請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49367
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 曾明宗 | |
dc.contributor.author | Ting-Wei Wu | en |
dc.contributor.author | 吳亭葦 | zh_TW |
dc.date.accessioned | 2021-06-15T11:25:31Z | - |
dc.date.available | 2026-12-31 | |
dc.date.copyright | 2016-08-26 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-18 | |
dc.identifier.citation | Arntz A, Dreessen L, Merckelbach H (1991) Attention, not anxiety, influences pain. Behaviour research and therapy 29:41-50.
Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I (2002) Imaging how attention modulates pain in humans using functional MRI. Brain : a journal of neurology 125:310-319. Bingel U, Tracey I (2008) Imaging CNS modulation of pain in humans. Physiology 23:371-380. Bingel U, Schoell E, Herken W, Buchel C, May A (2007) Habituation to painful stimulation involves the antinociceptive system. Pain 131:21-30. Condes-Lara M, Calvo JM, Fernandez-Guardiola A (1981) Habituation to bearable experimental pain elicited by tooth pulp electrical stimulation. Pain 11:185-200. Derbyshire SW, Vogt BA, Jones AK (1998) Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex. Experimental brain research 118:52-60. Ernst M, Lee MH, Dworkin B, Zaretsky HH (1986) Pain perception decrement produced through repeated stimulation. Pain 26:221-231. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic resonance in medicine 33:636-647. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. NeuroImage 6:218-229. Fruhstorfer H, Lindblom U, Schmidt WC (1976) Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry 39:1071-1075. Gracely RH, Petzke F, Wolf JM, Clauw DJ (2002) Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis and rheumatism 46:1333-1343. LeBlanc J, Potvin P (1966) Studies on habituation to cold pain. Canadian journal of physiology and pharmacology 44:287-293. Lineberry CG, Vierck CJ (1975) Attenuation of pain reactivity by caudate nucleus stimulation in monkeys. Brain research 98:119-134. McCracken LM, Klock PA, Mingay DJ, Asbury JK, Sinclair DM (1997) Assessment of satisfaction with treatment for chronic pain. Journal of pain and symptom management 14:292-299. Mobascher A, Brinkmeyer J, Warbrick T, Musso F, Schlemper V, Wittsack HJ, Saleh A, Schnitzler A, Winterer G (2010) Brain activation patterns underlying fast habituation to painful laser stimuli. International journal of psychophysiology : official journal of the International Organization of Psychophysiology 75:16-24. Neisser U (1959) Temperature thresholds for cutaneous pain. Journal of applied physiology 14:368-372. Nickel FT, Ott S, Mohringer S, Saake M, Dorfler A, Seifert F, Maihofner C (2014) Brain correlates of short-term habituation to repetitive electrical noxious stimulation. European journal of pain 18:56-66. O'Reilly JX, Woolrich MW, Behrens TE, Smith SM, Johansen-Berg H (2012) Tools of the trade: psychophysiological interactions and functional connectivity. Social cognitive and affective neuroscience 7:604-609. Pielsticker A, Haag G, Zaudig M, Lautenbacher S (2005) Impairment of pain inhibition in chronic tension-type headache. Pain 118:215-223. Price DD, McHaffie JG, Larson MA (1989) Spatial summation of heat-induced pain: influence of stimulus area and spatial separation of stimuli on perceived pain sensation intensity and unpleasantness. Journal of neurophysiology 62:1270-1279. Roelofs J, Peters ML, Zeegers MP, Vlaeyen JW (2002) The modified Stroop paradigm as a measure of selective attention towards pain-related stimuli among chronic pain patients: a meta-analysis. European journal of pain 6:273-281. Smith BW, Tooley EM, Montague EQ, Robinson AE, Cosper CJ, Mullins PG (2008) Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls. Pain 140:420-428. Taylor DC, Meyers WC, Moylan JA, Lohnes J, Bassett FH, Garrett WE, Jr. (1991) Abdominal musculature abnormalities as a cause of groin pain in athletes. Inguinal hernias and pubalgia. The American journal of sports medicine 19:239-242. Tseng MT, Kong Y, Chiang MC, Chao CC, Tseng WY, Hsieh ST (2015) Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception. NeuroImage 122:288-297. Woolf CJ (2011) Central sensitization: implications for the diagnosis and treatment of pain. Pain 152:S2-15. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49367 | - |
