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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蔡詩偉 | |
dc.contributor.author | Po-Chen Hung | en |
dc.contributor.author | 洪粕宸 | zh_TW |
dc.date.accessioned | 2021-06-15T06:48:11Z | - |
dc.date.available | 2014-10-03 | |
dc.date.copyright | 2011-10-03 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-05-12 | |
dc.identifier.citation | American Conference of Governmental Industrial Hygienists (ACGIH). 2010 TLVs® and BEIs®: based on the documentation of the Threshold Limit Values for chemical substances and physical agents & Biological Exposure Indices. ACGIH, Cincinnati, OH.
American Conference of Governmental Industrial Hygienists (ACGIH). Documentation of the threshold limit values and biological esposure indices: 2-butoxyethanol. 2003. ACGIH, Cincinnati, OH. American Conference of Governmental Industrial Hygienists (ACGIH). Documentation of the threshold limit values and biological esposure indices: 2-butoxyethanol BEI. 2007. ACGIH, Cincinnati, OH. American Conference of Governmental Industrial Hygienists (ACGIH). 2009 Guide to occupational exposure values. ACGIH, Cincinnati, OH. Amoore JE; Hautala E: Odor as an aid to chemical safety: odor thresholds compared with Threshold Limit Values and volatilities for 214 industrial chemicals in air and water dilution. J Appl Toxicol 3:272–290 (1983). Angerer J, Lichterbeck E, Begerow J, et al.: Occupational chronic exposure to organic solvents. XIII. Glycol ether exposure during the production of varnishes. Int Arch Occup Environ Health 62:123–126 (1990). Arand M, Muhlbauer R, Hengstler J, Jager E, Fuchs J, Winkler L, et al. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S - transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 236:184-6 (1996). Aratani Y, Kura F, Watanabe H, et al. In vivo role of myeloperoxidase for the host defense. Jpn J Infect Dis 57:S15 (2004). Asami S, Hirano T, Yamaguchi R, Tomioka Y, Itoh H, Kasai H. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. Cancer Res 56:2546-2549 (1996). Asami S, Manabe H, Miyake J, Tsurudome Y, Hirano T, Yamaguchi R, Itoh H, Kasai H. Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis 18: 1763-1766 (1997). Bartnik FG, Reddy AK, Kleack G, et al.: Percutaneous absorption of 2-butoxyethanol in man. Fundam Appl Toxicol 8:59–70 (1987). Bartnik FG, Reddy AK, Klecak G, et al.: Percutaneous absorption, metabolism, and hemolytic activity on nbutoxyethanol. Fundam Appl Toxicol 8:59–70 (1987). Blankenberg S, Rupprecht HJ, Bickel C, et al.: Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 349(17): 1605-13 (2003). Carpenter CP; Pozzani UC; Weil CS; et al.: The toxicity of butyl cellosolve solvent. AMA Arch Ind Health 14:114–131 (1956). Cascorbi I, Brockmoller J, Roots I. A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages and impact on lung cancer susceptibility. Cancer Res 56: 4965-9 (1996). Chen RY, Lin CK. Recognition of the Hazards and Uses of Glycol Ethers in Taiwan. Journal of National Public Health Association Republic of China 12: 40-56 (1993). Christine EW, Nevilee D. The influence of age on the spatial and temporal contrast sensitivity function. Documenta Ophthalmologica 59(4): 385-395 (1985). Cocker J: Correspondence on file at Headquarters. ACGIH, Cincinnati, OH (2003). Corley RA: Assessing the risk of hemolysis in humans exposed to 2-butoxyethanol using a