請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48311
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鄭益謙 | |
dc.contributor.author | Chung-Kung Chen | en |
dc.contributor.author | 陳俊光 | zh_TW |
dc.date.accessioned | 2021-06-15T06:52:08Z | - |
dc.date.available | 2013-02-20 | |
dc.date.copyright | 2011-02-20 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-02-14 | |
dc.identifier.citation | Air, G.M., 1981. Sequence relationships among the hemagglutinin genes of 12 subtypes of influenza A virus. Proc Natl Acad Sci U S A 78(12), 7639-7643.
Akarsu, H., Iwatsuki-Horimoto, K., Noda, T., Kawakami, E., Katsura, H., Baudin, F., Horimoto, T., Kawaoka, Y., 2010. Structure-based design of NS2 mutants for attenuated influenza A virus vaccines. Virus Res. Akey, B.L., 2003. Low-pathogenicity H7N2 avian influenza outbreak in Virgnia during 2002. Avian Dis 47(3 Suppl), 1099-1103. Alexander, D.J., 2000. A review of avian influenza in different bird species. Vet Microbiol 74(1-2), 3-13. Allen, H., McCauley, J., Waterfield, M., Gething, M.J., 1980. Influenza virus RNA segment 7 has the coding capacity for two polypeptides. Virology 107(2), 548-551. Aminoff, D., 1961. Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochem J 81, 384-392. Area, E., Martin-Benito, J., Gastaminza, P., Torreira, E., Valpuesta, J., Carrascosa, J., Ortin, J., 2004. 3D structure of the influenza virus polymerase complex: localization of subunit domains. Proceedings of the National Academy of Sciences of the United States of America 101(1), 308. Baum, L.G., Paulson, J.C., 1991. The N2 neuraminidase of human influenza virus has acquired a substrate specificity complementary to the hemagglutinin receptor specificity. Virology 180(1), 10-15. Bean, B., Moore, B.M., Sterner, B., Peterson, L.R., Gerding, D.N., Balfour, H.H., Jr., 1982. Survival of influenza viruses on environmental surfaces. J Infect Dis 146(1), 47-51. Beard, C., 1970. Avian influenza antibody detection by immunodiffusion. Avian diseases 14(2), 337-341. Beck, J.R., Swayne, D.E., Davison, S., Casavant, S., Gutierrez, C., 2003. Validation of egg yolk antibody testing as a method to determine influenza status in white leghorn hens. Avian Dis 47(3 Suppl), 1196-1199. Becker, W.B., Uys, C.J., 1967. Experimental infection of chickens with influenza A-Tern/South Africa/1961 and Chicken/Scotland/1959 viruses. I. Clinical picture and virology. J Comp Pathol 77(2), 159-165. Beigel, J., Bray, M., 2008. Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res 78(1), 91-102. Both, G.W., Sleigh, M.J., Cox, N.J., Kendal, A.P., 1983. Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. J Virol 48(1), 52-60. Bourmakina, S.V., Garcia-Sastre, A., 2003. Reverse genetics studies on the filamentous morphology of influenza A virus. J Gen Virol 84(Pt 3), 517-527. Brands, R., Visser, J., Medema, J., Palache, A.M., van Scharrenburg, G.J., 1999. Influvac: a safe Madin Darby Canine Kidney (MDCK) cell culture-based influenza vaccine. Dev Biol Stand 98, 93-100; discussion 111. Brown, E.G., 2000. Influenza virus genetics. Biomed Pharmacother 54(4), 196-209. Bui, M., Whittaker, G., Helenius, A., 1996. Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. J Virol 70(12), 8391-8401. Cambrosio, A., Keating, P., 1992. Between fact and technique: the beginnings of hybridoma technology. J Hist Biol 25(2), 175-230. Capua, I., Alexander, D.J., 2004. Avian influenza: recent developments. Avian Pathol 33(4), 393-404. Capua, I., Terregino, C., Cattoli, G., Mutinelli, F., Rodriguez, J.F., 2003. Development of a DIVA (Differentiating Infected from Vaccinated Animals) strategy using a vaccine containing a heterologous neuraminidase for the control of avian influenza. Avian Pathol 32(1), 47-55. Carrat, F., Flahault, A., 2007. Influenza vaccine: the challenge of antigenic drift. Vaccine 25(39-40), 6852-6862. Chan, P.K., 2002. Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clin Infect Dis 34 Suppl 2, S58-64. Chang, S., Zhang, J., Liao, X., Zhu, X., Wang, D., Zhu, J., Feng, T., Zhu, B., Gao, G.F., Wang, J., Yang, H., Yu, J., 2007. Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res 35(Database issue), D376-380. Chang, S.C., Chen, G.W., Mok, C.K., Tsao, K.C., Huang, C.G., Huang, Y.L., Shih, S.R., 2006. Subtyping of influenza A isolates in Taiwan--2003 to 2004. J Formos Med Assoc 105(11), 895-910. Chomel, J.J., Thouvenot, D., Onno, M., Kaiser, C., Gourreau, J.M., Aymard, M., 1989. Rapid diagnosis of influenza infection of NP antigen using an immunocapture ELISA test. J Virol Methods 25(1), 81-91. Compans, R.W., Content, J., Duesberg, P.H., 1972. Structure of the ribonucleoprotein of influenza virus. J Virol 10(4), 795-800. Compans, R.W., Klenk, H.D., Caliguiri, L.A., Choppin, P.W., 1970. Influenza virus proteins. I. Analysis of polypeptides of the virion and identification of spike glycoproteins. Virology 42(4), 880-889. Cox, N.J., Subbarao, K., 2000. Global epidemiology of influenza: past and present. Annu Rev Med 51, 407-421. Cros, J.F., Garcia-Sastre, A., Palese, P., 2005. An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein. Traffic 6(3), 205-213. Cui, S., Chen, C., Tong, G., 2008. A simple and rapid immunochromatographic strip test for monitoring antibodies to H5 subtype Avian Influenza Virus. J Virol Methods 152(1-2), 102-105. de StGroth, S.F., Scheidegger, D., 1980. Production of monoclonal antibodies: strategy and tactics. J Immunol Methods 35(1-2), 1-21. Du, A., Daidoji, T., Koma, T., Ibrahim, M.S., Nakamura, S., de Silva, U.C., Ueda, M., Yang, C.S., Yasunaga, T., Ikuta, K., Nakaya, T., 2009. Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody. Biochem Biophys Res Commun 378(2), 197-202. Eager, K.B., Hackett, C.J., Gerhard, W.U., Bennink, J., Eisenlohr, L.C., Yewdell, J., Ricciardi, R.P., 1989. Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes. J Immunol 143(7), 2328-2335. Fichtner, G.J., (Ed.) 1987. The Pennsylvania/Virginia Experience in Eradication of Avian Influenza (H5N2). Proceedings of the Second International Symposium on Avian Influenza. Edited by Esterday, B.C. U.S. Animal Health Association, Richmond, VA. Flint, S., Enquist, L., Krug, R., Racaniello, V., Skalka, A., 2000. Virus cultivation, detection, and genetics. Principles of Virology, 32-33. Fouchier, R.A., Munster, V., Wallensten, A., Bestebroer, T.M., Herfst, S., Smith, D., Rimmelzwaan, G.F., Olsen, B., Osterhaus, A.D., 2005. