於以色列地區使用。本實驗著眼於死毒疫苗的製作，透過福馬林去活化疫苗的接種，引發錦鯉魚隻的體液免疫反應，並配合弗氏完全佐劑（Freund’s complete adjuvant，FCA）與Montanide ISA 763A兩種佐劑，以增強魚隻的細胞免疫反應，旨在建立魚隻抵抗KHV感染的能力。結果顯示，在Naive魚隻上，未配合佐劑的死毒疫苗可引起高達1:128的血清中和抗體力價，相對存活率（relative percent survival，RPS）亦超過70%；而在Carrier上的RPS甚至可達100％。配合佐劑的疫苗，其血清表現中和抗體力價的時間，較未配合佐劑的超出一倍，在免疫後96天仍可偵測到1:32以上的中和抗體力價。 本實驗成功地在實驗室環境下，透過活體in vivo試驗，確認了KHV福馬林去活化疫苗的效果，未來將進一步將本死毒疫苗之製造條件予以最佳化，以求得更低的成本與更高的保護效率。 | zh_TW |
| dc.description.abstract | Koi Herpesvirus (KHV) which is also called Cyprinid herpes virus-3, (CyHV-3) or carp interstitial nephritis and gill necrosis virus (CNGV) is a icosahedral virus and grouped family Alloherpesviridae. The disease firstly reported in Israel in 1998, then outbreaked around the world until 2000. The huge economical losing has lead KHV to be recognized as certificated disease by World Organization for Animal Health (OIE). In Taiwan, the first case report has been found in December in 2002. The infection of KHV usually took place during season changing in Koi aquaculture field, and there are still no effective control strategies for KHV infection except quarenting, disinfection and pond liming. Therefore the establishment of vaccine is an urgent task to pursue.
Ronen et. al. have developed an attenuated KHV strain as a vaccine through series passaging methods. But the using of attenuated vaccine is totally restricted in Israel area due to the significant virulence recovery risks. This research was mentioned about the Formalin-inactivated method to produce high effective vaccine for inducing humeral immunity of fishes. On the other hand, we also select two adjuvants including Freund’s complete adjuvant (FCA) and Montanide ISA 763A to build up the cell-mediated immunity while vaccing inoculating. After immunizing naive fishes, the high titer serum neutralizing antibodies can be detected, and the relative percent survivol (RPS) was over 70%. And the RPS on Carriers was even approaching 100%. The neutralizing antibodies lasting of inactivated vaccine with adjuvant are two times longer than the vaccine without adjuvant. The titer of serum antibody still reached 1:32 at 96th day post-immunization. We successfully established an effective inactivated KHV vaccine in vivo. We will optimize the producing contidion in order to reduce the cost and raise the efficacy. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-15T17:51:40Z (GMT). No. of bitstreams: 1 ntu-103-R94629014-1.pdf: 6043772 bytes, checksum: e6a1d4d0c2f7a467dbbc0bfdf55bccf7 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 摘要………………………………………………………………………………… I
