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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李繼忠(Jih-Jong Lee) | |
| dc.contributor.author | Pei-Chin Huang | en |
| dc.contributor.author | 黃佩晴 | zh_TW |
| dc.date.accessioned | 2021-06-15T11:40:04Z | - |
| dc.date.available | 2017-08-24 | |
| dc.date.copyright | 2016-08-24 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-15 | |
| dc.identifier.citation | 1. 2011. Veterinary cooperative oncology group - common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1. Veterinary and comparative oncology.
2. 2013. 22 - Cancer of the Gastrointestinal Tract A2 - Withrow, Stephen J, In: Vail, D.M., Page, R.L. (Eds.) Withrow and MacEwen's Small Animal Clinical Oncology (Fifth Edition). W.B. Saunders, Saint Louis, 381-431. 3. Balkman, C., 2009. Hepatobiliary neoplasia in dogs and cats. The Veterinary clinics of North America. Small animal practice 39(3), 617-625. 4. Biller, B.J., Elmslie, R.E., Burnett, R.C., Avery, A.C., Dow, S.W., 2007. Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Veterinary immunology and immunopathology 116(1-2), 69-78. 5. Bray, J., Polton, G., 2016. Neoadjuvant and adjuvant chemotherapy combined with anatomical resection of feline injection-site sarcoma: results in 21 cats. Veterinary and comparative oncology 14(2), 147-160. 6. Chu, K.F., Dupuy, D.E., 2014. Thermal ablation of tumours: biological mechanisms and advances in therapy. Nature reviews. Cancer 14(3), 199-208. 7. Curley, S.A., 2001. Radiofrequency ablation of malignant liver tumors. The oncologist 6(1), 14-23. 8. Davidson, J.R., 2015. Current concepts in wound management and wound healing products. The Veterinary clinics of North America. Small animal practice 45(3), 537-564. 9. Hohenhaus, A.E., Kelsey, J.L., Haddad, J., Barber, L., Palmisano, M., Farrelly, J., Soucy, A., 2016. Canine Cutaneous and Subcutaneous Soft Tissue Sarcoma: An Evidence-Based Review of Case Management. Journal of the American Animal Hospital Association 52(2), 77-89. 10. Horiuchi, Y., Tominaga, M., Ichikawa, M., Yamashita, M., Jikumaru, Y., Nariai, Y., Nakajima, Y., Kuwabara, M., Yukawa, M., 2009. Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors. Microbiology and immunology 53(8), 468-474. 11. Huang, S.-C., Huang, C.-H., Lin, X.-Z., Lee, G.-B. 2009. High Frequency Electromagnetic Thermotherapy for Cancer Treatment, In: Lim, C.T., Goh, J.C.H. (Eds.) 13th International Conference on Biomedical Engineering: ICBME 2008 3–6 December 2008 Singapore. Springer Berlin Heidelberg, Berlin, Heidelberg, 574-577. 12. Huang, S.C., Chang, Y.Y., Chao, Y.J., Shan, Y.S., Lin, X.Z., Lee, G.B., 2012. Dual-row needle arrays under an electromagnetic thermotherapy system for bloodless liver resection surgery. IEEE transactions on bio-medical engineering 59(3), 824-831. 13. Kuntz, C.A., Dernell, W.S., Powers, B.E., Devitt, C., Straw, R.C., Withrow, S.J., 1997. Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986-1996). Journal of the American Veterinary Medical Association 211(9), 1147-1151. 14. Liptak, J.M., Dernell, W.S., Monnet, E., Powers, B.E., Bachand, A.M., Kenney, J.G., Withrow, S.J., 2004. Massive hepatocellular carcinoma in dogs: 48 cases (1992-2002). Journal of the American Veterinary Medical Association 225(8), 1225-1230. 15. Liptak, J.M., Forrest, L.J. 2013. 21 - Soft Tissue Sarcomas A2 - Withrow, Stephen J, In: Vail, D.M., Page, R.L. (Eds.) Withrow and MacEwen's Small Animal Clinical Oncology (Fifth Edition). W.B. Saunders, Saint Louis, 356-380. 16. Lu, D.S., Raman, S.S., Vodopich, D.J., Wang, M., Sayre, J., Lassman, C., 2002. Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the 'heat sink' effect. AJR. American journal of roentgenology 178(1), 47-51. 17. Lubner, M.G., Brace, C.L., Hinshaw, J.L., Lee, F.T., Jr., 2010. Microwave tumor ablation: mechanism of action, clinical results, and devices. Journal of vascular and interventional radiology : JVIR 21(8 Suppl), S192-203. 