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol 79(5), 2814-2822. Gall, A., Hoffmann, B., Harder, T., Grund, C., Ehricht, R., Beer, M., 2009. Rapid and highly sensitive neuraminidase subtyping of avian influenza viruses by use of a diagnostic DNA microarray. J Clin Microbiol 47(9), 2985-2988. Gimsa, U., Grotzinger, I., Gimsa, J., 1996. Two evolutionary strategies of influenza viruses to escape host non-specific inhibitors: alteration of hemagglutinin or neuraminidase specificity. Virus Res 42(1-2), 127-135. Goto, H., Kawaoka, Y., 1998. A novel mechanism for the acquisition of virulence by a human influenza A virus. Proc Natl Acad Sci U S A 95(17), 10224-10228. Grammaticos, P.C., Diamantis, A., 2008. Useful known and unknown views of the father of modern medicine, Hippocrates and his teacher Democritus. Hell J Nucl Med 11(1), 2-4. Greenspan, D., Krystal, M., Nakada, S., Arnheiter, H., Lyles, D.S., Palese, P., 1985. Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells. J Virol 54(3), 833-843. Hale, B.G., Randall, R.E., Ortin, J., Jackson, D., 2008. The multifunctional NS1 protein of influenza A viruses. J Gen Virol 89(Pt 10), 2359-2376. Hara, K., Schmidt, F.I., Crow, M., Brownlee, G.G., 2006. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J Virol 80(16), 7789-7798. He, F., Du, Q., Ho, Y., Kwang, J., 2009. Immunohistochemical detection of Influenza virus infection in formalin-fixed tissues with anti-H5 monoclonal antibody recognizing FFWTILKP. J Virol Methods 155(1), 25-33. He, Q., Velumani, S., Du, Q., Lim, C.W., Ng, F.K., Donis, R., Kwang, J., 2007. Detection of H5 avian influenza viruses by antigen-capture enzyme-linked immunosorbent assay using H5-specific monoclonal antibody. Clin Vaccine Immunol 14(5), 617-623. Herz, C., Stavnezer, E., Krug, R., Gurney, T., Jr., 1981. Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells. Cell 26(3 Pt 1), 391-400. Hinshaw, V.S., Air, G.M., Gibbs, A.J., Graves, L., Prescott, B., Karunakaran, D., 1982. Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls. J Virol 42(3), 865-872. Horimoto, T., Kawaoka, Y., 2005. Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3(8), 591-600. Horimoto, T., Rivera, E., Pearson, J., Senne, D., Krauss, S., Kawaoka, Y., Webster, R.G., 1995. Origin and molecular changes associated with emergence of a highly pathogenic H5N2 influenza virus in Mexico. Virology 213(1), 223-230. Ibricevic, A., Pekosz, A., Walter, M.J., Newby, C., Battaile, J.T., Brown, E.G., Holtzman, M.J., Brody, S.L., 2006. Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol 80(15), 7469-7480. Kaverin, N.V., Rudneva, I.A., Govorkova, E.A., Timofeeva, T.A., Shilov, A.A., Kochergin-Nikitsky, K.S., Krylov, P.S., Webster, R.G., 2007. Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J Virol 81(23), 12911-12917. Kawaoka, Y., Naeve, C.W., Webster, R.G., 1984. Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin? Virology 139(2), 303-316. Keawcharoen, J., Oraveerakul, K., Kuiken, T., Fouchier, R.A., Amonsin, A., Payungporn, S., Noppornpanth, S., Wattanodorn, S., Theambooniers, A., Tantilertcharoen, R., Pattanarangsan, R., Arya, N., Ratanakorn, P., Osterhaus, D.M., Poovorawan, Y., 2004. Avian influenza H5N1 in tigers and leopards. Emerg Infect Dis 10(12), 2189-2191. Kido, H., Yokogoshi, Y., Sakai, K., Tashiro, M., Kishino, Y., Fukutomi, A., Katunuma, N., 1992. Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein. J Biol Chem 267(19), 13573-13579. Kistner, O., Barrett, P.N., Mundt, W., Reiter, M., Schober-Bendixen, S., Eder, G., Dorner, F., 1999. Development of a Vero cell-derived influenza whole virus vaccine. Dev Biol Stand 98, 101-110; discussion 111. Klenk, H.D., Mastrosovich, M.N., Stech, J., (Eds.), 2008. Avian Influenza. Vol. 27. Monographs in Virology. Edited by Doerr, H.W. karger, Basel. Koelle, K., Cobey, S., Grenfell, B., Pascual, M., 2006. Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans. Science 314(5807), 1898-1903. Kohler, G., Milstein, C., 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497. Koopmans, M., Wilbrink, B., Conyn, M., Natrop, G., van der Nat, H., Vennema, H., Meijer, A., van Steenbergen, J., Fouchier, R., Osterhaus, A., Bosman, A., 2004. Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands. Lancet 363(9409), 587-593. Lamb, R., Krug, R., (Eds.), 2001. Orthomyxoviridae: the viruses and their replication. 4 ed. Vol. 1. Fields virology. Edited by Knipe, D.M., Howley, P.M., Griffin, D.E., Lamb, R.A., Martin, M.A., Roitman, B., Straus, S.E. Lippincott Williams & Wilkins, Philadelphia, Pa. Lang, G., Rouse, B.T., Narayan, O., Ferguson, A.E., Connell, M.C., 1968. A new influenza virus infection in turkeys. I. Isolation and characterization of virus 6213. Can Vet J 9(1), 22-29. Lee, M.S., Chang, P.C., Shien, J.H., Cheng, M.C., Shieh, H.K., 2001. Identification and subtyping of avian influenza viruses by reverse transcription-PCR. J Virol Methods 97(1-2), 13-22. Lee, M.S., Deng, M.C., Lin, Y.J., Chang, C.Y., Shieh, H.K., Shiau, J.Z., Huang, C.C., 2007. Characterization of an H5N1 avian influenza virus from Taiwan. Vet Microbiol 124(3-4), 193-201. Lim, A.P., Wong, S.K., Chan, A.H., Chan, C.E., Ooi, E.E., Hanson, B.J., 2008. Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1. Virol J 5, 80. Liu, T., Ye, Z., 2002. Restriction of viral replication by mutation of the influenza virus matrix protein. J Virol 76(24), 13055-13061. Luo, Q., Huang, H., Zou, W., Dan, H., Guo, X., Zhang, A., Yu, Z., Chen, H., Jin, M., 2009. An indirect sandwich ELISA for the detection of avian influenza H5 subtype viruses using anti-hemagglutinin protein monoclonal antibody. Vet Microbiol 137(1-2), 24-30. Lupiani, B., Reddy, S.M., 2009. The history of avian influenza. Comp Immunol Microbiol Infect Dis 32(4), 311-323. Meulemans, G., Carlier, M.C., Gonze, M., Petit, P., 1987. Comparison of hemagglutination-inhibition, agar gel precipitin, and enzyme-linked immunosorbent assay for measuring antibodies against influenza viruses in chickens. Avian Dis 31(3), 560-563. Mibayashi, M., Martinez-Sobrido, L., Loo, Y.M., Cardenas, W.B., Gale, M., Jr., Garcia-Sastre, A., 2007. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 81(2), 514-524. Naeem, K., Hussain, M., 1995. An outbreak of avian influenza in poultry in Pakistan. Vet Rec 137(17), 439. Neumann, G., Watanabe, T., Ito, H., Watanabe, S., Goto, H., Gao, P., Hughes, M., Perez, D.R., Donis, R., Hoffmann, E., Hobom, G., Kawaoka, Y., 1999. Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96(16), 9345-9350. O'Neill, R.E., Jaskunas, R., Blobel, G., Palese, P., Moroianu, J., 1995. Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import. J Biol Chem 270(39), 22701-22704. O'Neill, R.E., Talon, J., Palese, P., 1998. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J 17(1), 288-296. Palese, P., Shaw, M.L., (Eds.), 2007. Orthomyxoviridae: The Viruses and Their Replication. 5 ed. Fields Virology. Edited by D.M., K., P.M., H. Lippincott Williams & Wilkins, Philadelphia. Palese, P., Tobita, K., Ueda, M., Compans, R.W., 1974. Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology 61(2), 397-410. Palese, P., Young, J.F., 1982. Variation of influenza A, B, and C viruses. Science 215(4539), 1468-1474. Pasick, J., Handel, K., Robinson, J., Copps, J., Ridd, D., Hills, K., Kehler, H., Cottam-Birt, C., Neufeld, J., Berhane, Y., Czub, S., 2005. Intersegmental recombination between the haemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia. J Gen Virol 86(Pt 3), 727-731. Pedersen, J.C., 2008a. Hemagglutination-inhibition test for avian influenza virus subtype identification and the detection and quantitation of serum antibodies to the avian influenza virus. Methods Mol Biol 436, 53-66. Pedersen, J.C., 2008b. Neuraminidase-inhibition assay for the identification of influenza A virus neuraminidase subtype or neuraminidase antibody specificity. Methods Mol Biol 436, 67-75. Peiris, J.S., de Jong, M.D., Guan, Y., 2007. Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 20(2), 243-267. Perales, B., Sanz-Ezquerro, J.J., Gastaminza, P., Ortega, J., Santaren, J.F., Ortin, J., Nieto, A., 2000. The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis. J Virol 74(3), 1307-1312. Peterson, E., Ryser, T., Funk, S., Inouye, D., Sharma, M., Qin, H., Cross, T.A., Busath, D.D., 2011. Functional reconstitution of influenza A M2(22-62). Biochim Biophys Acta 1808(2), 516-521. Potter, C.W., 2001. A history of influenza. J Appl Microbiol 91(4), 572-579. Pregliasco, F., Mensi, C., Camorali, L., Anselmi, G., 1998. Comparison of RT-PCR with other diagnostic assays for rapid detection of influenza viruses. J Med Virol 56(2), 168-173. Regan, J.F., Liang, Y., Parslow, T.G., 2006. Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. J Virol 80(1), 252-261. Reichert, J., Pavolu, A., 2004. Monoclonal antibodies market. Nat Rev Drug Discov 3(5), 383-384. Richardson, J.C., Akkina, R.K., 1991. NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells. Arch Virol 116(1-4), 69-80. Rimmelzwaan, G.F., van Riel, D., Baars, M., Bestebroer, T.M., van Amerongen, G., Fouchier, R.A., Osterhaus, A.D., Kuiken, T., 2006. Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts. Am J Pathol 168(1), 176-183; quiz 364. Roberts, P.C., Lamb, R.A., Compans, R.W., 1998. The M1 and M2 proteins of influenza A virus are important determinants in filamentous particle formation. Virology 240(1), 127-137. Rohm, C., Zhou, N., Suss, J., Mackenzie, J., Webster, R.G., 1996. Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes. Virology 217(2), 508-516. Rossman, J.S., Jing, X., Leser, G.P., Balannik, V., Pinto, L.H., Lamb, R.A., 2010. Influenza virus m2 ion channel protein is necessary for filamentous virion formation. J Virol 84(10), 5078-5088. Saleem, M., Mustafa, K., 2010. Monoclonal antibodies in clinical diagnosis: A brief review application. African Journal of Biotechnology 7(8). Sawada, T., Fedorov, D.G., Kitaura, K., 2010. Role of the key mutation in the selective binding of avian and human influenza hemagglutinin to sialosides revealed by quantum-mechanical calculations. J Am Chem Soc 132(47), 16862-16872. Sawyer, L.A., 2000. Antibodies for the prevention and treatment of viral diseases. Antiviral Res 47(2), 57-77. Scholtissek, C., (Ed.) 2008. history of research on avian influenza. Vol. 27. avian