Abstract………………………………………………………………………………II 目錄…………………………………………………………………………………III 圖次…………………………………………………………………………………VI 表次…………………………………………………………………………………VII 第一章 緒論………………………………………………………………………1 第二章 文獻回顧…………………………………………………………………4 第一節 鯉魚疱疹病毒的感染與控制…………………………………………4 1.1 鯉魚疱疹病毒的分類……………………………………………………4 1.2 傳播方式…………………………………………………………………5 1.3 臨床症狀…………………………………………………………………6 1.4 控制………………………………………………………………………7 第二節 魚類的免疫系統………………………………………………………10 2.1 非特異性免疫……………………………………………………………10 2.1.1 補體（Complement）………………………………………………10 2.1.2 凝集素（lectin）……………………………………………………12 2.1.3 干擾素（interferon）…………………………………………………13 2.1.4 殺手細胞（killer cell）與巨噬細胞（Macrophage）………………15 2.2 特異性免疫………………………………………………………………17 2.2.1 體液免疫（Humoral immunity）……………………………………17 2.2.2 細胞免疫（Cell-mediated immunity）………………………………19 第三節 魚類病毒疫苗成效與施用方法………………………………………20 3.1 疫苗現況…………………………………………………………………20 3.2 疫苗投予方法……………………………………………………………25 3.2.1 注射…………………………………………………………………25 3.2.2 浸泡…………………………………………………………………26 3.2.3 口服…………………………………………………………………26 第三章 材料與方法………………………………………………………………28 第一節 實驗設計與流程………………………………………………………28 第二節 製作去活化疫苗………………………………………………………29 2.1 病毒液製備………………………………………………………………29 2.2 病毒去活化………………………………………………………………30 2.3 DNA萃取與聚合酶鏈鎖反應（Polymerase chain reaction）…………31 2.4 巢式聚合酶鏈鎖反應（Nested-polymerase chain reaction）…………34 第三節 實驗魚接種疫苗………………………………………………………35 3.1 實驗材料…………………………………………………………………35 3.2 實驗方法…………………………………………………………………35 3.2.1 Naive 魚隻疫苗接種………………………………………………36 3.2.2 Carrier 魚隻疫苗接種………………………………………………37 3.2.3 魚隻含佐劑疫苗接種………………………………………………38 第四節 實驗魚攻毒試驗………………………………………………………40 4.1 實驗材料…………………………………………………………………40 4.2 實驗方法…………………………………………………………………40 第五節 養殖場魚隻疫苗接種…………………………………………………41 5.1 實驗材料…………………………………………………………………41 5.2 實驗方法…………………………………………………………………41 第六節 血清取得與血清中和試驗……………………………………………42 6.1 實驗材料…………………………………………………………………42 6.2 實驗方法…………………………………………………………………42 第七節 組織中病毒定量………………………………………………………43 7.1 實驗材料…………………………………………………………………43 7.2 實驗方法…………………………………………………………………43 第四章 結果………………………………………………………………………45 第一節 病毒液製備結果與福馬林去活病毒液隻細胞檢測…………………45 第二節 Naive組血清中和抗體力價與疫苗保護效力………………………45 第三節 Carrier組血清中和抗體力價與疫苗保護效力………………………46 第四節 攻毒後魚體組織中之病毒量…………………………………………46 第五節 不同免疫路徑之血清抗體力價比較…………………………………47 第六節 不同魚隻來源之血清抗體力價比較…………………………………47 第七節 Naive魚隻接種含佐劑隻疫苗後，其中和抗體力價、疫苗保護效力病毒訊號偵測…………………………………………………………………………47 第八節 Carrier魚隻接種含佐劑隻疫苗後，其中和抗體力價、疫苗保護效力病毒訊號偵測…………………………………………………………………………48 第九節 養殖場接種疫苗後血清中和力價變化情形…………………………49 第五章 討論………………………………………………………………………63 第一節 福馬林去活化…………………………………………………………63 第二節 死毒疫苗之接種路徑…………………………………………………64 第三節 抗體與病毒感染的關聯性……………………………………………67 第四節 佐劑對於死毒疫苗之影響……………………………………………70 第六章 結論………………………………………………………………………73 第七章 參考文獻…………………………………………………………………74 | |
| dc.language.iso | zh-TW | |
| dc.subject | 錦鯉?疹病毒 | zh_TW |
| dc.subject | 死毒疫苗 | zh_TW |
| dc.subject | 佐劑 | zh_TW |
| dc.subject | adjuvant | en |
| dc.subject | Koi Herpesvirus | en |
| dc.subject | Inactivated vaccine | en |
| dc.title | 評估台灣錦鯉疱疹病毒福馬林去活化疫苗引起之免疫效果與保護效力 | zh_TW |
| dc.title | Evaluate the immunogenicity and protective effects of formalin inactivated Taiwan Koi Herpesvirus vaccine | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張本恆(Pen-Heng Chang),齊肖琪(Shau-Chi Chi),涂堅(Chien Tu) | |
| dc.subject.keyword | 錦鯉?疹病毒,死毒疫苗,佐劑, | zh_TW |
| dc.subject.keyword | Koi Herpesvirus,Inactivated vaccine,adjuvant, | en |
| dc.relation.page | 85 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2014-08-15 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-103-1.pdf | 5.9 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。