18. Nguyen, S.M., Thamm, D.H., Vail, D.M., London, C.A., 2015. Response evaluation criteria for solid tumours in dogs (v1.0): a Veterinary Cooperative Oncology Group (VCOG) consensus document. Veterinary and comparative oncology 13(3), 176-183. 19. O'Neill, K., Guth, A., Biller, B., Elmslie, R., Dow, S., 2009. Changes in regulatory T cells in dogs with cancer and associations with tumor type. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 23(4), 875-881. 20. Phelps, H.A., Kuntz, C.A., Milner, R.J., Powers, B.E., Bacon, N.J., 2011. Radical excision with five-centimeter margins for treatment of feline injection-site sarcomas: 91 cases (1998-2002). Journal of the American Veterinary Medical Association 239(1), 97-106. 21. Risselada, M., Mathews, K.G., Griffith, E., 2015. Surgically planned versus histologically measured lateral tumor margins for resection of cutaneous and subcutaneous mast cell tumors in dogs: 46 cases (2010-2013). Journal of the American Veterinary Medical Association 247(2), 184-189. 22. Srivastav, A., Kass, P.H., McGill, L.D., Farver, T.B., Kent, M.S., 2012. Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats. Journal of the American Veterinary Medical Association 241(5), 595-602. 23. Stefanello, D., Morello, E., Roccabianca, P., Iussich, S., Nassuato, C., Martano, M., Squassino, C., Avallone, G., Romussi, S., Buracco, P., 2008. Marginal excision of low-grade spindle cell sarcoma of canine extremities: 35 dogs (1996-2006). Veterinary surgery : VS 37(5), 461-465. 24. Toraya-Brown, S., Fiering, S., 2014. Local tumour hyperthermia as immunotherapy for metastatic cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 30(8), 531-539. 25. Villalobos, A.E., 2011. Quality-of-life assessment techniques for veterinarians. The Veterinary clinics of North America. Small animal practice 41(3), 519-529. 26. Zell, J.A., Chang, J.C., 2005. Neoplastic fever: a neglected paraneoplastic syndrome. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 13(11), 870-877. 27. Zerbini, A., Pilli, M., Penna, A., Pelosi, G., Schianchi, C., Molinari, A., Schivazappa, S., Zibera, C., Fagnoni, F.F., Ferrari, C., Missale, G., 2006. Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses. Cancer research 66(2), 1139-1146. 28. Zhang, Y., Zhang, W., Geng, C., Lin, T., Wang, X., Zhao, L., Tang, J., 2009. Thermal ablation versus conventional regional hyperthermia has greater anti-tumor activity against melanoma in mice by upregulating CD4+ cells and enhancing IL-2 secretion. Progress in Natural Science 19(12), 1699-1704. 29. Zou, W., 2006. Regulatory T cells, tumour immunity and immunotherapy. Nature reviews. Immunology 6(4), 295-307. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49654 | - |
| dc.description.abstract | 隨著日新月異的科技發展，癌症治療的選項推陳出新，目標都希望病患以最少的手術時間及術後的併發症達到更長的腫瘤控制。熱消融是一種於人類醫學行之有年針對局部腫瘤治療的技術，此研究中使用的電磁導針熱療法為國立成功大學研發的系統，相對於傳統的外科手術，可有效縮短手術時間並經由短時間的高溫減少出血量，此外，由於沒有探針的限制，可擴大腫瘤治療的大小及範圍。
於2014年至2016年間的臨床試驗，共有21隻動物納入試驗，包含8例口腔腫瘤、7例體表軟組織肉瘤、3例肝臟腫瘤及3例貓注射型相關肉瘤。治療成效至試驗結束，共有8隻動物（38%）仍維持完全消退及及2隻動物（10%）維持部分消退，整體反應率為48%。全體動物的中位存活時間為279天，於18隻動物的中位腫瘤相關存活時間為296天，中位無病期時間為225天，臨床分期及腫瘤治療相對位置影響存活時間及無病期。治療相關較嚴重的副作用，主要仍見於體表及軟組織的傷害。於12隻動物血液學於二個月內與術前並無顯著差異，而免疫細胞分析由於隻數樣本數目不足，因此無法由此研究得到有效資訊。研究結果，可在犬肢端軟組織肉瘤見到較高完全消退率及較長的無病期，於少數口腔腫瘤病患可以有緩解症狀的效果。 未來期許可經由電磁導針熱療法造福更多的小動物，也希望有更大量的病例數研究支持特定的腫瘤治療應用，甚至用於有轉移的病患合併觀察免疫T細胞的變化，來提升治療的成效。 | zh_TW |
| dc.description.abstract | Thermal ablation is a local application that uses extreme temperature to induce cell injury. It is a new modality for cancer treatment and popped up with advanced technology since 1990s. Electromagnetic thermotherapy system that we used in this study is designed by National Cheng Kung University. This newly developed system pertain advantages of not only shortened surgical time and less bleeding during operation by rapid high temperature but also no limitation on the total numbers of inserted needles.