influenza. Edited by Klenk, H.D., matrosovich, M.N., Stech, J. karger, Basel. Shaw, M.W., Lamon, E.W., Compans, R.W., 1982. Immunologic studies on the influenza A virus nonstructural protein NS1. J Exp Med 156(1), 243-254. Shinya, K., Ebina, M., Yamada, S., Ono, M., Kasai, N., Kawaoka, Y., 2006. Avian flu: influenza virus receptors in the human airway. Nature 440(7083), 435-436. Shope, R.E., 1931. Swine Influenza : I. Experimental Transmission and Pathology. J Exp Med 54(3), 349-359. Songserm, T., Amonsin, A., Jam-on, R., Sae-Heng, N., Pariyothorn, N., Payungporn, S., Theamboonlers, A., Chutinimitkul, S., Thanawongnuwech, R., Poovorawan, Y., 2006. Fatal avian influenza A H5N1 in a dog. Emerg Infect Dis 12(11), 1744-1747. Spackman, E., Senne, D.A., Myers, T.J., Bulaga, L.L., Garber, L.P., Perdue, M.L., Lohman, K., Daum, L.T., Suarez, D.L., 2002. Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes. J Clin Microbiol 40(9), 3256-3260. Spackman, E., Suarez, D.L., 2008. Detection and identification of the H5 hemagglutinin subtype by real-time RT-PCR. Methods Mol Biol 436, 27-33. Spackman, E., Suarez, D.L., Senne, D., (Eds.), 2008. Avian Influenza Diagnosis and Surveillance Methods. 1 ed. Avian Influenza. Edited by Swayne, D.E. Blackwell, Ames, Iowa. Stallknecht, D.E., Shane, S.M., Kearney, M.T., Zwank, P.J., 1990. Persistence of avian influenza viruses in water. Avian Dis 34(2), 406-411. Starick, E., Romer-Oberdorfer, A., Werner, O., 2000. Type- and subtype-specific RT-PCR assays for avian influenza A viruses (AIV). J Vet Med B Infect Dis Vet Public Health 47(4), 295-301. Suarez, D.L., 2000. Evolution of avian influenza viruses. Vet Microbiol 74(1-2), 15-27. Suarez, D.L., Schultz-Cherry, S., 2000. Immunology of avian influenza virus: a review. Dev Comp Immunol 24(2-3), 269-283. Suzuki, T., Takahashi, T., Guo, C.T., Hidari, K.I., Miyamoto, D., Goto, H., Kawaoka, Y., Suzuki, Y., 2005. Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication. J Virol 79(18), 11705-11715. Swayne, D.E., Halvorson, D.A., (Eds.), 2003. Influenza. 11 ed. Disease of Poultry. Edited by Saif, Y.M., Barnes, H.J., Glisson, J.R., Fadly, A.M., McDougald, L.R., Swayne, D.E. Iowa State University Pression. To, K.F., Chan, P.K., Chan, K.F., Lee, W.K., Lam, W.Y., Wong, K.F., Tang, N.L., Tsang, D.N., Sung, R.Y., Buckley, T.A., Tam, J.S., Cheng, A.F., 2001. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 63(3), 242-246. Tweed, S.A., Skowronski, D.M., David, S.T., Larder, A., Petric, M., Lees, W., Li, Y., Katz, J., Krajden, M., Tellier, R., Halpert, C., Hirst, M., Astell, C., Lawrence, D., Mak, A., 2004. Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis 10(12), 2196-2199. Van Deusen, R.A., Hinshaw, V.S., Senne, D.A., Pellacani, D., 1983. Micro neuraminidase-inhibition assay for classification of influenza A virus neuraminidases. Avian Dis 27(3), 745-750. Velkers, F.C., Bouma, A., Matthijs, M.G., Koch, G., Westendorp, S.T., Stegeman, J.A., 2006. Outbreak of avian influenza H7N3 on a turkey farm in the Netherlands. Vet Rec 159(13), 403-405. Velumani, S., Du, Q., Fenner, B.J., Prabakaran, M., Wee, L.C., Nuo, L.Y., Kwang, J., 2008. Development of an antigen-capture ELISA for detection of H7 subtype avian influenza from experimentally infected chickens. J Virol Methods 147(2), 219-225. Webster, R., Krauss, S., Programme, W.H.O.G.I., 