physiologically based-pharmacokinetic model. Occup Hyg 2:45–55 (1996). Corley RA; Bormett GA; Ghanayem BI: Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans. Toxicol Appl Pharmacol 129:61–79 (1994). Corley RA; Markham DA; Banks C; et al.: Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans. Fundam Appl Toxicol 39:120–130 (1997). Cosma G, Crofts F, Taioli E, Toniolo P, Garte S. Relationship between genotype and function of the human CYP1A1 gene. J Toxicol Environ health 40: 309-16 (1993). Cosmetic Ingredient Review Panel, Cosmetic, Toiletry, and Fragrance Association (CIRPCTFA): Final report on the safety assessment of butoxyethanol. J Am Coll Toxicol 15:462–526 (1996). Crofts F, Cosma GN, Currie D, Taioli E, Toniolo P, Garte SJ. A novel CYP1A1 gene polymorphism in African-Americans. Carcinogenesis 14: 1729-31 (1993). Curtis D. K., Casarett and Doull's toxicology : the basic science of poisons. New York : McGraw-Hill: 565-595 (2001). Deutche Forschungsgemeinschaft (DFG). List of MAK and BAT Values 2007. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Report 43. Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, FRG (2007). Dornow R; Knecht U; Matulla Ch; Woitowitz H-J: Influence of ethanol on biomonitoring after standardized exposure to butoxyethanol. Verh D Ges Arb Med 30:273–277 (1990). Dugard PH; Walker M; Mawdsley SJ; Scott RC: Absorption of some glycol ethers through human skin in vitro. Environ Health Perspect 57:193–197 (1984). European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). Butoxyethanol. Criteria Document 7. ECETOC, Belgium (1994). Franks SJ, Spendiff MK, Cocker J, Loizou GD. Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol. Toxicol Lett. 162(2-3): 164-73 (2006). Frenette B, Mergler D, Bowler R. Contrast-sensitivity loss in a group of former microelectronics workers with normal visual acuity. Optom Vis Sci 68(7): 556-560 (1991). Geller AM. A table of color distance scores for quantitative scoring of the Lanthony Desaturate color vision test. Neurotoxicol Teratol 23(3): 265-267 (2001). Ghanayem BI: Metabolic and cellular basis for 2-butoxyethanol induced hemolytic anemia in rats and assessment of human risk in vitro. Biochem Pharmacol 38:1670–1684 (1989). Ghanayem BI; Burka LT; Matthews HB: Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of alcohol and aldehyde dehydrogenases. J Pharmacol Exp Ther 242:222–231 (1987). Ghanayem BI; Burka LT; Sanders JM; Matthews HB: Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Drug Metab Disp 15:478–484 (1987). Ghanayem BI; Sullivan CA: Assessment of the hemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Human Exp Toxicol 12:305–311 (1993). Gingell R; Boatman RJ; Bus JS; et al.: Glycol ethers and other selected glycol derivatives. In: Patty's Industrial Hygiene and Toxicology, 4th ed., Vol. II, Part D, Toxicology, pp. 2761–2966. G.D. Clayton and F.E. Clayton, Eds. John Wiley & Sons, New York (1994). Ginsburg AP. Contrast sensitivity: determining the visual quality and function of cataract, intraocular lenses and refractive surgery. Current Opinion in Ophthalmology 17:19-26 (2006). Gobba F. Color vision: a sensitive indicator of exposure to neurotoxins. Neurotoxicology 21(5): 857-862 (2000). Good GW, Schepler A, Nichols JJ. The Reliability of the Lanthony Desaturated D-15 Test. Optometry and Vision Science 82(12): 1054-1059 (2005). Groeseneken V; Van Vlem E; Veulemans H; Masschelein R: Gas chromatographic determination of methoxyacetic acid and ethoxyacetic acid in urine. Br J Ind Med 43:62–65. (1986). Haufroid V; Thirion F; Mertens P; et al.: Biological monitoring of workers exposed to low levels of 2-butoxy-ethanol. Int Arch Occup Environ Health 70:232–236 (1997). Hayashi S, Watamabe J, Nakachi K, Kawajiri K. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in heme binding region of the human cytochrome P4501A1 gene. J Biochem 110: 407-11 (1991). Health and Safety Executive (HSE): 2-Butoxyethanol. In: Sum-mary Criteria for Occupational Exposure Limits 2-Butox-yethanol, D-90. EH64. HSE Books, Suffolk, UK (1998). Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Vainio H. The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population. Carcinogenesis 14: 85-8 (1993). Howe JW, Mitchell KW. The objective assessment of contrast sensitivity function by electrophysiological means. Br J Ophthalmol 68(9): 626-638 (1984). Jakasa I; Mohammadi N; Kruse J; Kezic S: Percutaneous absorption of neat and aqueous solutions of 2-butoxyethanol in volunteers. Int Arch Occup Environ Health 77(2):79–84 (2004). Johanson G: Physiologically based pharmacokinetic modeling of inhaled 2-butoxyethanol in man. Toxicol Lett 34:23–31 (1986). Johanson G; Boman A: Percutaneous absorption of 2-butoxyethanol vapour in human subjects. Br J Ind Med 48:788–792 (1991). Johanson G; Boman A; Dynesius B: Percutaneous absorption of 2-butoxyethanol in man. Scand J Work Environ Health 14:101–109 (1988). Johanson G; Fernstrom P: Influence of water on the percutaneous absorption of 2-butoxyethanol in guinea pigs. Scand J Work Environ Health 14:115–120 (1988). Johanson G; Fernstrom P: Percutaneous uptake rate of 2-butoxyethanol in the guinea pig. Scand J Work Environ Health 12:499–503 (1986). Johanson G; Johnsson S: Gas chromatographic determination of butoxyacetic acid in human blood after exposure to 2-butoxyethanol. Arch Toxicol 65:433–435 (1991). Johanson G; Kronborg H; Naslund PH; Byfalt NM: Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man. Scand J Work Environ Health 12:594-602 (1986). Jones K; Cocker J: A human exposure study to investigate biological monitoring methods for 2-butoxyethanol. Biomarkers 8:360–370 (2003). Jones K; Cocker J; Dodd L; Frazier I: Factors affecting the extent of dermal absorption of solvent vapours: a human volunteer study. Ann Occup Hyg 47:145–150 (2003). Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watunabe J. Identification of genetically high risk individuals to lung cancer by DNA polymorphism of the cytochrome P4501A1 gene. FEBS letter 263: 131-3 (1990). Kawajiri K, Watanable J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y. Structure and drug inducibility of the human cytochrome P-450c gene. Eur J Biochem 159: 219-25 (1986). Kezic S; Meuling JA; Jakasa I: Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers. Int Arch Occup Environ Health 77:580–586 (2004). Kiyosawa H, Suko M, Okudaira H, Murata K, Miyamoto T, Chung MH, Kasai H, Nishimura S. Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes. Free Radic Res Commun 11: 23-27 (1990). Knecht U; Woitowitz H-J: Glykol-Emissionen bei der handverklichen Verabeitung von Farben und Lackenosure to butoxyethanol. Verh D Ges Arb Med 30:317–320 (1990). Krasavage W: Subchronic oral toxicity of ethylene glycol monobutyl ether in male rats. Fundam Appl Toxicol 6:349–355 (1986). Lagorio S, Tagesson C, Forastiere F, Iavarone I, Axelson O, Carere A. Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative DNA damage. Occup Environ Med 51: 739-743 (1994). Laitinen J: Correspondence between occupational exposure limit and biological action level values for alkoxyethanols and their acetates. Int Arch Occup Environ Health 71:117–124 (1998). Laitinen J; Liesivuori J; Savolainen H: Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates. J Occup Environ Med 40:595–600 (1998) Lodovici M, Casalini C, Cariaggi R, Michelucci L, Dolara P. Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes. Free Radic Biol Med 28: 13-17 (2000). Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 13: 2241-2247 (1992). Mecocci P, Fano G, Fulle S, Macgarvey U, Shinobu L, et al.Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Rad Biol & Med 26: 303-308 (1999). Medinsky MA; Singh G; Bechtold WE; et al.: Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol 102:443–455 (1990). Merck & Co., Inc.: Butyl Cellosolve. In: The Merck Index, 12th edition on CD-ROM, Version 12:1. S Budavari, M O’Neil, A Smith, et al., Eds. Chapman & Hall, New York (1996). Nomiyama T, Nakashima H, Sano Y, Chen LL, Tanaka S, Miyauchi H, et al. Does the polymorphism of cytochrome P-450 2E1 affect the metabolism of N,N-dimethylformamide?Comparison of the half-lives of urinary N-methylformamide. Arch Toxicol 74:755-9 (2001). Park J, Kamendulis LM, Klaunig JE, Effects of 2-butoxyethanol on hepatic oxidative damage. Toxicology Letters. 126: 19–29 (2002). Petersen DD, McKinney CE, Ikeya K et al. Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. Am J Hum Genet 48: 720-5 (1991). Pilger A, Germadnik D, Riedel K, Meger-Kossien I, Scherer G, Rudiger HW. Longitudinal study of urinary 8-hydroxy-2’-deoxyguanosine excretion in healthy adults. Free Radic Res 35: 273- 280 (2001). Pilger A, Rüdiger HW. 8-Hydroxy-2’-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health 80: 1-15 (2006). Pourcelot S, Faure H, Firoozi F, Ducros V, Tripier M, Hee J, Cadet J, Favier A. Urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine and 5-(hydroxymethyl) uracil in smokers. Free Radic Res 30: 173- 180 (1999). Prieme H, Loft S, Klarlund M, Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation on oxidative DNA modiWcation estimated by 8-oxo-7,8-dihydro-2’-deoxyguanosine excretion. Carcinogenesis 19: 347- 351 (1998). Prieme H, Loft S, Nyyssonen K, Salonen JT, Poulsen HE. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2’-deoxyguanosine excretion in smokers. Am J Clin Nutr 65: 503-507 (1997). Rambourg-Schepens MO; Buffet M; Bertault R; et al.: Severe ethylene glycol butyl ether poisoning: Kinetics and metabolic pattern. Human Toxicol 7:187–189 (1988). Rettenmeier AW; Hennigs R; Wodarz R: Determination of butoxyacetic acid and N-butoxyacetyl-glutamine in urine of lacquerers exposed to 2-butoxyethanol. Int Arch Occup Environ Health 65:S151–S153 (1993). Romer KG; Balge F; Freundt KJ: Ethanol-induced accumulation of ethylene glycol monoalkyl ethers in rats. Drug and Chemical Toxicology 84:255–264 (1985) Sakai T; Araki T; Masuyama Y: Determination of urinary alkoxyacetic acids by a rapid and simple method for biological monitoring of workers exposed to glycol ethers and their acetates. Int Arch Occup Environ Health 64:495-498 (1993). Sakai T; Araki T; Morita Y; Masuyama Y: Gas chromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. Int Arch Occup Environ Health 66:249-254 (1994). Schreiber JS, Hudnell HK, Geller AM, House DE, Aldous KM, Force MS, Langguth K, Prohonic EJ, Parker JC. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ Health Perspect. 110(7): 655-664 (2002). Semple S, Dick F, Osborne A, et al. Impairment of colour vision in workers exposed to organic solvents. Occup Environ Med 57:582–587 (2000). Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the Total Antioxidant Capacity the right tool? Redox Rep 9(3): 145-152 (2004). Shukla V, Abusaria S, Dhankhar M, Sastry KV. Epidemiological studies on bicycle manufacturing industrial workers. J Environ Biol 28(3): 597-600 (2007). Söderkvist P, Ahmadi A, Åkerback A, et al. Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. Scand J Work Environ Health 22:360–3 (1996). Sohnlein B; Letzel S; Weltle D; et al.: HW, Angerer J. Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int Arch Occup Environ Health 64:479-484 (1993). Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-S-transferase family of enzymes. Mut Res 482: 21-6 (2001). Tagesson C, Chabiuk D, Axelson O, Baranski B, Palus J, Wyszynska K. Increased urinary excretion of the oxidative DNA adduct, 8-hydroxydeoxyguanosine, as a possible early indicator of occupational cancer hazards in the asbestos, rubber, and azo-dye industries. Pol J Occup Med Environ Health 6: 357-368 (1993). Tagesson C, Kallberg M, Wingren G. Urinary malondialdehyde and 8-hydroxydeoxyguanosine as potential markers of oxidative stress in industrial art glass workers. Int Arch Occup Environ Health 69: 5-13 (1996). Takeuchi Y. Visual disorders due to organic solvent poisoning. Sangyo Igaku 30(4): 236-247 (1988). Toshihiro K, Minoru k, Kazuhiro m, et al., Effects of ALDH2, CYP1A1, and CYP2E1 Genetic Polymorphisms and Smoking and Drinking Habits on Toluene Metabolism in Humans. Toxicology and Applied Pharmacology 133: 295-304 (1995). Traynor MJ, Wilkinson SC, Williams FM. Metabolism of butoxyethanol in excised human skin in vitro. Toxicol Lett 177(3): 151-5 (2008). Traynor MJ, Wilkinson SC, Williams FM. The influence of water mixtures on the dermal absorption of glycol ethers. Toxicol Appl Pharmacol 218(2): 128-34 (2007). Tung-Sheng Shih, Jui-Shu Chou, Cheng-Yo Chen; Thomas J Smith. Improved method to measure urinary alkoxyacetic acids. Occupational and environmental medicine 56(7): 460-7 (1999). Tyler TR: Acute and subchronic toxicity of ethylene glycol monobutyl ether. Environ Health Perspect 57:185–191 (1984). U.S. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate, Draft. DHHS, ATSDR, Atlanta, GA (1996). U.S. National Institute for Occupational Safety and Health (NIOSH): Criteria for a Recommended Standard: Occupational Exposure to Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate. DHHA (NIOSH) Pub. No. 90-188. NIOSH, Cincinnati, OH (1991). U.S. National Toxicology Program (NTP): Ethylene glycol ethers: 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3F1 mice. NTP Toxicity report series no. 26. NTP, Research Triangle Park, NC (1992). U.S. National Toxicology Program (NTP): Toxicology and carcinogenesis studies of 2-butoxyethanol (CAS NO. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). TR-484. NTP Research Triangle Park, NC (2000). Udden MM: Hemolysis and deformability of erythrocytes exposed to 2-butoxyacetic acid, a metabolite of 2-butoxyethanol. II. Resistance in red blood cells from humans with potential susceptibility. J Appl Toxicol 14:97–102 (1994). Udden MM; Patton CS: Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol. I. Sensitivity in rats and resistance in normal humans. J Appl Toxicol 14:91–96 (1994). Van Zeeland AA, de Groot AJL, Hall J, Donato F. 8-Hydroxydeoxyguanosine in DNA from leukocytes of healty adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coVee consumption. Mutat Res 439: 249-257 (1999). Vincent R; Cicolella A; Subra I; et al.: Occupational exposure to 2-butoxyethanol for workers using window cleaning agents. Appl Occup Environ Hyg.8:580–586 (1993). Vincent R; Reiger B; Subra I; Poirot P: Exposure assessment to glycol ethers by atmospheric and biological monitoring. Occup Hyg 2:79–90 (1996). Wilkinson SC; Willimams FM: Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. Int Arch Occup Environ Health 75:519–527 (2002). Wu MS, Chen CJ, Lin MT, Wang HP, Shun CT, Sheu JC, et al. Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan. Int J Colorectal Dis 17: 338-43 (2002). Yin B, Whyatt RM, Perera FP et al. Determination of 8-hydroxydeoxyquanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA. Free Radic Biol Med 18: 1023-1032 (1995). Yingyan G, Reiko K, Setsuko K et al. Visual Dysfunction in Workers Exposed to a Mixture of Organic Solvents. NeuroToxicology 24:703-710 (2003). Zavalić M, Mandić Z, Turk R, Bogadi-Šare A, Plavec D. Quantitative assessment of color vision impairment in workers exposed to toluene. Am. J. Ind. Med. 33:297–304 (1998). Zhu J; Cao XL; Beauchamp R: Determination of 2-butoxyethanol emissions from selected consumer products and its application in assessment of inhalation exposure associated with cleaning tasks. Environ Int 26:589–597 (2001). 王建彬:我國自行車產業回顧與展望。產業雜誌2009年8月。 行政院勞工委員會:勞工作業環境空氣中有害物容許濃度標準。中華民國99年1月5日行政院勞工委員會(99)勞安 3 字第 0980146513 號令修正發布。http://www.iosh.gov.tw/Law/LawPublish.aspx?LID=77#File。 行政院勞工委員會:勞委會勞工安全衛生設施規則。中華民國98年10月13日行政院勞工委員會(98)勞安 3 字第 0980146173 號令修正發布。http://www.iosh.gov.tw/law/LawPublish.aspx?LID=4。 莊淳宇、洪瑞琦、張祐剛、宋鴻樟,計程車司機尿液中1-羥基芘與氧化傷害的比對。台灣衛誌 2002;21(3):181-188。 陳妤瑄、張世沛、李名世、胡淼琳,心血管病人血漿中同半胱胺酸(Homocysteine)、丙二醛(MDA)及總抗氧化力(ORAC)之含量與其相關性。醫檢會報 2005(2):26-32。 蔡孟勳,探討通氣量對於樟芝醱酵生產抗氧化物質之影響。國立中央大學化學工程與材料工程研究所碩士論文。2004。 鄭淑芳、王守堅:自行車噴漆作業有機溶劑暴露調查研究。行政院勞工委員會勞工安全衛生研究所98年度研究報告。IOSH98-A316,2010。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48180 | - |
dc.description.abstract | 由於乙二醇醚類(glycol ethers)溶劑的物理及化學特性,其被廣泛地使用於工業及家庭中,如轉印高級自行車的車身圖騰時就需要使用乙二醇丁醚(2-butoxyethanol, 2-BE)溶劑。為了要讓產品更為精良,自行車貼標工人是以手工、未穿戴防護手套的方式工作,且需直接以雙手接觸約10%(v/v) 2-BE稀釋溶液,並控制2-BE溶液的溫度,在此種作業條件下,可能會大大地增加勞工2-BE攝入體內的風險,而2-BE的健康效應,主要是在紅血球細胞(red blood cells)的不良效應上。
本研究即是以較高2-BE攝入風險的自行車2-BE貼標工為採樣對象,分析其尿中總BAA濃度,來探討使用2-BE之職場勞工實際總攝入2-BE的情形,以及體內累積情形,並以血紅素濃度値評估2-BE對職場勞工造血系統的危害情形;進一步探討2-BE可能的氧化壓力及視覺功能影響,此外亦評估CYP 2E1的基因多形性對於2-BE代謝可能的影響。 研究總計有80位受測者,包括31位自行車2-BE貼標作業的勞工、25位主要黏貼一般標籤勞工及24位裝配工。在休假後的第1天及連續工作第5天時,進行作業環境空氣個人採樣及工作前後的尿液收集,之後以(gas chromatograph/flame ionization detector, GC/FID)進行空氣樣本2-BE、以(gas chromatography/mass spectrometry, GC/MS)進行尿中總丁氧基乙酸(total butoxyacetic acid, total BAA)的分析。除了進行受測者作業環境2-BE及其生物指標濃度的測定外,本研究亦進行問卷調查,並於連續工作第5天時抽血進行評估受測者的血紅素濃度、氧化性壓力程度、抗氧化能力、基因多型性及視覺功能情形。 結果顯示,31位自行車2-BE貼標作業的勞工,2天採樣的個人暴露環境2-BE濃度分別為1.89及1.57 ppm,工作後的尿中總丁氧基乙酸濃度分別為446.8及619.4 mg/g creatinine,勞工暴露2-BE的空氣濃度與工作後尿中total BAA濃度相關性不佳。