In this clinical trial between 2014 and 2016, total 21 patients were recruited and treated with tumor types including 8 oral tumors, 7 superficial soft tissue sarcomas, 3 hepatic tumors and 3 feline injection-site sarcomas. At the end of our trial, 8 (38%) patients were still in complete remission and 2 (10%) were in partial remission. Of the 21 patients, median overall survival time was 279 days and median progression free interval was 225 days. The median tumor specific survival time for the 18 patients was 296 days. In conclusions, patients with extremity STS had a better treatment efficacy and Progression free interval in the present study. Tumor-related adverse effects were mainly seen in superficial tumors with deep subcutaneous and soft tissue damage. During the follow up recheck time, no hematological changes were observed. A well-design study for specific tumor type or well-defined clinical staging underwent EMT treatment and synergic with T cell population analysis. may be required in order to apply in clinical setup. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T11:40:04Z (GMT). No. of bitstreams: 1 ntu-105-R02643009-1.pdf: 34250692 bytes, checksum: 237a5e8bb89d60ec671fdec6632bcbd2 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 口試委員會審定書 #
誌謝 ii 中文摘要 iii ABSTRACT iv CONTENTS v LIST OF FIGURES viii LIST OF TABLES ix Chapter 1 Introduction 1 Chapter 2 Literature Review 2 2.1 Thermal ablation of tumors 2 2.1.1 Thermal ablation 2 2.1.2 Electromagnetic thermotherapy 3 2.1.3 The zones of hyperthermic ablation 4 2.2 Hyperthermia therapy induced anti-tumor immunity 4 2.2.1 Mechanisms of local hyperthermia and immune response 4 2.2.2 T cell population change thermal ablation 5 2.2.3 Regulatory T cells and antitumor immunity 6 2.3 Superficial Tumors 7 2.3.1 Soft tissue sarcoma (STS) 7 2.3.2 Feline injection site sarcoma (FISS) 8 2.4 Canine Oral Tumors 9 2.5 Visceral Tumors 9 2.5.1 Hepatic tumors 9 Chapter 3 Materials and Methods 11 3.1 Patient selection 11 3.2 Pre-treatment evaluation 11 3.3 Operative procedures 12 3.4 Follow up 13 3.5 Flow cytometric analysis 13 3.5.1 Blood sample preparation 13 3.5.2 Flow cytometry 13 3.6 Assessment of therapeutic effect 14 3.7 Adverse Effect 15 3.8 Statistical Analysis 15 Chapter 4 Results 17 4.1 Patient Population 17 4.2 Tumor Characteristic 17 4.2.1 Tumor types and locations 17 4.2.2 Pre-operative treatment and tumor staging 18 4.3 Treatment Efficacy 18 4.4 Adverse Effect 19 4.5 Hematological changes 20 4.6 Flow cytometric analysis of T cell population 21 Chapter 5 Discussion 22 5.1 Treatment efficacy 22 5.1.1 Overall treatment response 22 5.1.2 Soft tissue sarcomas (STS) – extremity location 23 5.1.3 Oral tumors 24 5.1.4 Hepatic tumors 26 5.1.5 Feline injection-site sarcoma 27 5.2 Treatment related adverse effect and management 28 5.2.1 General performance 28 5.2.2 Overall skin and soft tissue damage and management 29 5.3 T cell population and immune response 30 5.4 Limitations 31 5.5 Future aspects 32 Chapter 7 Conclusion 33 FIGURES 34 TABLES 49 REFERENCE 63 | |
| dc.language.iso | en | |
| dc.title | 電磁腫瘤熱消融應用於小動物臨床治療成效及周邊血液變化 | zh_TW |
| dc.title | Treatment Efficacy of Electromagnetic Thermotherapy Used in Small Animals and Consequent Hematological Changes in Peripheral Bloods | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 葉力森,林辰栖,廖泰慶 | |
| dc.subject.keyword | 電磁熱導法,腫瘤熱消融,犬軟組織肉瘤,犬口腔腫瘤, | zh_TW |
| dc.subject.keyword | electromagnetic therapy,thermal ablation,small animals,soft tissue sarcoma, | en |
| dc.relation.page | 65 | |
| dc.identifier.doi | 10.6342/NTU201602573 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-08-16 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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