2002. WHO manual on animal influenza diagnosis and surveillance. World Health Organization, Dept. of Communicable Disease Surveillance and Response. Webster, R., Yakhno, M., Hinshaw, V., Bean, W., Copal Murti, K., 1978. Intestinal influenza: replication and characterization of influenza viruses in ducks. Virology 84(2), 268-278. Webster, R.G., Bean, W.J., Gorman, O.T., Chambers, T.M., Kawaoka, Y., 1992. Evolution and ecology of influenza A viruses. Microbiol Rev 56(1), 152-179. Webster, R.G., Shortridge, K.F., Kawaoka, Y., 1997. Influenza: interspecies transmission and emergence of new pandemics. FEMS Immunol Med Microbiol 18(4), 275-279. Wong, S.S., Yuen, K.Y., 2006. Avian influenza virus infections in humans. Chest 129(1), 156-168. Woolcock, P.R., 2008. Avian influenza virus isolation and propagation in chicken eggs. Methods Mol Biol 436, 35-46. Woolcock, P.R., Cardona, C.J., 2005. Commercial immunoassay kits for the detection of influenza virus type A: evaluation of their use with poultry. Avian Dis 49(4), 477-481. Wright, P.F., Webster, R.G., 2001. Orthomyxoviridae. fourth ed. Fields Virology, edited by Knipe, D.M., Howley, P.M., 1. Lippincott Williams and Wilkins, Philadelphia, PA. Xu, K., Klenk, C., Liu, B., Keiner, B., Cheng, J., Zheng, B.J., Li, L., Han, Q., Wang, C., Li, T., Chen, Z., Shu, Y., Liu, J., Klenk, H.D., Sun, B., 2011. Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1. J Virol 85(2), 1086-1098. Yang, M., Berhane, Y., Salo, T., Li, M., Hole, K., Clavijo, A., 2008. Development and application of monoclonal antibodies against avian influenza virus nucleoprotein. J Virol Methods 147(2), 265-274. Yuen, K.Y., Chan, P.K., Peiris, M., Tsang, D.N., Que, T.L., Shortridge, K.F., Cheung, P.T., To, W.K., Ho, E.T., Sung, R., Cheng, A.F., 1998. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 351(9101), 467-471. Zambon, M., 1999. Cell culture for surveillance on influenza. Dev Biol Stand 98, 65-71; discussion 73-64. Zanella, A., 2003. Avian influenza attributable to serovar H7N1 in light layers in Italy. Avian Dis 47(3 Suppl), 1177-1180. Zhang, A., Jin, M., Liu, F., Guo, X., Hu, Q., Han, L., Tan, Y., Chen, H., 2006. Development and evaluation of a DAS-ELISA for rapid detection of avian influenza viruses. Avian Dis 50(3), 325-330. Ziegler, A.F., Davison, S., Acland, H., Eckroade, R.J., 1999. Characteristics of H7N2 (nonpathogenic) avian influenza virus infections in commercial layers, in Pennsylvania, 1997-98. Avian Dis 43(1), 142-149. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48311 | - |
dc.description.abstract | 家禽流行性感冒病毒 (Avian influenza virus, AIV) 除了造成養禽場重大經濟損失外,因其具人畜共通之風險,近年來為世界所關注,快速、敏感性及特異性高的診斷方法或檢測工具便有迫切需求,而單源抗體 (MAb) 憑著對抗原的高特異性及專一性,乃為生醫領域所廣泛應用。本研究室利用2003年台灣分離到的病毒株A/chicken/Taiwan/1209/03 (H5N2),製備出抗AIV的MAb共3株,以血球凝集抑制試驗 (hemagglutination inhibition test, HI test) 及病毒中和試驗 (virus neutralization test, VN test) 發現,其中兩株UB-4a及YB-4a具有HI力價及病毒中和能力,且西方墨點法 (western blot assay) 結果顯示具有辨識病毒表面醣蛋白血球凝集素 (hemagglutinin, HA, 75 kDa) 的能力。另一株單源抗體WF-4b利用西方墨點法發現可辨識病毒核蛋白 (nucleoprotein, NP, 56 kDa),且與10種HA亞型病毒感染的狗腎細胞 (Madin-Darby canine kidney, MDCK) 之免疫螢光染色(immunofluorescence assay, IFA),均呈陽性反應,將其應用於實驗感染AIV雞隻免疫組織化學染色 (immunohistochemistry, IHC),及原核系統 (prokaryotic) 所表現AIV重組NP蛋白質等皆可辨識,希望未來能利用WF-4b之特性,發展敏感性與特異性均高之診斷工具與方法,如ELISA、免疫組織化學染色等,或是應用於病毒學的相關研究。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-15T06:52:08Z (GMT). No. of bitstreams: 1 ntu-100-R97629031-1.pdf: 2119368 bytes, checksum: 9746d4f3348107138561f3b0aa876d34 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 口試委員會審定書 i
