請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48506完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 湯志永(Chih-Yung Tang) | |
| dc.contributor.author | Jui-Hsiang Hu | en |
| dc.contributor.author | 胡瑞香 | zh_TW |
| dc.date.accessioned | 2021-06-15T06:59:40Z | - |
| dc.date.available | 2016-03-03 | |
| dc.date.copyright | 2011-03-03 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2011-01-25 | |
| dc.identifier.citation | Aiyar J, Grissmer S & Chandy KG. (1993). Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC. Am J Physiol 265, C1571-1578.
Akhavan A, Atanasiu R & Shrier A. (2003). Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels. J Biol Chem 278, 40105-40112. Aydar E & Palmer C. (2001). Functional characterization of the C-terminus of the human ether-a-go-go-related gene K(+) channel (HERG). J Physiol 534, 1-14. Babila T, Moscucci A, Wang H, Weaver FE & Koren G. (1994). Assembly of mammalian voltage-gated potassium channels: evidence for an important role of the first transmembrane segment. Neuron 12, 615-626. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M & Romey G. (1996). K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384, 78-80. Bauer CK, Engeland B, Wulfsen I, Ludwig J, Pongs O & Schwarz JR. (1998). RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells. Receptors Channels 6, 19-29. Bauer CK & Schwarz JR. (2001). Physiology of EAG K+ channels. J Membr Biol 182, 1-15. Brelidze TI, Carlson AE & Zagotta WN. (2009). Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. J Biol Chem 284, 27989-27997. Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M & Baram TZ. (2002). Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci 22, 4591-4599. Brewster AL, Bernard JA, Gall CM & Baram TZ. (2005). Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis 19, 200-207. Campomanes CR, Carroll KI, Manganas LN, Hershberger ME, Gong B, Antonucci DE, Rhodes KJ & Trimmer JS. (2002). Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem 277, 8298-8305. Chandrasekhar KD, Bas T & Kobertz WR. (2006). KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem 281, 40015-40023. Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L & Kaczmarek LK. (2009). The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. J Neurosci 29, 5654-5665. Chouinard SW, Wilson GF, Schlimgen AK & Ganetzky B. (1995). A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A 92, 6763-6767. Christie MJ, North RA, Osborne PB, Douglass J & Adelman JP. (1990). Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits. Neuron 4, 405-411. Clapham DE. (2003). TRP channels as cellular sensors. Nature 426, 517-524. Coetzee WA, Amarillo Y, Chiu J, Chow A, Lau D, McCormack T, Moreno H, Nadal MS, Ozaita A, Pountney D, Saganich M, Vega-Saenz de Miera E & Rudy B. (1999). Molecular diversity of K+ channels. Ann N Y Acad Sci 868, 233-285. Cole KS & Moore JW. (1960). Potassium ion current in the squid giant axon: dynamic characteristic. Biophys J 1, 1-14. Covarrubias M, Wei AA & Salkoff L. (1991). Shaker, Shal, Shab, and Shaw express independent K+ current systems. Neuron 7, 763-773. Craven KB & Zagotta WN. (2006). CNG and HCN channels: two peas, one pod. Annu Rev Physiol 68, 375-401. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED & Keating MT. (1995). A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803. Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S & Pfaffinger PJ. (2000). Voltage dependent activation of potassium channels is coupled to T1 domain structure. Nat Struct Biol 7, 403-407. Daram P, Urbach S, Gaymard F, Sentenac H & Cherel I. (1997). Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain. EMBO J 16, 3455-3463. Deschenes I & Tomaselli GF. (2002). Modulation of Kv4.3 current by accessory subunits. FEBS Lett 528, 183-188. Dhallan RS, Yau KW, Schrader KA & Reed RR. (1990). Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347, 184-187. Dingledine R, Borges K, Bowie D & Traynelis SF. (1999). The glutamate receptor ion channels. Pharmacol Rev 51, 7-61. Dreyer I, Antunes S, Hoshi T, Muller-Rober B, Palme K, Pongs O, Reintanz B & Hedrich R. (1997). Plant K+ channel alpha-subunits assemble indiscriminately. Biophys J 72, 2143-2150. Dreyer I, Poree F, Schneider A, Mittelstadt J, Bertl A, Sentenac H, Thibaud JB & Mueller-Roeber B. (2004). Assembly of plant Shaker-like K(out) channels requires two distinct sites of the channel alpha-subunit. Biophys J 87, 858-872. Drysdale R, Warmke J, Kreber R & Ganetzky B. (1991). Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster. Genetics 127, 497-505. Eertmoed AL & Green WN. (1999). Nicotinic receptor assembly requires multiple regions throughout the gamma subunit. J Neurosci 19, 6298-6308. Ehrhardt T, Zimmermann S & Muller-Rober B. (1997). Association of plant K+(in) channels is mediated by conserved C-termini and does not affect subunit assembly. FEBS Lett 409, 166-170. Erler I, Al-Ansary DM, Wissenbach U, Wagner TF, Flockerzi V & Niemeyer BA. (2006). Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281, 38396-38404. Etxeberria A, Aivar P, Rodriguez-Alfaro JA, Alaimo A, Villace P, Gomez-Posada JC, Areso P & Villarroel A. (2008). Calmodulin regulates the trafficking of KCNQ2 potassium channels. FASEB J 22, 1135-1143. Fakler B, Brandle U, Bond C, Glowatzki E, Konig C, Adelman JP, Zenner HP & Ruppersberg JP. (1994). A structural determinant of differential sensitivity of cloned inward rectifier K+ channels to intracellular spermine. FEBS Lett 356, 199-203. Fesenko EE, Kolesnikov SS & Lyubarsky AL. (1985). Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment. Nature 313, 310-313. Fleig A & Penner R. (2004). The TRPM ion channel subfamily: molecular, biophysical and functional features. Trends Pharmacol Sci 25, 633-639. Frings S, Brull N, Dzeja C, Angele A, Hagen V, Kaupp UB & Baumann A. (1998). Characterization of ether-a-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments. J Gen Physiol 111, 583-599. Ganetzky B, Robertson GA, Wilson GF, Trudeau MC & Titus SA. (1999). The eag family of K+ channels in Drosophila and mammals. Ann N Y Acad Sci 868, 356-369. Ganetzky B & Wu CF. (1983). Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet 1, 17-28. Garcia-Sanz N, Fernandez-Carvajal A, Morenilla-Palao C, Planells-Cases R, Fajardo-Sanchez E, Fernandez-Ballester G & Ferrer-Montiel A. (2004). Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci 24, 5307-5314. Gauss R, Seifert R & Kaupp UB. (1998). Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature 393, 583-587. Gilles-Gonzalez MA & Gonzalez G. (2004). Signal transduction by heme-containing PAS-domain proteins. J Appl Physiol 96, 774-783. Goldstein SA, Wang KW, Ilan N & Pausch MH. (1998). Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. J Mol Med 76, 13-20. Gong J, Xu J, Bezanilla M, van Huizen R, Derin R & Li M. (1999). Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science 285, 1565-1569. Gu C, Jan YN & Jan LY. (2003). A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science 301, 646-649. Gulbis JM, Zhou M, Mann S & MacKinnon R. (2000). Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science 289, 123-127. Gustina AS & Trudeau MC. (2009). A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc Natl Acad Sci U S A 106, 13082-13087. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W & Wang X. (2005). International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57, 473-508. Guy HR, Durell SR, Warmke J, Drysdale R & Ganetzky B. (1991). Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science 254, 730. Haitin Y & Attali B. (2008). The C-terminus of Kv7 channels: a multifunctional module. J Physiol 586, 1803-1810. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K & Mori Y. (2002). LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9, 163-173. Harris PC & Torres VE. (2009). Polycystic kidney disease. Annu Rev Med 60, 321-337. He Y, Ruiz M & Karpen JW. (2000). Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits. Proc Natl Acad Sci U S A 97, 895-900. Hopkins WF, Demas V & Tempel BL. (1994). Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channels. J Neurosci 14, 1385-1393. Howard RJ, Clark KA, Holton JM & Minor DL, Jr. (2007). Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron 53, 663-675. Isacoff EY, Jan YN & Jan LY. (1990). Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature 345, 530-534. Jan LY & Jan YN. (1994). Potassium channels and their evolving gates. Nature 371, 119-122. Jenke M, Sanchez A, Monje F, Stuhmer W, Weseloh RM & Pardo LA. (2003). C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J 22, 395-403. Jerng HH, Pfaffinger PJ & Covarrubias M. (2004). Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci 27, 343-369. Kameyama M, Kakei M, Sato R, Shibasaki T, Matsuda H & Irisawa H. (1984). Intracellular Na+ activates a K+ channel in mammalian cardiac cells. Nature 309, 354-356. Kaplan WD & Trout WE, 3rd. (1969). The behavior of four neurological mutants of Drosophila. Genetics 61, 399-409. Karpen JW, Zimmerman AL, Stryer L & Baylor DA. (1988). Gating kinetics of the cyclic-GMP-activated channel of retinal rods: flash photolysis and voltage-jump studies. Proc Natl Acad Sci U S A 85, 1287-1291. Kobrinsky E, Stevens L, Kazmi Y, Wray D & Soldatov NM. (2006). Molecular rearrangements of the Kv2.1 potassium channel termini associated with voltage gating. J Biol Chem 281, 19233-19240. Kubo Y, Baldwin TJ, Jan YN & Jan LY. (1993). Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362, 127-133. Kuhse J, Laube B, Magalei D & Betz H. (1993). Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11, 1049-1056. Kupershmidt S, Snyders DJ, Raes A & Roden DM. (1998). A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current. J Biol Chem 273, 27231-27235. Kupershmidt S, Yang T, Chanthaphaychith S, Wang Z, Towbin JA & Roden DM. (2002). Defective human Ether-a-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. J Biol Chem 277, 27442-27448. Lee TE, Philipson LH, Kuznetsov A & Nelson DJ. (1994). Structural determinant for assembly of mammalian K+ channels. Biophys J 66, 667-673. Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G & Barhanin J. (1996a). TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J 15, 1004-1011. Lesage F, Reyes R, Fink M, Duprat F, Guillemare E & Lazdunski M. (1996b). Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J 15, 6400-6407. Lewis A, McCrossan ZA & Abbott GW. (2004). MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J Biol Chem 279, 7884-7892. Li M, Jan YN & Jan LY. (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science 257, 1225-1230. Li X, Xu J & Li M. (1997). The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression. J Biol Chem 272, 705-708. Li Y, Um SY & McDonald TV. (2006). Voltage-gated potassium channels: regulation by accessory subunits. Neuroscientist 12, 199-210. Lopez GA, Jan YN & Jan LY. (1994). Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore. Nature 367, 179-182. Ludwig A, Zong X, Jeglitsch M, Hofmann F & Biel M. (1998). A family of hyperpolarization-activated mammalian cation channels. Nature 393, 587-591. Ludwig J, Owen D & Pongs O. (1997). Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-a-go-go potassium channel. EMBO J 16, 6337-6345. Ludwig J, Terlau H, Wunder F, Bruggemann A, Pardo LA, Marquardt A, Stuhmer W & Pongs O. (1994). Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO J 13, 4451-4458. Ludwig J, Weseloh R, Karschin C, Liu Q, Netzer R, Engeland B, Stansfeld C & Pongs O. (2000). Cloning and functional expression of rat eag2, a new member of the ether-a-go-go family of potassium channels and comparison of its distribution with that of eag1. Mol Cell Neurosci 16, 59-70. Lupica CR, Bell JA, Hoffman AF & Watson PL. (2001). Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. J Neurophysiol 86, 261-268. MacKinnon R. (1991). Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 350, 232-235. Magee JC. (1998). Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 18, 7613-7624. Magee JC. (1999). Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons. Nat Neurosci 2, 848. Maljevic S, Lerche C, Seebohm G, Alekov AK, Busch AE & Lerche H. (2003). C-terminal interaction of KCNQ2 and KCNQ3 K+ channels. J Physiol 548, 353-360. Marten I & Hoshi T. (1997). Voltage-dependent gating characteristics of the K+ channel KAT1 depend on the N and C termini. Proc Natl Acad Sci U S A 94, 3448-3453. Matsuda S, Kamiya Y & Yuzaki M. (2005). Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor. J Biol Chem 280, 20021-20029. McCrossan ZA & Abbott GW. (2004). The MinK-related peptides. Neuropharmacology 47, 787-821. McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA & Fishman GI. (1997). A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature 388, 289-292. McKemy DD, Neuhausser WM & Julius D. (2002). Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58. Mei ZZ, Xia R, Beech DJ & Jiang LH. (2006). Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2. J Biol Chem 281, 38748-38756. Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY & Berger JM. (2000). The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102, 657-670. Misaka T, Kusakabe Y, Emori Y, Gonoi T, Arai S & Abe K. (1997). Taste buds have a cyclic nucleotide-activated channel, CNGgust. J Biol Chem 272, 22623-22629. Mohapatra DP, Siino DF & Trimmer JS. (2008). Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel. J Neurosci 28, 4982-4994. Montell C. (2005). The TRP superfamily of cation channels. Sci STKE 2005, re3. Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M & Mackinnon R. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95, 649-655. Nakamura T & Gold GH. (1987). A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325, 442-444. Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR & Fischer-Lougheed J. (1998). Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett 434, 177-182. Ong AC & Harris PC. (2005). Molecular pathogenesis of ADPKD: the polycystin complex gets complex. Kidney Int 67, 1234-1247. Parcej DN & Dolly JO. (1989). Dendrotoxin acceptor from bovine synaptic plasma membranes. Binding properties, purification and subunit composition of a putative constituent of certain voltage-activated K+ channels. Biochem J 257, 899-903. Parcej DN, Scott VE & Dolly JO. (1992). Oligomeric properties of alpha-dendrotoxin-sensitive potassium ion channels purified from bovine brain. Biochemistry 31, 11084-11088. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S & Patapoutian A. (2002). A TRP channel that senses cold stimuli and menthol. Cell 108, 705-715. Pellequer JL, Brudler R & Getzoff ED. (1999). Biological sensors: More than one way to sense oxygen. Curr Biol 9, R416-418. Phartiyal P, Jones EM & Robertson GA. (2007). Heteromeric assembly of human ether-a-go-go-related gene (hERG) 1a/1b channels occurs cotranslationally via N-terminal interactions. J Biol Chem 282, 9874-9882. Phelps CB & Gaudet R. (2007). The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. J Biol Chem 282, 36474-36480. Ponting CP & Aravind L. (1997). PAS: a multifunctional domain family comes to light. Curr Biol 7, R674-677. Poolos NP, Migliore M & Johnston D. (2002). Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nat Neurosci 5, 767-774. Rehm H & Lazdunski M. (1988). Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A 85, 4919-4923. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO & Pongs O. (1994). Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature 369, 289-294. Robbins J. (2001). KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther 90, 1-19. Robertson GA, Warmke JM & Ganetzky B. (1996). Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes. Neuropharmacology 35, 841-850. Rogawski MA. (2000). KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci 23, 393-398. Safronov BV & Vogel W. (1996). Properties and functions of Na(+)-activated K+ channels in the soma of rat motoneurones. J Physiol 497 ( Pt 3), 727-734. Saganich MJ, Vega-Saenz de Miera E, Nadal MS, Baker H, Coetzee WA & Rudy B. (1999). Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex. J Neurosci 19, 10789-10802. Salkoff L, Baker K, Butler A, Covarrubias M, Pak MD & Wei A. (1992). An essential 'set' of K+ channels conserved in flies, mice and humans. Trends Neurosci 15, 161-166. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL & Keating MT. (1996). Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384, 80-83. Santoro B & Baram TZ. (2003). The multiple personalities of h-channels. Trends Neurosci 26, 550-554. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA & Tibbs GR. (1998). Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 93, 717-729. Schmitt N, Schwarz M, Peretz A, Abitbol I, Attali B & Pongs O. (2000). A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J 19, 332-340. Schonherr R, Lober K & Heinemann SH. (2000). Inhibition of human ether a go-go potassium channels by Ca(2+)/calmodulin. EMBO J 19, 3263-3271. Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P & Friedrich T. (2006). Structural determinants of M-type KCNQ (Kv7) K+ channel assembly. J Neurosci 26, 3757-3766. Schwake M, Jentsch TJ & Friedrich T. (2003). A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly. EMBO Rep 4, 76-81. Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P & Kaupp UB. (1999). Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A 96, 9391-9396. Shamgar L, Ma L, Schmitt N, Haitin Y, Peretz A, Wiener R, Hirsch J, Pongs O & Attali B. (2006). Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations. Circ Res 98, 1055-1063. Shammat IM & Gordon SE. (1999). Stoichiometry and arrangement of subunits in rod cyclic nucleotide-gated channels. Neuron 23, 809-819. Shen NV, Chen X, Boyer MM & Pfaffinger PJ. (1993). Deletion analysis of K+ channel assembly. Neuron 11, 67-76. Shen NV & Pfaffinger PJ. (1995). Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins. Neuron 14, 625-633. Sheng Z, Skach W, Santarelli V & Deutsch C. (1997). Evidence for interaction between transmembrane segments in assembly of Kv1.3. Biochemistry 36, 15501-15513. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D & Dixon JE. (1997). Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci 17, 9423-9432. Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ & Trimmer JS. (2003). A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem 278, 36445-36454. Soh H & Goldstein SA. (2008). I SA channel complexes include four subunits each of DPP6 and Kv4.2. J Biol Chem 283, 15072-15077. Strong M, Chandy KG & Gutman GA. (1993). Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol 10, 221-242. Sumikawa K & Nishizaki T. (1994). The amino acid residues 1-128 in the alpha subunit of the nicotinic acetylcholine receptor contain assembly signals. Brain Res Mol Brain Res 25, 257-264. Tang CY, Bezanilla F & Papazian DM. (2000). Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-a-Go-Go potassium channels. J Gen Physiol 115, 319-338. Tang CY & Papazian DM. (1997). Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-a-go-go K+ channel. J Gen Physiol 109, 301-311. Taylor RE & Bezanilla F. (1983). Sodium and gating current time shifts resulting from changes in initial conditions. J Gen Physiol 81, 773-784. Tempel BL, Jan YN & Jan LY. (1988). Cloning of a probable potassium channel gene from mouse brain. Nature 332, 837-839. Tempel BL, Papazian DM, Schwarz TL, Jan YN & Jan LY. (1987). Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science 237, 770-775. Terlau H, Heinemann SH, Stuhmer W, Pongs O & Ludwig J. (1997). Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. J Physiol 502 ( Pt 3), 537-543. Terlau H, Ludwig J, Steffan R, Pongs O, Stuhmer W & Heinemann SH. (1996). Extracellular Mg2+ regulates activation of rat eag potassium channel. Pflugers Arch 432, 301-312. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y & Tominaga M. (2006). TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 25, 1804-1815. Tran N, Proenza C, Macri V, Petigara F, Sloan E, Samler S & Accili EA. (2002). A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. J Biol Chem 277, 43588-43592. Tu L, Santarelli V & Deutsch C. (1995). Truncated K+ channel DNA sequences specifically suppress lymphocyte K+ channel gene expression. Biophys J 68, 147-156. Tu L, Santarelli V, Sheng Z, Skach W, Pain D & Deutsch C. (1996). Voltage-gated K+ channels contain multiple intersubunit association sites. J Biol Chem 271, 18904-18911. Tu L, Wang J, Helm A, Skach WR & Deutsch C. (2000). Transmembrane biogenesis of Kv1.3. Biochemistry 39, 824-836. VanDongen AM, Frech GC, Drewe JA, Joho RH & Brown AM. (1990). Alteration and restoration of K+ channel function by deletions at the N- and C-termini. Neuron 5, 433-443. Verrall S & Hall ZW. (1992). The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly. Cell 68, 23-31. Very AA & Sentenac H. (2002). Cation channels in the Arabidopsis plasma membrane. Trends Plant Sci 7, 168-175. Very AA & Sentenac H. (2003). Molecular mechanisms and regulation of K+ transport in higher plants. Annu Rev Plant Biol 54, 575-603. Viloria CG, Barros F, Giraldez T, Gomez-Varela D & de la Pena P. (2000). Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating. Biophys J 79, 231-246. Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA & Tibbs GR. (2001). Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805-810. Wang J, Trudeau MC, Zappia AM & Robertson GA. (1998). Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels. J Gen Physiol 112, 637-647. Warmke J, Drysdale R & Ganetzky B. (1991). A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 252, 1560-1562. Warmke JW & Ganetzky B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A 91, 3438-3442. Wehage E, Eisfeld J, Heiner I, Jungling E, Zitt C & Luckhoff A. (2002). Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 277, 23150-23156. Whitaker GM, Angoli D, Nazzari H, Shigemoto R & Accili EA. (2007). HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. J Biol Chem 282, 22900-22909. Wiener R, Haitin Y, Shamgar L, Fernandez-Alonso MC, Martos A, Chomsky-Hecht O, Rivas G, Attali B & Hirsch JA. (2008). The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J Biol Chem 283, 5815-5830. Wilson GF, Wang Z, Chouinard SW, Griffith LC & Ganetzky B. (1998). Interaction of the K channel beta subunit, Hyperkinetic, with eag family members. J Biol Chem 273, 6389-6394. Xicluna J, Lacombe B, Dreyer I, Alcon C, Jeanguenin L, Sentenac H, Thibaud JB & Cherel I. (2007). Increased functional diversity of plant K+ channels by preferential heteromerization of the shaker-like subunits AKT2 and KAT2. J Biol Chem 282, 486-494. Xu J, Yu W, Jan YN, Jan LY & Li M. (1995). Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits. J Biol Chem 270, 24761-24768. Yang B, Desai R & Kaczmarek LK. (2007). Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. J Neurosci 27, 2617-2627. Yellen G. (2002). The voltage-gated potassium channels and their relatives. Nature 419, 35-42. Young SH & Moore JW. (1981). Potassium ion currents in the crayfish giant axon. Dynamic characteristics. Biophys J 36, 723-733. Yu W, Xu J & Li M. (1996). NAB domain is essential for the subunit assembly of both alpha-alpha and alpha-beta complexes of shaker-like potassium channels. Neuron 16, 441-453. Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY & Yang J. (2009). Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A 106, 11558-11563. Zagotta WN, Olivier NB, Black KD, Young EC, Olson R & Gouaux E. (2003). Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425, 200-205. Zerangue N, Jan YN & Jan LY. (2000). An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1. Proc Natl Acad Sci U S A 97, 3591-3595. Zha Q, Brewster AL, Richichi C, Bender RA & Baram TZ. (2008). Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem 105, 68-77. Zhang M, Jiang M & Tseng GN. (2001). minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel? Circ Res 88, 1012-1019. Zhong H, Lai J & Yau KW. (2003). Selective heteromeric assembly of cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A 100, 5509-5513. Zhong H, Molday LL, Molday RS & Yau KW. (2002). The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Nature 420, 193-198. Ziechner U, Schonherr R, Born AK, Gavrilova-Ruch O, Glaser RW, Malesevic M, Kullertz G & Heinemann SH. (2006). Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. FEBS J 273, 1074-1086. Zimmermann S, Hartje S, Ehrhardt T, Plesch G & Mueller-Roeber B. (2001). The K+ channel SKT1 is co-expressed with KST1 in potato guard cells--both channels can co-assemble via their conserved KT domains. Plant J 28, 517-527. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48506 | - |
