帶狀皰疹治療期間與病患關聯性分析—以健保資料庫為例

Abstract

本研究使用健保資料庫之百萬人抽樣資料，透過資料分析與資料探勘技術，以帶狀皰疹作為研究之疾病，探討帶狀皰疹的發病趨勢及治療期間差異，協助醫師與病患了解帶狀皰疹的發病情形與變化，並評估使用何種類型的藥品能夠快速抑制病情，以期減少醫療資源的浪費與達到醫療資源有效利用之目標。 本研究透過三個議題探討帶狀皰疹，首先是帶狀皰疹的發病趨勢，欲了解在這十六年之中帶狀皰疹的發病情形，又從性別、年齡以及月份三個層面探討在不同的因素之下的差異與可能原因；接著是帶狀皰疹治療期間的分析，從性別與年齡兩個層面探討在這一些不同因素之下對於帶狀皰疹治療期間之差異；最後是帶狀皰疹藥品使用對於治療期間的分析研究，將十六年之中帶狀皰疹看診紀錄所使用過的所有藥品依照成份以及療效分成十七種類別，再利用邏輯迴歸分析，探討在發病前期的黃金治療期之內，使用何種類型的藥品能夠快速抑制病情並降低治療期間。 研究結果發現，十六年來整體帶狀皰疹的發病為上升之趨勢，在發病上女生會多於男生，年齡集中於51~60歲，且好發於六月到十月，其中又以七、八月為發病高峰期；治療期間上則是女生治療時間短於男生，且年齡越大治療時間越長；藥品使用分析結果顯示acetaminophen、amantadine、methisoprinol、vitb對於抑制帶狀皰疹有顯著的效果，其中amantadine與methisoprinol為抗病毒藥品。 本研究透過資料分析的方法歸納出帶狀皰疹的發病情形與趨勢，並在藥品分析方面提出可能有抑制病情之藥品種類，提供醫師在帶狀皰疹患病前期時治療與用藥的參考。

In order to analyze the epidemiological characteristics and treatment periods of herpes zoster in Taiwan, we use data analysis technology and data mining technology to extract valuable information from national health insurance research database. We believe that our results can help doctors and patients know more about the incidence and trends of herpes zoster, and also provide them some medications that could cure this disease more quickly and efficiently. There are three dimensions in the study. The first is to find the incidence trends of herpes zoster in Taiwan by gender, age and month, using data from 1997 to 2012. Then we divided them into groups, comparing the differences between each group. Moreover, we conducted the treatment periods analysis, which contains two aspects including gender and age. Finding relationship and difference between treatment periods and each factor. Finally, we use all medication data over sixteen years to find out the potential medicines that can cure herpes zoster more quickly. We classified all medicines into seventeen types by their ingredients and effects. And then used logistic regression to find out the positive and significant medicines. The results show that females’ incidence rate is higher than males’. And the incidence rate peaks at the group of 51~60 years old. The incidence rate is the highest from June to October, and the lowest in January and February. The treatment period of herpes zoster increases along with age. Though females have higher incidence rate than males, females’ treatment period is shorter. Moreover, our study shows that acetaminophen, amantadine, methisoprinol, and vitb could provide better effects on herpes zoster. This study used data analysis technology to examine epidemiological characteristics and treatment period differences of herpes zoster, and also to find out some medicines that could cure herpes zoster effectively. Hope through this study, doctors and patients can have better understandings on herpes zoster.