雖然本研究勞工個人暴露2-BE的濃度約只有ACGIH建議濃度的8.5%,但是,採樣2天工作後的尿中總BAA濃度卻分別超出ACGIH建議BEI値的123%及210%,但尚未發現造成勞工血色素降低的造血系統不良效應。本研究亦推測在自行車2-BE貼標作業條件下,皮膚直接接觸2-BE水溶液是造成勞工2-BE吸收的主要原因,且2-BE在此職場環境中有明顯的體內累積現象。因此建議在工作週最後一天的工作後進行尿液採樣,為進行2-BE生物偵測的較佳時機點。 雖然過去文獻建議可將視力異常做為有機溶劑中毒損傷的早期指標,但本研究中在顏色混亂指數(color confusion index, CCI)及對比敏感度(contrast sesitivity)項目,2-BE的貼標工和裝配工(未暴露任何溶劑)均無顯著差異,顯示暴露在約1.7ppm乙二醇單丁醚,並直接以雙手接觸約10%(v/v) 2-BE稀釋溶液的作業方式,似未造成視覺功能的異常。 使用2-BE的貼標工和裝配工,在採樣週第5天工作後尿中8-OhdG濃度値、血中骨髓過氧化酵素(MPO)濃度値平均值並沒有呈現顯著差異。由於受測者大都無抽煙和喝酒習慣,此意味著暴露在此濃度的乙二醇單丁醚,並未造成DNA氧化傷害和體內發炎異常的情形。 過去曾有研究發現CYP 2E1基因多型性,可能與造成尿中較低濃度free BAA有可能的相關性。在本研究中利用複回歸分析2-BE貼標工星期五工作後尿中BAA和CYP 2E1基因多型性、空氣中2BE濃度的相關性,結果發現在控制空氣中2BE濃度後,CYP 2E1基因多型性(Rsa I和 Dra I)和工作後尿中BAA並無顯著相關。因此依據本研究的結果,初步推測CYP 2E1基因多型性,可能並非2BE代謝的一個調節因子(modifying factor)。但是由於本研究並未估算2-BE貼標工皮膚暴露的情形,僅由空氣中2-BE濃度納入分析,並無法完全代表其暴露程度,此外alcohol dehydrogenase 2和aldehyde dehydrogenase 2在本研究中亦未進行分析,因此CYP 2E1基因多型性,對於2-BE代謝的可能影響仍有待進一步研究釐清。 | zh_TW |
dc.description.abstract | Glycol ethers are widely used in industrial and household applications because of their chemical and physical properties. During the manufacturing process of bicycles, the dilute aqueous solution of 2-butoxyethanol (2-BE) is used to transfer decals to the frames. Workers usually transfer the decals by hand without using protective gloves. The concentration of dilute aqueous solution of 2-BE is about 10% (vol/vol), and the temperature is kept at around 25-30℃. Such work pattern will increase the exposure risk of 2-BE. Various animal studies using different routes of exposure (oral, inhalation, and dermal) have shown 2-BE to cause decreases in red blood cell counts and hemoglobin concentration, as well as red blood cell hemolysis, hemolytic anemia, and red blood cell osmotic fragility.
The objectives of this study were to evaluate the 2-BE exposure and hydrolyzed 2-butoxyacetic acid of the 2-BE transfer workers, 2-BE effect on oxidative stress and visual function, and to test the effects of the CYP2E1 genetic polymorphism on metabolism of 2-BE. In the current study, 80 workers (including 31 2-BE transfer workers, 25 self-adhesive decals workers, and 24 assembly workers) were comprised at two bicycle manufacturing factories. Sociodemographics, work history, lifestyle factors, medical history, and subjective symptom were investigated by questionnaires. Subject 2-BE in personal air, pre- and post-work urines were sampled on the first (W1) and the fifth (W5) workday after a holiday. These samples were analyzed by gas chromatograph/flame ionization detector (2-BE in air) and gas chromatography/mass spectrometry (hydrolyzed 2-butoxyacetic acid, total BAA). Further, Subject blood was drawn from a vein for hemoglobin, oxidative stress, and polymorphism analysis. Color vision and contrast sensitivity were also conducted to evaluate the visual function of the subjects. Of the 31 2-BE transfer subjects, mean 2-BE air level was 1.89 (W1) and 1.57 ppm (W5), and average postshift urinary total BAA was 446.8 (W1) and 619.4 mg/g creatinine (W5). Correlation of 2-BE air levels and postshift urinary BAA levels on these two workdays was poor. Although 2-BE air level was around 8.5% of the current TLV–TWA, the postshift BAA in urine of W1 and W5 was 123% and 210% more than the value of BEI, respectively. No hematopoietic effect was found for the study subjects.We speculated that the main reason for 2-BE absorption