致謝 ii 中文摘要 iii Abstract iv 第一章 序言 8 第二章 文獻回顧 10 第一節 歷史背景 10 第二節 病毒之特性 12 2-2.1 病毒特徵 12 2-2.2 病毒型態、結構及功能 13 2-2.2.1 血球凝集素 (hemagglutinin, HA) 13 2-2.2.2 神經胺酸酶 (neuraminidase, NA) 14 2-2.2.3 核蛋白 (nucleoprotein, NP) 14 2-2.2.4 基質蛋白 (matrix protein, M) 15 2-2.2.5 非結構性蛋白 (nonstructural protein, NS) 15 2-2.2.6 聚合酶蛋白 (polymerase protein) 16 2-2.3 病毒複製 16 2-2.4 病毒的物理化學特性 17 2-2.5 病毒抗原變異性 17 第三節 實驗室診斷 18 2-3.1 偵測抗原 18 2-3.1.1 雞胚胎蛋增殖病毒 18 2-3.1.2 細胞培養 18 2-3.1.3 血球凝集試驗 (hemagglutination test, HA test) 19 2-3.1.4 反轉錄聚合酶鏈反應 (reverse transcription-polymerase chain reaction, RT-PCR) 19 2-3.1.5 抗原免疫偵測套組 (antigen detection immunoassay kit) 20 2-3.2 偵測抗體 20 2-3.2.1 瓊脂膠體免疫擴散法 (agar gel immunodiffusion, AGID) 20 2-3.2.2 血球凝集抑制試驗 (hemagglutination inhibition test, HI test) 20 2-3.2.3 神經胺酸酶抑制試驗 (neuraminidase inhibition test, NI test) 21 2-3.2.4 酵素連結免疫吸附法 (enzyme-linked immunosorbent assay, ELISA) 21 第四節 單源抗體 22 2-4.1 歷史背景 22 2-4.2 篩選融合瘤細胞原理 22 2-4.3 單源抗體之應用 23 第三章 材料方法 24 第一節 家禽流行性感冒病毒 24 3-1.1 家禽流行性感冒病毒毒株 24 3-1.2 家禽流行性感冒病毒增殖及濃縮 24 3-1.3 反向遺傳技術 (reverse genetic technique) 製備家禽流行性感冒病毒 25 第二節 抗家禽流行性感冒病毒之單源抗體製備 25 3-2.1 實驗動物 25 3-2.2 免疫計畫 25 3-2.3 骨髓瘤細胞培養 26 3-2.4 細胞融合 26 3-2.5 融合瘤細胞培養 27 3-2.6 陽性親代融合瘤細胞篩選 27 3-2.6.1 免疫螢光染色法(IFA) 27 3-2.7 陽性融合瘤細胞單株化 28 3-2.8 小鼠腹水之生產 28 第三節 單源抗體 29 3-3.1 單源抗體之亞型分析 29 3-3.2 單源抗體之特性分析 29 3-3.2.1 病毒中和試驗 (virus neutralization test, VN test) 29 3-3.2.2 紅血球凝集素抑制試驗 (hemagglutination inhibition test, HI test) 30 3-3.2.3 免疫螢光染色法(IFA) 30 3-3.2.4 聚丙烯醯胺膠片電泳 (sodium dodecyl sulfate-polyacrylamide gel electrophoresis, SDS-PAGE) 及西方墨點法 (western blot assay) 30 第四節 MAb辨識家禽流行性感冒病毒核蛋白 (neucleoprotein, NP) 之確認 32 3-4.1 免疫組織化學染色 ( IHC) 32 3-4.2 家禽流行性感冒病毒NP蛋白基因選殖 33 3-4.2.1 增幅基因 33 3-4.2.1.1 引子 (primer) 設計 33 3-4.2.1.2 質體之萃取 33 3-4.2.1.3 PCR 增幅NP蛋白基因 34 3-4.2.1.4 NP蛋白基因之確認 34 3-4.2.1.5 NP蛋白基因之純化 35 3-4.2.2 重組質體之構築 35 3-4.2.2.1 限制酶酵素切割 (digestion) 35 3-4.2.2.2 接合反應 (ligation) 36 3-4.2.2.3 轉型作用(transformation) 36 3-4.2.2.4 確認重組質體 36 3-4.2.2.5 重組質體之定序 37 3-4.3 重組NP蛋白質之分析 38 3-4.3.1 重組NP蛋白質之表現 38 3-4.3.2 重組NP蛋白之純化 38 3-4.3.3 重組NP蛋白質之電泳分析與確認 39 第四章 結果 40 第一節 H5亞型家禽流行性感冒病毒單源抗體製備 40 4-1.1 H5病毒濃縮之結果 40 4-1.2 融合瘤細胞之篩選 40 第二節 H5亞型家禽流行性感冒病毒單源抗體特性分析 40 4-2.1 單源抗體亞型分析 40 4-2.2 單源抗體中和能力之分析 41 4-2.3 單源抗體血球凝集抑制能力之分析 41 4-2.4 免疫螢光染色法 ( IFA) 41 4-2.5 SDS-PAGE及西方墨點法 41 第三節 抗家禽流行性感冒病毒核蛋白之確認 42 4-3.1 NP蛋白基因之確認 42 4-3.2 重組質體之構築 42 4-3.3 重組NP蛋白質之表現與純化 42 4-3.4 重組NP蛋白質之SDS-PAGE及西方墨點法 43 第四節 單源抗體WF-4b應用於IHC 43 第五章 討論 44 參考文獻 61 附錄 74 | |
dc.language.iso | zh-TW | |
dc.title | 抗家禽流行性感冒病毒單源抗體之特性分析及應用 | zh_TW |
dc.title | Characterization and Application of Monoclonal Antibodies against Avian Influenza Virus | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 王金和,蔡向榮,李淑慧,陳啟銘 | |
dc.subject.keyword | 家禽流行性感冒病毒,單源抗體,核蛋白,免疫螢光染色法,免疫組織化學染色, | zh_TW |
dc.subject.keyword | Avian infl,uenza virus (AIV),monoclonal antibody (MAb),nucleoprotein (NP),immunofluorescence assay (IFA),immunohistochemistry (IHC), | en |
dc.relation.page | 75 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-02-14 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-100-1.pdf 目前未授權公開取用 | 2.07 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。