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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 童世煌(Shih-Huang Tung) | |
dc.contributor.author | Chen-Shin Lin | en |
dc.contributor.author | 林晨歆 | zh_TW |
dc.date.accessioned | 2021-06-15T11:23:43Z | - |
dc.date.available | 2016-08-30 | |
dc.date.copyright | 2016-08-30 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-17 | |
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Striccoli: GISAXS and GIWAXS study on self-assembling processes of nanoparticle based superlattices. Cryst. Eng. Comm. 2014, 16, 9482–9492. 44. Patrick Garidel, Alfred Blume, Wigand Hübner: A Fourier transform infrared spectroscopic study of the interaction of alkaline earth cations with the negatively charged phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol. Biochim. Biophys. Acta. 2000, 1466 (1-2), 245–259 45. Z. Shervani, T. K. Jain, A. Maitra: Nonconventional lecithin gels in hydrocarbon oils. Colloid Polym. Sci. 1991, 269, 720–726. 46. Elena V. Shumilina, Yu. L. Khromova, Yurii A. Shchipunov: A study of the structure of lecithin organic gels by IR spectroscopy with Fourier-transform. Russ. J. Phys. Chem. 2000, 74 (7), 1210–1219. 47. Yurii A. Shchipunov, Elena V. Shumilina: Lecithin bridging by hydrogen bonds in the organogel. Materials Science and Engineering C 1995, 3 (1), 43–50. 48. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49324 | - |
dc.description.abstract | 雙親性分子在非極性有機溶劑中可以自組中形成反式微胞(reverse micelle),而從過去文獻中我們可以知道藉由無機鹽類的添加可以使卵磷脂(lecithin)在非極性有機溶劑中形成反蠕蟲狀微胞(reverse wormlike micelle)。陽離子會與卵磷脂中的磷酸根基團(PO2-)作用而形成不同的自組裝結構。
在本實驗中我們進一步探討磷脂質與無機鹽類混摻系統在薄膜樣品及塊材中鹽類所扮演的角色,如何去影響自組裝行為。我們選用了氯化鈣(CaCl2)、氯化鎂(MgCl2)和氯化鑭(LaCl3)三種無機鹽類,觀察它們對磷脂質結構的影響。利用原子力顯微鏡(AFM)探測薄膜表面結構,我們能夠觀察到,在特定的鹽類比例與不同種類的磷脂混摻系統中,會形成球狀、柱狀以及層狀等微結構。在這次實驗中,兩條疏水尾基各含有一個或兩個雙鍵的磷脂質,可以藉由增加鹽類的含量,而使結構從一開始的球狀結構轉變成六角堆積的柱狀結構,這種誘發結構轉變的能力因不同種類的鹽類添加而有所差異,其效率由高至低為LaCl3 > CaCl2 > MgCl2。然而,那些尾基只有一個雙鍵甚至不含雙鍵的磷脂質,結構幾乎則不受到鹽類的添加比例或種類所影響,一直保持層狀的堆疊結構。我們利用小角度Ⅹ光散射(SAXS,GISAXS)實驗進一步證實這些結構,並且發現這些磷脂質與鹽類系統自組裝所形成的有序結構,其週期僅有4奈米,相較於傳統由雙嵌段共聚物的微相分離所形成的結構要小得多。 | zh_TW |
dc.description.abstract | It has been known that amphiphilic molecules self-assembles into reverse spherical micelles in non-polar organic solvent and the addition of inorganic salts into lecithin organosol lead to the formation of reverse wormlike micelles. The cations of salt interact with phosphate group (PO2-) of lecithin, resulting in such a self-assembly behavior. In this work, instead of self-assembled structures in solutions, we focused on the bulk samples and thin films cast from phospholipid/salt mixtures in non-polar solvent, and studied how the salt affects the self-assembled structures of lipids without solvent. We investigated the effects of three inorganic salts on the formation of lipids, including calcium chloride (CaCl2), Magnesium chloride (MgCl2) and Lanthanum Chloride (LaCl3). With specific molar ratio of salt to different kinds of lipids, spherical, cylindrical, and lamellar domains can be observed by atomic force microscopy (AFM). For the lipids with one or two double bonds on each tail, the structure can be transformed from spherical to cylindrical microdomains as the fraction of the salts increases. The ability of the three inorganic salts to induce the structure transformation is in order of LaCl3 > CaCl2 > MgCl2. For the lipids with only one or no double bond, however, the structure is unaffected by the salts, remaining lamellar regardless of the type and the fraction of the salts. We also utilized small-angle X-ray scattering (SAXS and GISAXS) to analyze the structure and found the d-spacing of the ordered stuiructures in lecithin/salt mixtures is only 4 nm, which is much smaller than that of the phase-separated domains in typical block copolymer systems. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T11:23:43Z (GMT). No. of bitstreams: 1 ntu-105-R03549017-1.pdf: 7732284 bytes, checksum: 4fb20975dd36c2576d68ecc044d7c08e (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 目錄
口試委員會審定書 I 誌謝 II 摘要 III ABSTRACT IV 目錄 V 圖目錄 VII 第一章 緒論 1 1.1前言 1 1.2研究動機 2 第二章 文獻回顧 3 2.1嵌段共聚物的微相分離形態與薄膜製備 3 2.2雙親性分子的自組裝與蠕蟲狀微胞 5 2.3雙親性分子與添加物 7 2.4卵磷脂在有機溶劑的自組裝行為 8 2.5小角度X光散射(SAXS) 10 2.6掠入射小角度X光散射(GISAXS) 12 第三章 實驗方法與儀器 14 3.1 藥品 14 3.2實驗步驟 17 3.2.1樣品溶液製備 17 3.2.2薄膜樣品製備 17 3.2.3熱退火處理 17 3.3儀器使用 18 3.3.1傅立葉轉換紅外線光譜儀(Fourier Transform Infrared Spectrometer, FT-IR) 18 3.3.2原子力顯微鏡(Atomic Force Microscope, AFM) 18 3.3.3小角度X光散射(Small Angle X-ray Scattering, SAXS) 19 3.3.4示差掃描熱量分析儀(Differential Scanning Calorimetry, DSC) 20 第四章 實驗結果與討論 21 4.1磷脂質與無機鹽類於薄膜之自組裝行為 21 4.2利用小角度X光散射(SAXS)鑑定塊材與薄膜樣品之結構 33 4.3卵磷脂與無機鹽類間之作用力 48 4.4磷脂質與無機鹽類系統自組裝機制 59 4.5無機鹽類對卵磷脂之熱性質影響 61 第五章 結論 64 參考文獻 65 | |
dc.language.iso | zh-TW | |
dc.title | 卵磷脂與無機鹽類在薄膜上自組裝行為研究 | zh_TW |
dc.title | Self-assembled behaviors of lecithin/inorganic salt
in thin films | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃慶怡(Ching-I Huang),楊大毅(Ta-I Yang),陳儀帆(Yi-Fan Chen) | |
dc.subject.keyword | 磷脂質,自組裝,蠕蟲狀微胞,薄膜,sub-4nm結構, | zh_TW |
dc.subject.keyword | phospholipid,self-assembly,wormlike micelles,thin film,sub-4 nm structure, | en |
dc.relation.page | 70 | |
dc.identifier.doi | 10.6342/NTU201602818 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-08-18 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
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