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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳克強(Ke-Qiang Wu) | |
| dc.contributor.author | Hsin-Hsien Hsieh | en |
| dc.contributor.author | 謝欣憲 | zh_TW |
| dc.date.accessioned | 2021-06-15T12:51:37Z | - |
| dc.date.available | 2021-08-02 | |
| dc.date.copyright | 2016-08-02 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-07-20 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50667 | - |
| dc.description.abstract | JmjC 組蛋白去甲基化酶廣泛地存在於植物、真菌和動物當中。阿拉伯芥的21種JmjC組蛋白去甲基化酶會依其序列相似性被分為5個類型。在先前報導中，阿拉伯芥中JmjC家族成員參與在DNA甲基化、siRNA產生、開花時間、brassinosteroid訊息傳遞及植物生理週期調控中。在本研究中我們發現，屬於 KDM3/JHDM2 類的 JmjC 組蛋白去甲基化酶 JMJ28具有專一性去除組蛋白H3離胺酸9上二甲基及三甲基（H3K9Me2/Me3）的活性，並且會和組蛋白去乙醯化酶 HDA6 有交互作用。jmj28突變株有晚開花的表型，透過檢測jmj28突變株與野生型植株中的基因表現，我們發現調控開花的自主途徑中的FPA與FCA以及光週期途徑中的GI與CO的基因表現，相對於野生型在突變株中皆有降低。從這些結果我們推測，JMJ28可能會藉由其本身的組蛋白去甲基化酶活性促進阿拉伯芥自發性調控路徑中的FCA基因表現，來調控阿拉伯芥的開花時間。 | zh_TW |
| dc.description.abstract | JmjC domain-containing demethylases are conserved evolutionarily in plants, yeast and humans. In Arabidopsis, 21 jmjC domain-containing demethylases are divided into 5 distinct groups according to sequence similarities. Previous studies indicated that JmjC domain-containing demethylases are involved in the regulation of gene expression associated with DNA methylation, siRNA regeneration, flowering-time control, brassinosteroid signaling and circadian clock regulation. In this study, we showed that JMJ28, a member of KDM3/JHDM2 group, interacts with the histone deacetylase HDA6. Furthermore, JMJ28 has demethylase activity specific to H3K9me2 and H3K9me3. In addition, the JMJ28 T-DNA insertion knockout mutants, jmj28-1 and jmj28-2, have a late flowering phenotype under both long day and short day conditions. The expression of the autonomous pathway genes FPA and FCA as well as the photoperiod pathway genes GI, CO and FT are decreased in jmj28 mutants compared to wild type. In addition, the expression of FLC, MAF4 and MAF5 are also increased in jmj28 mutants compared to wild type. Furthermore, JMJ28 may activate the autonomous genes FCA through H3K9me3 demethylation in flowering time control. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T12:51:37Z (GMT). No. of bitstreams: 1 ntu-105-R03b42030-1.pdf: 2739474 bytes, checksum: 531c52f70e68fd654fb65d9818fc8ec8 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 致謝 I
中文摘要 II Abstract III Index IV List of Tables VI List of Figures VII List of Supplementary Figures IX List of Abbreviations X Introduction 1 Histone demethylases in Arabidopsis 2 Functions of JmjC domain-containing histone demethylases in Arabidopsis 4 Regulation of flowering time 8 Functions of JmjC domain-containing histone demethylases in controlling flowering time 10 Materials and Methods 13 Plant Materials 13 RNA isolation 14 DNase Treatment 15 Quantitative RT-PCR Analysis 16 Chromatin immunoprecipitation assays 17 Bimolecular Fluorescence Complementation (BiFC) assays 26 Transfection of tobaco leaves by Agrobacterium for BiFC assays 30 Histone demethylase assays 31 Results 35 Phylogenic analysis and sequence comparison of the KDM3/JHDM2 JmjC domain-containing proteins 35 Expression and subcellular localization of JMJ24, JMJ25 and JMJ28 36 Interaction of HDA6 with JMJ24, JMJ25 and JMJ28 37 Interaction of KYP with JMJ24, JMJ25 and JMJ28 37 Identification of T-DNA insertion mutants of JMJ28 38 JMJ28 had histone H3K9me2 and H3K9me3 demethylase activity 39 JMJ28 mutants displayed a delayed flowering phenotype 39 The expression of FLC was increased in jmj28 mutants 40 The late-flowering phenotype of jmj28 mutants was FLC dependent 41 JMJ28 regulated gene expression in autonomous and photoperiod pathways 41 JMJ28 may regulate FCA and FPA directly 42 Discussion 43 JMJ28 is a H3K9me2/3 demethylase and interacts with HDA6 and KYP 43 JMJ28 is involved in flowering time control in Arabidopsis 44 JMJ28 may induce FPA and FCA expression by histone H3K9 demethylation 46 Figures 48 Supplementary Figures 77 Tables 80 References 85 | |
| dc.language.iso | en | |
| dc.title | 阿拉伯芥組蛋白去甲基化酶JMJ28對開花調控之功能研究 | zh_TW |
| dc.title | Function of the histone demethylase JMJ28 in controlling flowering time in Arabidopsis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林讚標(Tsan-Piao Lin),葉開溫(Kai-Wun Yeh),涂世隆(Shih-Long Tu),陳柏仰(Pao-Yang Chen) | |
| dc.subject.keyword | 阿拉伯芥,組蛋白去乙醯?,HDA6,組蛋白去甲基化?,JMJ28,開花時間, | zh_TW |
| dc.subject.keyword | Arabidopsis,histone deacetylases,HDA6,histone demetylases,JMJ28,flowering time, | en |
| dc.relation.page | 98 | |
| dc.identifier.doi | 10.6342/NTU201601037 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-07-20 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 植物科學研究所 | zh_TW |
| 顯示於系所單位： | 植物科學研究所 | |
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