| dc.description.abstract | 大鼠的ether-à-gogo ( rEag ) 電位控制 ( voltage-gated ) 鉀離子通道屬於EAG家族的一種，可細分為rEag1與rEag2兩個類型。rEag1和rEag2是只表達於神經系統 ( neuron-specific ) 的鉀離子通道，所以對調控神經細胞的興奮性可能扮演重要角色。
一個具有功能性的電位控制鉀離子通道是由四個次單元( subunit )所聚合而成的四聚體 ( tetramer )。過去的研究顯示鉀離子通道之次單元之間的聚合可由特定的胺基酸序列調控來決定彼此之間的專一性或特異性，進而形成四聚體。例如在Kv1鉀離子通道目前研究已知其主要聚合區( assembly domain )位於細胞內N端 ( amino terminus ) 之T1區( tetramerization domain )。對rEag1鉀離子通道而言，目前的研究指出在其C端 ( carboxyl terminus ) 有一段包含41個胺基酸 ( 胺基酸897-937 ) 的區域，對rEag 鉀離子通道的次單元之間之聚合作用扮演重要角色，所以此一C端此區被稱為C端聚合區域( C-terminal assembly domain；CAD )。然而近年有報告顯示，對另一種EAG家族的鉀離子通道Herg而言，N端的部分序列可能與次單元的聚合機制有關。所以本篇論文的研究目的是要探討rEag1的CAD片段是否的確是決定其聚合作用的關鍵部位。 我們以rEag1正常型 ( wild-type ) 當模版，利用分子生物 mutagenesis方法產生十九種長短不同的刪除突變 ( truncation mutants ) ，並經由雙極電位箝制術 ( two-electrode voltage clamp ) 記錄判定各種不同的突變次單元是否能單獨聚合為具功能性的鉀離子通道。對於不具有功能性的突變種鉀離子通道，我們則將其以共同表現的方法 ( co-expression ) ，決定是否能對正常型rEag1次單元造成顯性抑制作用 ( Dominant-negative effect ) 。 根據我們的實驗結果證實兩個完全不具有CAD的刪除突變，確實能自行產生與正常型rEag1相似的鉀離子通道。另外，即使將缺乏C端刪除了485個胺基酸的突變也可以對正常型rEag1鉀離子通道產生顯著抑制作用。這樣的結果我們可以推論CAD對rEag1鉀離子通道的聚合機制來說，可能不是扮演著最主要或必要的角色；另外，除了S6以外，N端與大部份的穿膜段落也可能不是負責rEag1鉀離子通道聚合機制的主要區域。所以我們的實驗結果可提供未來研究rEag1鉀離子通道聚合機制的一個新方向。 | zh_TW |
| dc.description.abstract | The voltage-gated rat ether-à-gogo (rEag) potassium channel is a member of the EAG potassium channel family, and can be subdivided into two different subtypes: rEag1 and rEag2. rEag1 and rEag2 potassium channels have been shown to express exclusively in neurons, and are therefore thought to play an important role in determining the membrane excitability of neurons.
A functional voltage-gated potassium channel is a tetramer comprising the assembly of four subunits. The assembly of potassium channel subunits is usually mediated by specific amino acid sequence that dictates the specificity of tetramer formation within each potassium channel family. For example, the assembly of Kv1 channel is primarily determined by a region within the intracellular amino terminus (N-terminus) known as the tetramerization domain (T1-domain). For rEag1 potassium channel, a 41-amino-acid domain (amino acids 897-937), close to the carboxyl terminus (C-terminus), has been shown to be important for rEag1 potassium channel subunit interaction. Therefore, this C-terminal domain was named the C-terminal assembly domain (CAD). However, recent reports have demonstrated that in Herg channels, another member of the EAG potassium channel family, the N-terminus may contribute to the specific interaction between different splice variants. Therefore, in this study we aim to investigate whether the CAD of rEag1 is indeed the key assembly domain. More than 10 different truncation mutants, all of which without the CAD, have been introduced into rEag1 potassium channels. By using the two-electrode voltage clamp technique, we first determined whether some of these truncation mutants produced functional potassium channels. For nonfunctional mutants, we then decided if they displayed dominant-negative effects on wild-type rEag1 channels by performing co-expression experiments. Our electrophsyiological studies demonstrated that two truncation mutants lacking the CAD indeed generated functional potassium channels. In addition, significant dominant-negative effects on WT-rEag1 channels were observed for non-functional mutants with truncations up to 485 amino acids in the C-terminal region. These data indicate that the role of the CAD needs to be re-defined and that the S6 segment and the proximal region of C-terminus may contribute to the assembly of rEag1 channels. Our new findings may pave the way for a new direction for understanding the assmbly mechanism of EAG channel family. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T06:59:40Z (GMT). No. of bitstreams: 1 ntu-99-R95441008-1.pdf: 1531564 bytes, checksum: b10982520766373ce5edc232588fa0b9 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 誌謝 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥I