dc.description.abstract | 習慣化是一個自然的止痛歷程,但其背後的中樞神經機制仍有許多未知的部分。先前的研究展示了長期痛覺習慣化(給予重複的痛刺激多天後疼痛反應減少)發生在重複刺激的部位以及未接受刺激的部位,但這種現象是否出現在短期的痛覺習慣化則仍不清楚。為了解此議題,我們招募了十六位健康的受試者,在他們左前臂腹側 (left volar forearm) 施予疼痛刺激時使用功能性磁振造影來研究腦部相關的反應。我們藉由比較施予重複痛刺激前後的行為及影像反應來評估痛覺習慣化,且進一步與重複的無痛刺激所引起的習慣化相比以得知痛覺習慣化的程度。研究結果顯示,相對於長期痛覺習慣化,短期的痛覺習慣化僅發生在接受刺激的部位。前扣帶迴皮質 (perigenual anterior cingulate cortex) 的活動在痛覺習慣化中是特有的。此外,前扣帶迴皮質與前腦島 (anterior insular cortex) 以及外側前額葉皮質 (lateral prefrontal cortex) 之間的功能性連結和痛覺習慣化的程度有正相關。這些發現顯示短期痛覺習慣化牽涉到獨特的中樞神經元素,包含了與止痛、痛覺處理以及調節注意力相關的腦區。 | zh_TW |
dc.description.abstract | Habituation is a natural analgesic process, but the underlying central mechanisms are largely unknown. Prior studies have shown that long-term pain habituation (i.e., reduced responses to repetitive painful stimuli applied over several days) occurred in both the repetitively stimulated site and non-stimulated sites, but whether this phenomenon also exists in short-term pain habituation process (i.e., adaptation after a period of repetitive painful stimuli) remains unclear. To address these issues, we recruited sixteen healthy subjects and used functional MRI to investigate neural substrates underlying short-term pain habituation during repetitive painful stimuli applied to the left volar forearm. Pain-induced habituation was evaluated by comparing behavioral and neuroimaging responses before and after stimulation, and the extent of habituation was further analyzed against the habituation effects induced by repetitive nonpain stimuli. Different from long-term pain habituation, short-term pain habituation only developed in the stimulated site. Importantly, activity in the perigenual anterior cingulate cortex (pACC) was unique to the short-term habituation of pain. Moreover, the strength of functional connectivity from the pACC to the anterior insula and the lateral prefrontal cortex was parametrically associated with the degree of pain habituation. These findings suggest that short-term habituation to repetitive noxious stimuli involves a distinct central component, consisting of areas involved in antinociception, nociceptive processing, and attentional modulation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T11:25:31Z (GMT). No. of bitstreams: 1 ntu-105-R03454008-1.pdf: 1372840 bytes, checksum: 911027a5591bc3c117486099ec2e0aa7 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 誌謝 ii
中文摘要 iii ABSTRACT iv ABBREVIATION v CONTENTS vi LIST OF FIGURES viii LIST OF TABLES ix INTRODUCTION 1 METHODS 4 Subjects. 4 Stimuli. 4 Experimental protocol. 4 Behavioral test. 5 fMRI test. 5 Behavioral analysis. 6 fMRI data acquisition. 6 fMRI data analysis. 7 Psychophysiological interaction (PPI) analysis. 8 Statistical analysis. 9 RESULTS 10 Behavioral results 10 Brain activations to painful stimulation 10 Brain activations related to pain habituation 11 Functional connectivity related to pain habituation 11 DISCUSSION 13 Investigation on pain habituation 13 Neural correlates of short-term pain habituation 13 Functional connectivity with attention- and pain-related brain regions 14 Conclusion 15 REFERENCE 16 | |
dc.language.iso | en | |
dc.title | 人類疼痛特有習慣化的大腦特徵 | zh_TW |
dc.title | The Cerebral Signature for Pain-specific Habituation in Humans | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳恩賜,吳建德 | |
dc.subject.keyword | 功能性磁振造影,疼痛,習慣化,心理生理交互作用分析,電刺激, | zh_TW |
dc.subject.keyword | functional magnetic resonance imaging,pain,habituation,psychophysical interaction analysis,electrical stimulation, | en |
dc.relation.page | 28 | |
dc.identifier.doi | 10.6342/NTU201603091 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-08-18 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 腦與心智科學研究所 | zh_TW |
顯示於系所單位: | 腦與心智科學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-105-1.pdf 目前未授權公開取用 | 1.34 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。