of them could be ascribed to the direct dermal contact. The evidence of accumulation also appeared in current research with the exposures of low-level 2-BE. Therefore, for the biological monitoring, it is highly recommended that the urine sample should be collected at the end of the workweek. Many researches have already examined the effects of organic solvents on visual function. The color confusion index and visual contrast sensitivity test are some of the techniques purported to be a sensitive indicator. However, there was no significant difference between 2-BE transfer workers and assembly workers on these two indices. No visual dysfunction was found in the study subjects performed their tasks with hands direct contact to dilute aqueous solution of 2-BE (10%). Of the oxidative stress, such as 8-OhdG and myeloperoxidase, there was also no significant difference between 2-BE transfer workers and assembly workers. Most of the subjects did not have alcoholic drinking and smoking habits. It seemed that exposure to low-level 2-BE did not cause significant difference of oxidative stress. Previous study has reported a possible connection between mutant CYP2E1 genotype and low urinary excretion of free BAA in exposure to 2-BE. Our results showed that, after adjustment for 2-BE concentrations in personal air, neither Rsa I site polymorphism nor Dra I site polymorphism was significantly associated with the urinary BAA. This indicates that the CYP2E1 polymorphism may not be a modifying factor of 2-BE metabolism to modulate the excretion of urinary total BAA in our study population. Since 2-BE exposure from dermal route, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 were not evaluated in our study, the influence of the genetic polymorphism for CYP2E1 deserves further investigation for the interpretation of urinary BAA measurements. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T06:48:11Z (GMT). No. of bitstreams: 1 ntu-100-D94844004-1.pdf: 919997 bytes, checksum: 2fdba3c112fc3634ac695dd4a8bf6ff7 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 目錄
口試委員會審定書 i 誌謝 ii 摘要 iii Abstract v 第一章 前言 1 第一節 序論 1 第二節 研究目的 2 第二章 文獻探討 4 第一節 台灣地區自行車產業概況 4 第二節 自行車製造流程 4 第三節 自行車製造業職業衛生相關研究 5 第四節 乙二醇丁醚(2-butoxyethanol, 2-BE)及尿中代謝物-丁氧基乙酸(butoxyacetic acid, BAA)介紹 6 第五節 視力評估方法 23 第六節 氧化性壓力及抗氧化能力評估 26 第七節 研究架構 31 第三章 材料與方法 35 第一節 研究材料 35 第二節 研究方法 36 第四章 結果 53 第一節 問卷調查 53 第二節 作業環境測定 59 第三節 2-BE尿中代謝物-水解BAA 60 第四節 血紅素 63 第五節 視覺能力 64 第六節 氧化性壓力 70 第七節 抗氧化能力 71 第八節 個人基因多型性 72 第五章 討論 76 第一節 2-BE及水解BAA 76 第二節 血紅素 79 第三節 視覺能力 79 第四節 氧化性壓力 81 第五節 抗氧化能力 82 第六節 個人基因多型性 82 第六章 結論與建議 86 參考文獻 88 附錄一 研究問卷 96 | |
dc.language.iso | zh-TW | |
dc.title | 自行車貼標作業勞工乙二醇丁醚暴露調查及健康效應評估研究 | zh_TW |
dc.title | 2-Butoxyethanol Exposures and Health Effect Assessment for Decal Transfer Workers in Bicycle Manufacturing Factories | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 劉紹興 | |
dc.contributor.oralexamcommittee | 毛義方,郭育良,陳保中 | |
dc.subject.keyword | 乙二醇丁醚,貼標工人,丁氧基乙酸,生物偵測,視覺功能,氧化壓力,基因多型性, | zh_TW |
dc.subject.keyword | 2-butoxyethanol,transfer workers,butoxyacetic acid,biological monitoring,visual function,oxidative stress,genetic polymorphism, | en |
dc.relation.page | 108 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-05-16 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 環境衛生研究所 | zh_TW |
顯示於系所單位: | 環境衛生研究所 |
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