目錄 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥III 圖次 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥V 表次 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥VII 中文摘要 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥VIII 英文摘要 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥X 第一章、 導論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥1 I. 鉀離子通道概論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥1 II. Eag鉀離子通道介紹‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥2 II-1. 種類 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥2 II-2. 結構 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥3 II-3. Gating mechanism ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥4 III. Assembly of K+ channel subunits‥‥‥‥‥‥‥‥‥‥4 III-1. Kv鉀離子通道的聚合(assembly)作用 ‥‥‥‥‥‥‥4 III-2 其他離子通道之聚合機制‥‥‥‥‥‥‥‥‥‥‥‥‥‥8 III-3 輔助性蛋白之聚合作用‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥13 III-4. EAG鉀離子通道的聚合作用 ‥‥‥‥‥‥‥‥‥‥‥‥14 IV. 本實驗之研究目的 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥16 第二章、 材料與方法 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥18 I. Molecular Biology‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥18 I-1. cDNA clones ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥18 I-2. Construction of truncation mutants ‥‥‥‥‥‥‥18 I-3. Transformation and plasmid DNA extraction ‥‥‥‥23 I-4. In Vitro Transcription‥‥‥‥‥‥‥‥‥‥‥ ‥‥23 II. 電生理紀錄‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ ‥‥25 II-1. Xenopus laevis ( 南非爪蟾 ) oocyte之取得與處理‥‥26 II-2. cRNA injection‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥27 II-3. Co-injection of different cRNA constructs‥‥‥‥28 II-4. 電生理紀錄‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥28 II-5. 電生理紀錄之分析‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥29 第三章、 結果‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥31 I. 檢視rEag1、Myc-rEag1和rEag1-HA channel之生物物理特性31 II. 缺乏CAD 時仍可能形成具功能性的rEag1鉀離子通道‥‥‥33 III. 缺乏CAD 之C-terminus truncation mutants仍可能可與WT rEag1 channel形成co-assembly‥‥‥‥‥‥‥‥‥‥‥‥‥‥34 IV. N端與大部分的transmembranes domain可能不是負責媒介rEag1 channel assembly的主要區‥‥‥‥‥‥‥‥‥‥‥‥‥36 第四章、 討論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥38 I. 探討rEag1可能的assembly domain位置‥‥‥‥‥‥‥‥‥38 II. CAD 在rEag1 channel assembly之角色‥‥‥‥‥‥‥‥‥40 III. 後續進一步的實驗方向‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥44 結論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥45 參考文獻‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥79 | |
| dc.language.iso | zh-TW | |
| dc.subject | 顯性抑制作用 | zh_TW |
| dc.subject | 雙極電位箝制術 | zh_TW |
| dc.subject | 聚合區 | zh_TW |
| dc.subject | 聚合機制 | zh_TW |
| dc.subject | 次單元 | zh_TW |
| dc.subject | 四聚體 | zh_TW |
| dc.subject | EAG家族 | zh_TW |
| dc.subject | 電位控制 | zh_TW |
| dc.subject | 大鼠Eag1鉀離子通道 | zh_TW |
| dc.subject | assembly mechanism | en |
| dc.subject | CAD | en |
| dc.subject | C-terminal assembly domain | en |
| dc.subject | Dominant-negative effect | en |
| dc.subject | two-electrode voltage clamp | en |
| dc.subject | assembly domain | en |
| dc.subject | -gogo | en |
| dc.subject | assembly | en |
| dc.subject | tetramer | en |
| dc.subject | subunit | en |
| dc.subject | rEag1 | en |
| dc.subject | rat | en |
| dc.subject | ether-&agrave | en |
| dc.title | 大鼠Eag1鉀離子通道之聚合機制 | zh_TW |
| dc.title | Mechanistic examination of the assembly of rat Eag1 potassium channel | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭鐘金(Chung-Chin Kuo),符文美(Wen-Mei Fu) | |
| dc.subject.keyword | 大鼠Eag1鉀離子通道,電位控制,EAG家族,四聚體,次單元,聚合區,聚合機制,雙極電位箝制術,顯性抑制作用, | zh_TW |
| dc.subject.keyword | rEag1,rat,ether-&agrave,-gogo,assembly,assembly mechanism,tetramer,subunit,assembly domain,two-electrode voltage clamp,Dominant-negative effect,C-terminal assembly domain,CAD, | en |
| dc.relation.page | 103 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-01-25 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 生理學研究所 | zh_TW |
| 顯示於系所單位： | 生理學科所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-99-1.pdf 未授權公開取用 | 1.5 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。